Neuroanatomical correlates of encoding in episodic memory: levels of processing effect.

abstract：:The emergence of multidrug-resistant (MDR) tuberculosis (TB) highlights the urgent need to understand the mechanisms of resistance to the drugs used to treat this disease. The aminoglycosides kanamycin and amikacin are important bactericidal drugs used to treat MDR TB, and resistance to one or both of these drugs is a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zaunbrecher MA,Sikes RD Jr,Metchock B,Shinnick TM,Posey JE

更新日期：2009-11-24 00:00:00

abstract：:We have used restriction endonuclease mapping of cell DNA to investigate the structure of the beta-globin gene in beta-thalassemias. Among 17 individuals with beta +- and beta 0-thalassemia, we observed three patients of Indian origin with beta 0-thalassemia whose DNA revealed a consistent mapping abnormality. In one ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Orkin SH,Old JM,Weatherall DJ,Nathan DG

更新日期：1979-05-01 00:00:00

abstract：:The monomeric VDAC channel shows an accelerated pH titration of its transport properties with a Hill coefficient of about 2. This manifests itself as a sharp peak in conductance noise as well as a fast change in channel selectivity with pH. On the basis of the known structure of this channel, we propose that this coop...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rostovtseva TK,Liu TT,Colombini M,Parsegian VA,Bezrukov SM

更新日期：2000-07-05 00:00:00

abstract：:The clonal rat pituitary cell line GH4C1 expresses the genes for several voltage-dependent potassium channels including Kv1.5 and Kv1.4. Dexamethasone, a glucocorticoid agonist, induces a slowly inactivating potassium current in these cells but does not alter the amplitude of a rapidly inactivating component of potass...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chung S,Saal DB,Kaczmarek LK

更新日期：1995-06-20 00:00:00

abstract：:High molecular weight proteins extracted from the walking nerves of the shore crab (Carcinus maenas) exhibit a cycle of phosphorylation-dephosphorylation that is influenced by neurotropic compounds and inorganic ions. The net phosphorylation state of the proteins is increased in the presence of K+ ions and decreased w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schoffeniels E,Dandrifosse G

更新日期：1980-02-01 00:00:00

abstract：:The primary DNA lesion induced by malondialdehyde, a byproduct of lipid peroxidation and prostaglandin synthesis, is 3-(2'-deoxy-beta-D-erythro-pentofuranosyl)-pyrimido[1, 2-a]purin-10(3H)-one (M1G). When placed opposite cytosine (underlined) at neutral pH in either the d(GGTMTCCG).d(CGGACACC) or d(ATCGCMCGGCATG). d(C...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mao H,Schnetz-Boutaud NC,Weisenseel JP,Marnett LJ,Stone MP

更新日期：1999-06-08 00:00:00

abstract：:One of the most long-lived models in plant science is the belief that the long-distance transport and ratio of two plant hormones, auxin and cytokinin, at the site of action control major developmental events such as apical dominance. We have used in vivo deuterium labeling and mass spectrometry to investigate the dyn...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nordström A,Tarkowski P,Tarkowska D,Norbaek R,Astot C,Dolezal K,Sandberg G

更新日期：2004-05-25 00:00:00

abstract：:Type II platelet-activating factor-acetylhydrolase [PAF-AH (II)] is an N-myristoylated enzyme that contains a lipase/esterase catalytic motif and selectively hydrolyzes the sn-2 acetyl ester of PAF and other short-chain acyl groups attached to phosphoglycerides. However, the physiological role of this enzyme remains t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Inoue T,Sugimoto A,Suzuki Y,Yamamoto M,Tsujimoto M,Inoue K,Aoki J,Arai H

更新日期：2004-09-07 00:00:00

abstract：:High-throughput metagenomic sequencing offers an unbiased approach to identify pathogens in clinical samples. Conventional metagenomic sequencing, however, does not integrate information about the host, which is often critical to distinguish infection from infectious disease, and to assess the severity of disease. Her...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheng AP,Burnham P,Lee JR,Cheng MP,Suthanthiran M,Dadhania D,De Vlaminck I

更新日期：2019-09-10 00:00:00

abstract：:In previous papers of this series, emphasis has been placed on the steady-state phase transition and critical properties of large lattices of interacting, symmetrical, and identical enzyme molecules. The present paper is concerned with a number of examples of enzyme--enzyme interactions that do not belong to the class...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hill TL

