Abstract:
:The type-III secretion (T3S) systems of bacteria are part of self-assembling nanomachines: the bacterial flagellum that enables cells to propel themselves through liquid and across hydrated surfaces, and the injectisome that delivers pathogenic effector proteins into eukaryotic host cells. Although the flagellum and injectisome serve different purposes, they are evolutionarily related and share many structural similarities. Core features to these T3S systems are intrinsic length control mechanisms for external cellular projections: the hook of the flagellum and the injectisome needle. We present evidence that the Spi-1 injectisome, like the Salmonella flagellar hook, uses a secreted molecular ruler, InvJ, to determine needle length. This result supports a universal length control mechanism using molecular rulers for T3S systems.
journal_name
Proc Natl Acad Sci U S Aauthors
Wee DH,Hughes KTdoi
10.1073/pnas.1423492112subject
Has Abstractpub_date
2015-03-31 00:00:00pages
4098-103issue
13eissn
0027-8424issn
1091-6490pii
1423492112journal_volume
112pub_type
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