Changes in gamma-aminobutyrate type A receptor subunit mRNAs, translation product expression, and receptor function during neuronal maturation in vitro.

abstract：:CD31 is an Ig-like molecule expressed by leukocytes and endothelial cells with an established role in the regulation of leukocyte trafficking. Despite genetic deletion of CD31 being associated with exacerbation of T cell-mediated autoimmunity, the contribution of this molecule to T-cell responses is largely unknown. H...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ma L,Mauro C,Cornish GH,Chai JG,Coe D,Fu H,Patton D,Okkenhaug K,Franzoso G,Dyson J,Nourshargh S,Marelli-Berg FM

更新日期：2010-11-09 00:00:00

abstract：:The dominant theories of human placebo effects rely on a notion that consciously perceptible cues, such as verbal information or distinct stimuli in classical conditioning, provide signals that activate placebo effects. However, growing evidence suggest that behavior can be triggered by stimuli presented outside of co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jensen KB,Kaptchuk TJ,Kirsch I,Raicek J,Lindstrom KM,Berna C,Gollub RL,Ingvar M,Kong J

更新日期：2012-09-25 00:00:00

abstract：:In the primary visual cortex, neurons with similar response preferences are grouped into domains forming continuous maps of stimulus orientation and direction of movement. These properties are widely believed to result from the combination of ascending and lateral interactions in the visual system. We have tested this...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Galuske RA,Schmidt KE,Goebel R,Lomber SG,Payne BR

更新日期：2002-12-24 00:00:00

abstract：:Recently several attempts to identify oxygen-derived radicals in whole cells by spin trapping and electron spin resonance have been reported by using 5,5-dimethyl-1-pyrroline-N-oxide as the spin trap. In the present study, the feasibility of this method is examined. Chinese hamster V79 cells and human erythrocytes ser...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Samuni A,Carmichael AJ,Russo A,Mitchell JB,Riesz P

更新日期：1986-10-01 00:00:00

abstract：:Fish have somehow colonized isolated water bodies all over the world without human assistance. It has long been speculated that these colonization events are assisted by waterbirds, transporting fish eggs attached to their feet and feathers, yet empirical support for this is lacking. Recently, it was suggested that en...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lovas-Kiss Á,Vincze O,Löki V,Pallér-Kapusi F,Halasi-Kovács B,Kovács G,Green AJ,Lukács BA

更新日期：2020-07-07 00:00:00

abstract：:The transacting activator of transduction (TAT) protein plays a key role in the progression of AIDS. Studies have shown that a +8 charged sequence of amino acids in the protein, called the TAT peptide, enables the TAT protein to penetrate cell membranes. To probe mechanisms of binding and translocation of the TAT pept...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rao Y,Kwok SJ,Lombardi J,Turro NJ,Eisenthal KB

更新日期：2014-09-02 00:00:00

abstract：:The hepatic uptake of cholephilic organic anions is a carrier-mediated process. Three distinct proteins [bilitranslocase (BTL), sulfobromophthalein (BSP)/bilirubin-binding protein (BBBP), and organic anion-binding protein] have been isolated from the basolateral plasma-membrane domain of the hepatocyte. To investigate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Torres AM,Lunazzi GC,Stremmel W,Tiribelli C

更新日期：1993-09-01 00:00:00

abstract：:Hypermutation in immunoglobulin genes produces a high frequency of substitutions of all four bases, which are likely generated by low-fidelity DNA polymerases. Indeed, humans deficient for DNA polymerase (pol) eta have decreased substitutions of A.T base pairs in variable and switch regions. To study the role of pol e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Martomo SA,Yang WW,Wersto RP,Ohkumo T,Kondo Y,Yokoi M,Masutani C,Hanaoka F,Gearhart PJ

更新日期：2005-06-14 00:00:00

abstract：:A serum-free culture of dissociated neurons from embryonic rat hippocampus has been established as a rapid and quantitative in vitro test system for neurotrophic signals in the mammalian brain. By means of this cell culture bioassay, a novel low molecular weight neurotrophic factor (NTF) could be identified. NTF is es...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Müller HW,Beckh S,Seifert W

更新日期：1984-02-01 00:00:00

abstract：:We have examined the use of our bis(sulfonamide) diol ligand (1) in the asymmetric addition of phenyl groups to cyclic alpha,beta-unsaturated ketones. Good to excellent enantioselectivities have been obtained with cyclic enones bearing alkyl substituents in the 2 position (71-97% enantiomeric excess). Furthermore, exc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li H,García C,Walsh PJ

