Discovery of an intrinsic tenase complex inhibitor: Pure nonasaccharide from fucosylated glycosaminoglycan.

abstract：:The lipid monogalactosyl diacylglycerol (MGD) is a major structural component of photosynthetic membranes in chloroplasts. Its formation is catalyzed by the enzyme MGD synthase. In many plants, MGD derives from two different biosynthetic pathways: the prokaryotic pathway, which operates entirely within the plastid, an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jarvis P,Dörmann P,Peto CA,Lutes J,Benning C,Chory J

更新日期：2000-07-05 00:00:00

abstract：:Macropinocytosis is a highly conserved endocytic process by which extracellular fluid and solutes are internalized into cells. Macropinocytosis starts with the formation of membrane ruffles at the plasma membrane and ends with their closure. The transient and sequential emergence of phosphoinositides PI(3,4,5)P3 and P...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maekawa M,Terasaka S,Mochizuki Y,Kawai K,Ikeda Y,Araki N,Skolnik EY,Taguchi T,Arai H

更新日期：2014-03-18 00:00:00

abstract：:Natural products have long served as both a source and inspiration for pharmaceuticals. Modifying the structure of a natural product often improves the biological activity of the compound. Metabolic engineering strategies to ferment "unnatural" products have been enormously successful in microbial organisms. However, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Runguphan W,Maresh JJ,O'Connor SE

更新日期：2009-08-18 00:00:00

abstract：:An amine-functionalized derivative of 1,3-dipropyl-8-phenylxanthine has been prepared in tritiated form as a xanthine amine congener ([3H]XAC) for use as an antagonist radioligand for adenosine receptors. [3H]XAC has higher receptor affinity, higher specific activity, lower nonspecific membrane binding, and more favor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jacobson KA,Ukena D,Kirk KL,Daly JW

更新日期：1986-06-01 00:00:00

abstract：:Major histocompatibility complex (MHC) class II molecules displayed clustered patterns at the surfaces of T (HUT-102B2) and B (JY) lymphoma cells characterized by interreceptor distances in the micrometer range as detected by scanning force microscopy of immunogold-labeled antigens. Electron microscopy revealed that a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jenei A,Varga S,Bene L,Mátyus L,Bodnár A,Bacsó Z,Pieri C,Gáspár R Jr,Farkas T,Damjanovich S

更新日期：1997-07-08 00:00:00

abstract：:The phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway was recently shown to negatively regulate LPS-induced acute inflammatory responses. We previously observed that the metabolic thiol antioxidant alpha-lipoic acid (LA) inhibits LPS-induced expression of cellular adhesion molecules and adheren...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang WJ,Wei H,Hagen T,Frei B

更新日期：2007-03-06 00:00:00

abstract：:Using a comprehensive transcriptome analysis, a Z chromosome-linked chicken homolog of hemogen (cHEMGN) was identified and shown to be specifically involved in testis differentiation in early chicken embryos. Hemogen [Hemgn in mice, EDAG (erythroid differentiation-associated gene protein) in humans] was recently chara...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakata T,Ishiguro M,Aduma N,Izumi H,Kuroiwa A

更新日期：2013-02-26 00:00:00

abstract：:Exposure of Chinese hamster cells to reduced oxygen partial pressure results in a marked enhancement in the frequency of methotrexate resistance and dihydrofolate reductase gene amplification. The frequency of enhanced resistance is a function of the length of exposure to hypoxic conditions and the time after recovery...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rice GC,Hoy C,Schimke RT

更新日期：1986-08-01 00:00:00

abstract：:To investigate how T cells recognize allogeneic class I proteins encoded by the major histocompatibility complex (MHC), we examined the human cytotoxic T lymphocytes (CTL) elicited in a mixed lymphocyte reaction against a lymphoblastoid B-cell line (JY) whose MHC-class I proteins are HLA-A2 and -B7. By panning the res...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Elliott TJ,Eisen HN

更新日期：1988-04-01 00:00:00

abstract：:Lysinuric protein intolerance (LPI) is an autosomal recessive phenotype consistent with impaired transport of cationic amino acids at the basolateral membrane of intestinal and renal epithelia. On the assumption that the basolateral membrane of epithelial cells and plasma membrane of parenchymal cells are functional a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith DW,Scriver CR,Tenenhouse HS,Simell O

