Specific cleavage analysis of mammalian mitochondrial DNA.

abstract：:The symbiotic bacterium Wolbachia pipientis has been considered unique in its ability to cause multiple reproductive anomalies in its arthropod hosts. Here we report that an undescribed bacterium is vertically transmitted and associated with thelytokous parthenogenetic reproduction in Encarsia, a genus of parasitoid w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zchori-Fein E,Gottlieb Y,Kelly SE,Brown JK,Wilson JM,Karr TL,Hunter MS

更新日期：2001-10-23 00:00:00

abstract：:Searches of ribosomal RNA sequences for compensatory base changes preserving Watson-Crick base pairing have led to detailed models of the conserved secondary structures of these RNAs. In principle, tertiary interactions can also be detected by searches for phylogenetically covariant bases. Within a highly conserved re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ryan PC,Draper DE

更新日期：1991-07-15 00:00:00

abstract：:The conjugal transmission of plasmid ColE1 and its derivatives can lead to recA-independent recombination. The recombination is not observed during vegetative growth and takes place specifically between the sequences that are thought to represent the transfer origin of ColE1. This provides genetic evidence for breakag...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Warren GJ,Clark AJ

更新日期：1980-11-01 00:00:00

abstract：:An immature state of cellular differentiation--characterized by stem cell-like tendencies and impaired differentiation--is a hallmark of cancer. Using glioblastoma multiforme (GBM) as a model system, we sought to determine whether molecular determinants that drive cells toward terminal differentiation are also genetic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hu J,Ho AL,Yuan L,Hu B,Hua S,Hwang SS,Zhang J,Hu T,Zheng H,Gan B,Wu G,Wang YA,Chin L,DePinho RA

更新日期：2013-09-03 00:00:00

abstract：:DNA restriction fragments of the genes encoding HLA class II-beta antigens were compared in 34 patients with insulin-dependent diabetes mellitus and 34 HLA-DR-matched healthy individuals. Ninety-three fragments, determined by six restriction enzymes (EcoRI, EcoRV, HindIII, BamHI, Pvu II, and Taq I), were analyzed: (i)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cohen-Haguenauer O,Robbins E,Massart C,Busson M,Deschamps I,Hors J,Lalouel JM,Dausset J,Cohen D

更新日期：1985-05-01 00:00:00

abstract：:Lignocellulosic plant biomass is an attractive feedstock for the production of sustainable biofuels, but the commercialization of such products is hampered by the high costs of processing this material into fermentable sugars (saccharification). One approach to lowering these costs is to produce crops with cell walls ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marriott PE,Sibout R,Lapierre C,Fangel JU,Willats WG,Hofte H,Gómez LD,McQueen-Mason SJ

更新日期：2014-10-07 00:00:00

abstract：:Interest in cell-associated collagens led others to isolate A and B collagen chains, also known as type V collagen, from many tissues, but only after pepsin cleavage. Soluble precursors of these chains are synthesized in vitro by crop, a chicken embryo muscle tissue, and are converted by at least two processing steps ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kumamoto CA,Fessler JH

更新日期：1980-11-01 00:00:00

abstract：:Human embryonic stem cells have the potential to differentiate into various cell types and, thus, may be useful as a source of cells for transplantation or tissue engineering. We describe here the differentiation steps of human embryonic stem cells into endothelial cells forming vascular-like structures. The human emb...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levenberg S,Golub JS,Amit M,Itskovitz-Eldor J,Langer R

更新日期：2002-04-02 00:00:00

abstract：:Tadpole collagenase (EC 3.4.24.3) cleaved chick cranial bone procollagen into two triple-stranded fragments, PCA and PCB. Only PCB, with an estimated molecular weight of about 60,000 for each component chain after reduction, was found to contain interchain disulfide bonds. The analogous cleavage of collagen is known t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Byers PH,Click EM,Harper E,Bornstein P

