The POU domain protein Tst-1 and papovaviral large tumor antigen function synergistically to stimulate glia-specific gene expression of JC virus.

abstract：:In response to various pathological stresses, the heart undergoes a pathological remodeling process that is associated with cardiomyocyte hypertrophy. Because cardiac hypertrophy can progress to heart failure, a major cause of lethality worldwide, the intracellular signaling pathways that control cardiomyocyte growth ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Appert-Collin A,Cotecchia S,Nenniger-Tosato M,Pedrazzini T,Diviani D

更新日期：2007-06-12 00:00:00

abstract：:Clathrin-mediated endocytosis (CME) regulates the uptake of cell-surface receptors as well as their downstream signaling activities. We recently reported that signaling can reciprocally regulate CME in cancer cells and that this crosstalk can contribute to cancer progression. To further explore the nature and extent o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xiao GY,Mohanakrishnan A,Schmid SL

更新日期：2018-10-09 00:00:00

abstract：:Social and emotional skills are tightly interlinked in human development, and both are negatively impacted by disrupted social development. The same interplay between social and emotional skills, including expressions of empathy, has received scant attention in other primates however, despite the growing interest in c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clay Z,de Waal FB

更新日期：2013-11-05 00:00:00

abstract：:APOBEC3 (A3) genes are members of the AID/APOBEC gene family that are found exclusively in mammals. A3 genes encode antiviral proteins that restrict the replication of retroviruses by inducing G-to-A mutations in their genomes and have undergone extensive amplification and diversification during mammalian evolution. E...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ito J,Gifford RJ,Sato K

更新日期：2020-01-07 00:00:00

abstract：:Replication of plasmid DNA molecules containing the simian virus 40 (SV40) origin of DNA replication has been reconstituted with seven highly purified cellular proteins plus the SV40 large tumor (T) antigen. Initiation of DNA synthesis is absolutely dependent upon T antigen, replication protein A, and the DNA polymera...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weinberg DH,Collins KL,Simancek P,Russo A,Wold MS,Virshup DM,Kelly TJ

更新日期：1990-11-01 00:00:00

abstract：:In vitro tests for predicting the response of tumors to chemotherapeutic agents might be improved if they were modified to take into account tumor-cell heterogeneity. We have studied the heterogeneity of cellular growth rate and drug response in mouse fibroblast NIH 3T3 cells and in NIH 3T3 cells transformed with the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kuczek T,Axelrod DE

更新日期：1987-07-01 00:00:00

abstract：:The adrenergic receptors (ARs) (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. We have previously assigned the genes for ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang-Feng TL,Xue FY,Zhong WW,Cotecchia S,Frielle T,Caron MG,Lefkowitz RJ,Francke U

更新日期：1990-02-01 00:00:00

abstract：:We have previously shown that chronic activation of mitogenic signaling induced by over-expression of c-myc and transforming growth factor-alpha (TGFalpha) transgenes in mouse liver induces a state of oxidative stress. We therefore proposed that increased reactive oxygen species (ROS) generation might be responsible f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Factor VM,Laskowska D,Jensen MR,Woitach JT,Popescu NC,Thorgeirsson SS

更新日期：2000-02-29 00:00:00

abstract：:Understanding the mechanisms by which compounds discovered using cell-based phenotypic screening strategies might exert their effects would be highly augmented by new approaches exploring their potential interactions with the genome. For example, altered androgen receptor (AR) transcriptional programs, including castr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jin C,Yang L,Xie M,Lin C,Merkurjev D,Yang JC,Tanasa B,Oh S,Zhang J,Ohgi KA,Zhou H,Li W,Evans CP,Ding S,Rosenfeld MG

更新日期：2014-06-24 00:00:00

abstract：:The human T cell leukemia virus I basic leucine zipper protein (HTLV-1 HBZ) maintains chronic viral infection and promotes leukemogenesis through poorly understood mechanisms involving interactions with the KIX domain of the transcriptional coactivator CBP and its paralog p300. The KIX domain binds regulatory proteins...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang K,Stanfield RL,Martinez-Yamout MA,Dyson HJ,Wilson IA,Wright PE

