Circadian modulation of complex learning in diurnal and nocturnal Aplysia.

abstract：:Brn-4 is a member of the POU transcription factor family and is expressed in the central nervous system. In this study, we addressed whether Brn-4 regulates expression of the D1A dopamine receptor gene. We found a functional Brn-4 responsive element in the intron of this gene by means of cotransfection chloramphenical...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Okazawa H,Imafuku I,Minowa MT,Kanazawa I,Hamada H,Mouradian MM

更新日期：1996-10-15 00:00:00

abstract：:Cleavage of precursor proteins occurs during assembly of numerous viruses. Seven bacteriophage T4 head-related proteins areknown to be cleaved during morphogenesis. Sequences surrounding the cleavage sites in T4 head precursors P23 and IPIII are reported here. We previously determined the sequences of precursor and pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Isobe T,Black LW,Tsugita A

更新日期：1976-11-01 00:00:00

abstract：:Deinococcus radiodurans is among a small number of bacterial species that are extremely resistant to ionizing radiation, UV light, toxic chemicals, and desiccation. We measured proteome oxidation (i.e., protein carbonylation, PC) in D. radiodurans as well as in standard and evolved resistant strains of Escherichia col...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Krisko A,Radman M

更新日期：2010-08-10 00:00:00

abstract：:The formation of myelin by Schwann cells (SCs) occurs via a series of orchestrated molecular events. We previously used global expression profiling to examine peripheral nerve myelination and identified the NAD(+)-dependent deacetylase Sir-two-homolog 2 (Sirt2) as a protein likely to be involved in myelination. Here, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Beirowski B,Gustin J,Armour SM,Yamamoto H,Viader A,North BJ,Michán S,Baloh RH,Golden JP,Schmidt RE,Sinclair DA,Auwerx J,Milbrandt J

更新日期：2011-10-25 00:00:00

abstract：:Within the scientific community, much attention has focused on improving communications between scientists, policy makers, and the public. To date, efforts have centered on improving the content, accessibility, and delivery of scientific communications. Here we argue that in the current political and media environment...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Iyengar S,Massey DS

更新日期：2019-04-16 00:00:00

abstract：:Previously, we showed using a computational agent-based model that a group of animals moving together can make a collective decision on direction of motion, even if there is a conflict between the directional preferences of two small subgroups of "informed" individuals and the remaining "uninformed" individuals have n...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leonard NE,Shen T,Nabet B,Scardovi L,Couzin ID,Levin SA

更新日期：2012-01-03 00:00:00

abstract：:The binding of interferons to distinct cell surface receptors leads to the induction of synthesis of several unique polypeptides and their corresponding mRNAs (1-6). We have isolated two cDNAs that are complementary to nuclear RNA whose synthesis is induced from undetectable levels to maximal rates of transcription wi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Larner AC,Jonak G,Cheng YS,Korant B,Knight E,Darnell JE Jr

更新日期：1984-11-01 00:00:00

abstract：:Insulin provides a classical model of a globular protein, yet how the hormone changes conformation to engage its receptor has long been enigmatic. Interest has focused on the C-terminal B-chain segment, critical for protective self-assembly in β cells and receptor binding at target tissues. Insight may be obtained fro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Menting JG,Yang Y,Chan SJ,Phillips NB,Smith BJ,Whittaker J,Wickramasinghe NP,Whittaker LJ,Pandyarajan V,Wan ZL,Yadav SP,Carroll JM,Strokes N,Roberts CT Jr,Ismail-Beigi F,Milewski W,Steiner DF,Chauhan VS,Ward CW,Weis

更新日期：2014-08-19 00:00:00

abstract：:The counterintuitive features of quantum physics challenge many common-sense assumptions. In an interferometric quantum eraser experiment, one can actively choose whether or not to erase which-path information (a particle feature) of one quantum system and thus observe its wave feature via interference or not by perfo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ma XS,Kofler J,Qarry A,Tetik N,Scheidl T,Ursin R,Ramelow S,Herbst T,Ratschbacher L,Fedrizzi A,Jennewein T,Zeilinger A

更新日期：2013-01-22 00:00:00

abstract：:TCR-mediated recognition of beta-linked self-glycolipids bound to CD1d is poorly understood. Here, we have characterized the TCR repertoire of a CD1d-restricted type II NKT cell subset reactive to sulfatide involved in the regulation of autoimmunity and antitumor immunity. The sulfatide/CD1d-tetramer(+) cells isolated...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arrenberg P,Halder R,Dai Y,Maricic I,Kumar V

