Structure of activated aconitase: formation of the [4Fe-4S] cluster in the crystal.

abstract：:The transcription factor zinc-finger protein Miz1 represses TNF-α-induced JNK activation and the repression is relieved upon TNF-α stimulation. However, the underlying mechanism is incompletely understood. Here we report that Miz1 interferes with the ubiquitin conjugating enzyme (E2) Ubc13 for binding to the RING doma...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu J,Yan J,Jiang S,Wen J,Chen L,Zhao Y,Lin A

更新日期：2012-01-03 00:00:00

abstract：:Working memory (WM) is the ability to retain and associate information over brief time intervals. Functional imaging studies demonstrate that WM is mediated by a distributed network including frontal and posterior cortices, hippocampus, and cerebellum. In rodents, the presentation of stimuli in a WM task is followed b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tesche CD,Karhu J

更新日期：2000-01-18 00:00:00

abstract：:The sex pheromone biosynthetic pathways of lepidopterans require the concerted actions of multiple gene products. A number of pheromone gland (PG)-specific genes have been cloned in recent years and, whereas in vitro characterizations have indicated functions consistent with roles in pheromone production, there have b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ohnishi A,Hull JJ,Matsumoto S

更新日期：2006-03-21 00:00:00

abstract：:Among the pathogenic processes contributing to dopaminergic neuron (DN) death in Parkinson disease (PD), evidence points to non-cell-autonomous mechanisms, particularly chronic inflammation mounted by activated microglia. Yet little is known about endogenous regulatory processes that determine microglial actions in pa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ros-Bernal F,Hunot S,Herrero MT,Parnadeau S,Corvol JC,Lu L,Alvarez-Fischer D,Carrillo-de Sauvage MA,Saurini F,Coussieu C,Kinugawa K,Prigent A,Höglinger G,Hamon M,Tronche F,Hirsch EC,Vyas S

更新日期：2011-04-19 00:00:00

abstract：:Tunas are migratory fishes in offshore habitats and top predators with unique features. Despite their ecological importance and high market values, the open-ocean lifestyle of tuna, in which effective sensing systems such as color vision are required for capture of prey, has been poorly understood. To elucidate the ge...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakamura Y,Mori K,Saitoh K,Oshima K,Mekuchi M,Sugaya T,Shigenobu Y,Ojima N,Muta S,Fujiwara A,Yasuike M,Oohara I,Hirakawa H,Chowdhury VS,Kobayashi T,Nakajima K,Sano M,Wada T,Tashiro K,Ikeo K,Hattori M,Kuhara S,

更新日期：2013-07-02 00:00:00

abstract：:Circulating platelets have important functions in thrombosis and in modulating immune and inflammatory responses. However, the role of platelets in innate immunity to bacterial infection is largely unexplored. While human platelets rapidly kill Staphylococcus aureus, we found the neonatal pathogen group B Streptococcu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Uchiyama S,Sun J,Fukahori K,Ando N,Wu M,Schwarz F,Siddiqui SS,Varki A,Marth JD,Nizet V

更新日期：2019-04-09 00:00:00

abstract：:Antinuclear autoantibodies (ANA) appeared in the plasma of lethally irradiated H-2d histocompatible DBA/2 and BALB/c mice several weeks after intravenous transplantation of 2 to 4 x 10(6) bone marrow cells from 3-week-old animals of the autoimmune New Zealand Black (NZB) strain. Little or no ANA development was observ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morton JI,Siegel BV

更新日期：1974-06-01 00:00:00

abstract：:The extracellular matrix (ECM) is an intricate network composed of an array of macromolecules capable of regulating the functional responsiveness of cells. Its composition greatly varies among different types of tissue, and dysregulation of its metabolism may contribute to vascular remodeling during the pathogenesis o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roth M,Eickelberg O,Kohler E,Erne P,Block LH

更新日期：1996-05-28 00:00:00

abstract：:Previous work shows that the adolescent reward system is hyperactive, but this finding may be confounded by differences in how teens value money. To address this, we examined the neural ontogeny of objective value representation. Adolescent and adult participants performed a monetary gambling task in which they chose ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barkley-Levenson E,Galván A

更新日期：2014-01-28 00:00:00

abstract：:Androgen receptor (AR) protein expression and function are critical for survival and proliferation of androgen-sensitive (AS) prostate cancer cells. Besides its ability to function as a transcription factor, experimental observations suggest that AR becomes a licensing factor for DNA replication in AS prostate cancer ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Litvinov IV,Vander Griend DJ,Antony L,Dalrymple S,De Marzo AM,Drake CG,Isaacs JT

