Evaluating treatment protocols to prevent antibiotic resistance.

abstract：:Blot hybridization analysis that used labeled tubulin cDNA probes revealed that N6,O2'-dibutyryladenosine 3',5'-cyclic monophosphate [dibutyryl cyclic AMP (Bt2cAMP)] initially increases and later decreases the level of tubulin mRNA in a neuroblastoma-glioma hybrid cell line as well as in the parent cells. A significan...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ginzburg I,Rybak S,Kimhi Y,Littauer UZ

更新日期：1983-07-01 00:00:00

abstract：:B-1a cells, an anatomically, phenotypically, and functionally distinct subset of B cells that produce the bulk of natural serum IgM and much of gut-associated IgA, are an important component of the early response to pathogens. Because the induced expression of CD5, a hallmark of B-1a cells, requires a nuclear factor o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Berland R,Wortis HH

更新日期：2003-11-11 00:00:00

abstract：:Human Creutzfeldt-Jakob disease (CJD) and similar neurodegenerative diseases such as sheep scrapie are caused by a variety of related infectious agents. They are associated with abnormal host prion protein (PrP), which is assessed by limited proteolysis to yield resistant PrP bands (PrP-res). Although PrP-res has been...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arjona A,Simarro L,Islinger F,Nishida N,Manuelidis L

更新日期：2004-06-08 00:00:00

abstract：:Micron-scale robots require systems that can morph into arbitrary target configurations controlled by external agents such as heat, light, electricity, and chemical environment. Achieving this behavior using conventional approaches is challenging because the available materials at these scales are not programmable lik...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Agrawal M,Glotzer SC

更新日期：2020-04-21 00:00:00

abstract：:To investigate how cell population density influences the intracellular concentration of cyclic AMP we have measured adenylate cyclase and cyclic AMP phosphodiesterase activities and cyclic AMP levels at various stages of cell density in normal rat-kidney (NRK) cells, which exhibit contact-inhibition of growth, and in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Anderson WB,Russell TR,Carchman RA,Pastan I

更新日期：1973-12-01 00:00:00

abstract：:The importance of proper ion channel trafficking is underpinned by a number of channel-linked genetic diseases whose defect is associated with failure to reach the cell surface. Conceptually, it is reasonable to suggest that the function of ion channels depends critically on the precise subcellular localization and th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lu L,Timofeyev V,Li N,Rafizadeh S,Singapuri A,Harris TR,Chiamvimonvat N

更新日期：2009-10-27 00:00:00

abstract：:Clostridium ljungdahlii is an anaerobic homoacetogen, able to ferment sugars, other organic compounds, or CO(2)/H(2) and synthesis gas (CO/H(2)). The latter feature makes it an interesting microbe for the biotech industry, as important bulk chemicals and proteins can be produced at the expense of CO(2), thus combining...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Köpke M,Held C,Hujer S,Liesegang H,Wiezer A,Wollherr A,Ehrenreich A,Liebl W,Gottschalk G,Dürre P

更新日期：2010-07-20 00:00:00

abstract：:Murine and human cDNAs, related to but distinct from c-raf-1, have been isolated and designated mA-raf and hA-raf, respectively. The mA-raf and hA-raf cDNAs detect the same murine and human fragments in Southern blots of restriction enzyme-cleaved murine and human cellular DNA. The murine restriction enzyme fragments ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huebner K,ar-Rushdi A,Griffin CA,Isobe M,Kozak C,Emanuel BS,Nagarajan L,Cleveland JL,Bonner TI,Goldsborough MD

更新日期：1986-06-01 00:00:00

abstract：:Hierarchical cellular structures are ubiquitous in nature because of their low-density, high-specific properties, and multifunctionality. Inspired by these systems, we created lightweight ceramic architectures composed of closed-cell porous struts patterned in the form of hexagonal and triangular honeycombs by direct ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Muth JT,Dixon PG,Woish L,Gibson LJ,Lewis JA

更新日期：2017-02-21 00:00:00

abstract：:Pancreatic cancer is one of the most deadly cancers affecting the Western world. Because the disease is highly metastatic and difficult to diagnosis until late stages, the 5-y survival rate is around 5%. The identification of molecular cancer drivers is critical for furthering our understanding of the disease and deve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mann KM,Ward JM,Yew CC,Kovochich A,Dawson DW,Black MA,Brett BT,Sheetz TE,Dupuy AJ,Australian Pancreatic Cancer Genome Initiative.,Chang DK,Biankin AV,Waddell N,Kassahn KS,Grimmond SM,Rust AG,Adams DJ,Jenkins NA,Copela

