P2Y2 receptor activates nerve growth factor/TrkA signaling to enhance neuronal differentiation.

abstract：:Considerable effort has been directed toward controlling tuberculosis, which kills almost two million people yearly. High on the research agenda is the discovery of biomarkers of active tuberculosis (TB) for diagnosis and for monitoring treatment outcome. Rational biomarker discovery requires understanding host-pathog...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kunnath-Velayudhan S,Salamon H,Wang HY,Davidow AL,Molina DM,Huynh VT,Cirillo DM,Michel G,Talbot EA,Perkins MD,Felgner PL,Liang X,Gennaro ML

更新日期：2010-08-17 00:00:00

abstract：:The transport of moisture in the tropics is a critical process for the global energy budget and on geologic timescales, has markedly influenced continental landscapes, migratory pathways, and biological evolution. Here we present a continuous, first-of-its-kind 1.3-My record of continental hydroclimate and lake-level ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lyons RP,Scholz CA,Cohen AS,King JW,Brown ET,Ivory SJ,Johnson TC,Deino AL,Reinthal PN,McGlue MM,Blome MW

更新日期：2015-12-22 00:00:00

abstract：:Knowledge of vibratory patterns in the cochlea is crucial to understanding the stimulation of mechanosensory cells. Experiments to determine the motion of the cochlear partition and surrounding fluid are extremely challenging. As a result, the motion data are incomplete and often contradictory. The bending mechanism o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cai H,Shoelson B,Chadwick RS

更新日期：2004-04-20 00:00:00

abstract：:The Cercospora nicotianae SOR1 (singlet oxygen resistance) gene was identified previously as a gene involved in resistance of this fungus to singlet-oxygen-generating phototoxins. Although homologues to SOR1 occur in organisms in four kingdoms and encode one of the most highly conserved proteins yet identified, the pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ehrenshaft M,Bilski P,Li MY,Chignell CF,Daub ME

更新日期：1999-08-03 00:00:00

abstract：:Cellular progenitors of the coronary vasculature are believed to enter the chicken heart during epicardial morphogenesis between stages 17 and 27 (days 3-5) of egg incubation. To trace cells which give rise to the coronary arteries in vivo, we applied retroviral cell tagging procedures and analyzed clonal populations ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mikawa T,Fischman DA

更新日期：1992-10-15 00:00:00

abstract：:Actin polymerization and assembly into stress fibers (SFs) is central to many cellular processes. However, how SFs form in response to the mechanical interaction of cells with their environment is not fully understood. Here we have identified Piezo2 mechanosensitive cationic channel as a transducer of environmental ph...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pardo-Pastor C,Rubio-Moscardo F,Vogel-González M,Serra SA,Afthinos A,Mrkonjic S,Destaing O,Abenza JF,Fernández-Fernández JM,Trepat X,Albiges-Rizo C,Konstantopoulos K,Valverde MA

更新日期：2018-02-20 00:00:00

abstract：:The 23S twisted circular form of ColE(1) DNA has been isolated from Escherichia coli as a tightly associated DNA-protein complex with a sedimentation coefficient of approximately 24S. Treatment of this complex with pronase, trypsin, sodium dodecyl sulfate, Sarkosyl, or heat results in a conversion to a slower sediment...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clewell DB,Helinski DR

更新日期：1969-04-01 00:00:00

abstract：:Online education is rapidly expanding in response to rising demand for higher and continuing education, but many online students struggle to achieve their educational goals. Several behavioral science interventions have shown promise in raising student persistence and completion rates in a handful of courses, but evid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kizilcec RF,Reich J,Yeomans M,Dann C,Brunskill E,Lopez G,Turkay S,Williams JJ,Tingley D

更新日期：2020-06-30 00:00:00

abstract：:A peptide containing 31 amino acids with inhibin-like activity has been synthesized by the solid-phase method. The synthetic product was shown to be homogeneous in high-performance liquid chromatography and paper electrophoresis. In the mouse pituitary incubation system, the follitropin-suppressing activity of the syn...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamashiro D,Li CH,Ramasharma K,Sairam MR

更新日期：1984-09-01 00:00:00

abstract：:Replication through damaged sites in DNA requires in Escherichia coli the SOS stress-inducible DNA polymerase V (UmuC), which is specialized for lesion bypass. Homologs of the umuC gene were found on native conjugative plasmids, which often carry multiple antibiotic-resistant genes. MucB is a UmuC homolog present on p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goldsmith M,Sarov-Blat L,Livneh Z

