Maternal effort mediates the prevalence of trypanosomes in the offspring of a passerine bird.

abstract：:The avian predentary is a small skeletal structure located rostral to the paired dentaries found only in Mesozoic ornithuromorphs. The evolution and function of this enigmatic element is unknown. Skeletal tissues forming the predentary and the lower jaws in the basal ornithuromorph Yanornis martini are identified usin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bailleul AM,Li Z,O'Connor J,Zhou Z

更新日期：2019-12-03 00:00:00

abstract：:The perceptual quality of odors usually is robust to variability in concentration. However, maps of neural activation across the olfactory bulb glomerular layer are not stable in this respect; rather, glomerular odor representations both broaden and intensify as odorant concentrations are increased. The relative level...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cleland TA,Johnson BA,Leon M,Linster C

更新日期：2007-02-06 00:00:00

abstract：:Several overlapping chromosomal deletions spanning the albino locus in the mouse cause perinatal lethality when homozygous and a block in the transcriptional induction of various unlinked hepatocyte-specific genes. Studies of such lethal albino deletion homozygotes in perinatal stages revealed a deficiency in the tran...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zaret KS,Milos P,Lia M,Bali D,Gluecksohn-Waelsch S

更新日期：1992-07-15 00:00:00

abstract：:Plasmids that contain synthetic genes coding for small oligoribonucleotides called external guide sequences (EGSs) have been introduced into strains of Escherichia coli harboring antibiotic resistance genes. The EGSs direct RNase P to cleave the mRNAs transcribed from these genes thereby converting the phenotype of dr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guerrier-Takada C,Salavati R,Altman S

更新日期：1997-08-05 00:00:00

abstract：:Generation of nanomechanical cantilever motion from biomolecular interactions can have wide applications, ranging from high-throughput biomolecular detection to bioactuation. Although it has been suggested that such motion is caused by changes in surface stress of a cantilever beam, the origin of the surface-stress ch...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu G,Ji H,Hansen K,Thundat T,Datar R,Cote R,Hagan MF,Chakraborty AK,Majumdar A

更新日期：2001-02-13 00:00:00

abstract：:The yeast AAA-ATPase Cdc48 and the ubiquitin fusion degradation (UFD) proteins play important, evolutionarily conserved roles in ubiquitin dependent protein degradation. The N-terminal domain of Cdc48 interacts with substrate-recruiting cofactors, whereas the C terminus of Cdc48 binds to proteins such as Ufd3 that pro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhao G,Li G,Schindelin H,Lennarz WJ

更新日期：2009-09-22 00:00:00

abstract：:Mouse lymphocytic cells of the established line GF-14 were allowed to accumulate intracellular 3H-labeled aminoisobutyric acid (AIB), frozen, and stored over liquid N2. After internal radiation had reduced survival to 1 in 10(4), survivors were plated and tested for their ability to transport AIB. Out of 200 clones te...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Finkelstein MC,Slayman CW,Adelberg EA

更新日期：1977-10-01 00:00:00

abstract：:Recent theory and field observations suggest that a systematically varying weathering zone, that can be tens of meters thick, commonly develops in the bedrock underlying hillslopes. Weathering turns otherwise poorly conductive bedrock into a dynamic water storage reservoir. Infiltrating precipitation typically will pa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rempe DM,Dietrich WE

更新日期：2018-03-13 00:00:00

abstract：:Interleukin 1 (IL-1) and tumor necrosis factor alpha are thought to contribute to the inflammatory response associated with autoimmune diseases. Transforming growth factor beta 1 (TGF-beta 1) counteracts many effects of these cytokines and has various immunosuppressive properties. In the present study, it is shown tha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kuruvilla AP,Shah R,Hochwald GM,Liggitt HD,Palladino MA,Thorbecke GJ

更新日期：1991-04-01 00:00:00

abstract：:Thyroid cancer is a common endocrine malignancy that encompasses well-differentiated as well as dedifferentiated cancer types. The latter tumors have high mortality and lack effective therapies. Using a paired-end RNA-sequencing approach, we report the discovery of rearrangements involving the anaplastic lymphoma kina...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kelly LM,Barila G,Liu P,Evdokimova VN,Trivedi S,Panebianco F,Gandhi M,Carty SE,Hodak SP,Luo J,Dacic S,Yu YP,Nikiforova MN,Ferris RL,Altschuler DL,Nikiforov YE

