Network topology for the formation of solvated electrons in binary CaO-Al2O3 composition glasses.

abstract：:The rapid worldwide spread of severe acute respiratory syndrome demonstrated the potential threat an infectious disease poses in a closely interconnected and interdependent world. Here we introduce a probabilistic model that describes the worldwide spread of infectious diseases and demonstrate that a forecast of the g...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hufnagel L,Brockmann D,Geisel T

更新日期：2004-10-19 00:00:00

abstract：:New World tetraploid cottons (Gossypium spp.) originated through hybridization of ancestral diploid species that presently have allopatric ranges in Asia-Africa (the A genome) and the New World tropics and subtropics (the D genome). Despite intensive study, the identity of the parental diploids and the antiquity of po...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wendel JF

更新日期：1989-06-01 00:00:00

abstract：:Despite the proclamation of Lowenstam and Weiner that crustaceans are the "champions of mineral mobilization and deposition of the animal kingdom," relatively few proteins from the two main calcification sites in these animals, i.e., the exoskeleton and the transient calcium storage organs, have been identified, seque...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shechter A,Glazer L,Cheled S,Mor E,Weil S,Berman A,Bentov S,Aflalo ED,Khalaila I,Sagi A

更新日期：2008-05-20 00:00:00

abstract：:Nonspecific histone deacetylase (HDAC) inhibition has been shown to facilitate the extinction of drug-seeking behavior in a manner resistant to reinstatement. A key open question is which specific HDAC is involved in the extinction of drug-seeking behavior. Using the selective HDAC3 inhibitor RGFP966, we investigated ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Malvaez M,McQuown SC,Rogge GA,Astarabadi M,Jacques V,Carreiro S,Rusche JR,Wood MA

更新日期：2013-02-12 00:00:00

abstract：:Intergroup conflict is a persistent feature of many human societies yet little is known about why individuals participate when doing so imposes a mortality risk. To evaluate whether participation in warfare is associated with reproductive benefits, we present data on participation in small-scale livestock raids among ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Glowacki L,Wrangham R

更新日期：2015-01-13 00:00:00

abstract：:The kinetics of charge transfer depend crucially on the dielectric reorganization of the medium. In enzymatic reactions that involve charge transfer, atomic dielectric response of the active site and of its surroundings determines the efficiency of the protein as a catalyst. We report direct spectroscopic measurements...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mertz EL,Krishtalik LI

更新日期：2000-02-29 00:00:00

abstract：:Because xenon NMR is highly sensitive to the local environment, laser-polarized xenon could be a unique probe of living tissues. Realization of clinical and medical science applications beyond lung airspace imaging requires methods of efficient delivery of laser-polarized xenon to tissues, because of the short spin-la...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goodson BM,Song Y,Taylor RE,Schepkin VD,Brennan KM,Chingas GC,Budinger TF,Navon G,Pines A

更新日期：1997-12-23 00:00:00

abstract：:The mechanism of phosphosylation and dephosphorylation of spectrin from human erythrocyte membranes has been examined under closely physiological conditions. The results support the hypothesis that spectrin is an autophosphorylating and dephosphorylating system. (i) Extraction from ghosts of up to 85% of the kinase (c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Imhof BA,Acha-Orbea HJ,Libermann TA,Reber BF,Lanz JH,Winterhalter KH,Birchmeier W

更新日期：1980-06-01 00:00:00

abstract：:Auditory scene analysis requires the listener to parse the incoming flow of acoustic information into perceptual "streams," such as sentences from a single talker in the midst of background noise. Behavioral and neural data show that the formation of streams is not instantaneous; rather, streaming builds up over time ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kondo HM,Pressnitzer D,Toshima I,Kashino M

更新日期：2012-04-24 00:00:00

abstract：:The three-dimensional structures of avian H5 and swine H9 influenza hemagglutinins (HAs) from viruses closely related to those that caused outbreaks of human disease in Hong Kong in 1997 and 1999 were determined bound to avian and human cell receptor analogs. Emerging influenza pandemics have been accompanied by the e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ha Y,Stevens DJ,Skehel JJ,Wiley DC

