Synergism between hypersensitive sites confers long-range gene activation by the beta-globin locus control region.

abstract：:Previous research and theory suggest that two stable personality dimensions, extroversion and neuroticism, differentially influence emotional reactivity to a variety of pleasurable phenomena. Here, we use event-related functional MRI to address the putative neural and behavioral associations between humor appreciation...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mobbs D,Hagan CC,Azim E,Menon V,Reiss AL

更新日期：2005-11-08 00:00:00

abstract：:Recent evidence suggests that the microbial community in the human intestine may play an important role in the pathogenesis of obesity. We examined 184,094 sequences of microbial 16S rRNA genes from PCR amplicons by using the 454 pyrosequencing technology to compare the microbial community structures of 9 individuals,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang H,DiBaise JK,Zuccolo A,Kudrna D,Braidotti M,Yu Y,Parameswaran P,Crowell MD,Wing R,Rittmann BE,Krajmalnik-Brown R

更新日期：2009-02-17 00:00:00

abstract：:The human papillomavirus E7 protein is phosphorylated at the two serines in positions 31/32, which are part of a consensus sequence for casein kinase II (CKII). In this study, we have investigated the effect of CKII phosphorylation site mutations, all of which lead to unphosphorylated E7 proteins. The replacement of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Firzlaff JM,Lüscher B,Eisenman RN

更新日期：1991-06-15 00:00:00

abstract：:We have inserted the sequence 5'-AAG-GAGGU-3', which is complementary to the 3' terminus of Escherichia coli 16S rRNA, in a reading frame and analyzed its effect on the accuracy and overall rate of translation in vivo. Translation over the sequence yields a 50% ribosomal frameshift if the reading phase is A-AGG-AGG-U....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spanjaard RA,van Duin J

更新日期：1988-11-01 00:00:00

abstract：:The plasma concentration of the major vitamin D metabolites; 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, and 24,25-dihydroxyvitamin D were measured during pregnancy and lactation in the adult female rat. The concentrations of these metabolites were also measured in rat pups during lactation and after weaning. The pl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Halloran BP,Barthell EN,DeLuca HF

更新日期：1979-11-01 00:00:00

abstract：:Continuous and intensive exploitation of wildlife resources by early agricultural societies had major ecological consequences in the ancient Near East. In particular, hunting strategies of post-Neolithic societies involving the mass killing of wild ungulates contributed to the eventual extirpation of a number of wild ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bar-Oz G,Zeder M,Hole F

更新日期：2011-05-03 00:00:00

abstract：:Injection of exogenous mRNA purified from various tissue preparations into cellular translation systems such as Xenopus oocytes has allowed expression of complex proteins (e.g., receptors for neurotransmitters). No evidence for expression of injected exogenous mRNA, however, has been reported in terminally differentia...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mochida S,Poulain B,Eisel U,Binz T,Kurazono H,Niemann H,Tauc L

更新日期：1990-10-01 00:00:00

abstract：:A previously undescribed toothless flying reptile from northeastern China, Nemicolopterus crypticus gen. et sp. nov., was discovered in the lacustrine sediments of the Early Cretaceous Jiufotang Formation, western Liaoning, China. The specimen consists of an almost complete articulated skeleton (IVPP V14377) and, desp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang X,Kellner AW,Zhou Z,Campos Dde A

更新日期：2008-02-12 00:00:00

abstract：:Ubiquitylation of histone H2B at lysine 120 (H2B-Ub) plays a critical role in transcriptional elongation, chromatin conformation, as well as the regulation of specific histone H3 methylations. Herein, we report a strategy for the site-specific chemical attachment of ubiquitin to preassembled nucleosomes. This allowed ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Holt MT,David Y,Pollock S,Tang Z,Jeon J,Kim J,Roeder RG,Muir TW

更新日期：2015-08-18 00:00:00

abstract：:The conservation of endangered fish is of critical importance. Cryobanking could provide an effective backup measure for use in conjunction with the conservation of natural populations; however, methodology for cryopreservation of fish eggs and embryos has not yet been developed. The present study established a method...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee S,Iwasaki Y,Shikina S,Yoshizaki G

更新日期：2013-01-29 00:00:00

abstract：:Pancreatic cancer is one of the most deadly cancers affecting the Western world. Because the disease is highly metastatic and difficult to diagnosis until late stages, the 5-y survival rate is around 5%. The identification of molecular cancer drivers is critical for furthering our understanding of the disease and deve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mann KM,Ward JM,Yew CC,Kovochich A,Dawson DW,Black MA,Brett BT,Sheetz TE,Dupuy AJ,Australian Pancreatic Cancer Genome Initiative.,Chang DK,Biankin AV,Waddell N,Kassahn KS,Grimmond SM,Rust AG,Adams DJ,Jenkins NA,Copela

