Role for ERK1/2-dependent activation of FCHSD2 in cancer cell-selective regulation of clathrin-mediated endocytosis.

abstract：:Recent genome-wide association studies have revealed some genetic loci associated with serum uric acid levels and susceptibility to gout/hyperuricemia which contain potential candidates of physiologically important urate transporters. One of these novel loci is located upstream of SGK1 and SLC2A12, suggesting that var...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Toyoda Y,Takada T,Miyata H,Matsuo H,Kassai H,Nakao K,Nakatochi M,Kawamura Y,Shimizu S,Shinomiya N,Ichida K,Hosoyamada M,Aiba A,Suzuki H

更新日期：2020-08-04 00:00:00

abstract：:Citizenship endows legal protections and is associated with economic and social gains for immigrants and their communities. In the United States, however, naturalization rates are relatively low. Yet we lack reliable knowledge as to what constrains immigrants from applying. Drawing on data from a public/private natura...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hainmueller J,Lawrence D,Gest J,Hotard M,Koslowski R,Laitin DD

更新日期：2018-01-30 00:00:00

abstract：:The trilaminate vascular architecture provides biochemical regulation and mechanical integrity. Yet regulatory control can be regained after injury without recapitulating tertiary structure. Tissue-engineered (TE) endothelium controls repair even when placed in the perivascular space of injured vessels. It remains unc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zani BG,Kojima K,Vacanti CA,Edelman ER

更新日期：2008-05-13 00:00:00

abstract：:Positive-strand RNA viruses are the largest virus class and include many pathogens such as hepatitis C virus and the severe acute respiratory syndrome coronavirus (SARS). Brome mosaic virus (BMV) is a representative positive-strand RNA virus whose RNA replication, gene expression, and encapsidation have been reproduce...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kushner DB,Lindenbach BD,Grdzelishvili VZ,Noueiry AO,Paul SM,Ahlquist P

更新日期：2003-12-23 00:00:00

abstract：:Genetic and biochemical studies on enzymes known to be involved in regulating DNA supercoiling yield a complex spectrum of effects on the Escherichia coli SOS system. Previous studies indicated that only inhibition of DNA gyrase by antibiotics that act on the DNA gyrase A subunit results in turning on the E. coli SOS ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith CL

更新日期：1983-05-01 00:00:00

abstract：:We analyzed the relationship of genetic factors determining the expression of endogenous type-C RNA tumor viruses and other host-gene markers to tumorigenesis. A hybridization experiment was performed with mice of strains AKR/J and C57L, the first filial (F(1)) generation hybrids, the second filial (F(2)) generation h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meier H,Taylor BA,Cherry M,Buebner RJ

更新日期：1973-05-01 00:00:00

abstract：:We show that the stimulation of human immunodeficiency virus (HIV) brought about by tumor necrosis factor alpha and phorbol 12-myristate 13-acetate can be inhibited by adding N-acetyl-L-cysteine (NAC). NAC, which replenishes intracellular glutathione, effectively inhibits the tumor necrosis factor alpha- or phorbol es...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roederer M,Staal FJ,Raju PA,Ela SW,Herzenberg LA,Herzenberg LA

更新日期：1990-06-01 00:00:00

abstract：:Human T lymphotropic virus type 1 (HTLV-1) -associated myelopathy/tropic spastic paraparesis is a demyelinating inflammatory neurologic disease associated with HTLV-1 infection. HTLV-1 Tax11-19-specific cytotoxic T cells have been isolated from HLA-A2-positive patients. We have used a peptide-loaded soluble HLA-A2-Ig ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Greten TF,Slansky JE,Kubota R,Soldan SS,Jaffee EM,Leist TP,Pardoll DM,Jacobson S,Schneck JP

更新日期：1998-06-23 00:00:00

abstract：:Treatment strategies for severe cases of pandemic influenza have focused on antiviral therapies. In contrast, passive immunotherapy with convalescent blood products has received limited attention. We consider the hypothesis that a passive-immunotherapy program that collects plasma from a small percentage of recovered ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu JT,Lee CK,Cowling BJ,Yuen KY

更新日期：2010-02-16 00:00:00

abstract：:A central role for phenotypic plasticity in adaptive evolution is often posited yet lacks empirical support. Selection for the stable production of an induced phenotype is hypothesized to modify the regulation of preexisting developmental pathways, producing rapid adaptive change. We examined the role of plasticity in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scoville AG,Pfrender ME

