Adeno-associated virus Rep proteins antagonize phosphatase PP1 to counteract KAP1 repression of the latent viral genome.

abstract：:The early reactions in the catabolism of quinic acid in Neurospora crassa are controlled by at least four genes which are clustered on linkage group VII. Three of the loci (qa-2, qa-4, and qa-3) encode enzymes that convert quinic acid to protocatechuic acid. The fourth gene (qa-1) encodes a positive regulatory protein...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schweizer M,Case ME,Dykstra CC,Giles NH,Kushner SR

更新日期：1981-08-01 00:00:00

abstract：:Because of the relative inaccessibility of known calciferol target tissues (i.e., intestine and bone), we examined fibroblasts derived from normal human skin and grown in tissue culture as a means of evaluating the interaction of 1,25-dihydroxycholecalciferol [1,25(OH)2D3] and its effector system. When dispersed, inta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eil C,Marx SJ

更新日期：1981-04-01 00:00:00

abstract：:Heterotrimeric G proteins function as molecular relays that mediate signal transduction from heptahelical receptors in the cell membrane to intracellular effector proteins. Crystallographic studies have demonstrated that guanine nucleotide exchange on the Galpha subunit causes specific conformational changes in three ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oldham WM,Van Eps N,Preininger AM,Hubbell WL,Hamm HE

更新日期：2007-05-08 00:00:00

abstract：:Plant-made vaccines have been the subject of intense interest because they can be produced economically in large scale without the use of animal-derived components. Plant-made therapeutic vaccines against challenging chronic diseases, such as cancer, have received little research attention, and no previous human clini...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McCormick AA,Reddy S,Reinl SJ,Cameron TI,Czerwinkski DK,Vojdani F,Hanley KM,Garger SJ,White EL,Novak J,Barrett J,Holtz RB,Tusé D,Levy R

更新日期：2008-07-22 00:00:00

abstract：:Integrin alphanubeta3 is found on a subset of tumor blood vessels where it is associated with angiogenesis and malignant tumor growth. We designed an alphanubeta3-targeted nanoparticle (NP) encapsulating the cytotoxic drug doxorubicin (Dox) for targeted drug delivery to the alphanubeta3-expressing tumor vasculature. W...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murphy EA,Majeti BK,Barnes LA,Makale M,Weis SM,Lutu-Fuga K,Wrasidlo W,Cheresh DA

更新日期：2008-07-08 00:00:00

abstract：:A 3- to 5-year cycle of vole abundances is a characteristic phenomenon in the ecology of northern regions, and their explanation stands as a central theoretical challenge in population ecology. Although many species of voles usually coexist and are in severe competition for food and breeding space, the role of intersp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hansen TF,Stenseth NC,Henttonen H,Tast J

更新日期：1999-02-02 00:00:00

abstract：:The regular spacing of somites during vertebrate embryogenesis involves a dynamic gradient of FGF signaling that controls the timing of maturation of cells in the presomitic mesoderm (PSM). How the FGF signal is transduced by PSM cells is unclear. Here, we first show that the FGF gradient is translated into graded act...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Delfini MC,Dubrulle J,Malapert P,Chal J,Pourquié O

更新日期：2005-08-09 00:00:00

abstract：:The hypothalamic arcuate nucleus is involved in the control of energy intake and expenditure and may participate in the pathogenesis of eating disorders such as anorexia nervosa (AN) and bulimia nervosa (BN). Two systems are of particular interest in this respect, synthesizing alpha-melanocyte-stimulating hormone (alp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fetissov SO,Hallman J,Oreland L,Af Klinteberg B,Grenbäck E,Hulting AL,Hökfelt T

更新日期：2002-12-24 00:00:00

abstract：:All classes of antidepressants increase hippocampal cell proliferation and neurogenesis, which contributes, in part, to the behavioral actions of these treatments. Among antidepressant treatments, electroconvulsive seizure (ECS) is the most robust stimulator of hippocampal cell proliferation and the most efficacious t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Segi-Nishida E,Warner-Schmidt JL,Duman RS

更新日期：2008-08-12 00:00:00

abstract：:The cell surface proteome, the surfaceome, is the interface for engaging the extracellular space in normal and cancer cells. Here we apply quantitative proteomics of N-linked glycoproteins to reveal how a collection of some 700 surface proteins is dramatically remodeled in an isogenic breast epithelial cell line stabl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leung KK,Wilson GM,Kirkemo LL,Riley NM,Coon JJ,Wells JA

