Binding of purified multiple antibiotic-resistance repressor protein (MarR) to mar operator sequences.

abstract：:O-linked N-acetylglucosamine (GlcNAc) transferase (OGT) is the only known enzyme that catalyzes the O-GlcNAcylation of proteins at the Ser or Thr side chain hydroxyl group. OGT participates in transcriptional and epigenetic regulation, and dysregulation of OGT has been implicated in diseases such as cancer. However, t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chu CS,Lo PW,Yeh YH,Hsu PH,Peng SH,Teng YC,Kang ML,Wong CH,Juan LJ

更新日期：2014-01-28 00:00:00

abstract：:The persistent tetrodotoxin (TTX)-sensitive sodium current, detected in neurons of many regions of mammalian brains, is associated with many essential neuronal activities, including boosting of excitatory synaptic inputs, acceleration of firing rates, and promotion of oscillatory neuronal activities. However, the orig...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu Z,Song W,Dong K

更新日期：2004-08-10 00:00:00

abstract：:Familial adenomatous polyposis (FAP) is an autosomal-dominant disease characterized by the development of hundreds of adenomatous polyps of the colorectum. Approximately 80% of FAP patients can be shown to have truncating mutations of the APC gene. To determine the cause of FAP in the other 20% of patients, MAMA (mono...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Laken SJ,Papadopoulos N,Petersen GM,Gruber SB,Hamilton SR,Giardiello FM,Brensinger JD,Vogelstein B,Kinzler KW

更新日期：1999-03-02 00:00:00

abstract：:The Mecp2 gene has been shown to be mutated in most cases of human Rett syndrome, and mouse models deleted for the ortholog have been generated. Lineage-specific deletion of the gene indicated that the Rett-like phenotype is caused by Mecp2 deficiency in neurons. Biochemical evidence suggests that Mecp2 acts as a glob...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tudor M,Akbarian S,Chen RZ,Jaenisch R

更新日期：2002-11-26 00:00:00

abstract：:In this study, we defined the role of peroxisome proliferator-activated receptor beta/delta (PPARdelta) in metabolic homeostasis by using subtype selective agonists. Analysis of rat L6 myotubes treated with the PPARdelta subtype-selective agonist, GW501516, by the Affymetrix oligonucleotide microarrays revealed that P...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tanaka T,Yamamoto J,Iwasaki S,Asaba H,Hamura H,Ikeda Y,Watanabe M,Magoori K,Ioka RX,Tachibana K,Watanabe Y,Uchiyama Y,Sumi K,Iguchi H,Ito S,Doi T,Hamakubo T,Naito M,Auwerx J,Yanagisawa M,Kodama T,Sakai J

更新日期：2003-12-23 00:00:00

abstract：:The T lineage repertoire is shaped by T cell receptor (TCR)-dependent positive and negative thymic selection processes. Using TCR-transgenic (N15tg) beta2-microglobulin-deficient (beta2m-/-) RAG-2(-/-) H-2(b) mice specific for the VSV8 (RGYVYQGL) octapeptide bound to Kb, we identified a single weak agonist peptide var...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ghendler Y,Teng MK,Liu JH,Witte T,Liu J,Kim KS,Kern P,Chang HC,Wang JH,Reinherz EL

更新日期：1998-08-18 00:00:00

abstract：:Upon cytosolic viral DNA stimulation, cGMP-AMP synthase (cGAS) catalyzes synthesis of 2'3'cGMP-AMP (cGAMP), which binds to the adaptor protein MITA (mediator of IRF3 activation, also called STING, stimulator of IFN genes) and induces innate antiviral response. How the activity of MITA/STING is regulated to avoid exces...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xia T,Yi XM,Wu X,Shang J,Shu HB

更新日期：2019-10-01 00:00:00

abstract：:Previous work has demonstrated a role for the E2F1 gene product in signaling apoptosis, both as a result of the deregulation of the Rb/E2F pathway as well as in response to DNA damage. We now show that the ability of cells to suppress the apoptotic potential of E2F1, as might occur during the course of normal cellular...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hallstrom TC,Nevins JR

更新日期：2003-09-16 00:00:00

abstract：:Protection of poikilothermic animals from seasonal cold is widely regarded as being causally linked to changes in the unsaturation of membrane phospholipids, yet in animals this proposition remains formally untested. We have now achieved this by the genetic manipulation of lipid biosynthesis of Caenorhabditis elegans ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murray P,Hayward SA,Govan GG,Gracey AY,Cossins AR

