当前位置： SCI文献检索 > PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA期刊下所有文献 > Sparse production but preferential incorporation of recently produced naive T cells in the human peripheral pool.

Sparse production but preferential incorporation of recently produced naive T cells in the human peripheral pool.

Abstract：

:In mice, recent thymic emigrants (RTEs) make up a large part of the naïve T cell pool and have been suggested to be a distinct short-lived pool. In humans, however, the life span and number of RTEs are unknown. Although (2)H(2)O labeling in young mice showed high thymic-dependent daily naïve T cell production, long term up- and down-labeling with (2)H(2)O in human adults revealed a low daily production of naïve T cells. Using mathematical modeling, we estimated human naïve CD4 and CD8 T cell half-lives of 4.2 and 6.5 years, respectively, whereas memory CD4 and CD8 T cells had half-lives of 0.4 and 0.7 year. The estimated half-life of recently produced naïve T cells was much longer than these average half-lives. Thus, our data are incompatible with a substantial short-lived RTE population in human adults and suggest that the few naïve T cells that are newly produced are preferentially incorporated in the peripheral pool.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Vrisekoop N,den Braber I,de Boer AB,Ruiter AF,Ackermans MT,van der Crabben SN,Schrijver EH,Spierenburg G,Sauerwein HP,Hazenberg MD,de Boer RJ,Miedema F,Borghans JA,Tesselaar K

doi

10.1073/pnas.0709713105

subject

Has Abstract

pub_date

2008-04-22 00:00:00

pages

6115-20

issue

16

eissn

0027-8424

issn

1091-6490

pii

0709713105

journal_volume

105

pub_type

杂志文章

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