更新日期：1978-03-01 00:00:00

abstract：:Active opioid binding proteins were solubilized from rat brain membranes in high yield with sodium deoxycholate in the presence of NaCl. Purification of opioid binding proteins was accomplished by opioid antagonist affinity chromatography. Chromatography using the delta-opioid antagonist N,N-diallyl-Tyr-D-Leu-Gly-Tyr-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Loukas S,Mercouris M,Panetsos F,Zioudrou C

更新日期：1994-05-10 00:00:00

abstract：:Four major neutralizing regions of the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein were identified and characterized with a panel of 80 HIV-1 antibody-positive human sera. Levels of neutralizing antibodies against the HIV-1 strains IIIB, SF2, and RF were compared with reactivity in ELISAs against...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Broliden PA,von Gegerfelt A,Clapham P,Rosen J,Fenyö EM,Wahren B,Broliden K

更新日期：1992-01-15 00:00:00

abstract：:Inositol polyphosphate 4-phosphatase (4-phosphatase) is an enzyme that catalyses the hydrolysis of the 4-position phosphate from phosphatidylinositol 3,4-bisphosphate [PtdIns(3,4)P2]. In human platelets the formation of this phosphatidylinositol, by the actions of phosphatidylinositol 3-kinase (PI 3-kinase), correlate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Munday AD,Norris FA,Caldwell KK,Brown S,Majerus PW,Mitchell CA

更新日期：1999-03-30 00:00:00

abstract：:The Ser52Pro variant of transthyretin (TTR) produces aggressive, highly penetrant, autosomal-dominant systemic amyloidosis in persons heterozygous for the causative mutation. Together with a minor quantity of full-length wild-type and variant TTR, the main component of the ex vivo fibrils was the residue 49-127 fragme...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mangione PP,Porcari R,Gillmore JD,Pucci P,Monti M,Porcari M,Giorgetti S,Marchese L,Raimondi S,Serpell LC,Chen W,Relini A,Marcoux J,Clatworthy IR,Taylor GW,Tennent GA,Robinson CV,Hawkins PN,Stoppini M,Wood SP,Pepys

更新日期：2014-01-28 00:00:00

abstract：:Although genetic analysis has demonstrated that members of the winged helix, or forkhead, family of transcription factors play pivotal roles in the regulation of cellular differentiation and proliferation, both during development and in the adult, little is known of the mechanisms underlying their regulation. Here we ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Biggs WH 3rd,Meisenhelder J,Hunter T,Cavenee WK,Arden KC

更新日期：1999-06-22 00:00:00

abstract：:Using a proteomics screen, we have identified the methyltransferase G9a as an interacting partner of the hematopoietic activator NF-E2. We show that G9a is recruited to the beta-globin locus in a NF-E2-dependent manner and spreads over the entire locus. While G9a is often regarded as a corepressor, knocking down this ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chaturvedi CP,Hosey AM,Palii C,Perez-Iratxeta C,Nakatani Y,Ranish JA,Dilworth FJ,Brand M

更新日期：2009-10-27 00:00:00

abstract：:Influenza virus infections cause a wide variety of outcomes, from mild disease to 3 to 5 million cases of severe illness and ∼290,000 to 645,000 deaths annually worldwide. The molecular mechanisms underlying these disparate outcomes are currently unknown. Glycosylation within the human host plays a critical role in in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Heindel DW,Koppolu S,Zhang Y,Kasper B,Meche L,Vaiana CA,Bissel SJ,Carter CE,Kelvin AA,Elaish M,Lopez-Orozco J,Zhang B,Zhou B,Chou TW,Lashua L,Hobman TC,Ross TM,Ghedin E,Mahal LK

更新日期：2020-10-27 00:00:00

abstract：:The insulin and glucagon responses to 10 mM glucose and 10 mM arginine were studied in pancreata isolated from nondiabetic diabetes-prone and diabetes-resistant BB/W rats at 60, 80, and 140 days of age and in diabetic BB/W rats on the 1st and 14th days of their diabetes. In the former group the insulin response to glu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tominaga M,Komiya I,Johnson JH,Inman L,Alam T,Moltz J,Crider B,Stefan Y,Baetens D,McCorkle K

更新日期：1986-12-01 00:00:00

abstract：:Figure-ground discrimination refers to the perception of an object, the figure, against a nondescript background. Neural mechanisms of figure-ground detection have been associated with feedback interactions between higher centers and primary visual cortex and have been held to index the effect of global analysis on lo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jones HE,Andolina IM,Shipp SD,Adams DL,Cudeiro J,Salt TE,Sillito AM

