Novel plasticity rule can explain the development of sensorimotor intelligence.

abstract：:Blocking CD28-B7 T-cell costimulation by systemic administration of CTLA4Ig, a fusion protein which binds B7 molecules on the surface of antigen-presenting cells, prevents rejection and induces tolerance in experimental acute allograft rejection models. We tested the effect of CTLA4Ig therapy on the process of chronic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Azuma H,Chandraker A,Nadeau K,Hancock WW,Carpenter CB,Tilney NL,Sayegh MH

更新日期：1996-10-29 00:00:00

abstract：:The mammalian hair follicle unit consists of a central follicle and a series of associated structures: sebaceous glands, arrector pili muscles, Merkel cells, and sensory nerve endings. The architecture of this multicellular structure is highly polarized with respect to the body axes. Previous work has implicated Frizz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chang H,Nathans J

更新日期：2013-03-05 00:00:00

abstract：:Systemic anthrax, caused by inhalation or ingestion of Bacillus anthracis spores, is characterized by rapid microbial growth stages that require iron. Tightly bound and highly regulated in a mammalian host, iron is scarce during an infection. To scavenge iron from its environment, B. anthracis synthesizes by independe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Abergel RJ,Wilson MK,Arceneaux JE,Hoette TM,Strong RK,Byers BR,Raymond KN

更新日期：2006-12-05 00:00:00

abstract：:CPEB, a cytoplasmic polyadenylation element-binding protein, plays an important role in translational control of maternal mRNAs in early animal development. During Xenopus oocyte maturation, CPEB undergoes a Cdc2-mediated phosphorylation- and ubiquitin-dependent degradation that is required for proper entry into meios...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Setoyama D,Yamashita M,Sagata N

更新日期：2007-11-13 00:00:00

abstract：:A cloned segment of yeast DNA containing the structural gene for imidazoleglycerolphosphate dehydratase (D-erythro-imidazoleglycerolphosphate hydro-lase, EC 4.2.1.19) is transcribed and translated in Escherichia coli with sufficient fidelity to produce functional enzyme. This segment of yeast DNA was isolated as a via...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Struhl K,Davis RW

更新日期：1977-12-01 00:00:00

abstract：:Neurophysiology is increasingly focused on identifying coincident activity among neurons. Strong inferences about neural computation are made from the results of such studies, so it is important that these results be accurate. However, the preliminary step in the analysis of such data, the assignment of spike waveform...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ventura V,Gerkin RC

更新日期：2012-05-08 00:00:00

abstract：:An investigation by paramagnetic resonance spectroscopy of the photoreduction of ferredoxin, oxygenically by water and anoxygenically by a direct electron donor to photosystem I, led to the unexpected findings that different reductive mechanisms may be involved. Ferredoxin photoreduced by water was not reoxidized in t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arnon DI,Tsujimoto HY,Tang GM

更新日期：1980-05-01 00:00:00

abstract：:The WWOX gene is a recently cloned tumor suppressor gene that spans the FRA16D fragile region. Wwox protein contains two WW domains that are generally known to mediate protein-protein interaction. Here we show that Wwox physically interacts via its first WW domain with the p53 homolog, p73. The tyrosine kinase, Src, p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aqeilan RI,Pekarsky Y,Herrero JJ,Palamarchuk A,Letofsky J,Druck T,Trapasso F,Han SY,Melino G,Huebner K,Croce CM

更新日期：2004-03-30 00:00:00

abstract：:In eukaryotic cells, RAD52 protein plays a central role in genetic recombination and DNA repair by (i) promoting the annealing of complementary single-stranded DNA and (ii) stimulation of the RAD51 recombinase. The single-strand annealing domain resides in the N-terminal region of the protein and is highly conserved, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Singleton MR,Wentzell LM,Liu Y,West SC,Wigley DB

更新日期：2002-10-15 00:00:00

abstract：:Endothelial heterogeneity has important implications in health and disease. Molecular markers selectively expressed in the vasculature of different organs and tissues are currently being explored in targeted therapies with promising results in preclinical and clinical studies. Noteworthy is the role that combinatorial...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tang FHF,Staquicini FI,Teixeira AAR,Michaloski JS,Namiyama GM,Taniwaki NN,Setubal JC,da Silva AM,Sidman RL,Pasqualini R,Arap W,Giordano RJ

