Magnetic tests for magnetosome chains in Martian meteorite ALH84001.

abstract：:G protein-coupled receptors (GPCRs) play central roles in almost all physiological functions; mutations in GPCRs are responsible for more than 30 disorders. There is a great deal of information about GPCR structure but little information that directly relates structure to protein trafficking or to activation. The gona...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Janovick JA,Conn PM

更新日期：2010-03-02 00:00:00

abstract：:Changes in protein function can lead to changes in the selection acting on specific residues. This can often be detected as evolutionary rate changes at the sites in question. A maximum-likelihood method for detecting evolutionary rate shifts at specific protein positions is presented. The method determines significan...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Knudsen B,Miyamoto MM

更新日期：2001-12-04 00:00:00

abstract：:A key component of scientific communication is sufficient information for other researchers in the field to reproduce published findings. For computational and data-enabled research, this has often been interpreted to mean making available the raw data from which results were generated, the computer code that generate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stodden V,Seiler J,Ma Z

更新日期：2018-03-13 00:00:00

abstract：:Physiological and evolutionary adaptations operate at very different time scales. Nevertheless, there are reasons to believe there should be a strong relationship between the two, as together they modify the phenotype. Physiological adaptations change phenotype by altering certain microscopic parameters; evolutionary ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Milo R,Hou JH,Springer M,Brenner MP,Kirschner MW

更新日期：2007-10-23 00:00:00

abstract：:Activated RAS transforming genes that encode proteins (p21s) with amino acid substitutions at positions 12, 13, or 61 have been detected in 10-20% of human neoplasms. This report describes a monoclonal antibody (DWP) raised against a synthetic peptide corresponding to amino acids 5-16 of a mutated RAS gene encoding Va...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carney WP,Petit D,Hamer P,Der CJ,Finkel T,Cooper GM,Lefebvre M,Mobtaker H,Delellis R,Tischler AS

更新日期：1986-10-01 00:00:00

abstract：:We have developed a technology for analysis and sorting of live cells according to secreted molecules. An artificial affinity matrix, specific for the secreted product of interest, is created on the cell surface, and the cells are allowed to secrete for a defined time period. The secreted molecules bind to the affinit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Manz R,Assenmacher M,Pflüger E,Miltenyi S,Radbruch A

更新日期：1995-03-14 00:00:00

abstract：:The ATP-dependent enzyme dethiobiotin synthetase from Escherichia coli catalyses the formation of dethiobiotin from CO2 and 7, 8-diaminopelargonic acid. The reaction is initiated by the formation of a carbamate and proceeds through a phosphorylated intermediate, a mixed carbamic phosphoric anhydride. Here, we report t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Käck H,Gibson KJ,Lindqvist Y,Schneider G

更新日期：1998-05-12 00:00:00

abstract：:Among the tRNA population of the archaeal parasite Nanoarchaeum equitans are five species assembled from separate 5' and 3' tRNA halves and four species derived from tRNA precursors containing introns. In both groups an intervening sequence element must be removed during tRNA maturation. A bulge-helix-bulge (BHB) moti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Randau L,Calvin K,Hall M,Yuan J,Podar M,Li H,Söll D

更新日期：2005-12-13 00:00:00

abstract：:Usher syndrome type 1 (USH1) patients suffer from sensorineuronal deafness, vestibular dysfunction, and visual impairment. Several genetic loci have been linked to USH1, and four of the relevant genes have been identified. They encode the unconventional myosin VIIa, the PDZ-domain protein harmonin, and the putative ad...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Siemens J,Kazmierczak P,Reynolds A,Sticker M,Littlewood-Evans A,Müller U

更新日期：2002-11-12 00:00:00

abstract：:Prostate cancer is a leading cause of cancer death in men over 50 years of age, and there is a characteristic marked decrease in Zn content in the malignant prostate cells. The cause and consequences of this loss have thus far been unknown. We found that in middle-aged rats a Zn-deficient diet reduces prostatic Zn lev...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fong LY,Jing R,Smalley KJ,Wang ZX,Taccioli C,Fan S,Chen H,Alder H,Huebner K,Farber JL,Fiehn O,Croce CM

更新日期：2018-11-20 00:00:00

abstract：:Recognition of a particular individual occurs when we reactivate links between current perceptual inputs and the previously formed representation of that person. This recognition can be achieved by identifying, separately or simultaneously, distinct elements such as the face, silhouette, or voice as belonging to one i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sliwa J,Duhamel JR,Pascalis O,Wirth S

