Transplantation of autoimmune potential. I. Development of antinuclear antibodies in H-2 histocompatible recipients of bone marrow from New Zealand Black mice.

abstract：:It was reported that the rate of elongation of partially reconstituted RNA, if prepared without centrifugation, showed dependency upon the state of protein aggregation like that found when free RNA was used as the nucleic acid source [Butler, P. J. G. (1974) J. Mol. Biol. 82, 333-341]. Butler concluded from this resul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ohno T,Takahashi M,Okada Y

更新日期：1977-02-01 00:00:00

abstract：:Rabbit articular chondrocytes synthesize type II collagen [3alpha(1)(II)] in vivo and type I collagen [2alpha(1)(I).alpha(2)] in monolayer cultures. In suspension culture the nature of phenotype depends on extracellular Ca(2+). The relationship of Ca(2+) and 3':5'-cyclic AMP (cAMP) in regulation of collagen synthesis ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Deshmukh K,Sawyer BD

更新日期：1977-09-01 00:00:00

abstract：:The protein CopC from Pseudomonas syringae has been found capable of binding copper(I) and copper(II) at two different sites, occupied either one at a time or simultaneously. The protein, consisting of 102 amino acids, is known to bind copper(II) in a position that is now found consistent with a coordination arrangeme...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arnesano F,Banci L,Bertini I,Mangani S,Thompsett AR

更新日期：2003-04-01 00:00:00

abstract：:The time-dependent Schrödinger equation is a cornerstone of quantum physics and governs all phenomena of the microscopic world. However, despite its importance, its origin is still not widely appreciated and properly understood. We obtain the Schrödinger equation from a mathematical identity by a slight generalization...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schleich WP,Greenberger DM,Kobe DH,Scully MO

更新日期：2013-04-02 00:00:00

abstract：:The antigenic mosaic of the Archaebacterium Methanobacterium thermoautotrophicum, strain delta H, was analyzed with a panel of six monoclonal antibodies. Five antigenic determinants were identified. One contains N-acetyl-D-glucosamine, another contains N-acetyl-D-galactosamine, and a third contains gamma-glutamylalani...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Conway de Macario E,Macario AJ,Magariños MC,König H,Kandler O

更新日期：1983-10-01 00:00:00

abstract：:The monomeric VDAC channel shows an accelerated pH titration of its transport properties with a Hill coefficient of about 2. This manifests itself as a sharp peak in conductance noise as well as a fast change in channel selectivity with pH. On the basis of the known structure of this channel, we propose that this coop...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rostovtseva TK,Liu TT,Colombini M,Parsegian VA,Bezrukov SM

更新日期：2000-07-05 00:00:00

abstract：:Peroxisomes play an essential role in a number of different metabolic pathways, including the beta-oxidation of a distinct set of fatty acids and fatty acid derivatives. The importance of the peroxisomal beta-oxidation system in humans is made apparent by the existence of a group of inherited diseases in which peroxis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： van Grunsven EG,van Berkel E,Ijlst L,Vreken P,de Klerk JB,Adamski J,Lemonde H,Clayton PT,Cuebas DA,Wanders RJ

更新日期：1998-03-03 00:00:00

abstract：:Porphyromonas gingivalis is the major causative agent of periodontitis, and it may also be involved in the development of systemic diseases (atherosclerosis, rheumatoid arthritis). P. gingivalis is found on and within oral and gingival epithelial cells following binding to surface components of host cells, which serve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boisvert H,Lorand L,Duncan MJ

更新日期：2014-04-08 00:00:00

abstract：:Helix-hairpin-helix DNA glycosylases are typically small proteins that initiate repair of DNA by excising damaged or mispaired bases. An invariant aspartic acid in the active site is involved in catalyzing the excision reaction. Replacement of this critical residue with an asparagine severely reduces catalytic activit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Choi Y,Harada JJ,Goldberg RB,Fischer RL

更新日期：2004-05-11 00:00:00

abstract：:Complement receptors (CRs), expressed notably on myeloid and lymphoid cells, play an essential function in the elimination of complement-opsonized pathogens and apoptotic/necrotic cells. In addition, these receptors are crucial for the cross-talk between the innate and adaptive branches of the immune system. CR3 (also...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bajic G,Yatime L,Sim RB,Vorup-Jensen T,Andersen GR

