Tissue-specific regulation of bovine heart cytochrome-c oxidase activity by ADP via interaction with subunit VIa.

abstract：:Mitochondrial DNA from several mammalian species has been digested with a site-specific restriction endonuclease (HaeIII) from Haemophilus aegyptius. A quantitative analysis of the resulting specific fragments indicates that the mtDNA of any individual mammal is predominantly a single molecular clone. Gel analysis of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Potter SS,Newbold JE,Hutchison CA 3rd,Edgell MH

更新日期：1975-11-01 00:00:00

abstract：:Memory stretches over a lifetime. In controlled laboratory settings, the hippocampus and other medial temporal lobe brain structures have been shown to represent space and time on the scale of meters and seconds. It remains unclear whether the hippocampus also represents space and time over the longer scales necessary...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nielson DM,Smith TA,Sreekumar V,Dennis S,Sederberg PB

更新日期：2015-09-01 00:00:00

abstract：:Transcriptional activation of the HIV type 1 (HIV-1) long terminal repeat (LTR) promoter element by the viral Tat protein is an essential step in the HIV-1 life cycle. Tat function is mediated by the TAR RNA target element encoded within the LTR and is known to require the recruitment of a complex consisting of Tat an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bieniasz PD,Grdina TA,Bogerd HP,Cullen BR

更新日期：1999-07-06 00:00:00

abstract：:The murine pre-B leukemic cell line 70Z/3 contains both an unrearranged immunoglobulin kappa-light-chain gene and a functionally rearranged but silent kappa-light-chain gene. Mitogenic stimulation of growing 70Z/3 cells with bacterial lipopolysaccharide (LPS) activates kappa-light-gene transcription and results in a 1...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wall R,Briskin M,Carter C,Govan H,Taylor A,Kincade P

更新日期：1986-01-01 00:00:00

abstract：:Active center fractions have been prepared from Rhodopseudomonas spheroides strain Y. (de Klerk) using the cationic detergent cetyltrimethyl ammonium bromide and light particles from bacteria grown in two media differing in iron content. Spectral properties and composition of the fractions are presented. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jolchine G,Reiss-Husson F,Kamen MD

更新日期：1969-10-01 00:00:00

abstract：:The synthesis of the proteins laminin and collagen IV is stimulated approximately equal to 20-fold in F9 mouse teratocarcinoma stem cells after treatment of the cells with retinoic acid and N6, O2'-dibutyryl-cAMP (Bt2cAMP). A cDNA library from F9 cells treated with retinoic acid, Bt2cAMP, and theophylline (F9-R + DBC ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang SY,Gudas LJ

更新日期：1983-10-01 00:00:00

abstract：:One hundred fifty years ago glial cells were discovered as a second, non-neuronal, cell type in the central nervous system. To ascribe a function to these new, enigmatic cells, it was suggested that they either glue the neurons together (the Greek word "gammalambdaiotaalpha" means "glue") or provide a robust scaffold ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lu YB,Franze K,Seifert G,Steinhäuser C,Kirchhoff F,Wolburg H,Guck J,Janmey P,Wei EQ,Käs J,Reichenbach A

更新日期：2006-11-21 00:00:00

abstract：:The catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) is a classical nonhomologous end-joining (cNHEJ) factor. Loss of DNA-PKcs diminished mature B cell class switch recombination (CSR) to other isotypes, but not IgG1. Here, we show that expression of the kinase-dead DNA-PKcs (DNA-PKcsKD/KD ) severely compr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Crowe JL,Shao Z,Wang XS,Wei PC,Jiang W,Lee BJ,Estes VM,Alt FW,Zha S

更新日期：2018-08-21 00:00:00

abstract：:Glucagon-like peptide-1 (GLP-1), released from gut endocrine L cells in response to glucose, regulates appetite, insulin secretion, and gut motility. How glucose given orally, but not systemically, induces GLP-1 secretion is unknown. We show that human duodenal L cells express sweet taste receptors, the taste G protei...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jang HJ,Kokrashvili Z,Theodorakis MJ,Carlson OD,Kim BJ,Zhou J,Kim HH,Xu X,Chan SL,Juhaszova M,Bernier M,Mosinger B,Margolskee RF,Egan JM