更新日期：2006-10-10 00:00:00

abstract：:T-helper 17 (Th17) cells have important functions in adaptor immunity and have also been implicated in inflammatory disorders. The bromodomain and extraterminal domain (BET) family proteins regulate gene transcription during lineage-specific differentiation of naïve CD4+ T cells to produce mature T-helper cells. Inhib...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheung K,Lu G,Sharma R,Vincek A,Zhang R,Plotnikov AN,Zhang F,Zhang Q,Ju Y,Hu Y,Zhao L,Han X,Meslamani J,Xu F,Jaganathan A,Shen T,Zhu H,Rusinova E,Zeng L,Zhou J,Yang J,Peng L,Ohlmeyer M,Walsh MJ,Zhang DY,

更新日期：2017-03-14 00:00:00

abstract：:Eleven amino acid positions in the helix-turn-helix of lambda repressor have been mutagenized by using a combinatorial method in which alanine is substituted at each position with a probability of 0.5. Approximately 25% of the 2048 proteins in the resulting binomial library are active, including some variants with as ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gregoret LM,Sauer RT

更新日期：1993-05-01 00:00:00

abstract：:Interaction of the alpha beta T cell receptor (TCR) with major histocompatibility (MHC) molecules occupied with any of a large collection of peptides derived from self proteins is a critical step in driving T cell "positive" selection in the thymus. Interaction with this same pool of self-peptide/MHC ligands deletes T...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu CP,Crawford F,Marrack P,Kappler J

更新日期：1998-04-14 00:00:00

abstract：:Plants frequently respond to herbivorous insect attack by synthesizing defense proteins that deter insect feeding and prevent additional herbivory. Maize (Zea mays L.) lines, resistant to feeding by a number of lepidopteran species, rapidly mobilize a unique 33-kDa cysteine protease in response to caterpillar feeding....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pechan T,Cohen A,Williams WP,Luthe DS

更新日期：2002-10-01 00:00:00

abstract：:Glial cells are traditionally regarded as elements for structural support and ionic homeostasis, but have recently attracted attention as putative integral elements of the machinery involved in synaptic transmission and plasticity. Here, we demonstrate that calcium-binding protein S100B, which is synthesized in consid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nishiyama H,Knopfel T,Endo S,Itohara S

更新日期：2002-03-19 00:00:00

abstract：:Portable, single-sided NMR sensors can operate under conditions inaccessible to conventional NMR while featuring lower cost, portability, and the ability to analyze arbitrary-sized objects. Such sensors can nondestructively probe the interior of samples by collecting images and measuring relaxation and diffusion const...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Paulsen JL,Bouchard LS,Graziani D,Blümich B,Pines A

更新日期：2008-12-30 00:00:00

abstract：:A vitamin D(3) metabolite in intestine more polar than 25-hydroxy-vitamin D(3)(25-OH D(3)) has been detected by countercurrent distribution. The intestinal metabolite is found also after administration of labeled hydroxy D(3), indicating that it arises from vitamin D(3) via the intermediate 25-hydroxy derivative. The ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Haussler MR,Boyce DW,Littledike ET,Rasmussen H

更新日期：1971-01-01 00:00:00

abstract：:Elastogenesis is a hierarchical process by which cells form functional elastic fibers, providing elasticity and the ability to regulate growth factor bioavailability in tissues, including blood vessels, lung, and skin. This process requires accessory proteins, including fibulin-4 and -5, and latent TGF binding protein...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kumra H,Nelea V,Hakami H,Pagliuzza A,Djokic J,Xu J,Yanagisawa H,Reinhardt DP

更新日期：2019-10-08 00:00:00

abstract：:Assemblies formed by solid particles at interfaces have been widely studied because they serve as models of molecular phenomena, including molecular self-assembly. Solid particles adsorbed at interfaces also provide a means of stabilizing liquid-liquid emulsions and synthesizing materials with tunable mechanical, opti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koenig GM Jr,Lin IH,Abbott NL

更新日期：2010-03-02 00:00:00

abstract：:In many naturally occurring habitats, bacteria live in micrometer-size confined spaces. Although bacterial growth and motility in such constrictions is of great interest to fields as varied as soil microbiology, water purification, and biomedical research, quantitative studies of the effects of confinement on bacteria...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Männik J,Driessen R,Galajda P,Keymer JE,Dekker C

