PTPN1/2-mediated dephosphorylation of MITA/STING promotes its 20S proteasomal degradation and attenuates innate antiviral response.

abstract：:Two out of seven meningiomas tested in early cell cultures by indirect immunofluorescence staining showed simian virus 40 (SV40)-related tumor (T) antigen. In one tumor 90% of the cells were positive. An additional SV40-related antigen (U) was found in 10% of cells of a third tumor. These findings indicate that the me...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weiss AF,Portmann R,Fischer H,Simon J,Zang KD

更新日期：1975-02-01 00:00:00

abstract：:Increasing evidence suggests that amyloid polymorphism gives rise to different strains of amyloids with distinct toxicities and pathology-spreading properties. Validating this hypothesis is challenging due to a lack of tools and methods that allow for the direct characterization of amyloid polymorphism in hydrated and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cendrowska U,Silva PJ,Ait-Bouziad N,Müller M,Guven ZP,Vieweg S,Chiki A,Radamaker L,Kumar ST,Fändrich M,Tavanti F,Menziani MC,Alexander-Katz A,Stellacci F,Lashuel HA

更新日期：2020-03-24 00:00:00

abstract：:Chromogranin A (CGA) is a secretory protein present in the adrenal medulla and in a variety of endocrine organs. This protein may serve as precursor for pancreastatin (PST) and for other biologically active peptides. Recently, chromostatin (CST), a CGA derivative, has been identified that possesses high biological act...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cetin Y,Aunis D,Bader MF,Galindo E,Jörns A,Bargsten G,Grube D

更新日期：1993-03-15 00:00:00

abstract：:Psychostimulant use is an ever-increasing socioeconomic burden, including a dramatic rise during pregnancy. Nevertheless, brain-wide effects of psychostimulant exposure are incompletely understood. Here, we performed Fos-CreERT2-based activity mapping, correlated for pregnant mouse dams and their fetuses with amphetam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fuzik J,Rehman S,Girach F,Miklosi AG,Korchynska S,Arque G,Romanov RA,Hanics J,Wagner L,Meletis K,Yanagawa Y,Kovacs GG,Alpár A,Hökfelt TGM,Harkany T

更新日期：2019-12-17 00:00:00

abstract：:Understanding Hadean (>4 Ga) Earth requires knowledge of its crust. The composition of the crust and volatiles migrating through it directly influence the makeup of the atmosphere, the composition of seawater, and nutrient availability. Despite its importance, there is little known and less agreed upon regarding the n...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boehnke P,Bell EA,Stephan T,Trappitsch R,Keller CB,Pardo OS,Davis AM,Harrison TM,Pellin MJ

更新日期：2018-06-19 00:00:00

abstract：:Complementary DNA clones encoding the entire rat 1,25-dihydroxyvitamin D3 receptor were isolated, and the total 423-amino acid sequence was deduced. The amino acid sequence of the rat receptor is similar but not identical to the reported human receptor sequence. The cysteine-rich DNA-binding domain is completely conse...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burmester JK,Wiese RJ,Maeda N,DeLuca HF

更新日期：1988-12-01 00:00:00

abstract：:Accurate replication in the presence of DNA damage is essential to genome stability and viability in all cells. In Escherichia coli, DNA replication forks blocked by UV-induced damage undergo a partial resection and RecF-catalyzed regression before synthesis resumes. These processing events generate distinct structura...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jeiranian HA,Schalow BJ,Courcelle CT,Courcelle J

更新日期：2013-07-09 00:00:00

abstract：:The heat shock protein (Hsp)70 family of molecular chaperones interacts with unfolded proteins through a C-terminal substrate-binding domain (SBD) that is controlled by nucleotide binding to the N-terminal domain. The ATPase cycle is regulated by cochaperones, including DnaJ proteins that accelerate ATP hydrolysis to ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Awad W,Estrada I,Shen Y,Hendershot LM

更新日期：2008-01-29 00:00:00

abstract：:The Fbw7 (F-box/WD repeat-containing protein 7) ubiquitin ligase targets multiple oncoproteins for degradation and is commonly mutated in cancers. Like other pleiotropic tumor suppressors, Fbw7's complex biology has impeded our understanding of how Fbw7 mutations promote tumorigenesis and hindered the development of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Davis RJ,Gönen M,Margineantu DH,Handeli S,Swanger J,Hoellerbauer P,Paddison PJ,Gu H,Raftery D,Grim JE,Hockenbery DM,Margolin AA,Clurman BE