更新日期：2000-10-10 00:00:00

abstract：:Interaction of syntaxin 1 with the alpha(1D) subunit of the voltage-gated L type Ca(2+) channel was investigated in the pancreatic beta cell. Coexpression of the enhanced green fluorescent protein-linked alpha(1D) subunit with the enhanced blue fluorescent protein-linked syntaxin 1 and Western blot analysis together w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang SN,Larsson O,Bränström R,Bertorello AM,Leibiger B,Leibiger IB,Moede T,Köhler M,Meister B,Berggren PO

更新日期：1999-08-31 00:00:00

abstract：:Human embryonic stem cells have the potential to differentiate into various cell types and, thus, may be useful as a source of cells for transplantation or tissue engineering. We describe here the differentiation steps of human embryonic stem cells into endothelial cells forming vascular-like structures. The human emb...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levenberg S,Golub JS,Amit M,Itskovitz-Eldor J,Langer R

更新日期：2002-04-02 00:00:00

abstract：:CD4(+) T cells expand after transfer into lymphopenic H-2(b) A(beta)-/- mice (I-A(beta)-, I-E(alpha)-deficient mice) but not after transfer into lymphopenic MHC II(Delta/Delta) mice (I-A(alpha)-, I-A(beta)-, I-E(alpha)-, and I-E(beta)-deficient mice), implying that in H-2(b) A(beta)-/- mice, A(alpha) chain and E(beta)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Martin B,Bourgeois C,Dautigny N,Lucas B

更新日期：2003-05-13 00:00:00

abstract：:Seep sediments are dominated by intensive microbial sulfate reduction coupled to the anaerobic oxidation of methane (AOM). Through geochemical measurements of incubation experiments with methane seep sediments collected from Hydrate Ridge, we provide insight into the role of iron oxides in sulfate-driven AOM. Seep sed...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sivan O,Antler G,Turchyn AV,Marlow JJ,Orphan VJ

更新日期：2014-10-07 00:00:00

abstract：:It is shown that polyphosphates are not generated in significant amounts in the phosphoglycerate kinase reaction; polyphosphate is more effective than ATP in the formation of glucose 6-P by glucokinase, but the rate with ATP may be adequate to meet the requirements of glucose metabolism; PPi is far more effective than...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wood HG,Goss NH

更新日期：1985-01-01 00:00:00

abstract：:The recent discovery of superconductivity with relatively high transition temperature (Tc) in the layered iron-based quaternary oxypnictides La[O(1-x)F(x)] FeAs by Kamihara et al. [Kamihara Y, Watanabe T, Hirano M, Hosono H (2008) Iron-based layered superconductor La[O1-xFx] FeAs (x = 0.05-0.12) with Tc = 26 K. J Am C...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hsu FC,Luo JY,Yeh KW,Chen TK,Huang TW,Wu PM,Lee YC,Huang YL,Chu YY,Yan DC,Wu MK

更新日期：2008-09-23 00:00:00

abstract：:Abnormal H2O2 levels are closely related to many diseases, including inflammation and cancers. Herein, we simultaneously load HRP and its substrate, 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS), into liposomal nanoparticles, obtaining a Lipo@HRP&ABTS optical nanoprobe for in vivo H2O2-responsive chrom...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen Q,Liang C,Sun X,Chen J,Yang Z,Zhao H,Feng L,Liu Z

更新日期：2017-05-23 00:00:00

abstract：:Wnt/beta-catenin signaling inhibits adipogenesis. Genome-wide profiling studies have revealed the enrichment of histone H3K27 methyltransferase Ezh2 on Wnt genes. However, the functional significance of such a direct link between the two types of developmental regulators in mammalian cells, and the role of Ezh2 in adi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang L,Jin Q,Lee JE,Su IH,Ge K

更新日期：2010-04-20 00:00:00

abstract：:Sirtuin 2 (SIRT2) is a sirtuin family deacetylase that directs acetylome signaling, protects genome integrity, and is a murine tumor suppressor. We show that SIRT2 directs replication stress responses by regulating the activity of cyclin-dependent kinase 9 (CDK9), a protein required for recovery from replication arres...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang H,Park SH,Pantazides BG,Karpiuk O,Warren MD,Hardy CW,Duong DM,Park SJ,Kim HS,Vassilopoulos A,Seyfried NT,Johnsen SA,Gius D,Yu DS

更新日期：2013-08-13 00:00:00

abstract：:Understanding the relationship between genetic variation and phenotypic variation for quantitative traits is necessary for predicting responses to natural and artificial selection and disease risk in human populations, but is challenging because of large sample sizes required to detect and validate loci with small eff...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Swarup S,Huang W,Mackay TF,Anholt RR