更新日期：2018-10-02 00:00:00

abstract：:Recent studies have highlighted the importance of peripheral induction of Foxp3-expressing regulatory T cells (Tregs) in the dominant control of immunological tolerance. However, Foxp3(+) Treg differentiation from naïve CD4(+) T cells occurs only under selective conditions, whereas the classical T helper (Th) 1 and 2 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wei J,Duramad O,Perng OA,Reiner SL,Liu YJ,Qin FX

更新日期：2007-11-13 00:00:00

abstract：:Recent years have witnessed an increased public outcry in certain quarters about a perceived lack of attention given to successful members of disadvantaged groups relative to equally meritorious members of advantaged groups, exemplified by social media campaigns centered around hashtags, such as #OscarsSoWhite and #Wo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kteily NS,Rocklage MD,McClanahan K,Ho AK

更新日期：2019-01-29 00:00:00

abstract：:The dynamic responses of the hearing organ to acoustic overstimulation were investigated using the guinea pig isolated temporal bone preparation. The organ was loaded with the fluorescent Ca2+ indicator Fluo-3, and the cochlear electric responses to low-level tones were recorded through a microelectrode in the scala m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fridberger A,Flock A,Ulfendahl M,Flock B

更新日期：1998-06-09 00:00:00

abstract：:Many studies have demonstrated that the primary visual cortex contains multiple functional maps of visual properties (e.g., ocular dominance, orientation preference, and spatial-frequency preference), but as yet no consistent picture has emerged as to how these maps are related to one another. Three divergent, prior o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sirovich L,Uglesich R

更新日期：2004-11-30 00:00:00

abstract：:Climate change is expected to alter the distribution and abundance of many species. Predictions of climate-induced population extinctions are supported by geographic range shifts that correspond to climatic warming, but few extinctions have been linked mechanistically to climate change. Here we show that extinctions o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McLaughlin JF,Hellmann JJ,Boggs CL,Ehrlich PR

更新日期：2002-04-30 00:00:00

abstract：:Advanced personalized medical diagnostics depend on the availability of high-quality biological samples. These are typically biofluids, such as blood, saliva, or urine; and their collection and storage is critical to obtain reliable results. Without proper temperature regulation, protein biomarkers in particular can d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kluge JA,Li AB,Kahn BT,Michaud DS,Omenetto FG,Kaplan DL

更新日期：2016-05-24 00:00:00

abstract：:To identify the binding domain for dihydropyridine Ca2+ antagonists, skeletal muscle Ca2+ channels were photolabeled with [3H](+)-PN200-110 and [3H]azidopine. Regions of alpha 1 photolabeled by these ligands were then identified by antibody mapping of proteolytic fragments. Approximately 50% of the specific labeling b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Striessnig J,Murphy BJ,Catterall WA

更新日期：1991-12-01 00:00:00

abstract：:A variety of agricultural plant species, including corn, respond to insect herbivore damage by releasing large quantities of volatile compounds and, as a result, become highly attractive to parasitic wasps that attack the herbivores. An elicitor of plant volatiles, N-(17-hydroxylinolenoyl)-L-glutamine, named volicitin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Paré PW,Alborn HT,Tumlinson JH

更新日期：1998-11-10 00:00:00

abstract：:We introduce Pathifier, an algorithm that infers pathway deregulation scores for each tumor sample on the basis of expression data. This score is determined, in a context-specific manner, for every particular dataset and type of cancer that is being investigated. The algorithm transforms gene-level information into pa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Drier Y,Sheffer M,Domany E

更新日期：2013-04-16 00:00:00

abstract：:The flow orientation of anisotropic particles through narrow channels is of importance in many fields, ranging from the spinning and molding of fibers to the flow of cells and proteins through thin capillaries. It is commonly assumed that anisotropic particles align parallel to the flow direction. When flowing through...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Trebbin M,Steinhauser D,Perlich J,Buffet A,Roth SV,Zimmermann W,Thiele J,Förster S

更新日期：2013-04-23 00:00:00

abstract：:There exists a properly embedded minimal surface of genus one with a single end asymptotic to the end of the helicoid. This genus-one helicoid is constructed as the limit of a continuous one-parameter family of screw-motion invariant minimal surfaces, also asymptotic to the helicoid, that have genus equal to one in th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weber M,Hoffman D,Wolf M