更新日期：2014-03-18 00:00:00

abstract：:To optimize the use of modified adenoviruses as vectors for gene delivery to the myocardium, we have characterized infection of cultured fetal and adult rat cardiac myocytes in vitro and of adult cardiac myocytes in vivo by using a replication-defective adenovirus carrying the chloramphenicol acetyltransferase (CAT) r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kass-Eisler A,Falck-Pedersen E,Alvira M,Rivera J,Buttrick PM,Wittenberg BA,Cipriani L,Leinwand LA

更新日期：1993-12-15 00:00:00

abstract：:The conjugal transmission of plasmid ColE1 and its derivatives can lead to recA-independent recombination. The recombination is not observed during vegetative growth and takes place specifically between the sequences that are thought to represent the transfer origin of ColE1. This provides genetic evidence for breakag...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Warren GJ,Clark AJ

更新日期：1980-11-01 00:00:00

abstract：:Serotonin (5-HT) plays a key role in early brain development, and manipulation of 5-HT levels during this period can have lasting neurobiological and behavioral consequences. It is unclear how perinatal exposure to drugs, such as selective serotonin reuptake inhibitors (SSRIs), impacts cortical neural network function...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Simpson KL,Weaver KJ,de Villers-Sidani E,Lu JY,Cai Z,Pang Y,Rodriguez-Porcel F,Paul IA,Merzenich M,Lin RC

更新日期：2011-11-08 00:00:00

abstract：:Human-caused environmental changes are creating regional combinations of environmental conditions that, within the next 50 to 100 years, may fall outside the envelope within which many of the terrestrial plants of a region evolved. These environmental modifications might become a greater cause of global species extinc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tilman D,Lehman C

更新日期：2001-05-08 00:00:00

abstract：:Susceptibility of activated T cells to apoptosis must be tightly regulated to ensure sufficient T cell progeny for an effective response, while allowing a rapid depletion of them at the end of the immune response. We show here that a previously isolated, NF-kappa B/rel target gene IEX-1 (Immediate Early response gene ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang Y,Schlossman SF,Edwards RA,Ou CN,Gu J,Wu MX

更新日期：2002-01-22 00:00:00

abstract：:A 900-base-pair (bp) sequence from a cDNA clone of the rye endosperm-storage-protein gene Sec-1 was labeled with biotin and hybridized to Secale cereale 'Blanco' chromosomes. Hybridization was seen on the satellite part of the short arm of chromosome 1R, where the Sec-1 gene has been genetically mapped, in approximate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gustafson JP,Butler E,McIntyre CL

更新日期：1990-03-01 00:00:00

abstract：:The Late Heavy Bombardment (LHB), a hypothesized impact spike at ∼3.9 Ga, is one of the major scientific concepts to emerge from Apollo-era lunar exploration. A significant portion of the evidence for the existence of the LHB comes from histograms of (40)Ar/(39)Ar "plateau" ages (i.e., regions selected on the basis of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boehnke P,Harrison TM

更新日期：2016-09-27 00:00:00

abstract：:Although anatomy is often the first step in assigning functions to neural structures, it is not always clear whether architecturally distinct regions of the brain correspond to operational units. Whereas neuroarchitecture remains relatively static, functional connectivity may change almost instantaneously according to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weir PT,Dickinson MH

更新日期：2015-10-06 00:00:00

abstract：:Many models of morphogenesis are forced to assume specific mechanical properties of cells, because the actual mechanical properties of living tissues are largely unknown. Here, we measure the rheology of epithelial cells in the cellularizing Drosophila embryo by injecting magnetic particles and studying their response...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Doubrovinski K,Swan M,Polyakov O,Wieschaus EF

更新日期：2017-01-31 00:00:00

abstract：:Knowing how motile bacteria move near and along a solid surface is crucial to understanding such diverse phenomena as the migration of infectious bacteria along a catheter, biofilm growth, and the movement of bacteria through the pore spaces of saturated soil, a critical step in the in situ bioremediation of contamina...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Frymier PD,Ford RM,Berg HC,Cummings PT

更新日期：1995-06-20 00:00:00

abstract：:Corazonin is a highly conserved neuropeptide hormone of wide-spread occurrence in insects yet is associated with no universally recognized function. After discovery of the corazonin receptor in Drosophila, we identified its ortholog in the moth, Manduca sexta, as a prelude to physiological studies. The corazonin recep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim YJ,Spalovská-Valachová I,Cho KH,Zitnanova I,Park Y,Adams ME,Zitnan D