更新日期：2019-02-05 00:00:00

abstract：:Neurons vary in their capacity to produce, store, and release neuropeptides packaged in dense-core vesicles (DCVs). Specifically, neurons used for cotransmission have terminals that contain few DCVs and many small synaptic vesicles, whereas neuroendocrine neuron terminals contain many DCVs. Although the mechanistic ba...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bulgari D,Zhou C,Hewes RS,Deitcher DL,Levitan ES

更新日期：2014-03-04 00:00:00

abstract：:The formation of nerve-muscle junctions in monolayer cultures of embryonic muscle and spinal cord cells is described. Muscle-forming cells (myoblasts) from leg muscles of 12-day chick embryos were separated with trypsin and cultured on a collagen substrate for two days. Suspensions of ventral spinal cord cells from si...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shimada Y,Fischman DA,Moscona AA

更新日期：1969-03-01 00:00:00

abstract：:A human craniofacial cDNA library was screened with a degenerate oligonucleotide probe based on the conserved third helix of homeobox genes. From this screening, we identified a homeobox gene, H6, which shared only 57-65% amino acid identity to previously reported homeodomains. H6 was physically mapped to the 4p16.1 r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stadler HS,Padanilam BJ,Buetow K,Murray JC,Solursh M

更新日期：1992-12-01 00:00:00

abstract：:There exists a properly embedded minimal surface of genus one with a single end asymptotic to the end of the helicoid. This genus-one helicoid is constructed as the limit of a continuous one-parameter family of screw-motion invariant minimal surfaces, also asymptotic to the helicoid, that have genus equal to one in th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weber M,Hoffman D,Wolf M

更新日期：2005-11-15 00:00:00

abstract：:The G-protein-coupled metabotropic glutamate receptor mGluR1 alpha and the ionotropic glutamate receptor GluR6 were examined for posttranslational palmitoylation. Recombinant receptors were expressed in baculovirus-infected insect cells or in human embryonic kidney cells and were metabolically labeled with [3H]palmiti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pickering DS,Taverna FA,Salter MW,Hampson DR

更新日期：1995-12-19 00:00:00

abstract：:Artemisinins are effective against a variety of parasites and provide the first line of treatment for malaria. Laboratory studies have identified several mechanisms for artemisinin resistance in Plasmodium falciparum, including mutations in Kelch13 that are associated with delayed clearance in some clinical isolates, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rosenberg A,Luth MR,Winzeler EA,Behnke M,Sibley LD

更新日期：2019-12-05 00:00:00

abstract：:A model is presented for age-specific selection on the genotypes in a population. Each genotype is assigned a life table that specifies the viability and fecundity of its age classes. Breeding and reproduction occur at regular intervals, and generations overlap. Examples were generated on a digital computer. Gene freq...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Anderson WW,King CE

更新日期：1970-07-01 00:00:00

abstract：:Several yeast activators are phosphorylated by SRB10, a cyclin-dependent kinase associated with the transcriptional machinery. Sites of phosphorylation are found outside the activating region in each case, and the modification has different physiological consequences in different cases. We show here that certain acidi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ansari AZ,Koh SS,Zaman Z,Bongards C,Lehming N,Young RA,Ptashne M

更新日期：2002-11-12 00:00:00

abstract：:Cigarette smoke is the major cause of lung cancer, the leading cause of cancer death, and of chronic obstructive pulmonary disease, the fourth leading cause of death in the United States. Using high-density gene expression arrays, we describe genes that are normally expressed in a subset of human airway epithelial cel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spira A,Beane J,Shah V,Liu G,Schembri F,Yang X,Palma J,Brody JS

更新日期：2004-07-06 00:00:00

abstract：:Protein misfolding and deposition underlie an increasing number of debilitating human disorders. We have shown that model proteins unrelated to disease, such as the Src homology 3 (SH3) domain of the p58alpha subunit of bovine phosphatidyl-inositol-3'-kinase (PI3-SH3), can be converted in vitro into assemblies with st...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ventura S,Zurdo J,Narayanan S,Parreño M,Mangues R,Reif B,Chiti F,Giannoni E,Dobson CM,Aviles FX,Serrano L