更新日期：2004-04-13 00:00:00

abstract：:Plants and animals deploy intracellular immune receptors that perceive specific pathogen effector proteins and microbial products delivered into the host cell. We demonstrate that the ADR1 family of Arabidopsis nucleotide-binding leucine-rich repeat (NB-LRR) receptors regulates accumulation of the defense hormone sali...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bonardi V,Tang S,Stallmann A,Roberts M,Cherkis K,Dangl JL

更新日期：2011-09-27 00:00:00

abstract：:HD domain phosphohydrolase enzymes are characterized by a conserved set of histidine and aspartate residues that coordinate an active site metallocenter. Despite the important roles these enzymes play in nucleotide metabolism and signal transduction, few have been both biochemically and structurally characterized. Her...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bridwell-Rabb J,Kang G,Zhong A,Liu HW,Drennan CL

更新日期：2016-11-29 00:00:00

abstract：:The "WD40" domain is a widespread recognition module for linking partner proteins in intracellular networks of signaling and sorting. The clathrin amino-terminal domain, which directs incorporation of cargo into coated pits, is a beta-propeller closely related in structure to WD40 modules. The crystallographically det...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： ter Haar E,Harrison SC,Kirchhausen T

更新日期：2000-02-01 00:00:00

abstract：:It is possible, by using Fourier-transform infrared (FTIR) difference spectroscopy, to detect the conformational changes occurring in both the protein and the chromophore of bacteriorhodopsin during the photocycle. In contrast to Raman spectroscopy, a laser is unnecessary and hence the problem of a perturbing probe be...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rothschild KJ,Marrero H

更新日期：1982-07-01 00:00:00

abstract：:The parietal cell (PC) plays an important role in normal gastric physiology and in common diseases of the stomach. Although the genes involved in acid secretion are well known, there is limited molecular information about other aspects of PC function. We have generated a comprehensive database of genes expressed prefe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mills JC,Syder AJ,Hong CV,Guruge JL,Raaii F,Gordon JI

更新日期：2001-11-20 00:00:00

abstract：:We performed the first genome-wide expression analysis directly comparing the expression profile of highly enriched normal human hematopoietic stem cells (HSC) and leukemic stem cells (LSC) from patients with acute myeloid leukemia (AML). Comparing the expression signature of normal HSC to that of LSC, we identified 3...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Majeti R,Becker MW,Tian Q,Lee TL,Yan X,Liu R,Chiang JH,Hood L,Clarke MF,Weissman IL

更新日期：2009-03-03 00:00:00

abstract：:Cytoplasmic RNA extracted from human tissue culture cells infected with adenovirus type 2 was used to program protein synthesis in a cell-free system derived from mammalian cells. Analysis of the protein product by polyacrylamide gel electrophoresis revealed ten adenovirus-specific polypeptides. Five of these were fur...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Anderson CW,Lewis JB,Atkins JF,Gesteland RF

更新日期：1974-07-01 00:00:00

abstract：:Higher-level cognitive processes strongly depend on a complex interplay between mediodorsal thalamus nuclei and the prefrontal cortex (PFC). Alteration of thalamofrontal connectivity has been involved in cognitive deficits of schizophrenia. Prefrontal serotonin (5-HT)2A receptors play an essential role in cortical net...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barre A,Berthoux C,De Bundel D,Valjent E,Bockaert J,Marin P,Bécamel C

更新日期：2016-03-08 00:00:00

abstract：:Calcium oxalate monohydrate (COM), which plays a functional role in plant physiology, is a source of chronic human disease, forming the major inorganic component of kidney stones. Understanding molecular mechanisms of biological control over COM crystallization is central to development of effective stone disease ther...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qiu SR,Wierzbicki A,Orme CA,Cody AM,Hoyer JR,Nancollas GH,Zepeda S,De Yoreo JJ

更新日期：2004-02-17 00:00:00

abstract：:Depression, the most prevalent mental illness, is underdiagnosed and undertreated, highlighting the need to extend the scope of current screening methods. Here, we use language from Facebook posts of consenting individuals to predict depression recorded in electronic medical records. We accessed the history of Faceboo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eichstaedt JC,Smith RJ,Merchant RM,Ungar LH,Crutchley P,Preoţiuc-Pietro D,Asch DA,Schwartz HA

