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Theta oscillations index human hippocampal activation during a working memory task.

Abstract：

:Working memory (WM) is the ability to retain and associate information over brief time intervals. Functional imaging studies demonstrate that WM is mediated by a distributed network including frontal and posterior cortices, hippocampus, and cerebellum. In rodents, the presentation of stimuli in a WM task is followed by a reset of the phase of hippocampal theta. In this paper we report the observation of a similar phenomenon in normal human subjects. Neuromagnetic responses were recorded during presentation of a set of digits and a subsequent probe of the retained items. All stimuli were presented with a fixed temporal pattern. We observed phase reset of approximately 7 Hz theta in left hippocampus approximately 120 ms after probe stimuli, whereas reset of theta in right hippocampus was visible approximately 80 ms prior to these anticipated stimuli. The duration of stimulus-locked theta increased with memory load, with a limiting value of approximately 600 ms for 5-7 retained items. We suggest that, as in rats, stimulus-locked theta may index involvement of human hippocampal networks in the cognitive processing of sensory input. The anticipatory phase reset of theta indicates involvement of hippocampus in right hemisphere and cerebellar timing networks. Hippocampal structures are essential for orientation to perturbations in the sensory scene, a function that requires use of a context established by a constellation of stimuli. We suggest that the initiation and maintenance of stimulus-locked hippocampal theta observed here may facilitate processing of potentially salient and/or novel input with respect to a context established by the contents of WM.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Tesche CD,Karhu J

doi

10.1073/pnas.97.2.919

keywords:

subject

Has Abstract

pub_date

2000-01-18 00:00:00

pages

919-24

issue

2

eissn

0027-8424

issn

1091-6490

journal_volume

97

pub_type

临床试验,杂志文章,随机对照试验

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