更新日期：2007-03-27 00:00:00

abstract：:For almost a century, alcohols have been thought to produce their effects by actions on the membrane lipids of central nervous system neurons--the well known "lipid theory" of alcohol action. The rationale for this theory is the correlation of potency with oil/water or membrane/buffer partition coefficient. Although a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li C,Peoples RW,Weight FF

更新日期：1994-08-16 00:00:00

abstract：:Long-term synaptic plasticity requires both gene expression in the nucleus and local protein synthesis at synapses. The effector proteins that link molecular events in the cell body with local maintenance of synaptic strength are not known. We now show that treatment with serotonin (5-HT) that produces long-term facil...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Giustetto M,Hegde AN,Si K,Casadio A,Inokuchi K,Pei W,Kandel ER,Schwartz JH

更新日期：2003-11-11 00:00:00

abstract：:The role of protein kinase C (PKC) as a mediator of glucose-induced insulin secretion has been a subject of controversy. Glucose-induced translocation of PKC has not been reported, and the relevant PKC isoenzymes in islets have not been identified. To address these issues, we developed specific antibodies to the alpha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ganesan S,Calle R,Zawalich K,Smallwood JI,Zawalich WS,Rasmussen H

更新日期：1990-12-01 00:00:00

abstract：:Thousands of large intergenic noncoding RNAs (lincRNAs) have been identified in the mammalian genome, many of which have important roles in regulating a variety of biological processes. Here, we used a custom microarray to identify lincRNAs associated with activation of the innate immune response. A panel of 159 lincR...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li Z,Chao TC,Chang KY,Lin N,Patil VS,Shimizu C,Head SR,Burns JC,Rana TM

更新日期：2014-01-21 00:00:00

abstract：:Nonsense-mediated mRNA decay (NMD), which degrades transcripts harboring a premature termination codon (PTC), depends on the helicase up-frameshift 1 (UPF1). However, mRNAs that are not NMD targets also bind UPF1. What governs the timing, position, and function of UPF1 binding to mRNAs remains unclear. We provide evid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kurosaki T,Maquat LE

更新日期：2013-02-26 00:00:00

abstract：:In flowering plants, extensive male-female interactions are required for successful fertilization in which various signaling cascades are involved. Prevacuolar compartments (PVC) and vacuoles are two types of subcellular compartments that terminate signal transduction by sequestrating signaling molecules in yeast and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hao L,Liu J,Zhong S,Gu H,Qu LJ

更新日期：2016-05-31 00:00:00

abstract：:Resistance to thyroid hormone (RTH) is most often due to point mutations in the beta-isoform of the thyroid hormone (TH) receptor (TR-beta). The majority of mutations involve the ligand-binding domain, where they block TH binding and receptor function on both stimulatory and inhibitory TH response elements. In contras...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Machado DS,Sabet A,Santiago LA,Sidhaye AR,Chiamolera MI,Ortiga-Carvalho TM,Wondisford FE

更新日期：2009-06-09 00:00:00

abstract：:Intracellular transport is interspersed with frequent reversals in direction due to the presence of opposing kinesin and dynein motors on organelles that are carried as cargo. The cause and the mechanism of reversals are unknown, but are a key to understanding how cargos are delivered in a regulated manner to specific...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Soppina V,Rai AK,Ramaiya AJ,Barak P,Mallik R

更新日期：2009-11-17 00:00:00

abstract：:Adverse social conditions have been linked to a conserved transcriptional response to adversity (CTRA) in circulating leukocytes that may contribute to social gradients in disease. However, the CNS mechanisms involved remain obscure, in part because CTRA gene-expression profiles often track external social-environment...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mehl MR,Raison CL,Pace TWW,Arevalo JMG,Cole SW

更新日期：2017-11-21 00:00:00

abstract：:Drosophila melanogaster is a powerful model organism for dissecting the neurogenetic basis of appetitive and aversive behaviors. However, some methods used to assay food preference require or cause starvation. This can be problematic for fly ethanol research because it can be difficult to dissociate caloric preference...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park A,Tran T,Atkinson NS

更新日期：2018-09-04 00:00:00

abstract：:In the majority of human tumors, expression of the c-MYC oncogene becomes constitutive. Here, we report that c-MYC directly regulates the expression of AP4 via CACGTG motifs in the first intron of the AP4 gene. Induction of AP4 was required for c-MYC-mediated cell cycle reentry of anti-estrogen arrested breast cancer ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jung P,Menssen A,Mayr D,Hermeking H

