Distinct ontogenic and regional expressions of newly identified Cajal-Retzius cell-specific genes during neocorticogenesis.

Abstract:

:Cajal-Retzius (CR) cells are early-generated transient neurons and are important in the regulation of cortical neuronal migration and cortical laminar formation. Molecular entities characterizing the CR cell identity, however, remain largely elusive. We purified mouse cortical CR cells expressing GFP to homogeneity by fluorescence-activated cell sorting and examined a genome-wide expression profile of cortical CR cells at embryonic and postnatal periods. We identified 49 genes that exceeded hybridization signals by >10-fold in CR cells compared with non-CR cells at embryonic day 13.5, postnatal day 2, or both. Among these CR cell-specific genes, 25 genes, including the CR cell marker genes such as the reelin and calretinin genes, are selectively and highly expressed in both embryonic and postnatal CR cells. These genes, which encode generic properties of CR cell specificity, are eminently characterized as modulatory composites of voltage-dependent calcium channels and sets of functionally related cellular components involved in cell migration, adhesion, and neurite extension. Five genes are highly expressed in CR cells at the early embryonic period and are rapidly down-regulated thereafter. Furthermore, some of these genes have been shown to mark two distinctly different focal regions corresponding to the CR cell origins. At the late prenatal and postnatal periods, 19 genes are selectively up-regulated in CR cells. These genes include functional molecules implicated in synaptic transmission and modulation. CR cells thus strikingly change their cellular phenotypes during cortical development and play a pivotal role in both corticogenesis and cortical circuit maturation.

authors

Yamazaki H,Sekiguchi M,Takamatsu M,Tanabe Y,Nakanishi S

doi

10.1073/pnas.0406295101

keywords:

subject

Has Abstract

pub_date

2004-10-05 00:00:00

pages

14509-14

issue

40

eissn

0027-8424

issn

1091-6490

pii

0406295101

journal_volume

101

pub_type

杂志文章
  • Reversible single-molecule photoswitching in the GFP-like fluorescent protein Dronpa.

    abstract::Reversible photoswitching of individual molecules has been demonstrated for a number of mutants of the green fluorescent protein (GFP). To date, however, a limited number of switching events with slow response to light have been achieved at the single-molecule level. Here, we report reversible photoswitching character...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0500489102

    authors: Habuchi S,Ando R,Dedecker P,Verheijen W,Mizuno H,Miyawaki A,Hofkens J

    更新日期:2005-07-05 00:00:00

  • Combined deficiency for MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development.

    abstract::MAP kinase-interacting kinase 1 and 2 (Mnk1 and Mnk2) are protein-serine/threonine kinases that are activated by ERK or p38 and phosphorylate eIF4E, which is involved in cap-dependent translation initiation. However, Mnk1/2 double knockout (Mnk-DKO) mice show normal cell growth and development despite an absence of eI...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1008136107

    authors: Ueda T,Sasaki M,Elia AJ,Chio II,Hamada K,Fukunaga R,Mak TW

    更新日期:2010-08-10 00:00:00

  • CEACAMs serve as toxin-stimulated receptors for enterotoxigenic Escherichia coli.

    abstract::The enterotoxigenic Escherichia coli (ETEC) are among the most common causes of diarrheal illness and death due to diarrhea among young children in low-/middle-income countries (LMICs). ETEC have also been associated with important sequelae including malnutrition and stunting, placing children at further risk of death...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.2012480117

    authors: Sheikh A,Tumala B,Vickers TJ,Alvarado D,Ciorba MA,Bhuiyan TR,Qadri F,Singer BB,Fleckenstein JM

    更新日期:2020-11-17 00:00:00

  • Molecular cloning and amplification of the adenylate cyclase gene.

    abstract::A segment of DNA containing cya, the gene for adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1], has been isolated from Salmonella typhimurium. The phage lambda gt4 was used as a cloning vector and adenylate cyclase-positive hybrid phages were isolated that complemented adenylate cyclase-negative bac...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.78.8.4684

    authors: Wang JY,Clegg DO,Koshland DE Jr

    更新日期:1981-08-01 00:00:00

  • The scaling of frontal cortex in primates and carnivores.

    abstract::Size has a profound effect on the structure of the brain. Many brain structures scale allometrically, that is, their relative size changes systematically as a function of brain size. Here we use independent contrasts analysis to examine the scaling of frontal cortex in 43 species of mammals including 25 primates and 1...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0305760101

    authors: Bush EC,Allman JM

    更新日期:2004-03-16 00:00:00

  • Monte Carlo simulations of the folding of beta-barrel globular proteins.