更新日期：2009-09-01 00:00:00

abstract：:A gradual buildup of neuronal activity known as the "readiness potential" reliably precedes voluntary self-initiated movements, in the average time locked to movement onset. This buildup is presumed to reflect the final stages of planning and preparation for movement. Here we present a different interpretation of the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schurger A,Sitt JD,Dehaene S

更新日期：2012-10-16 00:00:00

abstract：:The human immunodeficiency virus 1 (HIV-1) long terminal repeat (LTR) sequences were inserted into adenovirus in place of the E1 region. The HIV-1 LTR contained in this recombinant adenovirus responds to trans-activation by tatIII in a HeLa cell line constitutively expressing that HIV-1 gene product. In addition, the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rice AP,Mathews MB

更新日期：1988-06-01 00:00:00

abstract：:Phosphocholine (PC) is an abundant primary form of organic phosphate that is transported in plant xylem sap. Addition of PC to the perfusate of compressed Pi-starved sycamore cells monitored by 31P NMR spectroscopy resulted in an accumulation of PC and all the other phosphate esters in the cytoplasmic compartment. Add...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gout E,Bligny R,Roby C,Douce R

更新日期：1990-06-01 00:00:00

abstract：:The expanding behavioral repertoire of the developing brain during childhood and adolescence is shaped by complex brain-environment interactions and flavored by unique life experiences. The transition into young adulthood offers opportunities for adaptation and growth but also increased susceptibility to environmental...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alnæs D,Kaufmann T,Marquand AF,Smith SM,Westlye LT

更新日期：2020-06-02 00:00:00

abstract：:Epstein-Barr virus-induced gene 3 (EBI3) is a widely expressed IL-12p40-related protein that associates as a heterodimer with either IL-12p35 or an IL-12p35 homologue, p28, to create a new cytokine (IL-27). To define the function of EBI3 in vivo, we generated knockout mice in which the ebi3 gene was targeted by homolo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nieuwenhuis EE,Neurath MF,Corazza N,Iijima H,Trgovcich J,Wirtz S,Glickman J,Bailey D,Yoshida M,Galle PR,Kronenberg M,Birkenbach M,Blumberg RS

更新日期：2002-12-24 00:00:00

abstract：:The technique of self-sustained sequence replication allows isothermal amplification of DNA and RNA molecules in vitro. This method relies on the activities of a reverse transcriptase and a DNA-dependent RNA polymerase to amplify specific nucleic acid sequences. We have modified this protocol to allow selective amplif...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Breaker RR,Joyce GF

更新日期：1994-06-21 00:00:00

abstract：:Cerebral arteriovenous malformations (AVMs) are common vascular malformations, which may result in hemorrhagic strokes and neurological deficits. Bone morphogenetic protein (BMP) and Notch signaling are both involved in the development of cerebral AVMs, but the cross-talk between the two signaling pathways is poorly u...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yao Y,Yao J,Radparvar M,Blazquez-Medela AM,Guihard PJ,Jumabay M,Boström KI

更新日期：2013-11-19 00:00:00

abstract：:Four polyimidazoles were used in the binding and cleavage studies with poly(U). The two polydisperse polyvinylimidazoles were previously described by others, while the other two new polymers of polyethyleneimines were prepared by cationic polymerization of oxazolines. The latter had imidazole units attached to each ni...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheng L,Abhilash KG,Breslow R

更新日期：2012-08-07 00:00:00

abstract：:Policy folklists present a set of alleged historical facts seen as relevant to some social issue. Although the validity of these folklists is dubious, leaders and writers circulate them in the media, variants arise, and the lists continue on, sometimes for decades. Folklists are repeated because their messages are app...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： O'Neill B

更新日期：2014-07-22 00:00:00

abstract：:Lysine to methionine (K-to-M) mutations in genes encoding histone H3 are thought to drive a subset of pediatric brain and bone cancers. These high-frequency K-to-M mutations occur at sites of methylation on histone H3, and tumors containing the mutant histones exhibit a global loss of specific histone methylation mark...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jayaram H,Hoelper D,Jain SU,Cantone N,Lundgren SM,Poy F,Allis CD,Cummings R,Bellon S,Lewis PW

更新日期：2016-05-31 00:00:00