更新日期：2007-09-18 00:00:00

abstract：:The resonance Raman excitation profiles of a number of charge transfer transitions in electron donor/acceptor complexes with tetracyanoethylene as acceptor in solution at room temperature are reported and compared with absorption and fluorescence spectra of these complexes. All complexes show distinct anomalies which ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Michaelian KH,Rieckhoff KE,Voigt EM

更新日期：1975-11-01 00:00:00

abstract：:Elongin is a heterotrimeric transcription elongation factor composed of subunits A, B, and C in mammals. Elongin A and C are F-box-containing and SKP1 homologue proteins, respectively, and are therefore of interest for their potential roles in cell cycle-dependent proteolysis. Mammalian elongin C interacts with both e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Botuyan MV,Koth CM,Mer G,Chakrabartty A,Conaway JW,Conaway RC,Edwards AM,Arrowsmith CH,Chazin WJ

更新日期：1999-08-03 00:00:00

abstract：:Targeted drug delivery critically depends on the binding selectivity of cargo-transporting colloidal particles. Extensive theoretical work has shown that two factors are necessary to achieve high selectivity for a threshold receptor density: multivalency and weak interactions. Here, we study a model system of DNA-coat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scheepers MRW,van IJzendoorn LJ,Prins MWJ

更新日期：2020-09-15 00:00:00

abstract：:The VX2 carcinoma-bearing rabbit is an animal model for tumor-induced hypercalcemia, thought to be due to increased bone destruction effected by prostaglandin E2. The present experiments suggest that the pathophysiology of the hypercalcemia differs from that previously proposed. Tumor was transplanted intramuscularly ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Doppelt SH,Slovik DM,Neer RM,Nolan J,Zusman RM,Potts JT Jr

更新日期：1982-01-01 00:00:00

abstract：:The F-box protein Skp2 (S-phase kinase-associated protein 2) positively regulates the G(1)-S transition by controlling the stability of several G(1) regulators, such as the cell cycle inhibitor p27. We show here that Skp2 expression correlates directly with grade of malignancy and inversely with p27 levels in human ly...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Latres E,Chiarle R,Schulman BA,Pavletich NP,Pellicer A,Inghirami G,Pagano M

更新日期：2001-02-27 00:00:00

abstract：:The diversity of the T cell receptor (TCR) repertoire is limited, because of the processes of positive and negative T cell selection. To obtain T cells with specificities beyond the immune system's capacity, we have developed a strategy for retroviral TCR display. In this approach, a library of T cell variants is gene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kessels HW,van Den Boom MD,Spits H,Hooijberg E,Schumacher TN

更新日期：2000-12-19 00:00:00

abstract：:With the collapse of fisheries in many parts of the world causing widespread economic harm, attention is focused on a possible cause and remedy of fishery collapse. Economic theory for managing a renewable resource, such as a fishery, leads to an ecologically unstable equilibrium as difficult to maintain as balancing ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roughgarden J,Smith F

更新日期：1996-05-14 00:00:00

abstract：:Evidence from more than 100 y of research indicates that conscientiousness (C) is the most potent noncognitive construct for occupational performance. However, questions remain about the magnitudes of its effect sizes across occupational variables, its defining characteristics and functions in occupational settings, a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wilmot MP,Ones DS

更新日期：2019-11-12 00:00:00

abstract：:KRAS interacts with the inner leaflet of the plasma membrane (PM) using a hybrid anchor that comprises a lysine-rich polybasic domain (PBD) and a C-terminal farnesyl chain. Electrostatic interactions have been envisaged as the primary determinant of interactions between KRAS and membranes. Here, we integrated molecula...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou Y,Prakash PS,Liang H,Gorfe AA,Hancock JF

更新日期：2021-02-09 00:00:00

abstract：:We studied the coupled binding and folding of alpha-synuclein, an intrinsically disordered protein linked with Parkinson's disease. Using single-molecule fluorescence resonance energy transfer and correlation methods, we directly probed protein membrane association, structural distributions, and dynamics. Results reve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ferreon AC,Gambin Y,Lemke EA,Deniz AA

更新日期：2009-04-07 00:00:00

abstract：:Cellular progenitors of the coronary vasculature are believed to enter the chicken heart during epicardial morphogenesis between stages 17 and 27 (days 3-5) of egg incubation. To trace cells which give rise to the coronary arteries in vivo, we applied retroviral cell tagging procedures and analyzed clonal populations ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mikawa T,Fischman DA