更新日期：2011-01-25 00:00:00

abstract：:The Abeta peptide of Alzheimer disease is derived from the proteolytic processing of the amyloid precursor proteins (APP), which are considered type I transmembrane glycoproteins. Recently, however, soluble forms of full-length APP were also detected in several systems including chromaffin granules. In this report we ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Efthimiopoulos S,Vassilacopoulou D,Ripellino JA,Tezapsidis N,Robakis NK

更新日期：1996-07-23 00:00:00

abstract：:Generating human single-nucleotide polymorphisms (SNPs) is no longer a rate-limiting step for genetic studies of disease. The number of SNPs in public databases already exceeds 200,000, and the total is expected to exceed 1,000,000 within a year. Rather, progress is limited by the inability to genotype large numbers o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hirschhorn JN,Sklar P,Lindblad-Toh K,Lim YM,Ruiz-Gutierrez M,Bolk S,Langhorst B,Schaffner S,Winchester E,Lander ES

更新日期：2000-10-24 00:00:00

abstract：:Proteins need to be tightly regulated as they control biological processes in most normal cellular functions. The precise mechanisms of regulation are rarely completely understood but can involve binding of endogenous ligands and/or partner proteins at specific locations on a protein that can modulate function. Often,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ludlow RF,Verdonk ML,Saini HK,Tickle IJ,Jhoti H

更新日期：2015-12-29 00:00:00

abstract：:Cities are concentrated areas of CO2 emissions and have become the foci of policies for mitigation actions. However, atmospheric measurement networks suitable for evaluating urban emissions over time are scarce. Here we present a unique long-term (decadal) record of CO2 mole fractions from five sites across Utah's met...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mitchell LE,Lin JC,Bowling DR,Pataki DE,Strong C,Schauer AJ,Bares R,Bush SE,Stephens BB,Mendoza D,Mallia D,Holland L,Gurney KR,Ehleringer JR

更新日期：2018-03-20 00:00:00

abstract：:The ATM gene is mutated in the syndrome of ataxia telangiectasia (AT), associated with neurologic dysfunction, growth abnormalities, and extreme radiosensitivity. Insulin-like growth factor-I receptor (IGF-IR) is a cell surface receptor with tyrosine kinase activity that can mediate mitogenesis, cell transformation, a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Peretz S,Jensen R,Baserga R,Glazer PM

更新日期：2001-02-13 00:00:00

abstract：:Mammalian thalamus is a critical site where early perception of sensorimotor signals is dynamically regulated by acetylcholine in a behavioral state-dependent manner. In this study, we examined how synaptic transmission is modulated by acetylcholine in auditory thalamus where sensory relay neurons form parallel lemnis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mooney DM,Zhang L,Basile C,Senatorov VV,Ngsee J,Omar A,Hu B

更新日期：2004-01-06 00:00:00

abstract：:The substance P (SP)-preferring receptor neurokinin-1 receptor (NK-1R) has two forms: a full-length receptor consisting of 407 aa and a truncated receptor consisting of 311 aa. These two receptors differ in the length of the C terminus of NK-1R. We studied the undifferentiated and phorbol myristate acetate (PMA)-diffe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lai JP,Ho WZ,Kilpatrick LE,Wang X,Tuluc F,Korchak HM,Douglas SD

更新日期：2006-05-16 00:00:00

abstract：:The 1,25-dihydroxyvitamin D3 [1,25-(OH)2vitamin D3] analog KH1060 exerts very potent effects on cell proliferation and cell differentiation via the vitamin D receptor (VDR). However, the activities of KH1060 are not associated with an increased affinity for the VDR. We now show that increased stabilization of the VDR-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： van den Bemd GC,Pols HA,Birkenhäger JC,van Leeuwen JP

更新日期：1996-10-01 00:00:00

abstract：:Metazoan embryogenesis is controlled by a limited number of signaling modules that are used repetitively at successive developmental stages. The development of social amoebas shows similar reiterated use of cAMP-mediated signaling. In the model Dictyostelium discoideum, secreted cAMP acting on 4 cAMP receptors (cARs1-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kawabe Y,Morio T,James JL,Prescott AR,Tanaka Y,Schaap P

更新日期：2009-04-28 00:00:00

abstract：:Without sufficient greenhouse gases in the atmosphere, the early Earth would have become a permanently frozen planet because the young Sun was less luminous than it is today. Several resolutions to this faint young Sun-frozen Earth paradox have been proposed, with an atmosphere rich in CO2 being the one generally favo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bada JL,Bigham C,Miller SL

