"...the tyranny of the lattice...".

abstract：:CCAAT/enhancer binding protein (C/EBP) epsilon is a recently cloned member of the C/EBP family of transcription factors and is expressed exclusively in cells of hematopoietic origin. The human C/EBPepsilon gene is transcribed by two alternative promoters, Palpha and Pbeta. A combination of differential splicing and al...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamanaka R,Kim GD,Radomska HS,Lekstrom-Himes J,Smith LT,Antonson P,Tenen DG,Xanthopoulos KG

更新日期：1997-06-10 00:00:00

abstract：:Bacteria in the human oral cavity often grow in an attached multispecies biofilm community. Members of this community display defined interactions that have an impact on the physiology of the individual and the group. Here, we show that during coculture growth with streptococci, the oral pathogen Aggregatibacter actin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ramsey MM,Whiteley M

更新日期：2009-02-03 00:00:00

abstract：:Because RNAs fold as they are being synthesized, their transcription rate can affect their folding. Here, we report the results of single-molecule fluorescence studies that characterize the ligand-dependent cotranscriptional folding of the Escherichia coli thiM riboswitch that regulates translation. We found that the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Uhm H,Kang W,Ha KS,Kang C,Hohng S

更新日期：2018-01-09 00:00:00

abstract：:The ganglioside pattern of both SV40- and polyoma virus-transformed mouse cell lines differs from that of the parent cell lines or of cell lines that have transformed spontaneously in tissue culture. This is manifested by a dramatic decrease of gangliosides with an oligosaccharide chain larger than sialyllactose. Pres...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cumar FA,Brady RO,Kolodny EH,McFarland VW,Mora PT

更新日期：1970-10-01 00:00:00

abstract：:Cultured skin fibroblasts from patients with Menkes disease, an X-linked disorder involving a defect in copper metabolism, were analyzed for copper concentration by means of atomic absorption spectrophotometry. These cultures consistently exhibited elevated copper concentrations (mean = 335.5 ng of copper per mg of pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goka TJ,Stevenson RE,Hefferan PM,Howell RR

更新日期：1976-02-01 00:00:00

abstract：:Electromyographic recordings from individual identified ankle muscles of the 7-day chick embryo (stage 31) were used to determine the organization of motor output at a developmental stage shortly after the onset of spontaneous motility in the leg. During spontaneous motility of the embryo, the electromyographic record...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bekoff A,Stein PS,Hamburger V

更新日期：1975-04-01 00:00:00

abstract：:The binding protein for the K+-channel toxin dendrotoxin I was purified from a detergent extract of rat brain membranes. The purification procedure utilized chromatography on DEAE-Trisacryl, affinity chromatography on a dendrotoxin-I-Aca 22 column, and wheat germ agglutinin-Affigel 10 with a final 3800- to 4600-fold e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rehm H,Lazdunski M

更新日期：1988-07-01 00:00:00

abstract：:DNA double-strand breaks (DSBs) are serious genomic insults that can lead to chromosomal rearrangements if repaired incorrectly. To gain insight into the nuclear mechanisms contributing to these rearrangements, we developed an assay in yeast to measure cis (same site) vs. trans (different site) repair for the majority...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sunder S,Wilson TE

更新日期：2019-05-07 00:00:00

abstract：:Scholander and his coworkers have described in These Proceedings several experiments in which the osmotic pressure exerted by colloidal particles appears to be altered when the particles are subject to an external force; they interpret the experiments as showing that the traditional explanation of osmotic pressure is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hobbie RK

更新日期：1974-08-01 00:00:00

abstract：:Toll-like receptor 3 (TLR3) is a key effector of the innate immune system against viruses. Activation of TLR3 exerts an antitumoral effect through a mechanism of action still poorly understood. Here we show that TLR3 activation by polyinosinic:polycytidylic acid induces up-regulation of microRNA-29b, -29c, -148b, and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Galli R,Paone A,Fabbri M,Zanesi N,Calore F,Cascione L,Acunzo M,Stoppacciaro A,Tubaro A,Lovat F,Gasparini P,Fadda P,Alder H,Volinia S,Filippini A,Ziparo E,Riccioli A,Croce CM