更新日期：2004-05-11 00:00:00

abstract：:Oxygen-derived free radicals have been implicated in the pathogenesis of vasogenic edema and infarction caused by ischemia and reperfusion injury. In earlier studies, exogenously supplied liposome-entrapped CuZn superoxide dismutase (CuZn-SOD) ameliorated ischemic brain edema and infarction in rats following focal cer...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kinouchi H,Epstein CJ,Mizui T,Carlson E,Chen SF,Chan PH

更新日期：1991-12-15 00:00:00

abstract：:TAL1 is a critical transcription factor required for hematopoiesis. However, perturbation of its activity often leads to T cell leukemia. Whether and how its transcriptional activities are regulated during hematopoiesis remains to be addressed. Here, we show that TAL1 is associated with histone demethylase complexes c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hu X,Li X,Valverde K,Fu X,Noguchi C,Qiu Y,Huang S

更新日期：2009-06-23 00:00:00

abstract：:A two-dimensional model of the expansion of a crack in an elastic medium is considered in which friction depends on the slip rate and the modulus of cohesion depends on the speed of expansion of the crack. Elastic waves are neglected (quasi-static model). Under some conditions, the expansion of the crack is realized b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barenblatt GI,Keilis-Borok VI,Vishik MM

更新日期：1981-09-01 00:00:00

abstract：:N-Acetylvalyl-tRNA1Val (AcVal-tRNA1Val) was bound to the P site of uniformly 32P-labeled 70S ribosomes from Escherichia coli and crosslinked to 16S RNA in the 30S ribosomal subunit by irradiation with light of 300-400 nm. To identify the crosslinked nucleotide in 16S RNA. AcVal-tRNA1Val-16S [32P]RNA was digested compl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Prince JB,Taylor BH,Thurlow DL,Ofengand J,Zimmermann RA

更新日期：1982-09-01 00:00:00

abstract：:MAC5 is a component of the conserved MOS4-associated complex. It plays critical roles in development and immunity. Here we report that MAC5 is required for microRNA (miRNA) biogenesis. MAC5 interacts with Serrate (SE), which is a core component of the microprocessor that processes primary miRNA transcripts (pri-miRNAs...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li S,Li M,Liu K,Zhang H,Zhang S,Zhang C,Yu B

更新日期：2020-09-22 00:00:00

abstract：:Fodrin, a protein composed of two polypeptides with molecular weights of 250,000 and 240,000, is concentrated in the cortical cytoplasm of neurons, and moves down the axons by the process of axonal transport. We have used immunofluorescence techniques to determine whether fodrin antigens also move in non-neuronal cell...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levine J,Willard M

更新日期：1983-01-01 00:00:00

abstract：:Mutations affecting mismatch repair result in elevated frequencies of microsatellite length alteration in prokaryotes and eukaryotes. However, the finding that microsatellite instability is found often in cells with a functional mismatch repair system prompted a search for other factors of tract alteration. In the pre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morel P,Reverdy C,Michel B,Ehrlich SD,Cassuto E

更新日期：1998-08-18 00:00:00

abstract：:Nine subjects were studied by high-speed magnetic resonance imaging while performing language-based tasks. Subjects were asked either to repeat or to generate verbs associated with nouns read by an experimenter while magnetic resonance images were obtained of the left inferior frontal lobe. The echo-planar imaging seq...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McCarthy G,Blamire AM,Rothman DL,Gruetter R,Shulman RG

更新日期：1993-06-01 00:00:00

abstract：:IL-33, a cytokine of the IL-1 family, is closely associated with type II T cell responses. Here, we report an unexpected proinflammatory role of IL-33 in inflammatory arthritis. IL-33 was expressed in synovial fibroblasts from patients with rheumatoid arthritis (RA). Expression was markedly elevated in vitro by inflam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu D,Jiang HR,Kewin P,Li Y,Mu R,Fraser AR,Pitman N,Kurowska-Stolarska M,McKenzie AN,McInnes IB,Liew FY

更新日期：2008-08-05 00:00:00

abstract：:Glyceraldehyde-3-phosphate dehydrogenase [GAPDH; D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating), EC 1.2.1.12] mRNA levels are induced by physiologic concentrations of insulin in cultured 3T3-F442A adipocyte and H35 hepatoma cell lines. To examine the mechanism by which insulin regulates GAPDH mRNA ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alexander MC,Lomanto M,Nasrin N,Ramaika C

更新日期：1988-07-01 00:00:00