更新日期：2010-03-02 00:00:00

abstract：:Regional differences in neurons, astrocytes, oligodendrocytes, and microglia exist in the brain during health, and regional differences in the transcriptome may occur for each cell type during neurodegeneration. Multiple sclerosis (MS) is multifocal, and regional differences in the astrocyte transcriptome occur in exp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Voskuhl RR,Itoh N,Tassoni A,Matsukawa MA,Ren E,Tse V,Jang E,Suen TT,Itoh Y

更新日期：2019-05-14 00:00:00

abstract：:A disulfide bond that is evidently conserved in the guanine nucleotide-binding protein-coupled receptors is present in rhodopsin between Cys-110 and Cys-187. We have replaced these two cysteine residues by alanine residues and now report on the properties of the resulting rhodopsin mutants. The mutant protein C110A/C1...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Davidson FF,Loewen PC,Khorana HG

更新日期：1994-04-26 00:00:00

abstract：:The N-methyl-D-aspartate (NMDA) receptor, a subtype of excitatory amino acid receptor, mediates synaptic responses in many regions of the central nervous system. This receptor plays a critical role in the mechanisms of both synaptic plasticity and excitotoxicity. Although these receptors were generally thought to be a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Monaghan DT,Olverman HJ,Nguyen L,Watkins JC,Cotman CW

更新日期：1988-12-01 00:00:00

abstract：:We have recently identified a family of rhesus monkeys with members exhibiting a spontaneous hypercholesterolemia associated with a low density lipoprotein receptor (LDLR) deficiency. By using the polymerase chain reaction, we now show that the affected monkeys are heterozygous for a nonsense mutation in exon 6 of the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hummel M,Li ZG,Pfaffinger D,Neven L,Scanu AM

更新日期：1990-04-01 00:00:00

abstract：:In an autoshaping experiment, food-deprived pigeons pecked rapidly at a moving dot that preceded the delivery of food. When the moving dot and food were no longer correlated, the rate of pecking dropped nearly to zero. When, subsequently, no food was given, pecking reappeared at a high rate (nearly 200 pecks per min f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Epstein R,Skinner BF

更新日期：1980-10-01 00:00:00

abstract：:Neural crest stem cells arise within the central nervous system but then undergo an epithelial-to-mesenchymal transition to migrate away and contribute to the peripheral nervous system and craniofacial skeleton. Here we show that DNA methyltransferase 3B (DNMT3B) is responsible for the loss of competence of dorsal neu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hu N,Strobl-Mazzulla PH,Simoes-Costa M,Sánchez-Vásquez E,Bronner ME

更新日期：2014-12-16 00:00:00

abstract：:High-resolution maps integrated with the enhanced location data base software (LDB+) give improved estimates of genetic parameters and reveal characteristics of cytogenetic bands. Chiasma interference is intermediate between Kosambi and Carter-Falconer levels, as in Drosophila and the mouse. The autosomal genetic map ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Collins A,Frezal J,Teague J,Morton NE

更新日期：1996-12-10 00:00:00

abstract：:Clinical and experimental observations indicate a role for VEGF secreted by the retinal pigment epithelium (RPE) in the maintenance of the choriocapillaris (CC). VEGF in mice is produced as three isoforms, VEGF120, VEGF164, and VEGF188, that differ in their ability to bind heparan sulfate proteoglycan. RPE normally pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saint-Geniez M,Kurihara T,Sekiyama E,Maldonado AE,D'Amore PA

更新日期：2009-11-03 00:00:00

abstract：:Endocrine therapy resistance invariably develops in advanced estrogen receptor-positive (ER+) breast cancer, but the underlying mechanisms are largely unknown. We have identified C-terminal SRC kinase (CSK) as a critical node in a previously unappreciated negative feedback loop that limits the efficacy of current ER-t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xiao T,Li W,Wang X,Xu H,Yang J,Wu Q,Huang Y,Geradts J,Jiang P,Fei T,Chi D,Zang C,Liao Q,Rennhack J,Andrechek E,Li N,Detre S,Dowsett M,Jeselsohn RM,Liu XS,Brown M

