Ganglioside inhibition of fibronectin-mediated cell adhesion to collagen.

abstract：:Fe(CN)6(-3) oxidation of the aerobically isolated 7Fe Azotobacter vinelandii ferredoxin I, (7Fe)FdI, is a degradative reaction. Destruction of the [4Fe-4S] cluster occurs first, followed by destruction of the [3Fe-3S] cluster. At a Fe(CN)6(-3)/(7Fe)FdI concentration ratio of 20, the product is a mixture of apoprotein ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stephens PJ,Morgan TV,Devlin F,Penner-Hahn JE,Hodgson KO,Scott RA,Stout CD,Burgess BK

更新日期：1985-09-01 00:00:00

abstract：:Three lines of evidence for abrupt tropical climate change, both past and present, are presented. First, annually and decadally averaged delta(18)O and net mass-balance histories for the last 400 and 2,000 yr, respectively, demonstrate that the current warming at high elevations in the mid- to low latitudes is unprece...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thompson LG,Mosley-Thompson E,Brecher H,Davis M,León B,Les D,Lin PN,Mashiotta T,Mountain K

更新日期：2006-07-11 00:00:00

abstract：:Poly(A)-containing HeLa cell mRNA prepared from cells labeled with [methyl-(3)H]methionine or [(32)P]phosphate was found to contain a variety of methylated, blocked 5'-terminal structures of two general types: m(7)GpppN(7)-Np and m(7)GpppN(m)-N(m)-Np. In addition, about one-third of the [(3)H]methyl label was present ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Furuichi Y,Morgan M,Shatkin AJ,Jelinek W,Salditt-Georgieff M,Darnell JE

更新日期：1975-05-01 00:00:00

abstract：:Growing knowledge of the key molecular components involved in biological processes such as endocytosis, exocytosis, and motility has enabled direct testing of proposed mechanistic models by reconstitution. However, current techniques for building increasingly complex cellular structures and functions from purified com...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Richmond DL,Schmid EM,Martens S,Stachowiak JC,Liska N,Fletcher DA

更新日期：2011-06-07 00:00:00

abstract：:We have compared chicken erythrocyte linker histones H1 and H5 binding to a synthetic four-way DNA junction. Each histone binds to form a single complex, with an affinity which permits competition against a large excess of linear duplex DNA. The affinity of H5 is higher than that of H1. The globular domain from either...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Varga-Weisz P,Zlatanova J,Leuba SH,Schroth GP,van Holde K

更新日期：1994-04-26 00:00:00

abstract：:Blood cells transplantation is largely replacing bone marrow transplantation because engraftment is more rapid. This accelerated engraftment is thought to be mediated by relatively mature committed hematopoietic progenitor cells. Herein, we have used a modified rhodamine (Rho) staining procedure to identify and purify...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zijlmans JM,Visser JW,Laterveer L,Kleiverda K,Heemskerk DP,Kluin PM,Willemze R,Fibbe WE

更新日期：1998-01-20 00:00:00

abstract：:The basidiomycete Ustilago maydis is the causative agent of the disease corn smut. To be pathogenic, strains of U. maydis must be heterozygous for a locus called "b," which appears to control both pathogenicity and sexual development. Two alleles of the b locus of U. maydis were isolated by complementation and hybridi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kronstad JW,Leong SA

更新日期：1989-02-01 00:00:00

abstract：:Group II intron RNAs self-splice in vitro but only at high salt and/or Mg2+ concentrations and have been thought to require proteins to stabilize their active structure for efficient splicing in vivo. Here, we show that a DEAD-box protein, CYT-19, can by itself promote the splicing and reverse splicing of the yeast aI...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mohr S,Matsuura M,Perlman PS,Lambowitz AM

更新日期：2006-03-07 00:00:00

abstract：:Extracts of cultured human leukemic tissues increased the spleen focus-forming activity of Friend leukemia virus preparations in BALB/c and other partially resistant mice. Such mice carry the Fv-1(b) gene, which inhibits the expression of helper virus indigenous to the Friend virus complex, and allows co-infecting leu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Steeves RA,Fjelde A,Mirand EA

更新日期：1971-10-01 00:00:00

abstract：:Chlorpromazine (3 x 10(-4)M) prevents the stimulation of adenyl cyclase activity in thyroid membranes produced by thyrotropin and prostaglandin, ACTH stimulation of adenyl cyclase in adrenal tissue, and glucagon- and epinephrine-stimulation of adenyl cyclase activity in liver. Baseline activity is unaffected. Parathyr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wolff J,Jones AB

