Generation of a stable, aminotyrosyl radical-induced α2β2 complex of Escherichia coli class Ia ribonucleotide reductase.

abstract：:A fungal colony is a syncytium composed of a branched and interconnected network of cells. Chimerism endows colonies with increased virulence and ability to exploit nutritionally complex substrates. Moreover, chimera formation may be a driver for diversification at the species level by allowing lateral gene transfer b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roper M,Simonin A,Hickey PC,Leeder A,Glass NL

更新日期：2013-08-06 00:00:00

abstract：:Adaptive radiation is the evolution of ecological and phenotypic diversity within a rapidly multiplying lineage. Recent studies have identified general patterns in adaptive radiation and inferred that resource competition is a primary factor driving phenotypic divergence. The role and importance of other processes, su...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nosil P,Crespi BJ

更新日期：2006-06-13 00:00:00

abstract：:We investigate the role of networks of alliances in preventing (multilateral) interstate wars. We first show that, in the absence of international trade, no network of alliances is peaceful and stable. We then show that international trade induces peaceful and stable networks: Trade increases the density of alliances ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jackson MO,Nei S

更新日期：2015-12-15 00:00:00

abstract：:To complete the set of synthetic analogs of the three recognized types of active sites in iron-sulfur redox proteins, the compound (Et4N)[Fe((SCH2)2C6H4)2], derived from o-xylyl-alpha,alpha'-dithiol, has been prepared and its structure has been determined by x-ray diffraction. The bischelate anion contains a near-tetr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lane RW,Ibers JA,Frankel RB,Holm RH

更新日期：1975-08-01 00:00:00

abstract：:Brn-4 is a member of the POU transcription factor family and is expressed in the central nervous system. In this study, we addressed whether Brn-4 regulates expression of the D1A dopamine receptor gene. We found a functional Brn-4 responsive element in the intron of this gene by means of cotransfection chloramphenical...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Okazawa H,Imafuku I,Minowa MT,Kanazawa I,Hamada H,Mouradian MM

更新日期：1996-10-15 00:00:00

abstract：:A theory is proposed to study the sensitivity of cylindrical explosives. Using the equations governing the conservation of mass, energy, and momentum, the equation of state, and Newtonian mechanics, we have derived the expression D = D(o)e(-a2/d), in which the apparent length of the reaction zone, a, takes into accoun...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eyring H,Walker FE,Ma SM,Coon N

更新日期：1980-05-01 00:00:00

abstract：:We have identified, cultured, characterized, and propagated adult pluripotent stem cells (PSC) from a subset of human peripheral blood monocytes. These cells, which in appearance resemble fibroblasts, expand in the presence of macrophage colony-stimulating factor and display monocytic and hematopoietic stem cell marke...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhao Y,Glesne D,Huberman E

更新日期：2003-03-04 00:00:00

abstract：:Male oriental fruit flies (Dacus dorsalis) from colonies in Taiwan and Hawaii were evaluated for limit of response to various analogues of methyl eugenol. The results are interpreted in terms of the geometry and allosteric requirements of the antennal receptor that triggers the characteristic methyl eugenol reflex. Th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Metcalf RL,Metcalf ER,Mitchell WC,Lee LW

更新日期：1979-04-01 00:00:00

abstract：:Peripheral nerve injury induces a robust proregenerative program that drives axon regeneration. While many regeneration-associated genes are known, the mechanisms by which injury activates them are less well-understood. To identify such mechanisms, we performed a loss-of-function pharmacological screen in cultured adu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Karney-Grobe S,Russo A,Frey E,Milbrandt J,DiAntonio A

更新日期：2018-10-16 00:00:00

abstract：:Aminoacyl-tRNAs are generally formed by direct attachment of an amino acid to tRNAs by aminoacyl-tRNA synthetases, but Gln-tRNA is an exception to this rule. Gln-tRNA(Gln) is formed by this direct pathway in the eukaryotic cytosol and in protists or fungi mitochondria but is formed by an indirect transamidation pathwa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pujol C,Bailly M,Kern D,Maréchal-Drouard L,Becker H,Duchêne AM