更新日期：2012-04-17 00:00:00

abstract：:An initiation complex has been formed in high yields from E. coli ribosomes, 9S messenger RNA for rabbit hemoglobin, and N-formylmethionine-tRNA. Initiation factor IF-3 is required for the binding and puromycin is required for the release of fMet. Valyl-tRNA fails to bind to the second codon, whereas a mixture of 15 a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Noll M,Noll H,Lingrel JB

更新日期：1972-07-01 00:00:00

abstract：:A convergent, highly stereoselective total synthesis of (-)-spinosyn A (1) is described. Key features of the synthesis include the transannular Diels-Alder reaction of macrocyclic pentaene 11 and the transannular Morita-Baylis-Hillman cyclization of 12 that generates tetracycle 26. The total synthesis of (-)-spinosyn ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mergott DJ,Frank SA,Roush WR

更新日期：2004-08-17 00:00:00

abstract：:Citrus bacterial canker (CBC) caused by Xanthomonas axonopodis pv. citri (Xac) was first documented in India and Java in the mid 19th century. Since that time, the known distribution of the disease has steadily increased. Concurrent with the dispersion of the pathogen, the diversity of described strains continues to i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li W,Song Q,Brlansky RH,Hartung JS

更新日期：2007-11-20 00:00:00

abstract：:The biosynthesis and endocrine regulation of sex pheromone production in the female German cockroach (Blattella germanica) were determined. Radio-TLC and radio-GLC were used to demonstrate the metabolism of 3,11-dimethylnonacosane, a major cuticular lipid component, to the corresponding alkan-2-ol and methyl ketone. [...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chase J,Touhara K,Prestwich GD,Schal C,Blomquist GJ

更新日期：1992-07-01 00:00:00

abstract：:DNA-based identification depends on the probability that two different individuals have the same phenotype, which is given by kinship theory. Together with the large and consistent body of evidence on human population structure, kinship theory provides a sound basis for forensic use of DNA markers. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morton NE

更新日期：1992-04-01 00:00:00

abstract：:To enable discovery of serum antibodies indicative of disease and simultaneously develop reagents suitable for diagnosis, in vitro directed evolution was applied to identify consensus peptides recognized by patients' serum antibodies. Bacterial cell-displayed peptide libraries were quantitatively screened for binders ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ballew JT,Murray JA,Collin P,Mäki M,Kagnoff MF,Kaukinen K,Daugherty PS

更新日期：2013-11-26 00:00:00

abstract：:Performance on the visual paired-comparison task depends on the integrity of the hippocampal formation in humans, monkeys, and, for an analogous task, in rats. The present study sought additional evidence in healthy volunteers concerning the nature of this task. We found that performance on the visual paired-compariso...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Manns JR,Stark CE,Squire LR

更新日期：2000-10-24 00:00:00

abstract：:The unicellular green alga Chlamydomonas swims with two flagella that can synchronize their beat. Synchronized beating is required to swim both fast and straight. A long-standing hypothesis proposes that synchronization of flagella results from hydrodynamic coupling, but the details are not understood. Here, we presen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Geyer VF,Jülicher F,Howard J,Friedrich BM

更新日期：2013-11-05 00:00:00

abstract：:Addition of acetylcholine to growing cultures of mouse neuroblastoma cells induced a 37-fold increase in the specific activity of acetylcholinesterase (EC 3.1.1.7). Morphological changes, consisting of neurite-extensions, were also observed during the logarithmic phase of growth of cells stimulated with acetylcholine....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harkins J,Arsenault M,Schlesinger K,Kates J

更新日期：1972-11-01 00:00:00

abstract：:Heymann nephritis is an experimental autoimmune disease model for human membranous nephropathy. We have recently identified a pathogenic epitope, clone 14 (C14), responsible for formation and deposition of glomerular immune complexes that is contained within the small subunit of the Heymann nephritis antigenic complex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kerjaschki D,Ullrich R,Diem K,Pietromonaco S,Orlando RA,Farquhar MG