    abstract::With the use of dynamic Monte Carlo simulations, the necessary conditions for the collapse from a random-coil denatured state to a structurally unique four-member beta-barrel native state of a model globular protein have been investigated. These systems are free to roam through all of configuration space--both native ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.85.14.5057

    authors: Skolnick J,Kolinski A,Yaris R

    更新日期:1988-07-01 00:00:00

  • Isolation and characterization of delta-subspecies of protein kinase C from rat brain.

    abstract::The delta-subspecies of protein kinase C (delta PKC) was purified to near homogeneity from the Triton X-100 extract of the rat brain particulate fraction by successive chromatographies on S-Sepharose fast flow, phenyl 5PW, heparin 5PW, hydroxyapatite, and Mono Q columns. The purified enzyme was a doublet with molecula...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.89.5.1592

    authors: Ogita K,Miyamoto S,Yamaguchi K,Koide H,Fujisawa N,Kikkawa U,Sahara S,Fukami Y,Nishizuka Y

    更新日期:1992-03-01 00:00:00

  • Functional interaction of erythropoietin and stem cell factor receptors is essential for erythroid colony formation.

    abstract::Production of mature erythrocytes requires multiple growth factors, but we do not know how their actions are coordinated. Here we show that erythroid progenitors from erythropoietin receptor (Epo-R)-/- fetal livers, infected in vitro with a retrovirus expressing the wild-type Epo-R, require addition of both Epo and st...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.94.5.1806

    authors: Wu H,Klingmüller U,Acurio A,Hsiao JG,Lodish HF

    更新日期:1997-03-04 00:00:00

  • Correlation of individual papilloma latency time with DNA adducts, 8-hydroxy-2'-deoxyguanosine, and the rate of DNA synthesis in the epidermis of mice treated with 7,12-dimethylbenz[alpha]anthracene.

    abstract::The question was addressed whether the risk of cancer of an individual in a heterogeneous population can be predicted on the basis of measurable biochemical and biological variables postulated to be associated with the process of chemical carcinogenesis. Using the skin tumor model with outbred male NMRI mice, the late...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.92.13.5900

    authors: Fischer WH,Lutz WK

    更新日期:1995-06-20 00:00:00

  • Expression of purine overproduction in a series of 8-azaguanine-resistant diploid human lymphoblast lines.

    abstract::For study of the basis of an X-linked form of gout in man, several clonal lines deficient in hypoxanthine-guanine phosphoribosyltransferase (EC 2.4.2.8) were selected from the human lymphoblast line WI-L2 by spontaneous and mutagen-induced resistance to 10 muM 8-azaguanine. Three groups could be defined: (1) clones wi...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.71.7.2679

    authors: Lever JE,Nuki G,Seegmiller JE

    更新日期:1974-07-01 00:00:00

  • HLA-C is the inhibitory ligand that determines dominant resistance to lysis by NK1- and NK2-specific natural killer cells.

    abstract::Natural killer (NK) cells recognize alloantigens on normal cells. One of these alloantigens correlates with homozygosity for a dimorphism of HLA-C at positions 77-80, which is shared by a number of HLA-C alleles. A second allelic alloantigen correlates with homozygosity for the alternative HLA-C dimorphism, which is s...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.90.24.12000

    authors: Colonna M,Borsellino G,Falco M,Ferrara GB,Strominger JL

    更新日期:1993-12-15 00:00:00

  • Radio frequency transmitter based on a laser frequency comb.

    abstract::Since the days of Hertz, radio transmitters have evolved from rudimentary circuits emitting around 50 MHz to modern ubiquitous Wi-Fi devices operating at gigahertz radio bands. As wireless data traffic continues to increase, there is a need for new communication technologies capable of high-frequency operation for hig...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1903534116

    authors: Piccardo M,Tamagnone M,Schwarz B,Chevalier P,Rubin NA,Wang Y,Wang CA,Connors MK,McNulty D,Belyanin A,Capasso F

    更新日期:2019-05-07 00:00:00

  • Spontaneous self-assembly and structure of perfluoroalkylalkane surfactant hemimicelles by molecular dynamics simulations.

    abstract::Fully atomistic molecular-dynamics (MD) simulations of perfluoroalkylalkane molecules at the surface of water show the spontaneous formation of aggregates whose size and topography closely resemble the experimentally observed hemimicelles for this system. Furthermore, the grazing incidence X-ray diffraction (GIXD) pat...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1906782116

    authors: Silva GMC,Morgado P,Lourenço P,Goldmann M,Filipe EJM

    更新日期:2019-07-23 00:00:00

  • Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-beta antibody in db/db diabetic mice.