更新日期：2013-06-11 00:00:00

abstract：:The apparent failure of infants to understand "object permanence" by reaching for hidden objects is perhaps the most striking and debated phenomenon in cognitive development. Of particular interest is the extent to which infants perceive and remember objects in a similar way to that of adults. Here we report two findi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaufman J,Csibra G,Johnson MH

更新日期：2005-10-18 00:00:00

abstract：:This paper's findings suggest that an arbitrary Chinese policy that greatly increases total suspended particulates (TSPs) air pollution is causing the 500 million residents of Northern China to lose more than 2.5 billion life years of life expectancy. The quasi-experimental empirical approach is based on China's Huai ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen Y,Ebenstein A,Greenstone M,Li H

更新日期：2013-08-06 00:00:00

abstract：:Gilles de la Tourette syndrome (TS) is characterized by tics, which are transiently worsened by stress, acute administration of dopaminergic drugs, and by subtle deficits in motor coordination and sensorimotor gating. It represents the most severe end of a spectrum of tic disorders that, in aggregate, affect ∼ 5% of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu M,Kobets A,Du JC,Lennington J,Li L,Banasr M,Duman RS,Vaccarino FM,DiLeone RJ,Pittenger C

更新日期：2015-01-20 00:00:00

abstract：:The heterodimeric Elongin BC complex has been shown to interact in vitro and in cells with a conserved BC-box motif found in an increasing number of proteins including RNA polymerase II elongation factor Elongin A, suppressor of cytokine signaling (SOCS)-box proteins, and the von Hippel-Lindau tumor suppressor protein...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brower CS,Sato S,Tomomori-Sato C,Kamura T,Pause A,Stearman R,Klausner RD,Malik S,Lane WS,Sorokina I,Roeder RG,Conaway JW,Conaway RC

更新日期：2002-08-06 00:00:00

abstract：:Tangier disease is a familial disorder characterized by orange tonsils, cholesterol ester deposition in reticuloendothelial cells, abnormal chylomicron remnants, and a marked reduction in high density lipoproteins. Plasma concentrations of the apolipoproteins apo-A-I and apoA-II in patients with Tangier disease are ap...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kay LL,Ronan R,Schaefer EJ,Brewer HB Jr

更新日期：1982-04-01 00:00:00

abstract：:Receptor-mediated endocytosis proceeds by transfer of receptor-ligand complexes from clathrin-coated pits at the cell surface to uncoated endocytic vesicles termed receptosomes (or endosomes). These vesicles have now been purified more than 37-fold based on their content of newly internalized epidermal growth factor. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dickson RB,Beguinot L,Hanover JA,Richert ND,Willingham MC,Pastan I

更新日期：1983-09-01 00:00:00

abstract：:Methane can be converted to triose dihydroxyacetone (DHA) by chemical processes with formaldehyde as an intermediate. Carbon dioxide, a by-product of various industries including ethanol/butanol biorefineries, can also be converted to formaldehyde and then to DHA. DHA, upon entry into a cell and phosphorylation to DHA...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang L,Chauliac D,Rhee MS,Panneerselvam A,Ingram LO,Shanmugam KT

更新日期：2018-04-24 00:00:00

abstract：:The microsomal triglyceride (TG) transfer protein (MTP) is a heterodimeric lipid transfer protein that catalyzes the transport of triglyceride, cholesteryl ester, and phosphatidylcholine between membranes. Previous studies showing that the proximal cause of abetalipoproteinemia is an absence of MTP indicate that MTP f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jamil H,Gordon DA,Eustice DC,Brooks CM,Dickson JK Jr,Chen Y,Ricci B,Chu CH,Harrity TW,Ciosek CP Jr,Biller SA,Gregg RE,Wetterau JR

更新日期：1996-10-15 00:00:00

abstract：:Poly(A)-containing RNA was isolated from ovaries of Xenopus laevis laevis and Triturus cristatus carnifex and used as a template for the synthesis of radioactive complementary DNA with RNA-dependent DNA polymerase. When annealed with an excess of homologous DNA, the complementary DNA is rendered double-stranded with k...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rosbash M,Ford PJ,Bishop JO

更新日期：1974-09-01 00:00:00

abstract：:A chimeric transforming growth factor beta (TGF-beta) molecule has been synthesized to map the amino acids responsible for the substantially greater activity of TGF-beta 1 than TGF-beta 2 on growth and migration of endothelial cells. This chimera consists of a dimer of a monomeric unit composed of amino acids 1-39 of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qian SW,Burmester JK,Merwin JR,Madri JA,Sporn MB,Roberts AB