更新日期：2018-10-30 00:00:00

abstract：:Cortical networks that have been found to operate close to a critical point exhibit joint activations of large numbers of neurons. However, in motor cortex of the awake macaque monkey, we observe very different dynamics: massively parallel recordings of 155 single-neuron spiking activities show weak fluctuations on th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dahmen D,Grün S,Diesmann M,Helias M

更新日期：2019-06-25 00:00:00

abstract：:We introduce Pathifier, an algorithm that infers pathway deregulation scores for each tumor sample on the basis of expression data. This score is determined, in a context-specific manner, for every particular dataset and type of cancer that is being investigated. The algorithm transforms gene-level information into pa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Drier Y,Sheffer M,Domany E

更新日期：2013-04-16 00:00:00

abstract：:HLA-DO (DO) is a nonclassic class II heterodimer that inhibits the action of the class II peptide exchange catalyst, HLA-DM (DM), and influences DM localization within late endosomes and exosomes. In addition, DM acts as a chaperone for DO and is required for its egress from the endoplasmic reticulum (ER). These recip...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yoon T,Macmillan H,Mortimer SE,Jiang W,Rinderknecht CH,Stern LJ,Mellins ED

更新日期：2012-07-10 00:00:00

abstract：:The kinetic inhibition of the gelation of hemoglobin S is compared to the change in hemoglobin S soulbility, when the solubility is altered by carbon monoxide, pH, or urea. By means of a new technique, the delay time and the extent of gelation are measured on the same sample. They delay time, td, is found to be propor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hofrichter J,Ross PD,Eaton WA

更新日期：1976-09-01 00:00:00

abstract：:Individuals with developmental dyslexia vary in their ability to improve reading skills, but the brain basis for improvement remains largely unknown. We performed a prospective, longitudinal study over 2.5 y in children with dyslexia (n = 25) or without dyslexia (n = 20) to discover whether initial behavioral or brain...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoeft F,McCandliss BD,Black JM,Gantman A,Zakerani N,Hulme C,Lyytinen H,Whitfield-Gabrieli S,Glover GH,Reiss AL,Gabrieli JD

更新日期：2011-01-04 00:00:00

abstract：:Aneuploidy, a chromosome content other than a multiple of the haploid number, is a common feature of cancer cells. Whole chromosomal aneuploidy accompanying ongoing chromosomal instability in mice resulting from reduced levels of the centromere-linked motor protein CENP-E has been reported to increase the incidence of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Silk AD,Zasadil LM,Holland AJ,Vitre B,Cleveland DW,Weaver BA

更新日期：2013-10-29 00:00:00

abstract：:During latent infection of humans with Mycobacterium tuberculosis, bacteria persist in the asymptomatic host within granulomas, organized collections of differentiated macrophages, and other immune cells. The mechanisms for persistence remain poorly understood, as is the metabolic and replicative state of the microbes...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chan K,Knaak T,Satkamp L,Humbert O,Falkow S,Ramakrishnan L

更新日期：2002-03-19 00:00:00

abstract：:Brain areas' functional repertoires are shaped by their incoming and outgoing structural connections. In empirically measured networks, most connections are short, reflecting spatial and energetic constraints. Nonetheless, a small number of connections span long distances, consistent with the notion that the functiona...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Betzel RF,Bassett DS

更新日期：2018-05-22 00:00:00

abstract：:The feasibility of long-term information storage by brain type II Ca2+/calmodulin-dependent protein kinase molecules is explored. Recent evidence indicates that this protein has switch-like properties. Equations are derived showing that a single kinase holoenzyme could form a bistable switch having the stability neces...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lisman JE,Goldring MA

更新日期：1988-07-01 00:00:00

abstract：:Despite a growing number of ion channel genes implicated in hereditary ataxia, it remains unclear how ion channel mutations lead to loss-of-function or death of cerebellar neurons. Mutations in the gene KCNMA1, encoding the α-subunit of the BK channel have emerged as responsible for a variety of neurological phenotype...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Du X,Carvalho-de-Souza JL,Wei C,Carrasquel-Ursulaez W,Lorenzo Y,Gonzalez N,Kubota T,Staisch J,Hain T,Petrossian N,Xu M,Latorre R,Bezanilla F,Gomez CM

更新日期：2020-03-17 00:00:00