    abstract::Emerging evidence suggests that transforming growth factor-beta (TGF-beta) is an important mediator of diabetic nephropathy. We showed previously that short-term treatment with a neutralizing monoclonal anti-TGF-beta antibody (alphaT) in streptozotocin-diabetic mice prevents early changes of renal hypertrophy and incr...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.120055097

    authors: Ziyadeh FN,Hoffman BB,Han DC,Iglesias-De La Cruz MC,Hong SW,Isono M,Chen S,McGowan TA,Sharma K

    更新日期:2000-07-05 00:00:00

  • Mechanophenotyping of 3D multicellular clusters using displacement arrays of rendered tractions.

    abstract::Epithelial tissues mechanically deform the surrounding extracellular matrix during embryonic development, wound repair, and tumor invasion. Ex vivo measurements of such multicellular tractions within three-dimensional (3D) biomaterials could elucidate collective dissemination during disease progression and enable prec...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1918296117

    authors: Leggett SE,Patel M,Valentin TM,Gamboa L,Khoo AS,Williams EK,Franck C,Wong IY

    更新日期:2020-03-17 00:00:00

  • Copper nanoparticle ensembles for selective electroreduction of CO2 to C2-C3 products.

    abstract::Direct conversion of carbon dioxide to multicarbon products remains as a grand challenge in electrochemical CO2 reduction. Various forms of oxidized copper have been demonstrated as electrocatalysts that still require large overpotentials. Here, we show that an ensemble of Cu nanoparticles (NPs) enables selective form...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1711493114

    authors: Kim D,Kley CS,Li Y,Yang P

    更新日期:2017-10-03 00:00:00

  • Stabilization of morphine tolerance with long-term dosing: association with selective upregulation of mu-opioid receptor splice variant mRNAs.

    abstract::Chronic morphine administration is associated with the development of tolerance, both clinically and in animal models. Many assume that tolerance is a continually progressive response to chronic opioid dosing. However, clinicians have long appreciated the ability to manage cancer pain in patients for months on stable ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1419183112

    authors: Xu J,Faskowitz AJ,Rossi GC,Xu M,Lu Z,Pan YX,Pasternak GW

    更新日期:2015-01-06 00:00:00

  • Temperature and manganese as determining factors in the presence of diatom or blue-green algal floras in streams.

    abstract::Diatoms are usually the major component of the algal flora in many streams, although green and blue-green algae may be present. These experiments were designed to determine if high temperature or a shift in the chemical composition of the water might bring about a dominance of blue-green algae and/or green algae rathe...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.64.2.472

    authors: Patrick R,Crum B,Coles J

    更新日期:1969-10-01 00:00:00

  • Two motion perception mechanisms revealed through distance-driven reversal of apparent motion.

    abstract::We demonstrate two kinds of visual stimuli that exhibit motion in one direction when viewed from near and in the opposite direction from afar. These striking reversals occur because each kind of stimulus is constructed to simultaneously activate two different mechanisms: a short-range mechanism that computes motion fr...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.86.8.2985

    authors: Chubb C,Sperling G

    更新日期:1989-04-01 00:00:00

  • Copper and the ACE1 regulatory protein reversibly induce yeast metallothionein gene transcription in a mouse extract.

    abstract::We describe a cell-free system in which the transcription of the yeast metallothionein gene is inducible by the addition of metal ions plus a specific regulatory protein. Efficient transcription requires the complete yeast ACE1 metalloregulatory protein, including both its DNA-binding and transactivation domains; a mo...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.86.21.8377

    authors: Culotta VC,Hsu T,Hu S,Fürst P,Hamer D

    更新日期:1989-11-01 00:00:00

  • Impaired attentional selection following lesions to human pulvinar: evidence for homology between human and monkey.

    abstract::We examined the contributions of the human pulvinar to goal directed selection of visual targets in 3 patients with chronic, unilateral lesions involving topographic maps in the ventral pulvinar. Observers completed 2 psychophysical tasks in which they discriminated the orientation of a lateralized target grating in t...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 临床试验,杂志文章

    doi:10.1073/pnas.0810086106

    authors: Snow JC,Allen HA,Rafal RD,Humphreys GW

    更新日期:2009-03-10 00:00:00

  • Plant mating system transitions drive the macroevolution of defense strategies.

    abstract::Understanding the factors that shape macroevolutionary patterns in functional traits is a central goal of evolutionary biology. Alternative strategies of sexual reproduction (inbreeding vs. outcrossing) have divergent effects on population genetic structure and could thereby broadly influence trait evolution. However,...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1213867110

    authors: Campbell SA,Kessler A

    更新日期:2013-03-05 00:00:00

  • Theory of muscular contraction extended to groups of actin sites.

