A redox switch in CopC: an intriguing copper trafficking protein that binds copper(I) and copper(II) at different sites.

abstract：:Two virus-specific RNA species of 7.5 and 7.0 kilobases have been identified in avian myeloblastosis virus (AMV) by denaturing gel electrophoresis and blot hybridization analysis, and they were found to be in a 10:1 ratio. The individual RNAs direccted the cell-free synthesis of the 76,000-dalton "gag" protein and the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schulz RA,Chirikjian JG,Papas TS

更新日期：1981-04-01 00:00:00

abstract：:We have used a motif-based structural search method to identify structural homologs of the hormone binding domains of the nuclear receptors from among a set of known protein structures and have found the closest similarity with members of the subtilisin-like serine proteases. These proteins consist of an open twisted ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goldstein RA,Katzenellenbogen JA,Luthey-Schulten ZA,Seielstad DA,Wolynes PG

更新日期：1993-11-01 00:00:00

abstract：:Activation of the CB2 receptor is apparently an endogenous protective mechanism. Thus, it restrains inflammation and protects the skeleton against age-related bone loss. However, the endogenous cannabinoids, as well as Δ(9)-tetrahydrocannabinol, the main plant psychoactive constituent, activate both cannabinoid recept...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smoum R,Baraghithy S,Chourasia M,Breuer A,Mussai N,Attar-Namdar M,Kogan NM,Raphael B,Bolognini D,Cascio MG,Marini P,Pertwee RG,Shurki A,Mechoulam R,Bab I

更新日期：2015-07-14 00:00:00

abstract：:Type beta transforming growth factor (TGF-beta) activity was found in conditioned medium harvested from fetal rat and neonatal mouse calvariae by using the anchorage-independent growth of normal rat kidney fibroblasts as an indicator system. Calvariae incubated with parathyroid hormone, 1,25-dihydroxyvitamin D3, and i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pfeilschifter J,Mundy GR

更新日期：1987-04-01 00:00:00

abstract：:The majority of outer membrane proteins (OMPs) from gram-negative bacteria and many of mitochondria and chloroplasts are β-barrels. Insertion and assembly of these proteins are catalyzed by the Omp85 protein family in a seemingly conserved process. All members of this family exhibit a characteristic N-terminal polypep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sommer MS,Daum B,Gross LE,Weis BL,Mirus O,Abram L,Maier UG,Kühlbrandt W,Schleiff E

更新日期：2011-08-16 00:00:00

abstract：:Intracellular calcium-binding proteins are abundantly expressed in many neuronal populations. Previous evidence suggests that calcium-binding proteins can modulate various neuronal properties, presumably by their action as calcium buffers. The importance of calcium-binding proteins for nervous system function in an in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Airaksinen MS,Eilers J,Garaschuk O,Thoenen H,Konnerth A,Meyer M

更新日期：1997-02-18 00:00:00

abstract：:The biosynthesis of beta-nerve growth factor (betaNGF) was studied in mouse submaxillary glands incubated with L-[(35)S]cystine. betaNGF was isolated from tissue extracts by the addition of antiserum against betaNGF and the washed immunoprecipitates were analyzed by sodium dodecyl sulfate gel electrophoresis. With sho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Berger EA,Shooter EM

更新日期：1977-09-01 00:00:00

abstract：:Most organisms are evolutionary conservatives; they may subdivide their niches but tend to remain within them. Yet the fossil record shows many cases of breakthrough to a new mode of life. How may such evolutionary innovation be recognized at this time level? Three species of Drosophila have accomplished an innovation...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carson HL

更新日期：1974-09-01 00:00:00

abstract：:The ultrastructure of the crystalline ferric mineral that forms the central core of ferritin macro-molecules has been examined by means of ultrahigh resolution electron microscopy at 100 kV. Very high magnification dark-field images reveal the presence of either a single large crystal or several smaller crystallites w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Massover WH,Cowley JM

更新日期：1973-12-01 00:00:00

abstract：:The combination of catalytic amounts of optically active dipyridylphosphine and CuF(2) along with hydride donor PhSiH(3) generated in situ a remarkably reactive catalyst system (substrate-to-ligand molar ratio up to 100,000) for the highly enantioselective hydrosilylation of a broad spectrum of aryl alkyl ketones (up ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu J,Ji JX,Chan AS

更新日期：2005-03-08 00:00:00

abstract：:Euarthropoda is one of the best-preserved fossil animal groups and has been the most diverse animal phylum for over 500 million years. Fossil Konservat-Lagerstätten, such as Burgess Shale-type deposits (BSTs), show the evolution of the euarthropod stem lineage during the Cambrian from 518 million years ago (Ma). The s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Daley AC,Antcliffe JB,Drage HB,Pates S