更新日期：2018-07-31 00:00:00

abstract：:A molecular model of poorly understood hydrophobic effects is heuristically developed using the methods of information theory. Because primitive hydrophobic effects can be tied to the probability of observing a molecular-sized cavity in the solvent, the probability distribution of the number of solvent centers in a ca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hummer G,Garde S,García AE,Pohorille A,Pratt LR

更新日期：1996-08-20 00:00:00

abstract：:Columnar stromatolites were abundant and widespread in the Proterozoic but are exceedingly rare in modern seas. Consequently, the stromatolites at Hamelin Pool in Shark Bay, Western Australia, have been widely interpreted as unique modern analogs of ancient stromatolites constructed by complex communities of cyanobact...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Awramik SM,Riding R

更新日期：1988-03-01 00:00:00

abstract：:Depolarization of neuroblastoma cells causes a 70-fold increase in the apparent dissociation constant KD for scorpion toxin enhancement of activation of the action potential Na+ ionophore by veratridine and a large increase in the rate of reversal of scorpion toxin action. Depolarization also inhibits binding of 125I-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Catterall WA,Ray R,Morrow CS

更新日期：1976-08-01 00:00:00

abstract：:Nations in the 21st century face a complex mix of environmental and social challenges, as highlighted by the on-going Sustainable Development Goals process. The "planetary boundaries" concept [Rockström J, et al. (2009) Nature 461(7263):472-475], and its extension through the addition of social well-being indicators t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cole MJ,Bailey RM,New MG

更新日期：2014-10-21 00:00:00

abstract：:The floating water bridge phenomenon is a freestanding rope-shaped connection of pure liquid water, formed under the influence of a high potential difference (approximately 15 kV). Several recent spectroscopic, optical, and neutron scattering studies have suggested that the origin of the bridge is associated with the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Skinner LB,Benmore CJ,Shyam B,Weber JK,Parise JB

更新日期：2012-10-09 00:00:00

abstract：:A rigorous numerical test of a hypothetical mechanism of a molecular motor should model explicitly the diffusive motion of the motor's degrees of freedom as well as the transition rates between the motor's chemical states. We present such a Brownian dynamics, mechanochemcial model of the coarse-grain structure of the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Craig EM,Linke H

更新日期：2009-10-27 00:00:00

abstract：:Pyrrolysine (Pyl), the 22nd natural amino acid and genetically encoded by UAG, becomes attached to its cognate tRNA by pyrrolysyl-tRNA synthetase (PylRS). We have determined three crystal structures of the Methanosarcina mazei PylRS complexed with either AMP-PNP, Pyl-AMP plus pyrophosphate, or the Pyl analogue N-epsil...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kavran JM,Gundllapalli S,O'Donoghue P,Englert M,Söll D,Steitz TA

更新日期：2007-07-03 00:00:00

abstract：:Parvalbumin (PV) is a Ca2+-binding protein found only in vertebrates. It is postulated to serve as a soluble relaxing factor in fast mammalian muscle. We have isolated a rat PV cDNA clone and used this as a probe to examine changes in PV mRNA during muscle and brain development. A cDNA library was constructed in PUC8/...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Berchtold MW,Means AR

更新日期：1985-03-01 00:00:00

abstract：:The mechanistic target of rapamycin complex 1 (mTORC1) growth pathway detects nutrients through a variety of sensors and regulators that converge on the Rag GTPases, which form heterodimers consisting of RagA or RagB tightly bound to RagC or RagD and control the subcellular localization of mTORC1. The Rag heterodimer ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shen K,Sabatini DM

更新日期：2018-09-18 00:00:00

abstract：:PTEN is an important tumor-suppressor gene associated with many cancers. Through expression profiling of glioblastoma tissue samples and prostate cancer xenografts, we identified a molecular signature for loss of the PTEN tumor suppressor in glioblastoma and prostate tumors. The PTEN signature consists of a minimum of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mehrian-Shai R,Chen CD,Shi T,Horvath S,Nelson SF,Reichardt JK,Sawyers CL

更新日期：2007-03-27 00:00:00

abstract：:One of the most basic predictions of almost any model of crime is that individual time preferences matter. However, empirical evidence on this fundamental property is essentially nonexistent. To our knowledge, this paper provides the first pieces of evidence on the link between time discounting and crime. We use a uni...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Åkerlund D,Golsteyn BH,Grönqvist H,Lindahl L

更新日期：2016-05-31 00:00:00