更新日期：2020-04-07 00:00:00

abstract：:Molecular beacons are DNA probes that form a stem-and-loop structure and possess an internally quenched fluorophore. When they bind to complementary nucleic acids, they undergo a conformational transition that switches on their fluorescence. These probes recognize their targets with higher specificity than probes that...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bonnet G,Tyagi S,Libchaber A,Kramer FR

更新日期：1999-05-25 00:00:00

abstract：:Despite their relative simplicity, bacteria have complex anatomy at the subcellular level. At the cell poles of Caulobacter crescentus, a 177-amino acid (aa) protein called PopZ self-assembles into 3D polymeric superstructures. Remarkably, we find that this assemblage interacts directly with at least eight different p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Holmes JA,Follett SE,Wang H,Meadows CP,Varga K,Bowman GR

更新日期：2016-11-01 00:00:00

abstract：:A series of small peptides corresponding to the amino termini of the fibrin alpha- and beta-chains has been synthesized. The peptides glycyl-L-prolyl-L-arginyl-L-proline and glycyl-L-prolyl-L-arginylsarcosine are potent inhibitors of fibrin polymerization. Moreover, these peptides have a natural stability stemming fro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Laudano AP,Doolittle RF

更新日期：1978-07-01 00:00:00

abstract：:The mechanism of nuclear DNA replication in radicles of germinating cotton (Gossypium barbadense) was investigated. Pulse-labeling with [(3)H]thymidine indicates that replication intermediates are of small molecular weight (4-10S) and behave as if single-stranded. Prolonged labeling indicates that intermediates are of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clay WF,Bartels PG,Katterman FR

更新日期：1976-09-01 00:00:00

abstract：:We have reexamined the balance between cell birth, cell maturation, and cell death in the thymus by labeling dividing thymocytes and their progeny in vivo with [3H]-thymidine, isolating clearly defined subpopulations by fluorescence-activated cell sorting, and determining the distribution of label by autoradiography. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Egerton M,Scollay R,Shortman K

更新日期：1990-04-01 00:00:00

abstract：:In the majority of human tumors, expression of the c-MYC oncogene becomes constitutive. Here, we report that c-MYC directly regulates the expression of AP4 via CACGTG motifs in the first intron of the AP4 gene. Induction of AP4 was required for c-MYC-mediated cell cycle reentry of anti-estrogen arrested breast cancer ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jung P,Menssen A,Mayr D,Hermeking H

更新日期：2008-09-30 00:00:00

abstract：:Two forms of lactoferrin, an intact lactoferrin and a "nicked" but apparently intact (i.e., 78-kDa) form, have been isolated from the urine of preterm infants fed human milk. These two forms of lactoferrin, demonstrated to be entirely of maternal origin, were copurified using affinity columns of immobilized single-str...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hutchens TW,Henry JF,Yip TT

更新日期：1991-04-15 00:00:00

abstract：:Complement-stimulated granulocytes adhere to and induce significant 51Cr release from endothelial cells in vitro. Platelets were stimulated to undergo release, and these release products significantly enhanced granulocyte-endothelial cell adherence and granulocyte-induced 51Cr release from endothelial cells. Platelet ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boogaerts MA,Yamada O,Jacob HS,Moldow CF

更新日期：1982-11-01 00:00:00

abstract：:The ubiquitin-conjugating enzyme Ubc13 mediates lysine-63-specific protein ubiquitination involved in signal transduction by immune receptors; however, the in vivo physiological functions of Ubc13 remain incompletely understood. Using Ubc13 conditional knockout mice, we show that somatic deletion of the Ubc13 gene cau...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu X,Yamamoto M,Akira S,Sun SC

更新日期：2009-12-08 00:00:00

abstract：:A highly specific radioimmunoassay for one of the putative adrenomedullary [Met]enkephalin precursors, BAM-12P (Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-Gly-Arg-Pro-Glu-OH), has been developed. The BAM-12P antibodies recognize the COOH-terminal fragment of the peptide from Arg7 to Glu12 and do not crossreact with [Met5]- or [L...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baird A,Ling N,Böhlen P,Benoit R,Klepper R,Guillemin R