更新日期：2018-05-22 00:00:00

abstract：:RNA interference (RNAi) is being used to develop methods to control pests and disease vectors. RNAi is robust and systemic in coleopteran insects but is quite variable in other insects. The determinants of efficient RNAi in coleopterans, as well as its potential mechanisms of resistance, are not known. RNAi screen ide...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yoon JS,Mogilicherla K,Gurusamy D,Chen X,Chereddy SCRR,Palli SR

更新日期：2018-08-14 00:00:00

abstract：:The rigidity of numerous biological filaments and crafted microrods has been conveniently deduced from the analysis of their thermal fluctuations. However, the difficulty of measuring nanometric displacements with an optical microscope has so far limited such studies to sufficiently flexible rods, of which the persist...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gerbal F,Wang Y

更新日期：2017-03-07 00:00:00

abstract：:The mitochondrial trifunctional protein (TFP) catalyzes three reactions in the fatty acid β-oxidation process. Mutations in the two TFP subunits cause mitochondrial trifunctional protein deficiency and acute fatty liver of pregnancy that can lead to death. Here we report a 4.2-Å cryo-electron microscopy α2β2 tetrameri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liang K,Li N,Wang X,Dai J,Liu P,Wang C,Chen XW,Gao N,Xiao J

更新日期：2018-07-03 00:00:00

abstract：:Ducks and wild waterfowl perpetuate all strains of influenza viruses in nature. In their natural host, influenza viruses typically cause asymptomatic infection and little pathology. Ducks are often resistant to influenza viruses capable of killing chickens. Here, we show that the influenza virus sensor, RIG-I, is pres...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barber MR,Aldridge JR Jr,Webster RG,Magor KE

更新日期：2010-03-30 00:00:00

abstract：:Cyanogen bromide fragments were isolated from the heavy chains of three human IgG myeloma proteins of the V(H)III subgroup, sequenced by an automated method, and localized to the variable region. Inspection of these sequences, together with corresponding stretches from both human and animal proteins (studied in other ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kehoe JM,Capra JD

更新日期：1971-09-01 00:00:00

abstract：:Plasmids containing the replication origin of the Escherichia coli chromosome (oriC plasmids) are unstable in certain recA strains of E. coli. However, they can be maintained more stably in other recA strains. This stable maintenance has allowed us to study the incompatibility properties of oriC plasmids. We have foun...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamaguchi K,Yamaguchi M,Tomizawa J

更新日期：1982-09-01 00:00:00

abstract：:The peroxidation of polyunsaturated fatty acids leads to numerous products, including 4-hydroxynonenal (HNE). That 4-hydroxy-2-alkenal compounds react with sulfhydryl groups of proteins to form thioether adducts possessing a carbonyl function has been established [Schauenstein, E. & Esterbauer, H. (1979) Ciba Found. S...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Uchida K,Stadtman ER

更新日期：1992-06-15 00:00:00

abstract：:We have investigated whether interleukin 3 (IL-3) supports the growth of cells of different lineages by the same mechanism(s). The experiments were carried out with Ea3 cells, a mouse pre-B cell line, and S-480-3 cells, a mouse basophil cell line, both of which are totally IL-3 dependent. We found that Ea3 lymphocytes...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Palacios R,Garland J

更新日期：1984-02-01 00:00:00

abstract：:Urbanization represents an extreme transformation of more natural systems. Populations of most species decline or disappear with urbanization, and yet some species persist and even thrive in cities. What determines which species persist or thrive in urban habitats? Direct competitive interactions among species can inf...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Martin PR,Bonier F

更新日期：2018-12-04 00:00:00

abstract：:In 1944, Freeman Dyson conjectured the existence of a "crank" function for partitions that would provide a combinatorial proof of Ramanujan's congruence modulo 11. Forty years later, Andrews and Garvan successfully found such a function and proved the celebrated result that the crank simultaneously "explains" the thre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mahlburg K

更新日期：2005-10-25 00:00:00

abstract：:Escherichia coli cells lacking the histone-like protein HU form filaments and have an abnormal number of anucleate cells. Furthermore, their phenotype resembles that of rfa mutants, the well-characterized deep-rough phenotype, as they show an enhanced permeability that renders them hypersensitive to chloramphenicol, n...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Painbeni E,Caroff M,Rouviere-Yaniv J

更新日期：1997-06-24 00:00:00

abstract：:Two photochromic activators of the electrogenic membrane of the electroplax of Electrophorus electricus are described. Trans-3,3'-bis[alpha-(trimethylammonium)methyl]azobenzene dibromide (Bis-Q), one of the most potent ever reported, is active at concentrations of less than 10(-7) M. Its cis isomer, which is obtained ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bartels E,Wassermann NH,Erlanger BF