更新日期：2010-06-15 00:00:00

abstract：:A mouse monoclonal antibody (7E6A5) of IgG isotype, reacting specifically with mucin-producing goblet cells of the human gastrointestinal tract, has been developed. 7E6A5 reacts by an ELISA with colonic protein eluted from a DEAE column. A screening by immunoperoxidase assay of 76 specimens from 19 different human tis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vecchi M,Sakamaki S,Diamond B,Novikoff AB,Novikoff PM,Das KM

更新日期：1987-05-01 00:00:00

abstract：:The modern concept of neurogenesis in the adult brain is predicated on the premise that multipotent glial cells give rise to new neurons throughout life. Although extensive evidence exists indicating that this is the case, the transition from glial to neuronal phenotype remains poorly understood. A unique monolayer ce...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scheffler B,Walton NM,Lin DD,Goetz AK,Enikolopov G,Roper SN,Steindler DA

更新日期：2005-06-28 00:00:00

abstract：:Explants of human endometrium were cultured to study the release of matrix metalloproteinases (MMPs). Analysis of conditioned media by zymography revealed latent and active forms of collagenase (MMP-1, EC 3.4.24.7), 72-kDa gelatinase A (MMP-2, EC 3.4.24.24), and 92-kDa gelatinase B (MMP-9, EC 3.4.24.35). These protein...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marbaix E,Donnez J,Courtoy PJ,Eeckhout Y

更新日期：1992-12-15 00:00:00

abstract：:Hendra virus (HeV) and Nipah virus (NiV) belong to the genus Henipavirus of the family Paramyxoviridae and are unique in that they exhibit a broad species tropism and cause fatal disease in both animals and humans. They infect cells through a pH-independent membrane fusion process mediated by their fusion and attachme...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bonaparte MI,Dimitrov AS,Bossart KN,Crameri G,Mungall BA,Bishop KA,Choudhry V,Dimitrov DS,Wang LF,Eaton BT,Broder CC

更新日期：2005-07-26 00:00:00

abstract：:pRK212.2, a derivative of the broad host range plasmid RK2, contains two EcoRI cleavage fragments, A and B, neither of which can replicate by itself in Escherichia coli. Fragment A (41.7 kilobases), but not fragment B (14.4 kilobases), can be cloned by insertion into the unrelated plasmids mini-F and ColE1. Fragment B...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Figurski DH,Helinski DR

更新日期：1979-04-01 00:00:00

abstract：:Band 3, the major intrinsic protein of the human erythrocyte membrane, was specifically labeled with the covalent fluorescent probe eosin isothiocyanate. The lateral mobility of labeled band 3 in the plane of the membrane under various conditions of ionic strength and temperature was examined by using the fluorescence...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Golan DE,Veatch W

更新日期：1980-05-01 00:00:00

abstract：:Most climate models are large dynamical systems involving a million (or more) variables on big computers. Given that they are nonlinear and not perfect, what can we expect to learn from them about the earth's climate? How can we determine which aspects of their output might be useful and which are noise? And how shoul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith LA

更新日期：2002-02-19 00:00:00

abstract：:Time-resolved optical measurements encompassing the femtoseconds to seconds time scales have been used to investigate Rhodobacter capsulatus reaction centers (RCs) in which the histidine residue at position 200 on the M polypeptide has been changed to a leucine by site-directed mutagenesis. The HisM200----Leu RC, whic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kirmaier C,Holten D,Bylina EJ,Youvan DC

更新日期：1988-10-01 00:00:00

abstract：:Elevated eukaryotic initiation factor 4E (eIF4E) levels frequently occur in a variety of human cancers. Overexpression of eIF4E promotes cellular transformation by selectively increasing the translation of proliferative and prosurvival mRNAs. These mRNAs possess highly structured 5'-UTRs that impede ribosome recruitme...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Feoktistova K,Tuvshintogs E,Do A,Fraser CS

更新日期：2013-08-13 00:00:00

abstract：:We have synthesized pulmonary surfactant apoprotein SP-B peptides by solid-phase chemistry and demonstrated their ability to enhance the surface-active properties of synthetic lipid mixtures. The synthetic peptides were reactive with antiserum generated against the native bovine surfactant peptide. Both peptides confe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sarin VK,Gupta S,Leung TK,Taylor VE,Ohning BL,Whitsett JA,Fox JL