更新日期：1975-08-01 00:00:00

abstract：:A labile selenium donor compound monoselenophosphate is synthesized from selenide and ATP by selenophosphate synthetase (SPS). In the present study, Sps1 and Sps2 were cloned from a cDNA library prepared from human lung adenocarcinoma cells (NCIH441). The human lung Sps1 has been cloned as an ORF of 1,179 bp, identica...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tamura T,Yamamoto S,Takahata M,Sakaguchi H,Tanaka H,Stadtman TC,Inagaki K

更新日期：2004-11-16 00:00:00

abstract：:Due to the small size of a nanoconfinement, the property of water contained inside is rather challenging to probe. Herein, we measured the amount of water molecules released during the folding of individual G-quadruplex and i-motif structures, from which water activities are estimated in the DNA nanocages prepared by ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jonchhe S,Pandey S,Emura T,Hidaka K,Hossain MA,Shrestha P,Sugiyama H,Endo M,Mao H

更新日期：2018-09-18 00:00:00

abstract：:In classical evolutionary theory, traits evolve because they facilitate organismal survival and/or reproduction. We discuss a different type of evolutionary mechanism that relies upon differential dispersal. Traits that enhance rates of dispersal inevitably accumulate at expanding range edges, and assortative mating b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shine R,Brown GP,Phillips BL

更新日期：2011-04-05 00:00:00

abstract：:The bidirectional self-assembly of tobacco mosaic virus (TMV, common or U1 strain) has been studied extensively in vitro. Foreign single-stranded RNA molecules containing the TMV origin-of-assembly sequence (OAS, 75-432 nt in length) are also packaged by TMV coat protein (CP) in vitro to form helical pseudovirus parti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hwang DJ,Roberts IM,Wilson TM

更新日期：1994-09-13 00:00:00

abstract：:One-electron oxidation of zinc tetraphenylbacteriochlorin and its metal-free base yielded stable cation radicals. Electron spin resonance hyperfine splittings were assigned by selective deuterations. These results indicate that the protons of the saturated rings of the bacteriochlorins carry large spin densities, in a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fajer J,Borg DC,Forman A,Felton RH,Dolphin D,Vegh L

更新日期：1974-03-01 00:00:00

abstract：:Nitrogen metabolism in bacteria and archaea is regulated by a ubiquitous class of proteins belonging to the P(II)family. P(II) proteins act as sensors of cellular nitrogen, carbon, and energy levels, and they control the activities of a wide range of target proteins by protein-protein interaction. The sensing mechanis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rajendran C,Gerhardt EC,Bjelic S,Gasperina A,Scarduelli M,Pedrosa FO,Chubatsu LS,Merrick M,Souza EM,Winkler FK,Huergo LF,Li XD

更新日期：2011-11-22 00:00:00

abstract：:The adrenergic receptors (ARs) (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. We have previously assigned the genes for ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang-Feng TL,Xue FY,Zhong WW,Cotecchia S,Frielle T,Caron MG,Lefkowitz RJ,Francke U

更新日期：1990-02-01 00:00:00

abstract：:The remarkable strength of glasses is examined using the random first order transition theory of the glass transition. The theory predicts that strength depends on elastic modulus but also on the configurational energy frozen in when the glass is prepared. The stress catalysis of cooperative rearrangements of the type...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wisitsorasak A,Wolynes PG

更新日期：2012-10-02 00:00:00

abstract：:Different strains of Newcastle disease virus vary in their ability to induce cell fusion. When administered to cells at high multiplicities of infection some strains induce cell fusion within three hours. This type of fusion is apparently caused by the virus particles in the inoculum, since it can be induced by noninf...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bratt MA,Gallaher WR

更新日期：1969-10-01 00:00:00

abstract：:Methods for the construction of ordered nanoscale arrays have been implicated in fields ranging from separation technologies to microelectronics. Yet, despite the plethora of nanoscale structures assembled in nature that use a templating strategy, chemists have been unable to replicate this success. A technology is re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Willis B,Eubanks LM,Wood MR,Janda KD,Dickerson TJ,Lerner RA

更新日期：2008-02-05 00:00:00

abstract：:Mammalian visual systems are characterized by their ability to recognize stimuli invariant to various transformations. Here, we investigate the hypothesis that this ability is achieved by the temporal encoding of visual stimuli. By using a model of a cortical network, we show that this encoding is invariant to several...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wyss R,Konig P,Verschure PF