更新日期：1971-08-01 00:00:00

abstract：:The DNA damage response is an essential process for the survival of living cells. In a subset of stress-responsive genes in humans, Elongin controls transcription in response to multiple stimuli, such as DNA damage, oxidative stress, and heat shock. Yeast Elongin (Ela1-Elc1), along with Def1, is known to facilitate ub...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Damodaren N,Van Eeuwen T,Zamel J,Lin-Shiao E,Kalisman N,Murakami K

更新日期：2017-12-12 00:00:00

abstract：:Previous work shows that the adolescent reward system is hyperactive, but this finding may be confounded by differences in how teens value money. To address this, we examined the neural ontogeny of objective value representation. Adolescent and adult participants performed a monetary gambling task in which they chose ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barkley-Levenson E,Galván A

更新日期：2014-01-28 00:00:00

abstract：:Transforming growth factor (TGF)-beta plays a pivotal role in regulation of progression of cancer through effects on tumor microenvironment as well as on cancer cells. TGF-beta inhibitors have recently been shown to prevent the growth and metastasis of certain cancers. However, there may be adverse effects caused by T...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kano MR,Bae Y,Iwata C,Morishita Y,Yashiro M,Oka M,Fujii T,Komuro A,Kiyono K,Kaminishi M,Hirakawa K,Ouchi Y,Nishiyama N,Kataoka K,Miyazono K

更新日期：2007-02-27 00:00:00

abstract：:Tropical forests hold most of Earth's biodiversity. Their continued loss through deforestation and agriculture is the main threat to species globally, more than disease, invasive species, and climate change. However, not all tropical forests have the same ability to sustain biodiversity. Those that have been disturbed...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hedges SB,Cohen WB,Timyan J,Yang Z

更新日期：2018-11-13 00:00:00

abstract：:The circular dichroism data on 17 adenine nucleosides show that the 260- and 207-mmu absorption systems of the adenine chromophore each contain at least two electronic transitions. The CD maxima are commonly found at around 260, 220, and 200 mmu, and occasionally at 240 mmu. Solvent studies suggest that these CD bands...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miles DW,Robins MJ,Robins RK,Eyring H

更新日期：1969-01-01 00:00:00

abstract：:The effect of fluctuations in rate constants on the kinetic behavior of cyclic reacting systems, caused by a fluctuating external parameter, is studied. It is shown (i) that the stochastic properties of the system can be analyzed analytically by using the usual master equation approach when the external parameter is f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen YD

更新日期：1987-02-01 00:00:00

abstract：:Here, we report the isolation and characterization of an endogenous peptide ligand of GPR103 from rat brains. The purified peptide was found to be the 43-residue RF-amide peptide QRFP. We also describe two mouse homologues of human GPR103, termed mouse GPR103A and GPR103B. QRFP binds and activates the human GPR103, as...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takayasu S,Sakurai T,Iwasaki S,Teranishi H,Yamanaka A,Williams SC,Iguchi H,Kawasawa YI,Ikeda Y,Sakakibara I,Ohno K,Ioka RX,Murakami S,Dohmae N,Xie J,Suda T,Motoike T,Ohuchi T,Yanagisawa M,Sakai J

更新日期：2006-05-09 00:00:00

abstract：:We have demonstrated the existence of human cytokine synthesis inhibitory factor (CSIF) [interleukin 10 (IL-10)]. cDNA clones encoding human IL-10 (hIL-10) were isolated from a tetanus toxin-specific human T-cell clone. Like mouse IL-10, hIL-10 exhibits strong DNA and amino acid sequence homology to an open reading fr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vieira P,de Waal-Malefyt R,Dang MN,Johnson KE,Kastelein R,Fiorentino DF,deVries JE,Roncarolo MG,Mosmann TR,Moore KW

更新日期：1991-02-15 00:00:00

abstract：:Unlike αβ-T lineage cells, where the role of ligand in intrathymic selection is well established, the role of ligand in the development of γδ-T cells remains controversial. Here we provide evidence for the role of a bona fide selecting ligand in shaping the γδ-T cell-receptor (TCR) repertoire. Reactivity of the γδ-TCR...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fahl SP,Coffey F,Kain L,Zarin P,Dunbrack RL Jr,Teyton L,Zúñiga-Pflücker JC,Kappes DJ,Wiest DL

更新日期：2018-02-20 00:00:00