更新日期：1970-02-01 00:00:00

abstract：:It has recently been demonstrated that coupled enzymatic processes may possess, for a particular choice of the state variables, multidimensional inflection points in thermodynamic force-flow space. The conditions for reciprocity in the linear region near such a reference state, which may be far from equilibrium, are o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Caplan SR

更新日期：1981-07-01 00:00:00

abstract：:The paradigmatic example of a continuous quantum phase transition is the transverse field Ising ferromagnet. In contrast to classical critical systems, whose properties depend only on symmetry and the dimension of space, the nature of a quantum phase transition also depends on the dynamics. In the transverse field Isi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maharaj AV,Rosenberg EW,Hristov AT,Berg E,Fernandes RM,Fisher IR,Kivelson SA

更新日期：2017-12-19 00:00:00

abstract：:Insulin resistance is a key factor in the etiology of type 2 diabetes. Insulin-stimulated glucose uptake is mediated by the glucose transporter 4 (GLUT4), which is expressed mainly in skeletal muscle and adipose tissue. Insulin-stimulated translocation of GLUT4 from its intracellular compartment to the plasma membrane...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baeza-Raja B,Li P,Le Moan N,Sachs BD,Schachtrup C,Davalos D,Vagena E,Bridges D,Kim C,Saltiel AR,Olefsky JM,Akassoglou K

更新日期：2012-04-10 00:00:00

abstract：:Levinthal's paradox is that finding the native folded state of a protein by a random search among all possible configurations can take an enormously long time. Yet proteins can fold in seconds or less. Mathematical analysis of a simple model shows that a small and physically reasonable energy bias against locally unfa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zwanzig R,Szabo A,Bagchi B

更新日期：1992-01-01 00:00:00

abstract：:We have isolated and characterized the complete human villin gene. The villin gene is located on chromosome 2q35-36 in humans and on chromosome 1 in mice. Villin belongs to a family of calcium-regulated actin-binding proteins that share structural and functional homologies. The villin gene is expressed mainly in cells...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pringault E,Robine S,Louvard D

更新日期：1991-12-01 00:00:00

abstract：:A gene's expression pattern provides clues to its role in normal physiology and disease. To provide quantitative expression levels on a genome-wide scale, the Cancer Genome Anatomy Project (CGAP) uses serial analysis of gene expression (SAGE). Over 5 million transcript tags from more than 100 human cell types have bee...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boon K,Osorio EC,Greenhut SF,Schaefer CF,Shoemaker J,Polyak K,Morin PJ,Buetow KH,Strausberg RL,De Souza SJ,Riggins GJ

更新日期：2002-08-20 00:00:00

abstract：:The activity of reconstituted cytochrome-c oxidase (EC 1.9.3.1) from bovine heart is stimulated by intraliposomal ADP but not by NaCl of the same ionic strength. A monoclonal antibody which reacts with subunits VIa-H (heart-type) and VIc, due to the evolutionary relationship between these subunits, also stimulates the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Anthony G,Reimann A,Kadenbach B

更新日期：1993-03-01 00:00:00

abstract：:Asexual freshwater planarians reproduce by tearing themselves into two pieces by a process called binary fission. The resulting head and tail pieces regenerate within about a week, forming two new worms. Understanding this process of ripping oneself into two parts poses a challenging biomechanical problem. Because pla...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Malinowski PT,Cochet-Escartin O,Kaj KJ,Ronan E,Groisman A,Diamond PH,Collins ES

更新日期：2017-10-10 00:00:00

abstract：:We have previously shown that chronic activation of mitogenic signaling induced by over-expression of c-myc and transforming growth factor-alpha (TGFalpha) transgenes in mouse liver induces a state of oxidative stress. We therefore proposed that increased reactive oxygen species (ROS) generation might be responsible f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Factor VM,Laskowska D,Jensen MR,Woitach JT,Popescu NC,Thorgeirsson SS

更新日期：2000-02-29 00:00:00

abstract：:The rat brain-derived neurotropic factor (BDNF) gene consists of four 5' exons linked to separate promoters and one 3' exon encoding the prepro-BDNF protein. To gain insights into the regulation of BDNF mRNA expression, probes specific for the different 5' exons were used to study the expression of BDNF mRNA in the br...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Metsis M,Timmusk T,Arenas E,Persson H

更新日期：1993-10-01 00:00:00

abstract：:A mutant of E. coli defective in DNA polymerase II activity was isolated. Extracts had about 0.1% of the normal activity of the DNA polymerase. The effect of the mutation on the ability of cells to replicate DNA of various sources was analyzed. Mutant bacteria grow normally, at 41 degrees as well as at 30 degrees . Al...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hirota Y,Gefter M,Mindich L

