Actively transcribed genes in the raf oncogene group, located on the X chromosome in mouse and human.

Abstract:

:Murine and human cDNAs, related to but distinct from c-raf-1, have been isolated and designated mA-raf and hA-raf, respectively. The mA-raf and hA-raf cDNAs detect the same murine and human fragments in Southern blots of restriction enzyme-cleaved murine and human cellular DNA. The murine restriction enzyme fragments homologous to mA-raf cDNA cosegregate with mouse chromosome X in a panel of Chinese hamster-mouse hybrid cells, thus localizing the mA-raf locus to mouse chromosome X. Two independently segregating loci, detected by the hA-raf cDNA (or mA-raf cDNA), hA-raf-1 and hA-raf-2, are located on human chromosomes X and 7, respectively. The mA-raf locus and the hA-raf-1 locus are actively transcribed in several mouse and human cell lines.

authors

Huebner K,ar-Rushdi A,Griffin CA,Isobe M,Kozak C,Emanuel BS,Nagarajan L,Cleveland JL,Bonner TI,Goldsborough MD

doi

10.1073/pnas.83.11.3934

subject

Has Abstract,Author List Incomplete

pub_date

1986-06-01 00:00:00

pages

3934-8

issue

11

eissn

0027-8424

issn

1091-6490

journal_volume

83

pub_type

杂志文章
  • Buffer gradient gels and 35S label as an aid to rapid DNA sequence determination.

    abstract::Two methods for increasing the length of DNA sequence data that can be read off a polyacrylamide gel are described. We have developed a rapid way to pour a buffer concentration gradient gel that, by altering the vertical band separation on an autoradiograph, allows more sequence to be obtained from a gel. We also show...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.80.13.3963

    authors: Biggin MD,Gibson TJ,Hong GF

    更新日期:1983-07-01 00:00:00

  • In vitro reconstitution and steady-state analysis of the fatty acid synthase from Escherichia coli.

    abstract::Microbial fatty acid derivatives are emerging as promising alternatives to fossil fuel derived transportation fuels. Among bacterial fatty acid synthases (FAS), the Escherichia coli FAS is perhaps the most well studied, but little is known about its steady-state kinetic behavior. Here we describe the reconstitution of...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1110852108

    authors: Yu X,Liu T,Zhu F,Khosla C

    更新日期:2011-11-15 00:00:00

  • Assembly of tobacco mosaic virus in vitro: elongation of partially reconstituted RNA.

    abstract::It was reported that the rate of elongation of partially reconstituted RNA, if prepared without centrifugation, showed dependency upon the state of protein aggregation like that found when free RNA was used as the nucleic acid source [Butler, P. J. G. (1974) J. Mol. Biol. 82, 333-341]. Butler concluded from this resul...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.74.2.552

    authors: Ohno T,Takahashi M,Okada Y

    更新日期:1977-02-01 00:00:00

  • A theory of measuring, electing, and ranking.

    abstract::The impossibility theorems that abound in the theory of social choice show that there can be no satisfactory method for electing and ranking in the context of the traditional, 700-year-old model. A more realistic model, whose antecedents may be traced to Laplace and Galton, leads to a new theory that avoids all imposs...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0702634104

    authors: Balinski M,Laraki R

    更新日期:2007-05-22 00:00:00

  • Coevolution of landesque capital intensive agriculture and sociopolitical hierarchy.

    abstract::One of the defining trends of the Holocene has been the emergence of complex societies. Two essential features of complex societies are intensive resource use and sociopolitical hierarchy. Although it is widely agreed that these two phenomena are associated cross-culturally and have both contributed to the rise of com...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1714558115

    authors: Sheehan O,Watts J,Gray RD,Atkinson QD

    更新日期:2018-04-03 00:00:00

  • Assembly and transport of a premessenger RNP particle.

    abstract::Salivary gland cells in the larvae of the dipteran Chironomus tentans offer unique possibilities to visualize the assembly and nucleocytoplasmic transport of a specific transcription product. Each nucleus harbors four giant polytene chromosomes, whose transcription sites are expanded, or puffed. On chromosome IV, ther...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章,评审

    doi:10.1073/pnas.111145498

    authors: Daneholt B

    更新日期:2001-06-19 00:00:00

  • Carboxylic acid reductase is a versatile enzyme for the conversion of fatty acids into fuels and chemical commodities.