更新日期：2005-11-15 00:00:00

abstract：:TGF-β activated kinase 1 (TAK1) is a critical signaling hub responsible for translating antigen binding signals to immune receptors for the activation of the AP-1 and NF-κB master transcriptional programs. Despite its importance, known substrates of TAK1 are limited to kinases of the MAPK and IKK families and include ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levin RS,Hertz NT,Burlingame AL,Shokat KM,Mukherjee S

更新日期：2016-08-16 00:00:00

abstract：:The recent success of antibody-drug conjugates (ADCs) in the treatment of cancer has led to a revived interest in microtubule-destabilizing agents. Here, we determined the high-resolution crystal structure of the complex between tubulin and maytansine, which is part of an ADC that is approved by the US Food and Drug A...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Prota AE,Bargsten K,Diaz JF,Marsh M,Cuevas C,Liniger M,Neuhaus C,Andreu JM,Altmann KH,Steinmetz MO

更新日期：2014-09-23 00:00:00

abstract：:BALB/c mice immunized with myeloma proteins 315 or 460 made antibodies to the individually specific ("idiotypic") determinants of these proteins and suppressed growth of the corresponding transplanted tumor cells (MOPC-315 or MOPC-460). Stable, variant MOPC-315 tumors that produce only the light chain of protein 315 g...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lynch RG,Graff RJ,Sirisinha S,Simms ES,Eisen HN

更新日期：1972-06-01 00:00:00

abstract：:Norepinephrine, epinephrine, and histamine cause a rapid increase in the concentration of adenosine 3':5'-cyclic monophosphate (cAMP) in a tumor astrocyte cell line derived from a primary culture of a human glioblastoma multiforme. The catecholamine-induced increase in cAMP is dependent on the cell density, being far ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clark RB,Perkins JP

更新日期：1971-11-01 00:00:00

abstract：:The oncoproteins MDM2 and MDMX negatively regulate the activity and stability of the tumor suppressor protein p53--a cellular process initiated by MDM2 and/or MDMX binding to the N-terminal transactivation domain of p53. MDM2 and MDMX in many tumors confer p53 inactivation and tumor survival, and are important molecul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pazgier M,Liu M,Zou G,Yuan W,Li C,Li C,Li J,Monbo J,Zella D,Tarasov SG,Lu W

更新日期：2009-03-24 00:00:00

abstract：:Recent research links diet-induced obesity (DIO) with impaired immunity, although the underlying mechanisms remain unclear. We find that the induction of inducible NO synthase (iNOS) and cytokines is suppressed in mice with DIO and in bone marrow macrophages (BMMPhi) from mice with DIO exposed to an oral pathogen, Por...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou Q,Leeman SE,Amar S

更新日期：2009-06-30 00:00:00

abstract：:Affinity-fractionated porcine heparin was randomly scissioned by chemical techniques to give hexasaccharides, octasaccharides, decasaccharides, and mucopolysaccharide fragments of approximately 14 residues and approximately 16 residues that were able to complex with the protease inhibitor. Direct measurements of the k...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oosta GM,Gardner WT,Beeler DL,Rosenberg RD

更新日期：1981-02-01 00:00:00

abstract：:Group A Streptococcus (GAS) and other bacterial pathogens are known to interact with integrins as an initial step in a complex pathway of bacterial ingestion by host cells. Efficient GAS invasion depends on the interaction of bound fibronectin (Fn) with integrins and activation of integrin signaling. TGF-beta1 regulat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang B,Li S,Southern PJ,Cleary PP

更新日期：2006-02-14 00:00:00

abstract：:Most guanine nucleotide binding protein (G protein)-coupled receptors have a conserved cysteine in the C-terminal cytoplasmic tail near the seventh transmembrane spanning region. This cysteine is known to be palmitoylated in rhodopsin, the beta 2-adrenergic receptor (beta 2AR) and the alpha 2A-adrenergic receptor (alp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eason MG,Jacinto MT,Theiss CT,Liggett SB

更新日期：1994-11-08 00:00:00