更新日期：2008-04-29 00:00:00

abstract：:Metastatic spread is the leading cause of cancer mortality. Breast cancer (BCa) metastatic recurrence can happen years after removal of the primary tumor. Here we show that Ubc13, an E2 enzyme that catalyzes K63-linked protein polyubiquitination, is largely dispensable for primary mammary tumor growth but is required ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu X,Zhang W,Font-Burgada J,Palmer T,Hamil AS,Biswas SK,Poidinger M,Borcherding N,Xie Q,Ellies LG,Lytle NK,Wu LW,Fox RG,Yang J,Dowdy SF,Reya T,Karin M

更新日期：2014-09-23 00:00:00

abstract：:The human T cell leukemia virus I basic leucine zipper protein (HTLV-1 HBZ) maintains chronic viral infection and promotes leukemogenesis through poorly understood mechanisms involving interactions with the KIX domain of the transcriptional coactivator CBP and its paralog p300. The KIX domain binds regulatory proteins...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang K,Stanfield RL,Martinez-Yamout MA,Dyson HJ,Wilson IA,Wright PE

更新日期：2018-10-02 00:00:00

abstract：:Epigenetic mechanisms are involved in the pathophysiology of depressive disorders and are unique potential targets for therapeutic intervention. The acetylating agent L-acetylcarnitine (LAC), a well-tolerated drug, behaves as an antidepressant by the epigenetic regulation of type 2 metabotropic glutamate (mGlu2) recep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nasca C,Xenos D,Barone Y,Caruso A,Scaccianoce S,Matrisciano F,Battaglia G,Mathé AA,Pittaluga A,Lionetto L,Simmaco M,Nicoletti F

更新日期：2013-03-19 00:00:00

abstract：:The chronic use of several drugs, including opiates, results in the stereotypical behaviors characteristic of addiction. Alterations in gene expression have been associated with the use of these addictive drugs. Previous studies, however, have been limited to describing changes in amounts of individual mRNAs from sing...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mackler SA,Eberwine JH

更新日期：1994-01-04 00:00:00

abstract：:Restricted fetal growth is associated with postnatal mortality and morbidity and may be directly related to alterations in the capacity of the placenta to supply nutrients. We proposed previously that imprinted genes can regulate nutrient supply by the placenta. Here, we tested the hypothesis that the insulin-like gro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sibley CP,Coan PM,Ferguson-Smith AC,Dean W,Hughes J,Smith P,Reik W,Burton GJ,Fowden AL,Constância M

更新日期：2004-05-25 00:00:00

abstract：:Hybridomas producing human monoclonal IgM antibodies (mAbs) against bacterial lipopolysaccharide (LPS) were generated by fusion of B lymphocytes from sensitized human spleen with heteromyeloma cells. The splenocytes were from patients undergoing splenectomy during staging for Hodgkin disease after vaccination with the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Teng NN,Kaplan HS,Hebert JM,Moore C,Douglas H,Wunderlich A,Braude AI

更新日期：1985-03-01 00:00:00

abstract：:Ceramide, a lipid mediator, has been most closely associated with antiproliferative activities. In this study, we examine the mechanism by which ceramide induces growth suppression and the role of the retinoblastoma gene product (Rb) in this process. Withdrawal of serum from the serum-dependent MOLT-4 cells resulted i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dbaibo GS,Pushkareva MY,Jayadev S,Schwarz JK,Horowitz JM,Obeid LM,Hannun YA

更新日期：1995-02-28 00:00:00

abstract：:We use a three-dimensional, higher-order ice flow model and a realistic initial condition to simulate dynamic perturbations to the Greenland ice sheet during the last decade and to assess their contribution to sea level by 2100. Starting from our initial condition, we apply a time series of observationally constrained...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Price SF,Payne AJ,Howat IM,Smith BE

更新日期：2011-05-31 00:00:00

abstract：:Forests and their soils contain the majority of the earth's terrestrial carbon stocks. Changes in patterns of tree growth can have a huge impact on atmospheric cycles, biogeochemical cycles, climate change, and biodiversity. Recent studies have shown increases in biomass across many forest types. This increase has bee...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McMahon SM,Parker GG,Miller DR

更新日期：2010-02-23 00:00:00

abstract：:The first crystal structure of the neurotransmitter/sodium symporter homolog LeuT revealed an occluded binding pocket containing leucine and 2 Na(+); later structures showed tricyclic antidepressants (TCAs) in an extracellular vestibule approximately 11 A above the bound leucine and 2 Na(+). We recently found this reg...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Quick M,Winther AM,Shi L,Nissen P,Weinstein H,Javitch JA