更新日期：2013-10-08 00:00:00

abstract：:The nonreceptor tyrosine phosphatase Shp2 (PTPN11) has been implicated in tyrosine kinase, cytokine, and integrin receptor signaling. We show here that conditional mutation of Shp2 in neural crest cells and in myelinating Schwann cells resulted in deficits in glial development that are remarkably similar to those obse...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grossmann KS,Wende H,Paul FE,Cheret C,Garratt AN,Zurborg S,Feinberg K,Besser D,Schulz H,Peles E,Selbach M,Birchmeier W,Birchmeier C

更新日期：2009-09-29 00:00:00

abstract：:As an electron transfer-driven proton pump, cytochrome c oxidase (ferrocytochrome-c:oxygen oxidoreductase, EC 1.9.3.1) must alternate between two conformations in each valence state of the redox element associated with ion translocation. Using second derivative absorption spectroscopy, the conformation of the cytochro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Copeland RA

更新日期：1991-08-15 00:00:00

abstract：:Motifs of neural circuitry seem surprisingly conserved over different areas of neocortex or of paleocortex, while performing quite different sensory processing tasks. This apparent paradox may be resolved by the fact that seemingly different problems in sensory information processing are related by transformations (ch...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hopfield JJ

更新日期：1996-12-24 00:00:00

abstract：:Cognitive studies of memory processes demonstrate that memory for stimuli is a function of how they are encoded; stimuli processed semantically are better remembered than those processed in a perceptual or shallow fashion. This study investigates the neural correlates of this cognitive phenomenon. Twelve subjects perf...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kapur S,Craik FI,Tulving E,Wilson AA,Houle S,Brown GM

更新日期：1994-03-15 00:00:00

abstract：:The molecular chaperone Hsp90 is a protein folding machine that is conserved from bacteria to man. Human, cytosolic Hsp90 is dedicated to folding of chiefly signal transduction components. The chaperoning mechanism of Hsp90 is controlled by ATP and various cochaperones, but is poorly understood and controversial. Here...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Karagöz GE,Duarte AM,Ippel H,Uetrecht C,Sinnige T,van Rosmalen M,Hausmann J,Heck AJ,Boelens R,Rüdiger SG

更新日期：2011-01-11 00:00:00

abstract：:Conversion of carbon dioxide into hydrocarbons using solar energy is an attractive strategy for storing such a renewable source of energy into the form of chemical energy (a fuel). This can be achieved in a system coupling a photovoltaic (PV) cell to an electrochemical cell (EC) for CO2 reduction. To be beneficial and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huan TN,Dalla Corte DA,Lamaison S,Karapinar D,Lutz L,Menguy N,Foldyna M,Turren-Cruz SH,Hagfeldt A,Bella F,Fontecave M,Mougel V

更新日期：2019-05-14 00:00:00

abstract：:Understanding the causes and consequences of wildfires in forests of the western United States requires integrated information about fire, climate changes, and human activity on multiple temporal scales. We use sedimentary charcoal accumulation rates to construct long-term variations in fire during the past 3,000 y in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marlon JR,Bartlein PJ,Gavin DG,Long CJ,Anderson RS,Briles CE,Brown KJ,Colombaroli D,Hallett DJ,Power MJ,Scharf EA,Walsh MK

更新日期：2012-02-28 00:00:00

abstract：:A cDNA library derived from human cerebral cortex was screened for the presence of sodium channel alpha subunit-specific clones. Ligation of three overlapping clones generated a full-length cDNA clone, HBA, that provided the complete nucleotide sequence coding for a protein of 2005 amino acids. The predicted structure...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ahmed CM,Ware DH,Lee SC,Patten CD,Ferrer-Montiel AV,Schinder AF,McPherson JD,Wagner-McPherson CB,Wasmuth JJ,Evans GA

更新日期：1992-09-01 00:00:00

abstract：:An early and a late histone H2B gene from the sea urchin Stronglyocentrotus purpuratus were linked in a single plasmid and injected into the eggs of the sea urchin Lytechinus pictus. The levels of transcripts of injected early and late genes and of endogenous early genes were monitored during development by a ribonucl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Colin AM,Catlin TL,Kidson SH,Maxson R

更新日期：1988-01-01 00:00:00

abstract：:We have generated eight mAbs (MW1-8) that bind the epitopes polyglutamine (polyQ), polyproline (polyP), or the C terminus of exon 1 in huntingtin (htt) protein. In the brains of Huntington's disease (HD) mouse models, the anti-polyQ mAbs bind to various cytoplasmic compartments, whereas the anti-polyP and anti-C termi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Khoshnan A,Ko J,Patterson PH

