Abstract:
:Murine and human cDNAs, related to but distinct from c-raf-1, have been isolated and designated mA-raf and hA-raf, respectively. The mA-raf and hA-raf cDNAs detect the same murine and human fragments in Southern blots of restriction enzyme-cleaved murine and human cellular DNA. The murine restriction enzyme fragments homologous to mA-raf cDNA cosegregate with mouse chromosome X in a panel of Chinese hamster-mouse hybrid cells, thus localizing the mA-raf locus to mouse chromosome X. Two independently segregating loci, detected by the hA-raf cDNA (or mA-raf cDNA), hA-raf-1 and hA-raf-2, are located on human chromosomes X and 7, respectively. The mA-raf locus and the hA-raf-1 locus are actively transcribed in several mouse and human cell lines.
journal_name
Proc Natl Acad Sci U S Aauthors
Huebner K,ar-Rushdi A,Griffin CA,Isobe M,Kozak C,Emanuel BS,Nagarajan L,Cleveland JL,Bonner TI,Goldsborough MDdoi
10.1073/pnas.83.11.3934subject
Has Abstract,Author List Incompletepub_date
1986-06-01 00:00:00pages
3934-8issue
11eissn
0027-8424issn
1091-6490journal_volume
83pub_type
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