Abstract:
:Carbon nanotube (CNT) membranes were employed as the active element of a switchable transdermal drug delivery device that can facilitate more effective treatments of drug abuse and addiction. Due to the dramatically fast flow through CNT cores, high charge density, and small pore dimensions, highly efficient electrophoretic pumping through functionalized CNT membrane was achieved. These membranes were integrated with a nicotine formulation to obtain switchable transdermal nicotine delivery rates on human skin (in vitro) and are consistent with a Fickian diffusion in series model. The transdermal nicotine delivery device was able to successfully switch between high (1.3 + or - 0.65 micromol/hr-cm(2)) and low (0.33 + or - 0.22 micromol/hr-cm(2)) fluxes that coincide with therapeutic demand levels for nicotine cessation treatment. These highly energy efficient programmable devices with minimal skin irritation and no skin barrier disruption would open an avenue for single application long-wear patches for therapies that require variable or programmable delivery rates.
journal_name
Proc Natl Acad Sci U S Aauthors
Wu J,Paudel KS,Strasinger C,Hammell D,Stinchcomb AL,Hinds BJdoi
10.1073/pnas.1004714107subject
Has Abstractpub_date
2010-06-29 00:00:00pages
11698-702issue
26eissn
0027-8424issn
1091-6490pii
1004714107journal_volume
107pub_type
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