更新日期：2015-06-02 00:00:00

abstract：:Neuroblastoma-glioma hybrid cells (NG108-15) in suspension accumulate the permeant lipophilic cation [(3)H]tetraphenylphosphonium (TPP(+)) against a concentration gradient. The steady-state level of TPP(+) accumulation is about twice as great in physiological media of low K(+) concentration (i.e., 5 mM K(+)/135 mM Na(...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lichtshtein D,Kaback HR,Blume AJ

更新日期：1979-02-01 00:00:00

abstract：:Pyochelin, an endogenous growth promoter that solubilizes ferric iron, has been isolated from Pseudomonas aeruginosa, including clinical strains. The structure of pyochelin has been assigned as 2-(2-o-hydroxyphenyl-2-thiazolin-4-yl)-3-methylthiazolidine-4-carboxylic acid and is of a different type from those previousl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cox CD,Rinehart KL Jr,Moore ML,Cook JC Jr

更新日期：1981-07-01 00:00:00

abstract：:The first step in the formation of the protease resistant form (PrPSc) of prion proteins involves a conformational transition of the monomeric cellular form of PrPC to a more stable aggregation prone state PrPC*. A search of PDBselect and Escherichia coli and yeast genomes shows that the exact pattern of charges in he...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dima RI,Thirumalai D

更新日期：2004-10-26 00:00:00

abstract：:Mice carrying mutations in either the dominant white-spotting (W) or Steel (Sl) loci exhibit deficits in melanogenesis, gametogenesis, and hematopoiesis. W encodes the Kit receptor tyrosine kinase, while Sl encodes the Kit ligand, Steel factor, and the receptor-ligand pair are contiguously expressed at anatomical site...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Motro B,Wojtowicz JM,Bernstein A,van der Kooy D

更新日期：1996-03-05 00:00:00

abstract：:The fluorescence decay of the rare earth terbium when bound to the protein calmodulin changes from a simple exponential decay to a complex nonexponential decay as the temperature is lowered below 200 K. We have fit the observed decay curves by assuming that the terbium emission is a forced electric dipole transition a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Austin RH,Stein DL,Wang J

更新日期：1987-03-01 00:00:00

abstract：:Untargeted metabolomics of environmental samples routinely detects thousands of small molecules, the vast majority of which cannot be identified. Meta-mass shift chemical (MeMSChem) profiling was developed to identify mass differences between related molecules using molecular networks. This approach illuminates metabo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hartmann AC,Petras D,Quinn RA,Protsyuk I,Archer FI,Ransome E,Williams GJ,Bailey BA,Vermeij MJA,Alexandrov T,Dorrestein PC,Rohwer FL

更新日期：2017-10-31 00:00:00

abstract：:Differences between early and late passage cell cultures on the organelle and macromolecular levels have been attributed to cellular "aging". However, concern has been expressed over whether changes in diploid cell populations after serial passage in vitro accurately reflect human cellular aging in vivo. Studies were ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schneider EL,Mitsui Y

更新日期：1976-10-01 00:00:00

abstract：:Assemblies formed by solid particles at interfaces have been widely studied because they serve as models of molecular phenomena, including molecular self-assembly. Solid particles adsorbed at interfaces also provide a means of stabilizing liquid-liquid emulsions and synthesizing materials with tunable mechanical, opti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koenig GM Jr,Lin IH,Abbott NL

更新日期：2010-03-02 00:00:00

abstract：:The histidine periplasmic permease of Salmonella typhimurium has been partially purified and reconstituted into proteoliposomes. In this in vitro preparation, transport activity is completely dependent on the presence of all four permease proteins (HisJ, HisQ, HisM, and HisP) and on internal ATP. The reconstituted sys...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bishop L,Agbayani R Jr,Ambudkar SV,Maloney PC,Ames GF

更新日期：1989-09-01 00:00:00

abstract：:Climate change impacts island communities all over the world. Sea-level rise, an increase in the frequency and intensity of severe weather events, and changes in distribution and health of marine organisms are among the most significant processes affecting island communities worldwide. On islands of the Caribbean and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Douglass K,Cooper J

更新日期：2020-04-14 00:00:00

abstract：:The region of the simian virus 40 genome complementary to the 5' end of the most abundant poly(A)-containing 19S and 16S mRNAs was mapped by hybridization of double-labeled RNA ([3H]methyl group and [14C]uridine) to specific DNA fragments. Chemical identification of methylated residues indicated that a common "leader"...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lavi S,Groner Y

更新日期：1977-12-01 00:00:00