更新日期：2012-04-17 00:00:00

abstract：:We have studied androgen binding characteristics of cells for androgen insensitivity from an obligate heterozygote, who is the mother of three male pseudohermaphrodites with dihydrotestosterone (17beta-hydroxy-5alpha-androstan-3-one) receptor deficiency. Specific dihydrotestosterone binding by skin fibroblasts from he...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meyer WJ 3rd,Migeon BR,Migeon CJ

更新日期：1975-04-01 00:00:00

abstract：:Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system postulated to be a cell-mediated autoimmune disease in which interferon gamma (IFN-gamma) plays an important role. There is increased IFN-gamma secretion in MS, and IFN-gamma administration induces exacerbations of disease. We foun...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Balashov KE,Smith DR,Khoury SJ,Hafler DA,Weiner HL

更新日期：1997-01-21 00:00:00

abstract：:The pineal organ of the lizard Anolis carolinensis can be maintained for up to 10 days in superfused organ culture. During this time it synthesizes and releases melatonin into the medium flowing slowly over it. Collection of timed aliquots of medium and subsequent analysis for melatonin by radioimmunoassay reveal circ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Menaker M,Wisner S

更新日期：1983-10-01 00:00:00

abstract：:Fibronectin mediates the adhesion of cells to collagen by first binding to the collagen substrate, followed by attachment of the cells to the fibronectin-collagen complex. Bovine brain gangliosides were found to block fibronectin-mediated cell adhesion to collagen in a concentration-dependent manner. The gangliosides ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kleinman HK,Martin GR,Fishman PH

更新日期：1979-07-01 00:00:00

abstract：:The baculovirus Autographa californica nuclear polyhedrosis virus (AcMNPV, which is representative of the MNPV subtype in which the virions may contain many nucleocapsids within a single viral envelope) encodes a protein, v-ubi, that has 76% identity with the eukaryotic protein ubiquitin. Transcriptional mapping indic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guarino LA

更新日期：1990-01-01 00:00:00

abstract：:Cerebral arteriovenous malformations (AVMs) are common vascular malformations, which may result in hemorrhagic strokes and neurological deficits. Bone morphogenetic protein (BMP) and Notch signaling are both involved in the development of cerebral AVMs, but the cross-talk between the two signaling pathways is poorly u...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yao Y,Yao J,Radparvar M,Blazquez-Medela AM,Guihard PJ,Jumabay M,Boström KI

更新日期：2013-11-19 00:00:00

abstract：:In spite of the diversity of possible biological forms observed in nature, a limited range of morphospace is frequently occupied for a given trait. Several mechanisms have been proposed to explain this bias in the distribution of phenotypes including selection, drift, and developmental constraints. Despite extensive w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Malagón JN,Ahuja A,Sivapatham G,Hung J,Lee J,Muñoz-Gómez SA,Atallah J,Singh RS,Larsen E

更新日期：2014-09-30 00:00:00

abstract：:Guanylyl cyclase C (GCC) has been detected only in intestinal mucosa and colon carcinoma cells of placental mammals. However, this receptor has been identified in several tissues in marsupials, and its expression has been suggested in tissues other than intestine in placental mammals. Selective expression of GCC by co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carrithers SL,Barber MT,Biswas S,Parkinson SJ,Park PK,Goldstein SD,Waldman SA

更新日期：1996-12-10 00:00:00

abstract：:We describe a role for ECM as a biosensor for inflammatory microenvironments that plays a critical role in peripheral immune tolerance. We show that hyaluronan (HA) promotes induction of Foxp3- IL-10-producing regulatory T cells (TR1) from conventional T-cell precursors in both murine and human systems. This is, to ou...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bollyky PL,Wu RP,Falk BA,Lord JD,Long SA,Preisinger A,Teng B,Holt GE,Standifer NE,Braun KR,Xie CF,Samuels PL,Vernon RB,Gebe JA,Wight TN,Nepom GT

更新日期：2011-05-10 00:00:00

abstract：:The present study determined the effect of [Sar(1)-Ile(8)]-angiotensin II on steroidogenesis and induced aldosterone synthesis by the octapeptide angiotensin II, the heptapeptide des-Asp(1)-angiotensin II, and adrenocorticotropic hormone. Rabbit adrenal cells were suspended by incubation of the capsular cortical tissu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chiu AT,Peach MJ