更新日期：2001-09-25 00:00:00

abstract：:N-methyl-D-aspartate (NMDA) glutamate receptor-mediated increases in intracellular calcium are thought to play a critical role in synaptic plasticity. The mechanisms by which changes in cytoplasmic calcium transmit the glutamate signal to the nucleus, which is ultimately important for long-lasting neuronal responses, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yun HY,Gonzalez-Zulueta M,Dawson VL,Dawson TM

更新日期：1998-05-12 00:00:00

abstract：:Mutations induced by (+/-)trans-benzo-[a]pyrene-7,8-dihydrodiol-9,10-epoxide (BaP-diol epoxide-1) were selected by using a recombinant plasmid vector system designed for the study of transcription termination signals. The plasmid contains a transcription terminator positioned between a promotor signal and the Escheric...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mizusawa H,Lee CH,Kakefuda T,McKenney K,Shimatake H,Rosenberg M

更新日期：1981-11-01 00:00:00

abstract：:Regulated proteolysis is required to execute many cellular programs. In Caulobacter crescentus, timely degradation of the master regulator CtrA by ClpXP protease is essential for cell-cycle progression and requires the colocalization of CtrA and RcdA. Here, we establish a biochemical framework to understand regulated ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chien P,Perchuk BS,Laub MT,Sauer RT,Baker TA

更新日期：2007-04-17 00:00:00

abstract：:Time-resolved optical measurements encompassing the femtoseconds to seconds time scales have been used to investigate Rhodobacter capsulatus reaction centers (RCs) in which the histidine residue at position 200 on the M polypeptide has been changed to a leucine by site-directed mutagenesis. The HisM200----Leu RC, whic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kirmaier C,Holten D,Bylina EJ,Youvan DC

更新日期：1988-10-01 00:00:00

abstract：:Enteritis caused by Clostridium difficile toxin (Tx) is a nosocomial disease of increasing clinical concern, but the local mediators of C. difficile TxA inflammation are unknown. The potent vasodilator calcitonin gene-related peptide mediates neurogenic inflammation via the calcitonin receptor-like receptor (CLR). Her...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bhargava A,Clifton MS,Mhaske P,Liao M,Pothoulakis C,Leeman SE,Grady EF

更新日期：2013-01-08 00:00:00

abstract：:Collagen fibrils can exceed thousands of microns in length and are therefore the longest, largest, and most size-pleomorphic protein polymers in vertebrates; thus, knowing how cells transport collagen fibrils is essential for a more complete understanding of protein transport and its role in tissue morphogenesis. Here...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kalson NS,Starborg T,Lu Y,Mironov A,Humphries SM,Holmes DF,Kadler KE

更新日期：2013-12-03 00:00:00

abstract：:Optical imaging of individual vesicle exocytosis is providing new insights into the mechanism and regulation of secretion by cells. To study calcium-triggered secretion from astrocytes, we used acridine orange (AO) to label vesicles. Although AO is often used for imaging exocytosis, we found that imaging vesicles labe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jaiswal JK,Fix M,Takano T,Nedergaard M,Simon SM

更新日期：2007-08-28 00:00:00

abstract：:The phylogenetic affinities of the grass family (Poaceae) have long been debated. The chloroplast genomes of at least some grasses have been known to possess three inversions relative to the typical gene arrangement found in most flowering plants. We have surveyed for the presence of these inversions in grasses and ot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Doyle JJ,Davis JI,Soreng RJ,Garvin D,Anderson MJ

更新日期：1992-08-15 00:00:00

abstract：:Glyco-immune checkpoint receptors, molecules that inhibit immune cell activity following binding to glycosylated cell-surface antigens, are emerging as attractive targets for cancer immunotherapy. Defining biologically relevant ligands that bind and activate such receptors, however, has historically been a significant...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wisnovsky S,Möckl L,Malaker SA,Pedram K,Hess GT,Riley NM,Gray MA,Smith BAH,Bassik MC,Moerner WE,Bertozzi CR

更新日期：2021-02-02 00:00:00

abstract：:Ion channel proteins control ionic flux across biological membranes through conformational changes in their transmembrane pores. An exponentially increasing number of channel structures captured in different conformational states are now being determined; however, these newly resolved structures are commonly classifie...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rao S,Klesse G,Stansfeld PJ,Tucker SJ,Sansom MSP