更新日期：2013-01-15 00:00:00

abstract：:The DEMETER (DME) DNA glycosylase initiates active DNA demethylation via the base-excision repair pathway and is vital for reproduction in Arabidopsis thaliana DME-mediated DNA demethylation is preferentially targeted to small, AT-rich, and nucleosome-depleted euchromatic transposable elements, influencing expression ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park JS,Frost JM,Park K,Ohr H,Park GT,Kim S,Eom H,Lee I,Brooks JS,Fischer RL,Choi Y

更新日期：2017-02-21 00:00:00

abstract：:An inductive interaction between the sevenless (sev) transmembrane tyrosine kinase receptor and the bride of sevenless (boss) transmembrane ligand is required for the development of the R7 photoreceptor neuron in the compound eye of Drosophila melanogaster. The boss protein is proposed to contain a large N-terminal ex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hart AC,Harrison SD,Van Vactor DL Jr,Rubin GM,Zipursky SL

更新日期：1993-06-01 00:00:00

abstract：:The subdivision of all the experimental days of the Whitetop project into two approximately equal groups, group W with predominantly westerly winds aloft and group E with frequent easterly winds, shows a remarkable difference in the apparent effect of seeding. On W days there was no detectable effect of seeding on rai...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lovasich JL,Neyman J,Scott EL,Smith JA

更新日期：1969-11-01 00:00:00

abstract：:The plant hormone abscisic acid (ABA) is produced in response to abiotic stresses and mediates stomatal closure in response to drought via recently identified ABA receptors (pyrabactin resistance/regulatory component of ABA receptor; PYR/RCAR). SLAC1 encodes a central guard cell S-type anion channel that mediates ABA-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brandt B,Brodsky DE,Xue S,Negi J,Iba K,Kangasjärvi J,Ghassemian M,Stephan AB,Hu H,Schroeder JI

更新日期：2012-06-26 00:00:00

abstract：:The ability of estrogens to stimulate the transcriptional activity of the estrogen receptor can be inhibited by a diverse range of estrogen antagonists. Here we show that the antiestrogen ICI 164,384, N-(n-butyl)-11-[3,17 beta-dihydroxy-estra-1,3,5(10)-trien-7 alpha-yl]N-methylundecanamide, rapidly reduces the levels ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dauvois S,Danielian PS,White R,Parker MG

更新日期：1992-05-01 00:00:00

abstract：:Although it has been known for decades that the tight junctions of fluid-transporting epithelia are leaky to ions, it has not been possible to determine directly whether significant transjunctional water movement also occurs. An optical microscopic technique was developed for the direct visualization of the flow veloc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kovbasnjuk O,Leader JP,Weinstein AM,Spring KR

更新日期：1998-05-26 00:00:00

abstract：:We have examined the effects of a stromal cell-derived cytokine designated interleukin 11 (IL-11) on the proliferation of murine hemopoietic progenitors in methylcellulose culture. COS cell-conditioned medium containing IL-11 supported formation of granulocyte/macrophage colonies and a small number of multilineage col...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Musashi M,Yang YC,Paul SR,Clark SC,Sudo T,Ogawa M

更新日期：1991-02-01 00:00:00

abstract：:A subpopulation of phenobarbital-induced cytochrome P-450 in rat liver has been shown to consist of four closely related forms of the enzyme that appeared to be strain-related. In the present study, polypeptides composing this family were analyzed by two-dimensional electrophoresis of hepatic microsomes from 64 indivi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rampersaud A,Walz FG Jr

更新日期：1983-11-01 00:00:00

abstract：:In adult mammalian brain, occurrence of the synthesis of estradiol from endogenous cholesterol has been doubted because of the inability to detect dehydroepiandrosterone synthase, P45017alpha. In adult male rat hippocampal formation, significant localization was demonstrated for both cytochromes P45017alpha and P450 a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hojo Y,Hattori TA,Enami T,Furukawa A,Suzuki K,Ishii HT,Mukai H,Morrison JH,Janssen WG,Kominami S,Harada N,Kimoto T,Kawato S

更新日期：2004-01-20 00:00:00

abstract：:Junctions that mediate excitation-contraction (e-c) coupling are formed between the sarcoplasmic reticulum (SR) and either the surface membrane or the transverse (T) tubules in normal skeletal muscle. Two structural components of the junctions, the feet of the SR and the tetrads of T tubules, have been identified resp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takekura H,Nishi M,Noda T,Takeshima H,Franzini-Armstrong C

更新日期：1995-04-11 00:00:00