更新日期：2002-01-22 00:00:00

abstract：:A density-shift method is described for analyzing insulin receptor synthesis and turnover in cultured cells labeled with "heavy" amino acids (2H, 13C, and 15N). Solubilized newly synthesized heavy and old "light" receptors are separated by isopycnic banding on CsCl gradients and then quantitated. Insulin receptor synt...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reed BC,Lane MD

更新日期：1980-01-01 00:00:00

abstract：:A general repressor extensively studied in vitro is the human Dr1/DRAP1 heterodimeric complex. To elucidate the function of Dr1 and DRAP1 in vivo, the yeast Saccharomyces cerevisiae Dr1/DRAP1 repressor complex was identified. The repressor complex is encoded by two essential genes, designated YDR1 and BUR6. The inviab...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim S,Na JG,Hampsey M,Reinberg D

更新日期：1997-02-04 00:00:00

abstract：:Theory predicts that double-core-hole (DCH) spectroscopy can provide a new powerful means of differentiating between similar chemical systems with a sensitivity not hitherto possible. Although DCH ionization on a single site in molecules was recently measured with double- and single-photon absorption, double-core hole...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Berrah N,Fang L,Murphy B,Osipov T,Ueda K,Kukk E,Feifel R,van der Meulen P,Salen P,Schmidt HT,Thomas RD,Larsson M,Richter R,Prince KC,Bozek JD,Bostedt C,Wada S,Piancastelli MN,Tashiro M,Ehara M

更新日期：2011-10-11 00:00:00

abstract：:Studies in animals demonstrate a crucial role for the amygdala in emotional and social behavior, especially as related to fear and aggression. Whereas lesion and functional-imaging studies in humans indicate the amygdala's participation in assessing the significance of nonverbal as well as paralinguistic cues, direct ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Isenberg N,Silbersweig D,Engelien A,Emmerich S,Malavade K,Beattie B,Leon AC,Stern E

更新日期：1999-08-31 00:00:00

abstract：:It has been recognized since ancient times that malaria fever is highly periodic but the mechanism has been poorly understood. Malaria fever is related to the parasite growth cycle in erythrocytes. After a fixed period of replication, a mature parasite (schizont) causes the infected erythrocyte to rupture, releasing p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kwiatkowski D,Nowak M

更新日期：1991-06-15 00:00:00

abstract：:Rat brain and adrenal gland were analyzed by hybridization histochemistry using an RNA probe complementary to mRNA for tyrosine 3-hydroxylase (TyrOHase; tyrosine 3-monooxygenase, EC 1.14.16.2), by immunohistochemistry using TyrOHase antiserum, and by retrograde tracing using the fluorescent compound Fast blue. Cell bo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schalling M,Hökfelt T,Wallace B,Goldstein M,Filer D,Yamin C,Schlesinger DH

更新日期：1986-08-01 00:00:00

abstract：:We have isolated two recombinant cDNAs whose corresponding RNAs have an increased abundance in scrapie-infected hamster brain. DNA sequence analysis has shown that these two recombinants represent the genes for sulfated glycoprotein 2 and transferrin. The abundance of sulfated glycoprotein 2 RNA is increased in hippoc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Duguid JR,Bohmont CW,Liu NG,Tourtellotte WW

更新日期：1989-09-01 00:00:00

abstract：:To evaluate [3H]phencyclidine ([3H]PCP)as a probe for the ionic channel of the nicotinic receptor, the characteristics of its binding to electric organ membranes od Torpedo ocellata and its effects on frog sartorius muscle were studied. Similar to PCP, [3H]PCP depressed the peak amplitude of endplate current, caused n...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eldefrawi ME,Eldefrawi AT,Aronstam RS,Maleque MA,Warnick JE,Albuquerque EX

更新日期：1980-12-01 00:00:00

abstract：:Ectopic activation of the Wnt signaling pathway is highly oncogenic for many human tissues. Here, we show that ectopic Wnt signaling increases the effective stem cell activity in mouse mammary glands in vivo. Furthermore, Wnt effectors induce the accumulation of mouse mammary epithelial progenitors (assayed by Hoechst...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu BY,McDermott SP,Khwaja SS,Alexander CM

更新日期：2004-03-23 00:00:00

abstract：:Bacteria use membrane-integral sensor histidine kinases (HK) to perceive stimuli and transduce signals from the environment to the cytosol. Information on how the signal is transmitted across the membrane by HKs is still scarce. Combining both liquid- and solid-state NMR, we demonstrate that structural rearrangements ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Salvi M,Schomburg B,Giller K,Graf S,Unden G,Becker S,Lange A,Griesinger C

更新日期：2017-03-21 00:00:00