更新日期：2019-07-09 00:00:00

abstract：:The lactose-H+ symport protein (LacS) of Streptococcus thermophilus has a C-terminal hydrophilic domain that is homologous to IIA protein(s) domains of the phosphoenolpyruvate:sugar phosphotransferase system (PTS). C-terminal truncation mutants were constructed and expressed in Escherichia coli and their properties we...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Poolman B,Knol J,Mollet B,Nieuwenhuis B,Sulter G

更新日期：1995-01-31 00:00:00

abstract：:Posttranslational modifications (PTMs) of α-synuclein (α-syn), e.g., phosphorylation, play an important role in modulating α-syn pathology in Parkinson's disease (PD) and α-synucleinopathies. Accumulation of phosphorylated α-syn fibrils in Lewy bodies and Lewy neurites is the histological hallmark of these diseases. H...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhao K,Lim YJ,Liu Z,Long H,Sun Y,Hu JJ,Zhao C,Tao Y,Zhang X,Li D,Li YM,Liu C

更新日期：2020-08-18 00:00:00

abstract：:We show in climate model experiments that large-scale afforestation in northern mid-latitudes warms the Northern Hemisphere and alters global circulation patterns. An expansion of dark forests increases the absorption of solar energy and increases surface temperature, particularly in regions where the land surface is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Swann AL,Fung IY,Chiang JC

更新日期：2012-01-17 00:00:00

abstract：:Activated transcription of the bacteriophage T4 late genes, which is coupled to concurrent DNA replication, is accomplished by an initiation complex containing the host RNA polymerase associated with two phage-encoded proteins, gp55 (the basal promoter specificity factor) and gp33 (the coactivator), as well as the DNA...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Twist KA,Campbell EA,Deighan P,Nechaev S,Jain V,Geiduschek EP,Hochschild A,Darst SA

更新日期：2011-12-13 00:00:00

abstract：:Tangier disease is a familial disorder characterized by orange tonsils, cholesterol ester deposition in reticuloendothelial cells, abnormal chylomicron remnants, and a marked reduction in high density lipoproteins. Plasma concentrations of the apolipoproteins apo-A-I and apoA-II in patients with Tangier disease are ap...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kay LL,Ronan R,Schaefer EJ,Brewer HB Jr

更新日期：1982-04-01 00:00:00

abstract：:Ascorbic acid metabolism is associated with a number of mechanisms known to be involved in host resistance to malignant disease. Cancer patients are significantly depleted of ascorbic acid, and in our opinion this demonstrable biochemical characteristic indicates a substantially increased requirement and utilization o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cameron E,Pauling L

更新日期：1976-10-01 00:00:00

abstract：:Ethylenediaminetetraacetate and other divalent-cation-complexing agents greatly stimulate the cellular binding of DNA molecules to competent pneumococci, while the appearance of genetic transformants and nuclease-resistant DNA binding are completely inhibited. Based on this finding, we developed an experimental system...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seto H,Tomasz A

更新日期：1974-04-01 00:00:00

abstract：:A mutation in RPB5 (rpb5-9), an essential RNA polymerase subunit assembled into RNA polymerases I, II, and III, revealed a role for this subunit in transcriptional activation. Activation by GAL4-VP16 was impaired upon in vitro transcription with mutant whole-cell extracts. In vivo experiments using inducible reporter ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miyao T,Woychik NA

更新日期：1998-12-22 00:00:00

abstract：:Sulfoquinovose (SQ; 6-deoxy-6-sulfoglucose) is the polar head group of the plant sulfolipid SQ-diacylglycerol, and SQ comprises a major proportion of the organosulfur in nature, where it is degraded by bacteria. A first degradation pathway for SQ has been demonstrated recently, a "sulfoglycolytic" pathway, in addition...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Felux AK,Spiteller D,Klebensberger J,Schleheck D

更新日期：2015-08-04 00:00:00

abstract：:We introduce Pathifier, an algorithm that infers pathway deregulation scores for each tumor sample on the basis of expression data. This score is determined, in a context-specific manner, for every particular dataset and type of cancer that is being investigated. The algorithm transforms gene-level information into pa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Drier Y,Sheffer M,Domany E

更新日期：2013-04-16 00:00:00