更新日期：2018-05-22 00:00:00

abstract：:Glass formation in the CaO-Al2O3 system represents an important phenomenon because it does not contain typical network-forming cations. We have produced structural models of CaO-Al2O3 glasses using combined density functional theory-reverse Monte Carlo simulations and obtained structures that reproduce experiments (X-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Akola J,Kohara S,Ohara K,Fujiwara A,Watanabe Y,Masuno A,Usuki T,Kubo T,Nakahira A,Nitta K,Uruga T,Weber JK,Benmore CJ

更新日期：2013-06-18 00:00:00

abstract：:Exposure of cholera toxin to membrane particles prepared from sarcoma 180 cells gives rise to a variety of fragments which are capable of activating adenylate cyclase [ATP:pyrophosphate-lyase (cyclizing), EC 4.6.1.1]. A major component of these fragments has an apparent molecular weight in the 8,000-10,000 range. The ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Matuo Y,Wheeler MA,Bitensky MW

更新日期：1976-08-01 00:00:00

abstract：:Human embryonic zeta-globin chains are alpha-globin-like chains that are normally present during the first three months of gestation. In this investigation, zeta-globin chains measured by a specific and sensitive radioimmunoassay and by an electrophoretic technique were found to be present in all 7 patients studied wi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chung SW,Wong SC,Clarke BJ,Patterson M,Walker WH,Chui DH

更新日期：1984-10-01 00:00:00

abstract：:The spread of bacteria resistant to antimicrobial agents calls for population-wide treatment strategies to delay or reverse the trend toward antibiotic resistance. Here we propose new criteria for the evaluation of the population-wide effects of treatment protocols for directly transmitted bacterial infections and dis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bonhoeffer S,Lipsitch M,Levin BR

更新日期：1997-10-28 00:00:00

abstract：:The ability to modulate the collective properties of correlated electron systems at their interfaces and surfaces underpins the burgeoning field of "designer" quantum materials. Here, we show how an electronic reconstruction driven by surface polarity mediates a Stoner-like magnetic instability to itinerant ferromagne...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mazzola F,Sunko V,Khim S,Rosner H,Kushwaha P,Clark OJ,Bawden L,Marković I,Kim TK,Hoesch M,Mackenzie AP,King PDC

更新日期：2018-12-18 00:00:00

abstract：:Inflammation is a major factor in heart disease. IκB kinase (IKK) and its downstream target NF-κB are regulators of inflammation and are activated in cardiac disorders, but their precise contributions and targets are unclear. We analyzed IKK/NF-κB function in the heart by a gain-of-function approach, generating an ind...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maier HJ,Schips TG,Wietelmann A,Krüger M,Brunner C,Sauter M,Klingel K,Böttger T,Braun T,Wirth T

更新日期：2012-07-17 00:00:00

abstract：:Lung adenocarcinomas harboring activating mutations in the epidermal growth factor receptor (EGFR) represent a common molecular subset of non-small cell lung cancer (NSCLC) cases. EGFR mutations predict sensitivity to EGFR tyrosine kinase inhibitors (TKIs) and thus represent a dependency in NSCLCs harboring these alte...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sharifnia T,Rusu V,Piccioni F,Bagul M,Imielinski M,Cherniack AD,Pedamallu CS,Wong B,Wilson FH,Garraway LA,Altshuler D,Golub TR,Root DE,Subramanian A,Meyerson M

更新日期：2014-12-30 00:00:00

abstract：:The baculovirus Autographa californica nuclear polyhedrosis virus (AcMNPV, which is representative of the MNPV subtype in which the virions may contain many nucleocapsids within a single viral envelope) encodes a protein, v-ubi, that has 76% identity with the eukaryotic protein ubiquitin. Transcriptional mapping indic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guarino LA

更新日期：1990-01-01 00:00:00

abstract：:Polymorphism in materials often leads to significantly different physical properties--the rutile and anatase polymorphs of TiO2 are a prime example. Polytypism is a special type of polymorphism, occurring in layered materials when the geometry of a repeating structural layer is maintained but the layer-stacking sequen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luo H,Xie W,Tao J,Inoue H,Gyenis A,Krizan JW,Yazdani A,Zhu Y,Cava RJ