更新日期：1992-07-15 00:00:00

abstract：:The structural gene for plasmid-mediated ampicillin resistance resides upon a 3.2 X 10(6) dalton transposable sequence (TnA) flanked by short inverted repeated sequences that accompany its insertion. TnA was transposed to pMB8, a 1.8 X 10(6) dalton derivative of the colicingenic plasmid ColE1. Random deletions were in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heffron F,Bedinger P,Champoux JJ,Falkow S

更新日期：1977-02-01 00:00:00

abstract：:Practicing a motor skill triggers a process of memory consolidation that continues for hours after practice has ended, and becomes manifest in an improved skill at later testing. We used a sequential motor task (finger-to-thumb opposition task) to show that, in humans, the formation of motor skill memories essentially...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fischer S,Hallschmid M,Elsner AL,Born J

更新日期：2002-09-03 00:00:00

abstract：:Deletion of 5 residues (Delta5) from the central cytoplasmic loop of the lactose permease of Escherichia coli has no significant effect on expression or activity, whereas Delta12 leads to increased rates of permease turnover after membrane insertion and decreased transport activity, and Delta20 abolishes insertion and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weinglass AB,Kaback HR

更新日期：2000-08-01 00:00:00

abstract：:When infants and adults communicate, they exchange social signals of availability and communicative intention such as eye gaze. Previous research indicates that when communication is successful, close temporal dependencies arise between adult speakers' and listeners' neural activity. However, it is not known whether s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leong V,Byrne E,Clackson K,Georgieva S,Lam S,Wass S

更新日期：2017-12-12 00:00:00

abstract：:Microstructural, δ(13)C isotope and C/N ratio investigations were conducted on excavated material from the black Younger Dryas boundary in Lommel, Belgium, aiming for a characterisation of the carbon content and structures. Cubic diamond nanoparticles are found in large numbers. The larger ones with diameters around o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tian H,Schryvers D,Claeys P

更新日期：2011-01-04 00:00:00

abstract：:The "false thumb" of pandas is a carpal bone, the radial sesamoid, which has been enlarged and functions as an opposable thumb. If the giant panda (Ailuropoda melanoleuca) and the red panda (Ailurus fulgens) are not closely related, their sharing of this adaptation implies a remarkable convergence. The discovery of pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Salesa MJ,Antón M,Peigné S,Morales J

更新日期：2006-01-10 00:00:00

abstract：:Ion channels in excitable cells function in macromolecular complexes in which auxiliary proteins modulate the biophysical properties of the pore-forming subunits. Hyperpolarization-activated, cyclic nucleotide-sensitive HCN4 channels are critical determinants of membrane excitability in cells throughout the body, incl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Peters CH,Myers ME,Juchno J,Haimbaugh C,Bichraoui H,Du Y,Bankston JR,Walker LA,Proenza C

更新日期：2020-07-28 00:00:00

abstract：:We have isolated lentivirus strains that are related to the human immunodeficiency virus (HIV) from African green monkeys (Cercopithecus aethiops; AGM). Although immunologically related, these SIVagm are clearly distinct from other simian immunodeficiency virus (SIV) isolates, including isolates from Macaca mulatta (S...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kraus G,Werner A,Baier M,Binniger D,Ferdinand FJ,Norley S,Kurth R

更新日期：1989-04-01 00:00:00

abstract：:We have examined the use of our bis(sulfonamide) diol ligand (1) in the asymmetric addition of phenyl groups to cyclic alpha,beta-unsaturated ketones. Good to excellent enantioselectivities have been obtained with cyclic enones bearing alkyl substituents in the 2 position (71-97% enantiomeric excess). Furthermore, exc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li H,García C,Walsh PJ

更新日期：2004-04-13 00:00:00

abstract：:Fluorescence imaging in the second near-infrared window (NIR-II, 1,000-1,700 nm) features deep tissue penetration, reduced tissue scattering, and diminishing tissue autofluorescence. Here, NIR-II fluorescent probes, including down-conversion nanoparticles, quantum dots, single-walled carbon nanotubes, and organic dyes...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dang X,Gu L,Qi J,Correa S,Zhang G,Belcher AM,Hammond PT

更新日期：2016-05-10 00:00:00