更新日期：1994-02-01 00:00:00

abstract：:Ammonia-oxidizing archaea are ubiquitous in marine and terrestrial environments and now thought to be significant contributors to carbon and nitrogen cycling. The isolation of Candidatus "Nitrosopumilus maritimus" strain SCM1 provided the opportunity for linking its chemolithotrophic physiology with a genomic inventor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Walker CB,de la Torre JR,Klotz MG,Urakawa H,Pinel N,Arp DJ,Brochier-Armanet C,Chain PS,Chan PP,Gollabgir A,Hemp J,Hügler M,Karr EA,Könneke M,Shin M,Lawton TJ,Lowe T,Martens-Habbena W,Sayavedra-Soto LA,Lang D,Sieve

更新日期：2010-05-11 00:00:00

abstract：:Oxidative stress is a ubiquitous threat to all aerobic organisms and has been implicated in numerous pathological conditions such as cancer. Here we demonstrate a pivotal role for E2F1, a cell cycle regulatory transcription factor, in cell tolerance of oxidative stress. Cells lacking E2F1 are hypersensitive to oxidati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Graves JD,Lee YJ,Liu K,Li G,Lin FT,Lin WC

更新日期：2020-06-30 00:00:00

abstract：:Adipose tissue dysfunction is causally implicated in the impaired metabolic homeostasis associated with obesity; however, detailed mechanisms underlying dysregulated adipocyte functions in obesity remain to be elucidated. Here we searched for genes that provide a previously unknown mechanism in adipocyte metabolic fun...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wardhana DA,Ikeda K,Barinda AJ,Nugroho DB,Qurania KR,Yagi K,Miyata K,Oike Y,Hirata KI,Emoto N

更新日期：2018-02-13 00:00:00

abstract：:The failure to induce self-tolerance of simian virus 40 large tumor antigen (T antigen) expressed in the pancreatic beta cells of transgenic mice results in an autoimmune response against this protein and the cells that synthesize it. In every transgenic mouse with delayed onset of T-antigen expression and consequent ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Skowronski J,Jolicoeur C,Alpert S,Hanahan D

更新日期：1990-10-01 00:00:00

abstract：:Most guanine nucleotide binding protein (G protein)-coupled receptors have a conserved cysteine in the C-terminal cytoplasmic tail near the seventh transmembrane spanning region. This cysteine is known to be palmitoylated in rhodopsin, the beta 2-adrenergic receptor (beta 2AR) and the alpha 2A-adrenergic receptor (alp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eason MG,Jacinto MT,Theiss CT,Liggett SB

更新日期：1994-11-08 00:00:00

abstract：:Total cellular poly(A)-enriched RNA from a variety of fresh human leukemic blood cells and hematopoietic cell lines was analyzed for homology with molecularly cloned DNA probes containing the onc sequence of Abelson murine leukemia virus (Ab-MuLV), Harvey murine sarcoma virus (Ha-MuSV), simian sarcoma virus (SSV), and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Westin EH,Wong-Staal F,Gelmann EP,Dalla-Favera R,Papas TS,Lautenberger JA,Eva A,Reddy EP,Tronick SR,Aaronson SA,Gallo RC

更新日期：1982-04-01 00:00:00

abstract：:Comparative genomics of closely related bacterial isolates is a powerful method for uncovering virulence and other important genome elements. We determined draft sequences (8-fold coverage) of the genomes of strains JD1 and N40 of Borrelia burgdorferi sensu stricto, the causative agent of Lyme disease, and we compared...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qiu WG,Schutzer SE,Bruno JF,Attie O,Xu Y,Dunn JJ,Fraser CM,Casjens SR,Luft BJ

更新日期：2004-09-28 00:00:00

abstract：:Human telomeres terminate with a single-stranded 3' G overhang, which can be recognized as a DNA damage site by replication protein A (RPA). The protection of telomeres (POT1)/POT1-interacting protein 1 (TPP1) heterodimer binds specifically to single-stranded telomeric DNA (ssTEL) and protects G overhangs against RPA ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ray S,Bandaria JN,Qureshi MH,Yildiz A,Balci H

更新日期：2014-02-25 00:00:00

abstract：:Factor VII is a precursor to a serine protease that is present in mammalian plasma. In its activated form, it participates in blood coagulation by activating factor X and/or factor IX in the presence of tissue factor and calcium. Clones coding for factor VII were obtained from two cDNA libraries prepared from poly(A) ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hagen FS,Gray CL,O'Hara P,Grant FJ,Saari GC,Woodbury RG,Hart CE,Insley M,Kisiel W,Kurachi K

更新日期：1986-04-01 00:00:00