更新日期：2004-04-27 00:00:00

abstract：:The aspartate receptor involved in chemotaxis is modified by methyl esterification at four distinct glutamate residues during the adaptive response of this receptor. To explain the high degree of specificity of this modification, it has been proposed that the methyltransferase recognizes the sequence Glu-Glu-Xaa-Xaa-A...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Terwilliger TC,Wang JY,Koshland DE Jr

更新日期：1986-09-01 00:00:00

abstract：:Four new members of the fibroblast growth factor (FGF) family, referred to as fibroblast growth factor homologous factors (FHFs), have been identified by a combination of random cDNA sequencing, data base searches, and degenerate PCR. Pairwise comparisons between the four FHFs show between 58% and 71% amino acid seque...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smallwood PM,Munoz-Sanjuan I,Tong P,Macke JP,Hendry SH,Gilbert DJ,Copeland NG,Jenkins NA,Nathans J

更新日期：1996-09-03 00:00:00

abstract：:Membrane proteins of cytotoxic T cells specifically reorganize to form an immunological synapse (IS) on interaction with their specific target. In this paper, we investigated the redistribution of Kv1.3 channels, which are the dominant voltage-gated potassium channels, in the plasma membrane of allogen-activated human...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Panyi G,Vámosi G,Bacsó Z,Bagdány M,Bodnár A,Varga Z,Gáspár R,Mátyus L,Damjanovich S

更新日期：2004-02-03 00:00:00

abstract：:Historical data provide a baseline against which to judge the significance of recent ecological shifts and guide conservation strategies, especially for species decimated by pre-20th century harvesting. Northern fur seals (NFS; Callorhinus ursinus) are a common pinniped species in archaeological sites from southern Ca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Newsome SD,Etnier MA,Gifford-Gonzalez D,Phillips DL,van Tuinen M,Hadly EA,Costa DP,Kennett DJ,Guilderson TP,Koch PL

更新日期：2007-06-05 00:00:00

abstract：:There is a tightly coupled bidirectional interaction between visual cortex and visual thalamus [lateral geniculate nucleus (LGN)]. Using drifting sinusoidal grating stimuli, we compared the response of cells in the LGN with and without feedback from the visual cortex. Raster plots revealed a striking difference in the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Andolina IM,Jones HE,Wang W,Sillito AM

更新日期：2007-01-30 00:00:00

abstract：:The discovery of a steadily growing number of tumor antigens (TAs) has made generic, cell-free, peptide-based cancer vaccines a possible alternative to cytokine-transfected autologous cellular cancer vaccines. The major drawback of peptide vaccines, however, is the poor immunogenicity of peptides. It is commonly thoug...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Buschle M,Schmidt W,Zauner W,Mechtler K,Trska B,Kirlappos H,Birnstiel ML

更新日期：1997-04-01 00:00:00

abstract：:We have cloned four lambda light chain constant region (C) genes from mouse embryo DNA. Each carries its own joining (J) segment approximately 1.3 kilobases to its 5' side. The four C genes occur in two clusters, 5' J3C3J1C13' and 5' J2C2J4C43', with C4 being a new C lambda gene. We have also shown that V lambda 1 is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blomberg B,Traunecker A,Eisen H,Tonegawa S

更新日期：1981-06-01 00:00:00

abstract：:The spectra of the alpha, beta, and gamma forms of zinc monoarsanilazotyrosine-248 carboxypeptidase A are indistinguishable. At pH 8.2 their crystals are yellow, while their solutions are red, lambda(max) 510 nm. Absorption and circular dichroism-pH titrations of the modified zinc and apoenzymes demonstrate that the a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Johansen JT,Vallee BL

更新日期：1973-07-01 00:00:00

abstract：:Microcalcifications geographically target the location of abnormalities within the breast and are of critical importance in breast cancer diagnosis. However, despite stereotactic guidance, core needle biopsy fails to retrieve microcalcifications in up to 15% of patients. Here, we introduce an approach based on diffuse...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Soares JS,Barman I,Dingari NC,Volynskaya Z,Liu W,Klein N,Plecha D,Dasari RR,Fitzmaurice M

更新日期：2013-01-08 00:00:00