    abstract::Aliphatic hydrocarbons such as fatty alcohols and petroleum-derived alkanes have numerous applications in the chemical industry. In recent years, the renewable synthesis of aliphatic hydrocarbons has been made possible by engineering microbes to overaccumulate fatty acids. However, to generate end products with the de...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1216516110

    authors: Akhtar MK,Turner NJ,Jones PR

    更新日期:2013-01-02 00:00:00

  • Increased efficiency of exogenous messenger RNA translation in a Krebs ascites cell lysate.

    abstract::Addition of a 0.5 M KCl wash fraction from rabbit reticulocyte ribosomes causes a 3- to 10-fold increase in the extent of translation of natural mRNAs by Krebs-cell lysates. In the presence of the wash fraction, 1 pmol of rabbit or mouse 10S RNA directs the incorporation of 80 pmol of leucine into rabbit globin. The a...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.69.5.1299

    authors: Metafora S,Terada M,Dow LW,Marks PA,Bank A

    更新日期:1972-05-01 00:00:00

  • The solubilization of model Alzheimer tangles: reversing the beta-sheet conformation induced by aluminum with silicates.

    abstract::Neurofibrillary tangles are one of two lesions found in the brain of Alzheimer disease victims. With synthetic peptide fragments of human neurofilament NF-M17 (Glu-Glu-Lys-Gly-Lys-Ser-Pro- Val-Pro-Lys-Ser-Pro-Val-Glu-Glu-Lys-Gly, phosphorylated and unphosphorylated), CD studies were done to examine the effect of sodiu...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.91.23.11232

    authors: Fasman GD,Moore CD

    更新日期:1994-11-08 00:00:00

  • Adeno-associated virus type-2 expression of pigmented epithelium-derived factor or Kringles 1-3 of angiostatin reduce retinal neovascularization.

    abstract::Neovascular diseases of the retina include age-related macular degeneration and diabetic retinopathy, and together they comprise the leading causes of adult-onset blindness in developed countries. Current surgical, pharmaceutical, and laser therapies for age-related macular degeneration (AMD) rarely result in improved...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.122247299

    authors: Raisler BJ,Berns KI,Grant MB,Beliaev D,Hauswirth WW

    更新日期:2002-06-25 00:00:00

  • Serum half-life and tumor localization of a chimeric antibody deleted of the CH2 domain and directed against the disialoganglioside GD2.

    abstract::Recombinant techniques allow one to engineer an antibody molecule and, in this way, manipulate its properties and functions. We engineered a chimeric human/mouse antibody to the tumor-associated antigen ganglioside GD2, with the aim of decreasing its serum half-life, maintaining its full antigen-binding capacity, and ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.87.15.5702

    authors: Mueller BM,Reisfeld RA,Gillies SD

    更新日期:1990-08-01 00:00:00

  • Platelet and osteoclast beta3 integrins are critical for bone metastasis.

    abstract::Mice with a targeted deletion of beta3 integrin were used to examine the process by which tumor cells metastasize and destroy bone. Injection of B16 melanoma cells into the left cardiac ventricle resulted in osteolytic bone metastasis in 74% of beta3+/+ mice by 14 days. In contrast, only 4% of beta3-/- mice developed ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.2234372100

    authors: Bakewell SJ,Nestor P,Prasad S,Tomasson MH,Dowland N,Mehrotra M,Scarborough R,Kanter J,Abe K,Phillips D,Weilbaecher KN

    更新日期:2003-11-25 00:00:00

  • Homeobox genes are expressed in the retina and brain of adult goldfish.

    abstract::The goldfish (Carassius auratus) visual pathway displays continuous growth and plasticity throughout life. Since homeobox genes are important transcriptional regulators in development, we searched for homeobox genes in the adult goldfish retina and brain. Using the PCR, we discovered a repertoire of homeobox sequences...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.90.7.2729

    authors: Levine EM,Schechter N

    更新日期:1993-04-01 00:00:00

  • Bves directly interacts with GEFT, and controls cell shape and movement through regulation of Rac1/Cdc42 activity.

    abstract::Bves is an integral membrane protein with no determined function and no homology to proteins outside of the Popdc family. It is widely expressed throughout development in myriad organisms. Here, we demonstrate an interaction between Bves and guanine nucleotide exchange factor T (GEFT), a GEF for Rho-family GTPases. Th...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0802345105

    authors: Smith TK,Hager HA,Francis R,Kilkenny DM,Lo CW,Bader DM

    更新日期:2008-06-17 00:00:00

  • Formylmethionyl-tRNA alters RNA polymerase specificity.