更新日期：2008-09-30 00:00:00

abstract：:The identification and targeting of key molecular drivers of melanoma and breast and lung cancer have substantially improved their therapy. However, subtypes of each of these three common, lethal solid tumors lack identified molecular drivers, and are thus not amenable to targeted therapies. Here we show that pleckstr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： de Semir D,Bezrookove V,Nosrati M,Dar AA,Wu C,Shen J,Rieken C,Venkatasubramanian M,Miller JR 3rd,Desprez PY,McAllister S,Soroceanu L,Debs RJ,Salomonis N,Schadendorf D,Cleaver JE,Kashani-Sabet M

更新日期：2018-06-19 00:00:00

abstract：:Cells from the spleens and thymuses of BALB/c mice whose Moloney sarcoma virus (MSV)-induced, primary sarcomas have regressed 2-3 months earlier ("MSV regressors") or are in the process of regressing can, when adoptively transferred to syngeneic mice given MSV at the age of 20 days, prevent the natural regression of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hellström I,Hellström KE,Bernstein ID

更新日期：1979-10-01 00:00:00

abstract：:Proparathyroid hormone (calcemic fraction-A) is a biosynthetic precursor of parathyroid hormone in bovine glands. Limited amounts of the isolated prohormone have been obtained for the purpose of initial structural studies. The results of automated sequence analysis on two separate preparations indicate that the N-term...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hamilton JW,Niall HD,Jacobs JW,Keutmann HT,Potts JT Jr,Cohn DV

更新日期：1974-03-01 00:00:00

abstract：:The phenomenon of selective translation of T4 template RNA by ribosomes from T4-infected cells, or factors derived therefrom, has been extended to studies on the initiation of protein synthesis. A high-salt extract derived from T4-infected ribosomes inhibits the formation of initiation complexes of MS2 and Escherichia...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Klem EB,Hsu WT,Weiss SB

更新日期：1970-10-01 00:00:00

abstract：:We have developed a high-throughput approach to the labor-intensive problems of DNA cyclization, which we use to characterize DNA curvature and mechanical properties. The method includes a combinatorial approach to make the DNA constructs needed and automated real-time measurement of the kinetics using fluorescence. W...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang Y,Crothers DM

更新日期：2003-03-18 00:00:00

abstract：:Recent data indicate that sustained elevations in plasma insulin suppress the mRNA for IRS-2, a component of the insulin signaling pathway in liver, and that this deficiency contributes to hepatic insulin resistance and inappropriate gluconeogenesis. Here, we use nuclear run-on assays to show that insulin inhibits tra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang J,Ou J,Bashmakov Y,Horton JD,Brown MS,Goldstein JL

更新日期：2001-03-27 00:00:00

abstract：:Recent advances indicate that, in various chronic inflammatory disorders, the activation of the immune system is triggered locally rather than in lymphoid organs. In this study, we have evaluated whether the humoral alloimmune response involved in chronic rejection is elicited within the graft. We used the rat aortic ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thaunat O,Field AC,Dai J,Louedec L,Patey N,Bloch MF,Mandet C,Belair MF,Bruneval P,Meilhac O,Bellon B,Joly E,Michel JB,Nicoletti A

更新日期：2005-10-11 00:00:00

abstract：:It is well known from Hardin's "Tragedy of the Commons" [Hardin G (1968) Science 162:1243-1248] that, if open access is allowed, overgrazing typically results. Hardin, and most authors of the subsequent literature, adopted a static view of the underlying ecosystem. Here we extend this tragedy of the commons to conside...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brekke KA,Øksendal B,Stenseth NC

更新日期：2007-09-11 00:00:00

abstract：:A recently described organ culture system for human thymocytes is shown to support the generation of a diverse T-cell receptor repertoire in vitro: thymocytes of the alpha beta lineage, including representatives of the V beta families 5.2/5.3, 6.7, and 8, accounted for the majority of T-cell receptor-positive cells th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Merkenschlager M,Fisher AG

更新日期：1992-05-15 00:00:00

abstract：:mRNA localization is a complex pathway. Besides mRNA sorting per se, this process includes aspects of regulated translation. It requires protein factors that interact with defined sequences (or sequence motifs) of the transcript, and the protein/RNA complexes are finally guided along the cytoskeleton to their ultimate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mohr E,Prakash N,Vieluf K,Fuhrmann C,Buck F,Richter D

更新日期：2001-06-19 00:00:00