L-acetylcarnitine causes rapid antidepressant effects through the epigenetic induction of mGlu2 receptors.

abstract：:Transthyretin (TTR) is a globular tetrameric transport protein in plasma. Nearly 140 single amino acid substitutions in TTR cause life-threatening amyloid disease. We report a one-of-a-kind pathological variant featuring a Glu51, Ser52 duplication mutation (Glu51_Ser52dup). The proband, heterozygous for the mutation, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Klimtchuk ES,Prokaeva T,Frame NM,Abdullahi HA,Spencer B,Dasari S,Cui H,Berk JL,Kurtin PJ,Connors LH,Gursky O

更新日期：2018-07-10 00:00:00

abstract：:Many physical and chemical properties of the light rare-earths and actinides are governed by the active role of f electrons, and despite intensive efforts the details of the mechanisms of phase stability and transformation are not fully understood. A prominent example which has attracted a lot of interest, both experi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Krisch M,Farber DL,Xu R,Antonangeli D,Aracne CM,Beraud A,Chiang TC,Zarestky J,Kim DY,Isaev EI,Ahuja R,Johansson B

更新日期：2011-06-07 00:00:00

abstract：:Double fertilization is a key innovation for the evolutionary success of angiosperms by which the two fertilized female gametes, the egg cell and central cell, generate the embryo and endosperm, respectively. The female gametophyte (embryo sac) enclosed in the sporophyte is derived from a one-celled haploid cell linea...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang MX,Zhu SS,Xu YC,Guo YL,Yang WC,Li HJ

更新日期：2020-03-17 00:00:00

abstract：:How likely is it that someone would approve of using a nuclear weapon to kill millions of enemy civilians in the hope of ending a ground war that threatens thousands of American troops? Ask them how they feel about prosecuting immigrants, banning abortion, supporting the death penalty, and protecting gun rights and yo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Slovic P,Mertz CK,Markowitz DM,Quist A,Västfjäll D

更新日期：2020-08-25 00:00:00

abstract：:We use quantized molecular dynamics simulations to characterize the role of enzyme vibrations in facilitating dihydrofolate reductase hydride transfer. By sampling the full ensemble of reactive trajectories, we are able to quantify and distinguish between statistical and dynamical correlations in the enzyme motion. We...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boekelheide N,Salomón-Ferrer R,Miller TF 3rd

更新日期：2011-09-27 00:00:00

abstract：:High-resolution maps integrated with the enhanced location data base software (LDB+) give improved estimates of genetic parameters and reveal characteristics of cytogenetic bands. Chiasma interference is intermediate between Kosambi and Carter-Falconer levels, as in Drosophila and the mouse. The autosomal genetic map ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Collins A,Frezal J,Teague J,Morton NE

更新日期：1996-12-10 00:00:00

abstract：:The cycles of carbon and oxygen at the Earth surface are intimately linked, where the burial of organic carbon into sediments represents a source of oxygen to the surface environment. This coupling is typically quantified through the isotope records of organic and inorganic carbon. Yet, the late Neoproterozoic Eon, th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bjerrum CJ,Canfield DE

更新日期：2011-04-05 00:00:00

abstract：:Cyanobacteria are phototrophic prokaryotes that evolved oxygenic photosynthesis ∼2.7 billion y ago and are presently responsible for ∼10% of total global photosynthetic production. To cope with the evolutionary pressure of dropping ambient CO2 concentrations, they evolved a CO2-concentrating mechanism (CCM) to augment...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Selim KA,Haase F,Hartmann MD,Hagemann M,Forchhammer K

更新日期：2018-05-22 00:00:00

abstract：:We obtain a collection of multilinear Littlewood-Paley estimates, which we then apply to two problems in partial differential equations. The first problem is the estimation of the square root of an elliptic operator in divergence form, and the second is the estimation of solutions to the Cauchy problem for nondivergen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fabes EB,Jerison DS,Kenig CE

更新日期：1982-09-01 00:00:00

abstract：:Drugs with poor oral bioavailability usually are administered by hypodermic injection, which causes pain, poor patient compliance, the need for trained personnel, and risk of infectious disease transmission. Transdermal (TD) delivery provides an excellent alternative, but the barrier of skin's outer stratum corneum (S...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wermeling DP,Banks SL,Hudson DA,Gill HS,Gupta J,Prausnitz MR,Stinchcomb AL

