Abstract:
:Adult naive T cells, which are at rest in normal conditions, proliferate strongly when transferred to lymphopenic hosts. In neonates, the first mature thymocytes to migrate to the periphery reach a compartment devoid of preexisting T cells. We have extensively analyzed the proliferation rate and phenotype of peripheral T cells from normal C57BL/6 and T cell antigen receptor transgenic mice as a function of age. We show that, like adult naive T cells transferred to lymphopenic mice, neonatal naive T cells proliferate strongly. By using bone-marrow transfer and thymic-graft models, we demonstrate that the proliferation of the first thymic emigrants reaching the periphery requires T cell antigen receptor-self-peptide/self-MHC interactions and is regulated by the size of the peripheral T cell pool.
journal_name
Proc Natl Acad Sci U S Aauthors
Le Campion A,Bourgeois C,Lambolez F,Martin B,Léaument S,Dautigny N,Tanchot C,Pénit C,Lucas Bdoi
10.1073/pnas.062621699keywords:
subject
Has Abstractpub_date
2002-04-02 00:00:00pages
4538-43issue
7eissn
0027-8424issn
1091-6490pii
062621699journal_volume
99pub_type
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