Abstract:
:Disease tolerance, the capacity of tissues to withstand damage caused by a stimulus without a decline in host fitness, varies across tissues, environmental conditions, and physiologic states. While disease tolerance is a known strategy of host defense, its role in noninfectious diseases has been understudied. Here, we provide evidence that a thermogenic fat-epithelial cell axis regulates intestinal disease tolerance during experimental colitis. We find that intestinal disease tolerance is a metabolically expensive trait, whose expression is restricted to thermoneutral mice and is not transferable by the microbiota. Instead, disease tolerance is dependent on the adrenergic state of thermogenic adipocytes, which indirectly regulate tolerogenic responses in intestinal epithelial cells. Our work has identified an unexpected mechanism that controls intestinal disease tolerance with implications for colitogenic diseases.
journal_name
Proc Natl Acad Sci U S Aauthors
Man K,Bowman C,Braverman KN,Escalante V,Tian Y,Bisanz JE,Ganeshan K,Wang B,Patterson A,Bayrer JR,Turnbaugh PJ,Chawla Adoi
10.1073/pnas.2012003117subject
Has Abstractpub_date
2020-12-15 00:00:00pages
32029-32037issue
50eissn
0027-8424issn
1091-6490pii
2012003117journal_volume
117pub_type
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