更新日期：2008-02-12 00:00:00

abstract：:Ubiquitin C-terminal hydrolase L1 (UCH-L1) is one of the most abundant and enigmatic enzymes of the CNS. Based on existing UCH-L1 knockout models, UCH-L1 is thought to be required for the maintenance of axonal integrity, but not for neuronal development despite its high expression in neurons. Several lines of evidence...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reinicke AT,Laban K,Sachs M,Kraus V,Walden M,Damme M,Sachs W,Reichelt J,Schweizer M,Janiesch PC,Duncan KE,Saftig P,Rinschen MM,Morellini F,Meyer-Schwesinger C

更新日期：2019-04-16 00:00:00

abstract：:A cDNA of the human terminal deoxynucleotidyltransferase (TdT; "terminal transferase," EC 2.7.7.31) was isolated from a human lymphoblastoid cell cDNA library in lambda gt 11 by using immunological procedures. Four inserts containing 723 to 939 base pairs were recloned in pBR322 for hybridization and preliminary seque...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Peterson RC,Cheung LC,Mattaliano RJ,Chang LM,Bollum FJ

更新日期：1984-07-01 00:00:00

abstract：:Inferring evolutionary relationships among highly divergent protein sequences is a daunting task. In particular, when pairwise sequence alignments between protein sequences fall <25% identity, the phylogenetic relationships among sequences cannot be estimated with statistical certainty. Here, we show that phylogenetic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chang GS,Hong Y,Ko KD,Bhardwaj G,Holmes EC,Patterson RL,van Rossum DB

更新日期：2008-09-09 00:00:00

abstract：:It is found that the addition of hexamethylphosphoramide to the solution of an alkyne, Et(2)Zn, and (S)-1,1'-bi-2-naphthol in methylene chloride allows the generation of an alkynylzinc at room temperature and shows highly enantioselective additions to aldehydes. The mild condition for the formation of the alkynylzinc ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gao G,Xie RG,Pu L

更新日期：2004-04-13 00:00:00

abstract：:Echoviruses are enteroviruses that belong to Picornaviridae. Many echoviruses use decay-accelerating factor (DAF) as their cellular receptor. DAF is a glycosylphosphatidyl inositol-anchored complement regulatory protein found on most cell surfaces. It functions to protect cells from complement attack. The cryo-electro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： He Y,Lin F,Chipman PR,Bator CM,Baker TS,Shoham M,Kuhn RJ,Medof ME,Rossmann MG

更新日期：2002-08-06 00:00:00

abstract：:Mutations of von Hippel-Lindau disease (VHL) tumor-suppressor gene product (pVHL) are found in patients with dominant inherited VHL syndrome and in the vast majority of sporadic clear cell renal carcinomas. The function of the pVHL protein has not been clarified. pVHL has been shown to form a complex with elongin B an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Iwai K,Yamanaka K,Kamura T,Minato N,Conaway RC,Conaway JW,Klausner RD,Pause A

更新日期：1999-10-26 00:00:00

abstract：:Thiopurine S-methyltransferase (TPMT) catalyzes the S-methylation of thiopurine drugs. TPMT genetic polymorphisms represent a striking example of the potential clinical value of pharmacogenetics. Subjects homozygous for TPMT*3A, the most common variant allele for low activity, an allele that encodes a protein with two...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang L,Nguyen TV,McLaughlin RW,Sikkink LA,Ramirez-Alvarado M,Weinshilboum RM

更新日期：2005-06-28 00:00:00

abstract：:The c-myc protooncogene has been implicated in control of growth and differentiation of mammalian cells. For instance, growth arrest is often preceded by reduction in c-myc mRNA and gene transcription. To elucidate the mechanisms of control of c-myc gene transcription, we have begun to characterize the interaction of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Duyao MP,Buckler AJ,Sonenshein GE

更新日期：1990-06-01 00:00:00

abstract：:A graph-theoretic condition is given for the existence of stable solutions to the Volterra-Lotka equations. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yorke JA,Anderson WN

更新日期：1973-07-01 00:00:00

abstract：:We describe the use of a series of gradually expanded thymine nucleobase analogs in probing steric effects in DNA polymerase efficiency and fidelity. In these nonpolar compounds, the base size was increased incrementally over a 1.0-A range by use of variably sized atoms (H, F, Cl, Br, and I) to replace the oxygen mole...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim TW,Delaney JC,Essigmann JM,Kool ET