    abstract::Escherichia coli fMet-tRNAfMet alters the pattern of promoter selection of E. coli RNA polymerase (RNA nucleotidyltransferase, nucleosidetriphosphate:RNA nucleotidyltransferase; EC 2.7.7.6), affecting RNA synthesis from the rRNA, suIII+tRNA, and lac promoters in different ways. The in vitro synthesis of the stable RNA...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.77.2.870

    authors: Debenham PG,Pongs O,Travers AA

    更新日期:1980-02-01 00:00:00

  • The gene regulatory program of Acrobeloides nanus reveals conservation of phylum-specific expression.

    abstract::The evolution of development has been studied through the lens of gene regulation by examining either closely related species or extremely distant animals of different phyla. In nematodes, detailed cell- and stage-specific expression analyses are focused on the model Caenorhabditis elegans, in part leading to the view...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1720817115

    authors: Schiffer PH,Polsky AL,Cole AG,Camps JIR,Kroiher M,Silver DH,Grishkevich V,Anavy L,Koutsovoulos G,Hashimshony T,Yanai I

    更新日期:2018-04-24 00:00:00

  • Gene targeting of the transcription factor Mohawk in rats causes heterotopic ossification of Achilles tendon via failed tenogenesis.

    abstract::Cell-based or pharmacological approaches for promoting tendon repair are currently not available because the molecular mechanisms of tendon development and healing are not well understood. Although analysis of knockout mice provides many critical insights, small animals such as mice have some limitations. In particula...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1522054113

    authors: Suzuki H,Ito Y,Shinohara M,Yamashita S,Ichinose S,Kishida A,Oyaizu T,Kayama T,Nakamichi R,Koda N,Yagishita K,Lotz MK,Okawa A,Asahara H

    更新日期:2016-07-12 00:00:00

  • Adult and larval traits as determinants of geographic range size among tropical reef fishes.

    abstract::Most marine organisms disperse via ocean currents as larvae, so it is often assumed that larval-stage duration is the primary determinant of geographic range size. However, empirical tests of this relationship have yielded mixed results, and alternative hypotheses have rarely been considered. Here we assess the relati...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1304074110

    authors: Luiz OJ,Allen AP,Robertson DR,Floeter SR,Kulbicki M,Vigliola L,Becheler R,Madin JS

    更新日期:2013-10-08 00:00:00

  • Characterizing the proton loading site in cytochrome c oxidase.

    abstract::Cytochrome c oxidase (CcO) uses the energy released by reduction of O2 to H2O to drive eight charges from the high pH to low pH side of the membrane, increasing the electrochemical gradient. Four electrons and protons are used for chemistry, while four more protons are pumped. Proton pumping requires that residues on ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1407187111

    authors: Lu J,Gunner MR

    更新日期:2014-08-26 00:00:00

  • Functional role for vasoactive intestinal polypeptide in the caudate nucleus: a 2-deoxy[14C]glucose investigation.

    abstract::The quantitative autoradiographic 2-deoxy-[14C]glucose technique has been used with conscious rats to investigate the functional consequences (reflected as alterations in local rates of glucose utilization) of unilateral intrastriatal administration of vasoactive intestinal polypeptide. Intrastriatal administration of...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.80.5.1472

    authors: McCulloch J,Kelly PA,Uddman R,Edvinsson L

    更新日期:1983-03-01 00:00:00

  • Adaptive aneuploidy protects against thiol peroxidase deficiency by increasing respiration via key mitochondrial proteins.

    abstract::Aerobic respiration is a fundamental energy-generating process; however, there is cost associated with living in an oxygen-rich environment, because partially reduced oxygen species can damage cellular components. Organisms evolved enzymes that alleviate this damage and protect the intracellular milieu, most notably t...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1505315112

    authors: Kaya A,Gerashchenko MV,Seim I,Labarre J,Toledano MB,Gladyshev VN

    更新日期:2015-08-25 00:00:00

  • Receptors for oxidized low-density lipoprotein on elicited mouse peritoneal macrophages can recognize both the modified lipid moieties and the modified protein moieties: implications with respect to macrophage recognition of apoptotic cells.

    abstract::It has been shown previously that the binding of oxidized low-density lipoprotein (OxLDL) to resident mouse peritoneal macrophages can be inhibited (up to 70%) by the apoprotein B (apoB) isolated from OxLDL, suggesting that macrophage recognition of OxLDL is primarily dependent on its modified protein moiety. However,...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.96.11.6347

    authors: Bird DA,Gillotte KL,Hörkkö S,Friedman P,Dennis EA,Witztum JL,Steinberg D

    更新日期:1999-05-25 00:00:00

  • Midgut microbiota and host immunocompetence underlie Bacillus thuringiensis killing mechanism.