更新日期：1992-10-15 00:00:00

abstract：:Several models have been proposed for the infectious agents that cause human Creutzfeldt-Jakob disease (CJD) and sheep scrapie. Purified proteins and extracted nucleic acids are not infectious. To further identify the critical molecular components of the CJD agent, 120S infectious material with reduced prion protein (...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Manuelidis L,Sklaviadis T,Akowitz A,Fritch W

更新日期：1995-05-23 00:00:00

abstract：:We introduce a new genetic distance for microsatellite loci, incorporating features of the stepwise mutation model, and test its performance on microsatellite polymorphisms in humans, chimpanzees, and gorillas. We find that it performs well in determining the relations among the primates, but less well than other dist...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goldstein DB,Ruiz Linares A,Cavalli-Sforza LL,Feldman MW

更新日期：1995-07-18 00:00:00

abstract：:The increasing prevalence of antibiotic-resistant pathogens reinforces the need for structures of antibiotic-ribosome complexes that are accurate enough to enable the rational design of novel ribosome-targeting therapeutics. Structures of many antibiotics in complex with both archaeal and eubacterial ribosomes have be...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bulkley D,Innis CA,Blaha G,Steitz TA

更新日期：2010-10-05 00:00:00

abstract：:Human herpesvirus 6 (HHV-6) like other herpesviruses, expresses sequentially immediate early (IE), early, and late genes during lytic infection. Evidence of ability to establish latent infection has not been available, but by analogy with other herpesviruses it could be expected that IE genes that regulate and transac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rotola A,Ravaioli T,Gonelli A,Dewhurst S,Cassai E,Di Luca D

更新日期：1998-11-10 00:00:00

abstract：:2-[4-(3,4-Dichlorophenylureido)phenoxy]-2-methylpropionic acid, LR16, combines with two symmetrically related sites in the central cavity of deoxyhemoglobin, 20 A away from the binding site of 2,3-bisphosphoglycerate, and acts as an allosteric effector synergistic with 2,3-bisphosphoglycerate. LR16 (1 mM) raises P50, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lalezari I,Rahbar S,Lalezari P,Fermi G,Perutz MF

更新日期：1988-08-01 00:00:00

abstract：:The present studies were conducted to determine whether prostaglandin F2 alpha (PGF2 alpha) stimulates the production of "second messengers" derived from inositol phospholipid hydrolysis and increases intracellular free Ca2+ ([Ca2+]i) in isolated bovine luteal cells. PGF2 alpha provoked rapid (10 sec) and sustained (u...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Davis JS,Weakland LL,Weiland DA,Farese RV,West LA

更新日期：1987-06-01 00:00:00

abstract：:We recently found that scatter factor (SF), a cell motility factor with a multimodular structure, is identical to hepatocyte growth factor (HGF), a potent mitogen of various cell types. SF/HGF is the ligand of the c-Met receptor tyrosine kinase. Here we used transient expression of naturally occurring and in vitro mut...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hartmann G,Naldini L,Weidner KM,Sachs M,Vigna E,Comoglio PM,Birchmeier W

更新日期：1992-12-01 00:00:00

abstract：:We have isolated a human gastrin gene from a genomic library by employing a human gastrin cDNA clone as a hybridization probe. The total length of the gene is approximately 4.0 kilobase pairs, and the gene is separated into three exons and two introns. A 130-base-pair intron interrupts the coding region and a 3.0-kilo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ito R,Sato K,Helmer T,Jay G,Agarwal K

更新日期：1984-08-01 00:00:00

abstract：:Chromosome movement during mitosis is powered in part by energy released through the depolymerization of kinetochore microtubules (MTs). Strong but indirect evidence suggests the existence of a specialized coupling between kinetochores and MT plus ends that enables this transduction of chemical energy into mechanical ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Molodtsov MI,Grishchuk EL,Efremov AK,McIntosh JR,Ataullakhanov FI

更新日期：2005-03-22 00:00:00

abstract：:Periodicities in the polar/apolar character of the amino acid sequence of a protein can be examined by assigning to each residue a numerical hydrophobicity and searching for periodicity in the resulting one-dimensional function. The strength of each periodic component is the quantity that has been termed the hydrophob...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eisenberg D,Weiss RM,Terwilliger TC

更新日期：1984-01-01 00:00:00