更新日期：2009-04-07 00:00:00

abstract：:Bacterial chemotaxis receptors can detect a small concentration gradient of attractants and repellents in the environment over a wide range of background concentration. The clustering of these receptors to form patches observed in vivo and in vitro has been suspected as a reason for the high sensitivity, and such wide...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim SH,Wang W,Kim KK

更新日期：2002-09-03 00:00:00

abstract：:Recent sequencing efforts have led to estimates of human cytomegalovirus (HCMV) genome-wide intrahost diversity that rival those of persistent RNA viruses [Renzette N, Bhattacharjee B, Jensen JD, Gibson L, Kowalik TF (2011) PLoS Pathog 7:e1001344]. Here, we deep sequence HCMV genomes recovered from single and longitud...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cudini J,Roy S,Houldcroft CJ,Bryant JM,Depledge DP,Tutill H,Veys P,Williams R,Worth AJJ,Tamuri AU,Goldstein RA,Breuer J

更新日期：2019-03-19 00:00:00

abstract：:In epidemiological studies, both positive and negative correlations have been found between cardiovascular disease and mortality and the presence of several inorganic ions in the drinking water. In an attempt to resolve this apparent disagreement, we exposed White Carneau pigeons to drinking water containing calcium (...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Revis NW,Zinsmeister AR,Bull R

更新日期：1981-10-01 00:00:00

abstract：:The environments we humans encounter daily are sources of exposure to diverse microbial communities, some of potential concern to human health. In this study, we used culture-independent technology to investigate the microbial composition of biofilms inside showerheads as ecological assemblages in the human indoor env...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Feazel LM,Baumgartner LK,Peterson KL,Frank DN,Harris JK,Pace NR

更新日期：2009-09-22 00:00:00

abstract：:Recent laboratory studies have demonstrated that isoprene oxidation products can partition to atmospheric aerosols by reacting with condensed phase sulfuric acid, forming low-volatility organosulfate compounds. We have identified organosulfate compounds in free tropospheric aerosols by single particle mass spectrometr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Froyd KD,Murphy SM,Murphy DM,de Gouw JA,Eddingsaas NC,Wennberg PO

更新日期：2010-12-14 00:00:00

abstract：:A key element for the development of suitable anti-cancer drugs is the identification of cancer-specific enzymatic activities that can be therapeutically targeted. Mucosa-associated lymphoid tissue transformation protein 1 (MALT1) is a proto-oncogene that contributes to tumorigenesis in diffuse large B-cell lymphoma (...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hailfinger S,Lenz G,Ngo V,Posvitz-Fejfar A,Rebeaud F,Guzzardi M,Penas EM,Dierlamm J,Chan WC,Staudt LM,Thome M

更新日期：2009-11-24 00:00:00

abstract：:The counterintuitive features of quantum physics challenge many common-sense assumptions. In an interferometric quantum eraser experiment, one can actively choose whether or not to erase which-path information (a particle feature) of one quantum system and thus observe its wave feature via interference or not by perfo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ma XS,Kofler J,Qarry A,Tetik N,Scheidl T,Ursin R,Ramelow S,Herbst T,Ratschbacher L,Fedrizzi A,Jennewein T,Zeilinger A

更新日期：2013-01-22 00:00:00

abstract：:Our long-term goal is the in vivo expression of intrinsically colored proteins without the need for further posttranslational modification or chemical functionalization by externally added reagents. Biocompatible (Aza)Indoles (Inds)/(Aza)Tryptophans (Trp) as optical probes represent almost ideal isosteric substitutes ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lepthien S,Hoesl MG,Merkel L,Budisa N

更新日期：2008-10-21 00:00:00

abstract：:The body-wall muscle cells of the nematode Caenorhabditis elegans produce thick filaments during embryonic, larval, and adult stages. These thick filaments contain two myosin isoforms, A and B, which assemble into different zones along the 10-microns lengths. Paramyosin, a protein homologous to myosin rods, forms a su...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Honda S,Epstein HF

更新日期：1990-02-01 00:00:00

abstract：:We report an approach for the detection of magnetic resonance imaging without superconducting magnets and cryogenics: optical atomic magnetometry. This technique possesses a high sensitivity independent of the strength of the static magnetic field, extending the applicability of magnetic resonance imaging to low magne...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu S,Yashchuk VV,Donaldson MH,Rochester SM,Budker D,Pines A

更新日期：2006-08-22 00:00:00