更新日期：1992-12-01 00:00:00

abstract：:To repurpose compounds for diffuse large B cell lymphoma (DLBCL), we screened a library of drugs and other targeted compounds approved by the US Food and Drug Administration on 9 cell lines and validated the results on a panel of 32 genetically characterized DLBCL cell lines. Dasatinib, a multikinase inhibitor, was ef...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scuoppo C,Wang J,Persaud M,Mittan SK,Basso K,Pasqualucci L,Rabadan R,Inghirami G,Grandori C,Bosch F,Dalla-Favera R

更新日期：2019-08-20 00:00:00

abstract：:Bacteriophage lambda encodes a number of genes involved in the recombinational repair of DNA double-strand breaks. The product of one of these genes, rap, has been purified. Truncated Rap proteins that copurify with the full-length form are derived, at least in part, from a rho-dependent transcription terminator locat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sharples GJ,Corbett LM,Graham IR

更新日期：1998-11-10 00:00:00

abstract：:Clostridium botulinum neurotoxins (BoNTs), the most potent toxins known, disrupt neurotransmission through proteolysis of proteins involved in neuroexocytosis. The light chains of BoNTs are unique zinc proteases that have stringent substrate specificity and require exceptionally long substrates. We have determined the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Segelke B,Knapp M,Kadkhodayan S,Balhorn R,Rupp B

更新日期：2004-05-04 00:00:00

abstract：:Glyceraldehyde-3-phosphate dehydrogenase [GAPDH; D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating), EC 1.2.1.12] mRNA levels are induced by physiologic concentrations of insulin in cultured 3T3-F442A adipocyte and H35 hepatoma cell lines. To examine the mechanism by which insulin regulates GAPDH mRNA ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alexander MC,Lomanto M,Nasrin N,Ramaika C

更新日期：1988-07-01 00:00:00

abstract：:Campylobacter jejuni has a general N-linked glycosylation pathway (encoded by the pgl gene cluster), which culminates in the transfer of a heptasaccharide: GalNAc-alpha1,4-GalNAc-alpha1,4-(Glcbeta1,3)-GalNAc-alpha1,4-GalNAc-alpha1,4-GalNAc-alpha1,3-Bac [where Bac is bacillosamine (2,4-diacetamido-2,4,6-trideoxyglucose...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Glover KJ,Weerapana E,Imperiali B

更新日期：2005-10-04 00:00:00

abstract：:The day we understand the time evolution of subcellular events at a level of detail comparable to physical systems governed by Newton's laws of motion seems far away. Even so, quantitative approaches to cellular dynamics add to our understanding of cell biology. With data-guided frameworks we can develop better predic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ronquist S,Patterson G,Muir LA,Lindsly S,Chen H,Brown M,Wicha MS,Bloch A,Brockett R,Rajapakse I

更新日期：2017-11-07 00:00:00

abstract：:Two types of progenitor cells of the human granulocytic and monocytic lineages (CFU-GM) can be distinguished by using mouse monoclonal antibodies against human hemopoietic cells. Type 1 CFU-GM contribute all of the peripheral blood CFU-GM as well as a small fraction of bone marrow CFU-GM and express surface antigens r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ferrero D,Broxmeyer HE,Pagliardi GL,Venuta S,Lange B,Pessano S,Rovera G

更新日期：1983-07-01 00:00:00

abstract：:Whereas several apoptosis-related proteins have been linked to the antiapoptotic effects of Akt serine-threonine kinase, the search continues to explain the Akt signaling role in promoting cell survival via antiapoptotic effects. Here, we demonstrate that Akt phosphorylates the androgen receptor (AR) at Ser-210 and Se...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin HK,Yeh S,Kang HY,Chang C

更新日期：2001-06-19 00:00:00

abstract：:Inhibitory postsynaptic currents occurring spontaneously in the teleost Mauthner cell were analyzed with the single-electrode voltage-clamp technique. They were collected during depolarizing steps and were outward-going; this procedure allowed them to be isolated from possible excitatory currents flowing in the opposi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Korn H,Burnod Y,Faber DS

更新日期：1987-08-01 00:00:00

abstract：:The decrease with age of the adrenal-secreted dehydroepiandrosterone sulfate (DHEAS) in serum has suggested that it may be causally related to longevity. For the PAQUID [People (Personnes) Aged (Agées) About What (Quid, in Latin)] cohort of elderly subjects, we have previously reported higher DHEAS in men than in wome...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mazat L,Lafont S,Berr C,Debuire B,Tessier JF,Dartigues JF,Baulieu EE

更新日期：2001-07-03 00:00:00