更新日期：1987-11-01 00:00:00

abstract：:Individuals with developmental dyslexia vary in their ability to improve reading skills, but the brain basis for improvement remains largely unknown. We performed a prospective, longitudinal study over 2.5 y in children with dyslexia (n = 25) or without dyslexia (n = 20) to discover whether initial behavioral or brain...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoeft F,McCandliss BD,Black JM,Gantman A,Zakerani N,Hulme C,Lyytinen H,Whitfield-Gabrieli S,Glover GH,Reiss AL,Gabrieli JD

更新日期：2011-01-04 00:00:00

abstract：:Interleukin (IL)-1beta is a pluripotent proinflammatory cytokine that signals through the type-I IL-1 receptor (IL-1RI), a member of the Toll-like receptor family. In hypothalamic neurons, binding of IL-1beta to IL-1RI mediates transcription-dependent changes that depend on the recruitment of the cytosolic adaptor pro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Davis CN,Mann E,Behrens MM,Gaidarova S,Rebek M,Rebek J Jr,Bartfai T

更新日期：2006-02-21 00:00:00

abstract：:In some countries across the globe, tropical forest cover is increasing. The national-scale reforestation of Vietnam since 1992 is assumed to contribute to this recovery. It is achieved, however, by the displacement of forest extraction to other countries on the order of 49 (34-70) M m(3), or approximately 39% of the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meyfroidt P,Lambin EF

更新日期：2009-09-22 00:00:00

abstract：:The plant Mentzelia pumila (family Loasaceae) has leaves and stems densely covered with tiny hooked trichomes. The structures entrap and kill insects and therefore are most probably protective. But they are also maladaptive in that they incapacitate a coccinellid beetle (Hippodamia convergens) that preys upon an aphid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eisner T,Eisner M,Hoebeke ER

更新日期：1998-04-14 00:00:00

abstract：:Data drawn from a global compilation of studies quantitatively confirm the long-articulated contention that erosion rates from conventionally plowed agricultural fields average 1-2 orders of magnitude greater than rates of soil production, erosion under native vegetation, and long-term geological erosion. The general ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Montgomery DR

更新日期：2007-08-14 00:00:00

abstract：:Exposure of receptor-rich membrane fragments from Torpedo marmorata to carbamylcholine causes a slow (half-time of 5--10 min) and reversible change of properties of the cholinergic receptor protein manifested by a decrease of the initial rate of Naja nigricollis alpha-[3H]toxin binding in the presence of carbamylcholi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weber M,David-Pfeuty T,Changeux JP

更新日期：1975-09-01 00:00:00

abstract：:Delayed implantation (embryonic diapause) occurs when the embryo at the blastocyst stage achieves a state of suspended animation. During this period, blastocyst growth is very slow, with minimal or no cell division. Nearly 100 mammals in seven different orders undergo delayed implantation, but the underlying molecular...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hamatani T,Daikoku T,Wang H,Matsumoto H,Carter MG,Ko MS,Dey SK

更新日期：2004-07-13 00:00:00

abstract：:Several inhibitors of gamma-glutamyl transpeptidase in vitro [L-serine plus borate, 6-diazo-5-oxo-L-norleucine, and L- and D-gamma-glutamyl-(o-carboxy)phenylhydrazide] are active in vivo, as indicated by their effect in decreasing the conversion of administered D-gamma-glutamyl-L-alpha-amino[(14)C]butyrate to respirat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Griffith OW,Meister A

更新日期：1979-01-01 00:00:00

abstract：:The rugged folding-energy landscapes of RNAs often display many competing minima. How do RNAs discriminate among competing conformations in their search for the native state? By using optical tweezers, we show that the folding-energy landscape can be manipulated to control the fate of an RNA: individual RNA molecules ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li PT,Bustamante C,Tinoco I Jr

更新日期：2007-04-24 00:00:00

abstract：:The mechanism of proton transfer from the bulk into the membrane protein interior was studied. The light-induced reduction of a bound ubiquinone molecule Q(B) by the photosynthetic reaction center is accompanied by proton trapping. We used kinetic spectroscopy to measure (i) the electron transfer to Q(B) (at 450 nm), ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gopta OA,Cherepanov DA,Junge W,Mulkidjanian AY