更新日期：1990-04-01 00:00:00

abstract：:We previously demonstrated that the primary region of factor IX and IXa responsible for saturable specific binding to bovine aortic endothelial cells resides in residues 3-11 at the amino terminus of factor IX. We also demonstrated that mutations of lysine to alanine at residue 5, factor IX K5A, or valine to lysine at...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheung WF,van den Born J,Kühn K,Kjellén L,Hudson BG,Stafford DW

更新日期：1996-10-01 00:00:00

abstract：:CCAAT displacement protein (CDP), a nuclear protein of 180-190 kDa, contains a triplicated motif, the cut domain, similar (80-90% conserved) to three repeats of 60-65 amino acids first identified in Drosophila cut, a homeo-domain protein involved in cell-fate decisions in development. Cut repeats bind DNA and exhibit ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aufiero B,Neufeld EJ,Orkin SH

更新日期：1994-08-02 00:00:00

abstract：:Lithium-sulfur batteries (Li-S batteries) have attracted intense interest because of their high specific capacity and low cost, although they are still hindered by severe capacity loss upon cycling caused by the soluble lithium polysulfide intermediates. Although many structure innovations at the material and device l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu W,Jiang J,Yang KR,Mi Y,Kumaravadivel P,Zhong Y,Fan Q,Weng Z,Wu Z,Cha JJ,Zhou H,Batista VS,Brudvig GW,Wang H

更新日期：2017-04-04 00:00:00

abstract：:The deadly symptoms of malaria occur as Plasmodium parasites replicate within blood cells. Members of several variant surface protein families are expressed on infected blood cell surfaces. Of these, the largest and most ubiquitous are the Plasmodium-interspersed repeat (PIR) proteins, with more than 1,000 variants in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harrison TE,Reid AJ,Cunningham D,Langhorne J,Higgins MK

更新日期：2020-12-15 00:00:00

abstract：:Unlike other cation channels, each subunit of most transient receptor potential (TRP) channels has an additional TRP-domain helix with an invariant tryptophan immediately trailing the gate-bearing S6. Recent cryo-electron microscopy of TRP vanilloid subfamily, member 1 structures revealed that this domain is a five-tu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Teng J,Loukin SH,Anishkin A,Kung C

更新日期：2015-03-17 00:00:00

abstract：:The vascular endothelial growth factor (VEGF) family has recently expanded by the identification and cloning of three additional members, namely VEGF-B, VEGF-C, and VEGF-D. In this study we demonstrate that VEGF-B binds selectively to VEGF receptor-1/Flt-1. This binding can be blocked by excess VEGF, indicating that t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Olofsson B,Korpelainen E,Pepper MS,Mandriota SJ,Aase K,Kumar V,Gunji Y,Jeltsch MM,Shibuya M,Alitalo K,Eriksson U

更新日期：1998-09-29 00:00:00

abstract：:Amorphous silicon oxycarbide polymer-derived ceramics (PDCs), synthesized from organometallic precursors, contain carbon- and silica-rich nanodomains, the latter with extensive substitution of carbon for oxygen, linking Si-centered SiO(x)C(4-x) tetrahedra. Calorimetric studies demonstrated these PDCs to be thermodynam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sen S,Widgeon SJ,Navrotsky A,Mera G,Tavakoli A,Ionescu E,Riedel R

更新日期：2013-10-01 00:00:00

abstract：:Chicken ovalbumin upstream promoter-transcription factor (COUP-TF) genes encode transcription factors belonging to the orphan subfamily of the steroid/thyroid hormone receptor superfamily. Two COUP-TF counterparts have been cloned from mouse. In an attempt to study the function of these genes in the developing central...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qiu Y,Cooney AJ,Kuratani S,DeMayo FJ,Tsai SY,Tsai MJ

更新日期：1994-05-10 00:00:00

abstract：:Aberrant promoter hypermethylation is frequently observed in cancer. The potential for this mechanism to contribute to tumor development depends on whether the genes affected are repressed because of their methylation. Many aberrantly methylated genes play important roles in development and are bivalently marked in ES...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sproul D,Nestor C,Culley J,Dickson JH,Dixon JM,Harrison DJ,Meehan RR,Sims AH,Ramsahoye BH

更新日期：2011-03-15 00:00:00

abstract：:Pyramidal cells in piriform cortex receive excitatory inputs from two different sources that are segregated onto adjacent segments of their apical dendrites. The present studies show that excitatory postsynaptic potentials (EPSPs) evoked by primary olfactory tract afferents that terminate on distal apical segments dis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bower JM,Haberly LB

更新日期：1986-02-01 00:00:00