更新日期：2005-11-01 00:00:00

abstract：:Three criteria have been used to distinguish among different systems of embryonic cell adhesion: dependence on Ca2+, involvement of particular cell-surface molecules, and binding specificity. The characterization of the adhesion with respect to cell-surface molecules was carried out by using specific antibodies agains...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brackenbury R,Rutishauser U,Edelman GM

更新日期：1981-01-01 00:00:00

abstract：:A number of distressing trends, including a decline in the share of key research grants going to younger scientists, as well as a steady rise in the age at which investigators receive their first funding, are now a decades-long feature of the US biomedical research workforce. Working committees have proposed recommend...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Daniels RJ

更新日期：2015-01-13 00:00:00

abstract：:Fungi must recognize plant-specific signals to initiate subsequent morphogenetic events such as filamentation that lead to infection. Here we show that the plant hormone indoleacetic acid (IAA) induces adhesion and filamentation of Saccharomyces cerevisiae. Genome expression profiling of cells treated with IAA identif...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Prusty R,Grisafi P,Fink GR

更新日期：2004-03-23 00:00:00

abstract：:The binding of transcription factors (TFs) to DNA controls most aspects of cellular function, making the understanding of their binding kinetics imperative. The standard description of bimolecular interactions posits that TF off rates are independent of TF concentration in solution. However, recent observations have r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kamar RI,Banigan EJ,Erbas A,Giuntoli RD,Olvera de la Cruz M,Johnson RC,Marko JF

更新日期：2017-04-18 00:00:00

abstract：:Individual organisms are complex in a special way. The organization and function of their parts seem directed toward a purpose: the survival and reproduction of that individual. Groups of organisms are different. They may also be complex, but that is usually because their parts, the individual organisms, are working a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Strassmann JE,Queller DC

更新日期：2007-05-15 00:00:00

abstract：:Pseudohypoparathyroidism type Ia (PHP-Ia) results from the loss of one allele of G(salpha), causing resistance to parathyroid hormone and other hormones that transduce signals via G(s). Most G(salpha)mutations cause the complete loss of protein expression, but some cause loss of function only, and these have provided ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Makita N,Sato J,Rondard P,Fukamachi H,Yuasa Y,Aldred MA,Hashimoto M,Fujita T,Iiri T

更新日期：2007-10-30 00:00:00

abstract：:The conformational change in amyloid beta (Abeta) peptide from its monomeric form to aggregates is crucial in the pathogenesis of Alzheimer's disease (AD). In the healthy brain, some unidentified chaperones appear to prevent the aggregation of Abeta. Here we reported that lipocalin-type prostaglandin D synthase (L-PGD...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kanekiyo T,Ban T,Aritake K,Huang ZL,Qu WM,Okazaki I,Mohri I,Murayama S,Ozono K,Taniike M,Goto Y,Urade Y

更新日期：2007-04-10 00:00:00

abstract：:Cytochrome c oxidase (COX) is a 13-subunit protein complex that catalyzes the last step in mitochondrial electron transfer in mammals. Of the 10 subunits encoded by nuclear DNA (three are mtDNA products), some are expressed as tissue- and/or development-specific isoforms. For COX subunit VIII, previous work showed tha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goldberg A,Wildman DE,Schmidt TR,Huttemann M,Goodman M,Weiss ML,Grossman LI

更新日期：2003-05-13 00:00:00

abstract：:Knowledge of how insects are actually affected by sex pheromones deployed throughout a crop so as to disrupt mating has lacked a mechanistic framework sufficient for guiding optimization of this environmentally friendly pest-control tactic. Major hypotheses are competitive attraction, desensitization, and camouflage. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miller JR,McGhee PS,Siegert PY,Adams CG,Huang J,Grieshop MJ,Gut LJ

更新日期：2010-01-05 00:00:00

abstract：:A predictive coarse-grained protein force field [associative memory, water-mediated, structure, and energy model for molecular dynamics (AWSEM)-MD] is used to study the energy landscapes and relative stabilities of amyloid-β protein (1-40) in the monomer and all of its oligomeric forms up to an octamer. We find that a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zheng W,Tsai MY,Chen M,Wolynes PG

更新日期：2016-10-18 00:00:00