更新日期：2003-01-07 00:00:00

abstract：:Physiological sensing of O(2) tension (partial O(2) pressure, pO(2)) plays an important role in some mammalian cellular systems, but striated muscle generally is not considered to be among them. Here we describe a molecular mechanism in skeletal muscle that acutely couples changes in pO(2) to altered calcium release t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sun QA,Hess DT,Nogueira L,Yong S,Bowles DE,Eu J,Laurita KR,Meissner G,Stamler JS

更新日期：2011-09-20 00:00:00

abstract：:Cysteine site-directed mutagenesis was used to create variants of Escherichia coli ribosomal protein L7/L12 that have single cysteine substitutions, at residues 63 or 89, located in different exposed loops in the structure of the globular C-terminal domain indicated by the crystallographic structure. That structure sh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oleinikov AV,Jokhadze GG,Traut RR

更新日期：1993-11-01 00:00:00

abstract：:The neutrality theory predicts that the rate of neutral molecular evolution is constant over time, and thus that there is a molecular clock for timing evolutionary events. It has been observed that the variance of the rate of evolution is generally larger than expected according to the neutrality theory, which has rai...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rodríguez-Trelles F,Tarrío R,Ayala FJ

更新日期：2001-09-25 00:00:00

abstract：:Epithelial cells are organized into either a single layer (simple epithelia) or multiple layers (stratified epithelia). Maintenance of these cellular organizations requires distinct adhesive mechanisms involving many cell surface molecules. One such molecule is a cell surface proteoglycan, named syndecan, that contain...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sanderson RD,Bernfield M

更新日期：1988-12-01 00:00:00

abstract：:Adoptive cellular immunotherapy, infusions of interleukin 2 (IL-2) in conjunction with in vitro-activated killer cells, has brought new hope to patients with cancer. The broad application of this strategy, however, is constrained by the need for repeated leukapheresis and by the labor-intensive process of in vitro act...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakajima F,Khanna A,Xu G,Lagman M,Haschemeyer R,Mouradian J,Wang JC,Stenzel KH,Rubin AL,Suthanthiran M

更新日期：1994-08-16 00:00:00

abstract：:We study atomic models of the thermodynamics of the structural transition of peptides that form alpha-helices. The effect of sequence variation on alpha-helix formation for alanine-rich peptides, Ac-Ala21-methyl amide (A21) and Ac-A5 (AAARA)3A-methyl amide (Fs peptide), is investigated by atomic simulation studies of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： García AE,Sanbonmatsu KY

更新日期：2002-03-05 00:00:00

abstract：:Various enzymatic derivatives of the murine myeloma protein IgA(MOPC-315) were subjected to hapten-binding quantitation and circular dichroic analysis in an attempt to ascertain the structural localization and functional definition of the immunoglobulin active site. The extrinsic Cotton effects observed with near satu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Merz DC,Litman GW,Good RA

更新日期：1974-05-01 00:00:00

abstract：:Yawn contagion in humans has been proposed to be related to our capacity for empathy. It is presently unclear whether this capacity is uniquely human or shared with other primates, especially monkeys. Here, we show that in gelada baboons (Theropithecus gelada) yawning is contagious between individuals, especially thos...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Palagi E,Leone A,Mancini G,Ferrari PF

更新日期：2009-11-17 00:00:00

abstract：:Efforts to understand the dramatic declines in mortality over the past century have focused on life expectancy. However, understanding changes in disparity in age of death is important to understanding mechanisms of mortality improvement and devising policy to promote health equity. We derive a novel decomposition of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seligman B,Greenberg G,Tuljapurkar S

更新日期：2016-07-26 00:00:00

abstract：:One of the serious limitations of tokamaks as reactors is the occurrence of disruptions. Stellarators designed by advanced computational methods provide an attractive alternative for a major experiment in magnetic fusion research. Configurations with approximate two-dimensional magnetic symmetry have been found with h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Garabedian PR

更新日期：2000-02-01 00:00:00