更新日期：1999-11-09 00:00:00

abstract：:Guanine nucleotide-binding regulatory protein (G protein)-coupled receptor kinases (GRKs) constitute a family of serine/threonine kinases that play a major role in the agonist-induced phosphorylation and desensitization of G-protein-coupled receptors. Herein we describe the generation of monoclonal antibodies (mAbs) t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Oppermann M,Diversé-Pierluissi M,Drazner MH,Dyer SL,Freedman NJ,Peppel KC,Lefkowitz RJ

更新日期：1996-07-23 00:00:00

abstract：:Osedax is a recently discovered group of siboglinid annelids that consume bones on the seafloor and whose evolutionary origins have been linked with Cretaceous marine reptiles or to the post-Cretaceous rise of whales. Here we present whale bones from early Oligocene bathyal sediments exposed in Washington State, which...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kiel S,Goedert JL,Kahl WA,Rouse GW

更新日期：2010-05-11 00:00:00

abstract：:Much recent attention in the study of adaptation of organismal form has centered on developmental regulation. As such, the highly conserved respiratory machinery of eukaryotic cells might seem an unlikely target for selection supporting novel morphologies. We demonstrate that a dramatic molecular evolutionary rate inc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jobson RW,Nielsen R,Laakkonen L,Wikström M,Albert VA

更新日期：2004-12-28 00:00:00

abstract：:The detrimental effects of elevated intensities of mid-UV radiation (UVB), a result of stratospheric ozone depletion during the austral spring, on the primary producers of the Antarctic marine ecosystem have been well documented. Here we report that natural populations of Antarctic zooplankton also sustain significant...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Malloy KD,Holman MA,Mitchell D,Detrich HW 3rd

更新日期：1997-02-18 00:00:00

abstract：:The peripheral axonal branch of primary sensory neurons readily regenerates after peripheral nerve injury, but the central branch, which courses in the dorsal columns of the spinal cord, does not. However, if a peripheral nerve is transected before a spinal cord injury, sensory neurons that course in the dorsal column...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Neumann S,Skinner K,Basbaum AI

更新日期：2005-11-15 00:00:00

abstract：:Oxygen-derived free radicals have been implicated in the pathogenesis of vasogenic edema and infarction caused by ischemia and reperfusion injury. In earlier studies, exogenously supplied liposome-entrapped CuZn superoxide dismutase (CuZn-SOD) ameliorated ischemic brain edema and infarction in rats following focal cer...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kinouchi H,Epstein CJ,Mizui T,Carlson E,Chen SF,Chan PH

更新日期：1991-12-15 00:00:00

abstract：:Whole-cell voltage clamp was used to investigate the properties and spatial distribution of fast-deactivating (FD) Ca channels in squid giant fiber lobe (GFL) neurons. Squid FD Ca channels are reversibly blocked by the spider toxin omega-Agatoxin IVA with an IC50 of 240-420 nM with no effect on the kinetics of Ca chan...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McFarlane MB,Gilly WF

更新日期：1996-05-14 00:00:00

abstract：:Von Willebrand factor-binding protein (VWbp), secreted by Staphylococcus aureus, displays secondary structural homology to the 3-helix bundle, D1 and D2 domains of staphylocoagulase (SC), a potent conformational activator of the blood coagulation zymogen, prothrombin (ProT). In contrast to the classical proteolytic ac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kroh HK,Panizzi P,Bock PE

更新日期：2009-05-12 00:00:00

abstract：:Hitherto it has not been possible to obtain spore and stalk cell differentiation of the cellular slime molds in submerged cultures. It is shown here that cells, when placed in roller tubes under an atmosphere of oxygen, will form clumps and differentiate in 48-72 hr into mature spores and stalk cells. Although differe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sternfeld J,Bonner JT

更新日期：1977-01-01 00:00:00

abstract：:We present quantitative optical images of human breast in vivo. The images were obtained by using near-infrared diffuse optical tomography (DOT) after the administration of indocyanine green (ICG) for contrast enhancement. The optical examination was performed concurrently with a magnetic resonance imaging (MRI) exam ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ntziachristos V,Yodh AG,Schnall M,Chance B

更新日期：2000-03-14 00:00:00