    abstract::Bacillus thuringiensis is a widely used bacterial entomopathogen producing insecticidal toxins, some of which are expressed in insect-resistant transgenic crops. Surprisingly, the killing mechanism of B. thuringiensis remains controversial. In particular, the importance of the septicemia induced by the host midgut mic...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1521741113

    authors: Caccia S,Di Lelio I,La Storia A,Marinelli A,Varricchio P,Franzetti E,Banyuls N,Tettamanti G,Casartelli M,Giordana B,Ferré J,Gigliotti S,Ercolini D,Pennacchio F

    更新日期:2016-08-23 00:00:00

  • MAL6 of Saccharomyces: a complex genetic locus containing three genes required for maltose fermentation.

    abstract::The MAL6 locus is one of five closely related unlinked loci, any one of which is sufficient for fermentation of maltose in Saccharomyces. Previous genetic analysis indicated that this locus is defined by two complementation groups, MALp and MALg. MALp reportedly is a regulatory gene required for inducible synthesis of...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.81.9.2811

    authors: Needleman RB,Kaback DB,Dubin RA,Perkins EL,Rosenberg NG,Sutherland KA,Forrest DB,Michels CA

    更新日期:1984-05-01 00:00:00

  • Concomitant combination therapy for HIV infection preferable over sequential therapy with 3TC and non-nucleoside reverse transcriptase inhibitors.

    abstract::Exposure to 3TC of HIV-1 mutant strains containing non-nucleoside reverse transcriptase inhibitor (NNRTI)-specific mutations in their reverse transcriptase (RT) easily selected for double-mutant viruses that had acquired the characteristic 184-Ile mutation in their RT in addition to the NNRTI-specific mutations. Conve...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.93.23.13152

    authors: Balzarini J,Pelemans H,Karlsson A,De ClercQ E,Kleim JP

    更新日期:1996-11-12 00:00:00

  • Systemic anti-VEGF treatment strongly reduces skin inflammation in a mouse model of psoriasis.

    abstract::Although(,) vascular remodeling is a hallmark of many chronic inflammatory disorders such as rheumatoid arthritis, inflammatory bowel disease, and psoriasis, anti-vascular strategies to treat these conditions have received little attention to date. We investigated the anti-inflammatory activity of systemic blockade of...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0907550106

    authors: Schonthaler HB,Huggenberger R,Wculek SK,Detmar M,Wagner EF

    更新日期:2009-12-15 00:00:00

  • Structural basis of nonnatural amino acid recognition by an engineered aminoacyl-tRNA synthetase for genetic code expansion.

    abstract::The genetic code in a eukaryotic system has been expanded by the engineering of Escherichia coli tyrosyl-tRNA synthetase (TyrRS) with the Y37V and Q195C mutations (37V195C), which specifically recognize 3-iodo-L-tyrosine rather than L-tyrosine. In the present study, we determined the 3-iodo-L-tyrosine- and L-tyrosine-...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0407039102

    authors: Kobayashi T,Sakamoto K,Takimura T,Sekine R,Kelly VP,Kamata K,Nishimura S,Yokoyama S

    更新日期:2005-02-01 00:00:00

  • Dissociable contribution of prefrontal and striatal dopaminergic genes to learning in economic games.

    abstract::Game theory describes strategic interactions where success of players' actions depends on those of coplayers. In humans, substantial progress has been made at the neural level in characterizing the dopaminergic and frontostriatal mechanisms mediating such behavior. Here we combined computational modeling of strategic ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1316259111

    authors: Set E,Saez I,Zhu L,Houser DE,Myung N,Zhong S,Ebstein RP,Chew SH,Hsu M

    更新日期:2014-07-01 00:00:00

  • Charge selectivity at the lipid-protein interface of membranous Na,K-ATPase.

    abstract::Lipid interactions with the integral membrane protein Na,K-ATPase (ATP phosphohydrolase, EC 3.6.1.3) purified from the electric organ of Electrophorus electricus were studied by spin labeling. A protein-associated component (boundary layer) in equilibrium with the fluid bilayer is clearly evident in the electron spin ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.77.1.272

    authors: Brotherus JR,Jost PC,Griffith OH,Keana JF,Hokin LE

    更新日期:1980-01-01 00:00:00

  • Surface photometry of celestial sources from a space vehicle: introduction and observational procedures.

    abstract::Diffuse celestial sources of relatively low surface brightness such as the Milky Way, zodiacal light, and gegenschein (or contre lumière) can be studied most reliably from above the earth's atmosphere with equipment flown in artificial satellites. We review the techniques used and some of the difficulties encountered ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.69.3.694

    authors: Roach FE,Carroll B,Aller LH,Smith L

    更新日期:1972-03-01 00:00:00