Abstract:
:Mast cells with the morphological and biochemical properties of mucosal mast cells (MMC) appear and proliferate to form the predominant cell type in rat bone marrow cultures stimulated with factors from antigen- or mitogen-activated lymphocytes. Conditioned media causing a selective proliferation of MMC were derived from mesenteric lymph node cells of Nippostrongylus brasiliensis-infected rats restimulated in vitro with specific antigen or from normal or infected rat mesenteric lymph node cells stimulated with concanavalin A. MMC growth factor is not produced by T-cell-depleted mesenteric lymph node cells or by the mesenteric lymph node cells of athymic rats. By contrast, MMC precursors are present in the bone marrow of athymic rats and are normally receptive to the growth factor produced by the lymphocytes of thymus-intact rats. The thymus dependence of MMC hyperplasia is thus based on the requirement of a thymus-independent precursor for a T-cell-derived growth promoter.
journal_name
Proc Natl Acad Sci U S Aauthors
Haig DM,McMenamin C,Gunneberg C,Woodbury R,Jarrett EEdoi
10.1073/pnas.80.14.4499subject
Has Abstractpub_date
1983-07-01 00:00:00pages
4499-503issue
14eissn
0027-8424issn
1091-6490journal_volume
80pub_type
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