更新日期：1982-03-01 00:00:00

abstract：:Coherent oscillations in the theta-to-gamma frequency range have been proposed as a mechanism that coordinates neural activity in large-scale cortical networks in sensory, motor, and cognitive tasks. Whether this mechanism also involves coherent oscillations at delta frequencies (1-4 Hz) is not known. Rather, delta os...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nácher V,Ledberg A,Deco G,Romo R

更新日期：2013-09-10 00:00:00

abstract：:[3H]Forskolin bound to high- and low-affinity sites in the rat brain. The high-affinity site was discretely located, with highest densities in the striatum, nucleus accumbens, olfactory tubercule, substantia nigra, hippocampus, and the molecular layers of the cerebellum. This site did not correlate well with the distr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Poat JA,Cripps HE,Iversen LL

更新日期：1988-05-01 00:00:00

abstract：:Streptococcus pneumoniae is a major human pathogen that successfully adapts to the host environment via an efficient uptake system for free DNA liberated from other organisms in the upper respiratory tract, facilitating immune evasion and drug resistance. Although the initial signaling events leading to pneumococcal c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Balaban M,Bättig P,Muschiol S,Tirier SM,Wartha F,Normark S,Henriques-Normark B

更新日期：2014-02-18 00:00:00

abstract：:RNA-dependent RNA polymerases (RdRps) of the Nidovirales (Coronaviridae, Arteriviridae, and 12 other families) are linked to an amino-terminal (N-terminal) domain, called NiRAN, in a nonstructural protein (nsp) that is released from polyprotein 1ab by the viral main protease (Mpro). Previously, self-GMPylation/UMPylat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Slanina H,Madhugiri R,Bylapudi G,Schultheiß K,Karl N,Gulyaeva A,Gorbalenya AE,Linne U,Ziebuhr J

更新日期：2021-02-09 00:00:00

abstract：:Serotonin (5-hydroxytryptamine; 0.5 microM and above) stimulated the synthesis of prostacyclin (as measured by radioimmunoassay of 6-ketoprostaglandin F1 alpha) by bovine aortic smooth muscle cells in culture. This effect was structurally specific; a similar response was not elicited by the other indoles (tryptophan, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Coughlin SR,Moskowitz MA,Antoniades HN,Levine L

更新日期：1981-11-01 00:00:00

abstract：:We develop a potential landscape approach to quantitatively describe experimental data from a fibroblast cell line that exhibits a wide range of GFP expression levels under the control of the promoter for tenascin-C. Time-lapse live-cell microscopy provides data about short-term fluctuations in promoter activity, and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sisan DR,Halter M,Hubbard JB,Plant AL

更新日期：2012-11-20 00:00:00

abstract：:Nuclear factor-erythroid 2-related factor 2 (Nrf2) is a key transcriptional regulator for antioxidant and anti-inflammation enzymes that binds to its endogenous inhibitor protein, Kelch-like ECH (erythroid cell-derived protein with CNC homology)-associated protein 1, in the cytoplasm under normal conditions. Various e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim SB,Pandita RK,Eskiocak U,Ly P,Kaisani A,Kumar R,Cornelius C,Wright WE,Pandita TK,Shay JW

更新日期：2012-10-23 00:00:00

abstract：:Recent laboratory studies have demonstrated that isoprene oxidation products can partition to atmospheric aerosols by reacting with condensed phase sulfuric acid, forming low-volatility organosulfate compounds. We have identified organosulfate compounds in free tropospheric aerosols by single particle mass spectrometr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Froyd KD,Murphy SM,Murphy DM,de Gouw JA,Eddingsaas NC,Wennberg PO

更新日期：2010-12-14 00:00:00

abstract：:The blood-aqueous barrier plays a key role in regulating aqueous humor homeostasis by selectively restricting passage of proteins into the eye. The kinetics of aqueous flow are traditionally measured using artificial markers; however, these marker molecules do not address the barrier's selective permeability to plasma...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu P,Thomson BR,Khalatyan N,Feng L,Liu X,Savas JN,Quaggin SE,Jin J

更新日期：2018-09-04 00:00:00

abstract：:The Escherichia coli flagellar motor senses the intracellular concentration of the response regulator CheY-P and responds by varying the bias between its counterclockwise (CCW) and clockwise (CW) rotational states. The response is ultrasensitive with a large Hill coefficient (approximately 10). Recently, the detailed ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tu Y

更新日期：2008-08-19 00:00:00