更新日期：2015-03-17 00:00:00

abstract：:Dopamine supersensitivity occurs in schizophrenia and other psychoses, and after hippocampal lesions, antipsychotics, ethanol, amphetamine, phencyclidine, gene knockouts of Dbh (dopamine beta-hydroxylase), Drd4 receptors, Gprk6 (G protein-coupled receptor kinase 6), Comt (catechol-O-methyltransferase), or Th-/-, DbhTh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seeman P,Weinshenker D,Quirion R,Srivastava LK,Bhardwaj SK,Grandy DK,Premont RT,Sotnikova TD,Boksa P,El-Ghundi M,O'dowd BF,George SR,Perreault ML,Männistö PT,Robinson S,Palmiter RD,Tallerico T

更新日期：2005-03-01 00:00:00

abstract：:Mutant I1A cells, lacking IL-1 receptor-associated kinase (IRAK) mRNA and protein, have been used to study the involvement of IRAK in NFkappaB and c-Jun N-terminal kinase (JNK) activation. A series of IRAK deletion constructs were expressed in I1A cells, which were then tested for their ability to respond to IL-1. Bot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li X,Commane M,Jiang Z,Stark GR

更新日期：2001-04-10 00:00:00

abstract：:By the combined use of DNase I footprinting, electrophoretic mobility-shift assay, and methylation interference analysis, we have identified a series of sequence-specific protein-DNA interactions in the 5' flanking region of the rat osteocalcin gene. Stimulation of osteocalcin gene expression by 1,25-dihydroxyvitamin ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Markose ER,Stein JL,Stein GS,Lian JB

更新日期：1990-03-01 00:00:00

abstract：:The structural and functional organization of the Cct complex was addressed by genetic analyses of subunit interactions and catalytic cooperativity among five of the eight different essential subunits, Cct1p-Cct8p, in the yeast Saccharomyces cerevisiae. The cct1-1, cct2-3, and cct3-1 alleles, containing mutations at t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin P,Sherman F

更新日期：1997-09-30 00:00:00

abstract：:Ribonucleotide reductase (RNR) catalyzes the conversion of nucleoside diphosphates to deoxynucleoside diphosphates (dNDPs). The Escherichia coli class Ia RNR uses a mechanism of radical propagation by which a cysteine in the active site of the RNR large (α2) subunit is transiently oxidized by a stable tyrosyl radical ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Minnihan EC,Ando N,Brignole EJ,Olshansky L,Chittuluru J,Asturias FJ,Drennan CL,Nocera DG,Stubbe J

更新日期：2013-03-05 00:00:00

abstract：:Phylogenetic differences in acetylcholine receptors from skeletal neuromuscular synapses of various species of snakes and lizards have been investigated, using the snake venom alpha-neurotoxins alpha-atratoxin (cobrotoxin) and alpha-bungarotoxin. The acetylcholine receptors of the phylogenetically primitive lizards, l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burden SJ,Hartzell HC,Yoshikami D

更新日期：1975-08-01 00:00:00

abstract：:n-Type Si electrodes in MeOH solvent with 0.2 M (1-hydroxyethyl)ferrocene, 0.5 mM (1-hydroxyethyl)ferricenium, and 1.0 M LiClO(4) exhibit air mass 2 conversion efficiencies of 10.1% for optical energy into electricity. We observe open-circuit voltages of 0.53 V and short-circuit quantum efficiencies for electron flow ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gronet CM,Lewis NS,Cogan G,Gibbons J

更新日期：1983-02-01 00:00:00

abstract：:The human cytokine I-309 is a small glycoprotein secreted by activated T lymphocytes and structurally related to a number of inflammatory cytokines. To investigate the biological activities of I-309 protein, we produced a stable Chinese hamster ovary cell transfectant, CDI.10, which constitutively secretes I-309 prote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miller MD,Krangel MS

更新日期：1992-04-01 00:00:00

abstract：:ATP-dependent RNA ligases are agents of RNA repair that join 3'-OH and 5'-PO4 RNA ends. Naegleria gruberi RNA ligase (NgrRnl) exemplifies a family of RNA nick-sealing enzymes found in bacteria, viruses, and eukarya. Crystal structures of NgrRnl at three discrete steps along the reaction pathway-covalent ligase-(lysyl-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Unciuleac MC,Goldgur Y,Shuman S

更新日期：2015-11-10 00:00:00

abstract：:Amnesia produced by protein synthesis inhibitors such as anisomycin provides major support for the prevalent view that the formation of long-lasting memories requires de novo protein synthesis. However, inhibition of protein synthesis might disrupt other neural functions to interfere with memory formation. Intraamygda...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Canal CE,Chang Q,Gold PE

更新日期：2007-07-24 00:00:00