更新日期：1974-02-01 00:00:00

abstract：:The polymerase chain reaction was used to amplify DNA surrounding the codon 12 region of the c-Ki-ras gene from C3H/10T1/2 cells and from a number of 3-methylcholanthrene (MCA)-transformed derivatives of these cells. Sequence analysis demonstrated that tumorigenic MCAC116/39 cells, known by DNA-mediated transfection t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen AC,Herschman HR

更新日期：1989-03-01 00:00:00

abstract：:Double-strand breaks (DSBs) in DNA are lethal unless repaired. Faithful repair requires processing of the DSB ends and interaction with intact homologous DNA, which can produce genetic recombinants. To determine the role of nucleases in DSB end-processing and joint molecule resolution, we studied recombination at the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Farah JA,Cromie GA,Smith GR

更新日期：2009-06-09 00:00:00

abstract：:Combinations of low dosages of purified murine hematopoietic colony-stimulating factors (CSFs)--L-cell CSF type 1 (CSF-1), recombinant interleukin 3 (IL-3), and recombinant granulocyte/macrophage CSF (GM-CSF)--were compared with single CSFs for their influence on the cycling rates and numbers of bone marrow granulocyt...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Broxmeyer HE,Williams DE,Hangoc G,Cooper S,Gillis S,Shadduck RK,Bicknell DC

更新日期：1987-06-01 00:00:00

abstract：:Germ-line missense mutations of the receptor-like tyrosine kinase ret are the causative genetic event of the multiple endocrine neoplasia (MEN) type 2A and type 2B syndromes and of the familial medullary thyroid carcinoma. We have used the rat pheochromocytoma cell line, PC12, as a model system to investigate the mech...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Califano D,D'Alessio A,Colucci-D'Amato GL,De Vita G,Monaco C,Santelli G,Di Fiore PP,Vecchio G,Fusco A,Santoro M,de Franciscis V

更新日期：1996-07-23 00:00:00

abstract：:Permanent transfer of genetic information from chromosomes isolated from human diploid cells to recipient cells has been demonstrated. Human metaphase chromosomes were incubated with mouse A9 fibroblasts deficient in hypoxanthine phosphoribosyltransferase (IMP:pyrophosphate phosphoribosyltransferase, EC 2.4.2.8) and a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burch JW,McBride OW

更新日期：1975-05-01 00:00:00

abstract：:We have isolated overlapping phage genomic clones covering an area of 26 kilobases that encodes the human alpha 2-plasmin inhibitor. The alpha 2-plasmin inhibitor gene contains 10 exons and 9 introns distributed over approximately 16 kilobases of DNA. To our knowledge, the number of introns is the highest yet reported...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hirosawa S,Nakamura Y,Miura O,Sumi Y,Aoki N

更新日期：1988-09-01 00:00:00

abstract：:Apolipoprotein A-I (apo A-I), the major apolipoprotein in human high density lipoproteins, is involved in the disease atherosclerosis. Cloned apo A-I cDNA (pA1-3) was used as a probe in chromosome mapping studies to detect the human apo A-I structural gene sequence in human-Chinese hamster cell hybrids. Southern blot ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheung P,Kao FT,Law ML,Jones C,Puck TT,Chan L

更新日期：1984-01-01 00:00:00

abstract：:Current models of the formation and distribution of gold deposits on Earth are based on the long-standing paradigm that hydrogen sulfide and chloride are the ligands responsible for gold mobilization and precipitation by fluids across the lithosphere. Here we challenge this view by demonstrating, using in situ X-ray a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pokrovski GS,Kokh MA,Guillaume D,Borisova AY,Gisquet P,Hazemann JL,Lahera E,Del Net W,Proux O,Testemale D,Haigis V,Jonchière R,Seitsonen AP,Ferlat G,Vuilleumier R,Saitta AM,Boiron MC,Dubessy J

更新日期：2015-11-03 00:00:00

abstract：:Incubation of a human beta-globin pre-mRNA in a HeLa cell nuclear extract under conditions permissive for efficient splicing resulted in the assembly of the RNA into ribonucleoprotein (RNP) complexes. This RNP formation occurred largely within the characteristic lag period that precedes splicing. Two classes of RNP we...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mayrand SH,Pedersen N,Pederson T

更新日期：1986-06-01 00:00:00