    abstract::It was shown in an earlier paper how to connect, in principle, the biochemical states of a cross-bridge with the mechanics of muscular contraction, by the methods of statistical mechanics. The treatment applies to cross-bridges that are able to interact with only one actin site at a time. The present paper shows that ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.70.10.2732

    authors: Hill TL

    更新日期:1973-10-01 00:00:00

  • Mitogen-activated protein kinase kinase 3 is a pivotal pathway regulating p38 activation in inflammatory arthritis.

    abstract::p38 mitogen-activated protein kinase (MAPK) regulates cytokines in arthritis and is, in turn, regulated by MAPK kinase (MKK) 3 and MKK6. To modulate p38 function but potentially minimize toxicity, we evaluated the utility of targeting MKK3 by using MKK3(-/-) mice. These studies showed that TNF-alpha increased phosphor...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0509188103

    authors: Inoue T,Boyle DL,Corr M,Hammaker D,Davis RJ,Flavell RA,Firestein GS

    更新日期:2006-04-04 00:00:00

  • Shoot circumnutation and winding movements require gravisensing cells.

    abstract::Circumnutation and winding in plants are universal growth movements that allow plants to survive despite their sessile nature. However, the detailed molecular mechanisms controlling these phenomena remain unclear. We previously found that a gravitropic mutant of Japanese morning glory (Pharbitis nil or Ipomoea nil), S...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0504617102

    authors: Kitazawa D,Hatakeda Y,Kamada M,Fujii N,Miyazawa Y,Hoshino A,Iida S,Fukaki H,Morita MT,Tasaka M,Suge H,Takahashi H

    更新日期:2005-12-20 00:00:00

  • Elevated serum ribonuclease in patients with pancreatic cancer.

    abstract::Serum RNase (ribonuclease) of normal persons and of patients with pancreatitis, carcinoma of pancreas, or other neoplasms was determined with poly(C) as substrate. Strikingly abnormal elevations occur in the serum RNase of patients with pancreatic cancer. There is no elevation in the serum RNase level of patients with...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.73.7.2308

    authors: Reddi KK,Holland JF

    更新日期:1976-07-01 00:00:00

  • Adaptive evolution of cytochrome c oxidase: Infrastructure for a carnivorous plant radiation.

    abstract::Much recent attention in the study of adaptation of organismal form has centered on developmental regulation. As such, the highly conserved respiratory machinery of eukaryotic cells might seem an unlikely target for selection supporting novel morphologies. We demonstrate that a dramatic molecular evolutionary rate inc...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0408092101

    authors: Jobson RW,Nielsen R,Laakkonen L,Wikström M,Albert VA

    更新日期:2004-12-28 00:00:00

  • A p60 polypeptide in the feline leukemia virus pseudotype of Moloney sarcoma virus with murine leukemia virus p30 antigenic determinants.

    abstract::A 60,000-dalton polypeptide (p60) has been identified in the feline leukemia virus (FeLV) pseudotype of Moloney sarcoma virus [MSV(FeLV)]. This polypeptide is present in the purified virus complex in concentrations greater than either the murine p30 or the feline p27. Purified p60 crossreacts immunologically with muri...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.72.6.2380

    authors: Oskarsson MK,Robey WG,Harris CL,Fischinger PJ,Haapala DK,Vande Woude GF

    更新日期:1975-06-01 00:00:00

  • Use of riboflavin-binding protein to investigate steric and electronic relationships in flavin analogs and models.

    abstract::We have examined the affinity of two recently synthesized flavin analogs for the isoalloxazine binding site of riboflavin-binding protein (RBP). The results showed that pyrimidopteridines could bind to RBP (Kd 160-250 microM). This suggested that, at the FMN or FAD level, these analogs might also bind to other apoflav...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.81.14.4246

    authors: Wessiak A,Schopfer LM,Yuan LC,Bruice TC,Massey V

    更新日期:1984-07-01 00:00:00

  • The impact of rising CO2 and acclimation on the response of US forests to global warming.

    abstract::The response of forests to climate change depends in part on whether the photosynthetic benefit from increased atmospheric CO2 (∆Ca = future minus historic CO2) compensates for increased physiological stresses from higher temperature (∆T). We predicted the outcome of these competing responses by using optimization the...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1913072116

    authors: Sperry JS,Venturas MD,Todd HN,Trugman AT,Anderegg WRL,Wang Y,Tai X

    更新日期:2019-12-17 00:00:00