更新日期：1972-11-01 00:00:00

abstract：:The hippocampus has a well-documented role for spatial navigation across species, but its role for spatial memory in nonnavigational tasks is uncertain. In particular, when monkeys are tested in tasks that do not require navigation, spatial memory seems unaffected by lesions of the hippocampus. However, the interpreta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Forcelli PA,Palchik G,Leath T,DesJardin JT,Gale K,Malkova L

更新日期：2014-03-18 00:00:00

abstract：:Cytochrome c oxidase (ferrocytochrome c: oxygen oxidoreductase, EC 1.9.3.1) has been resolved into a pair of complexes of unequal molecular weight. The larger complex (electron transfer complex) contains exclusively the oxidation-reduction proteins characteristic of cytochrome oxidase; the smaller complex (ion transfe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fry M,Vande Zande H,Green DE

更新日期：1978-12-01 00:00:00

abstract：:Despite early speculation to the contrary, all tropical forests studied to date display seasonal variations in the presence of new leaves, flowers, and fruits. Past studies were focused on the timing of phenological events and their cues but not on the accompanying changes in leaf area that regulate vegetation-atmosph...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Myneni RB,Yang W,Nemani RR,Huete AR,Dickinson RE,Knyazikhin Y,Didan K,Fu R,Negrón Juárez RI,Saatchi SS,Hashimoto H,Ichii K,Shabanov NV,Tan B,Ratana P,Privette JL,Morisette JT,Vermote EF,Roy DP,Wolfe RE,Friedl MA,

更新日期：2007-03-20 00:00:00

abstract：:The DNA of functional cis-regulatory modules displays extensive sequence conservation in comparisons of genomes from modestly distant species. Patches of sequence that are several hundred base pairs in length within these modules are often seen to be 80-95% identical, although the flanking sequence cannot even be alig...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cameron RA,Chow SH,Berney K,Chiu TY,Yuan QA,Krämer A,Helguero A,Ransick A,Yun M,Davidson EH

更新日期：2005-08-16 00:00:00

abstract：:A series of small peptides corresponding to the amino termini of the fibrin alpha- and beta-chains has been synthesized. The peptides glycyl-L-prolyl-L-arginyl-L-proline and glycyl-L-prolyl-L-arginylsarcosine are potent inhibitors of fibrin polymerization. Moreover, these peptides have a natural stability stemming fro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Laudano AP,Doolittle RF

更新日期：1978-07-01 00:00:00

abstract：:A computer code to investigate the equilibrium and stability of a diffuse plasma in three dimensions is described that generalizes earlier work on a sharp free boundary model. Toroidal equilibria of a plasma are determined by considering paths of steepest descent associated with a new version of the variational princi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Betancourt O,Garabedian P

更新日期：1976-04-01 00:00:00

abstract：:Full-length tissue factor (flTF), the coagulation initiator, is overexpressed in breast cancer (BrCa), but associations between flTF expression and clinical outcome remain controversial. It is currently not known whether the soluble alternatively spliced TF form (asTF) is expressed in BrCa or impacts BrCa progression....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kocatürk B,Van den Berg YW,Tieken C,Mieog JS,de Kruijf EM,Engels CC,van der Ent MA,Kuppen PJ,Van de Velde CJ,Ruf W,Reitsma PH,Osanto S,Liefers GJ,Bogdanov VY,Versteeg HH

更新日期：2013-07-09 00:00:00

abstract：:A protein that specifically binds leukemia inhibitory factor (LIF) has been isolated from normal mouse serum by using four successive fractionation steps: chromatography on a LIF affinity matrix, anion-exchange chromatography, size-exclusion chromatography, and preparative native gel electrophoresis. The purified LIF-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Layton MJ,Cross BA,Metcalf D,Ward LD,Simpson RJ,Nicola NA

更新日期：1992-09-15 00:00:00

abstract：:Nodules harboring nitrogen-fixing rhizobia are a well-known trait of legumes, but nodules also occur in other plant lineages, with rhizobia or the actinomycete Frankia as microsymbiont. It is generally assumed that nodulation evolved independently multiple times. However, molecular-genetic support for this hypothesis ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： van Velzen R,Holmer R,Bu F,Rutten L,van Zeijl A,Liu W,Santuari L,Cao Q,Sharma T,Shen D,Roswanjaya Y,Wardhani TAK,Kalhor MS,Jansen J,van den Hoogen J,Güngör B,Hartog M,Hontelez J,Verver J,Yang WC,Schijlen E,Repin

更新日期：2018-05-15 00:00:00