Period determination in the food-entrainable and methamphetamine-sensitive circadian oscillator(s).

abstract：:Specific viral transformation rather than cell selection can explain the previously observed increase in the proportion of type III procollagen compared to type I procollagen in BALB 3T3 cells transformed by Kirsten murine sarcoma virus (Ki-MSV). Two subclones of BALB 3T3 A31 were productively infected with with a tem...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bateman JF,Peterkofsky B

更新日期：1981-10-01 00:00:00

abstract：:The rRNA intervening sequence of Tetrahymena is a catalytic RNA molecule, or "ribozyme." A tertiary-structure model of the active site of this ribozyme has been constructed based on comparative sequence analysis of related group I intervening sequences, data on the accessibility of each nucleotide to chemical and enzy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim SH,Cech TR

更新日期：1987-12-01 00:00:00

abstract：:The plasma concentration of the major vitamin D metabolites; 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, and 24,25-dihydroxyvitamin D were measured during pregnancy and lactation in the adult female rat. The concentrations of these metabolites were also measured in rat pups during lactation and after weaning. The pl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Halloran BP,Barthell EN,DeLuca HF

更新日期：1979-11-01 00:00:00

abstract：:We test the conjecture that becoming unemployed erodes the extent to which a person acknowledges earned entitlement. We use behavioral experiments to generate incentive-compatible measures of individuals' tendencies to acknowledge earned entitlement and incorporate these experiments in a two-stage study. In the first ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barr A,Miller L,Ubeda P

更新日期：2016-04-26 00:00:00

abstract：:Snakes are limbless predators, and many species use venom to help overpower relatively large, agile prey. Snake venoms are complex protein mixtures encoded by several multilocus gene families that function synergistically to cause incapacitation. To examine venom evolution, we sequenced and interrogated the genome of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vonk FJ,Casewell NR,Henkel CV,Heimberg AM,Jansen HJ,McCleary RJ,Kerkkamp HM,Vos RA,Guerreiro I,Calvete JJ,Wüster W,Woods AE,Logan JM,Harrison RA,Castoe TA,de Koning AP,Pollock DD,Yandell M,Calderon D,Renjifo C,Cur

更新日期：2013-12-17 00:00:00

abstract：:The multiplication in gases of ionization electrons, by the effect of the electric fields between parallel electrodes, leads to the emission of light from the molecules excited in the avalanche process. The optical imaging of this light, with intensifiers, on charge-coupled devices permits the localization, in the gas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Charpak G,Dominik W,Zaganidis N

更新日期：1989-03-01 00:00:00

abstract：:A key idea in Lashley's formulation of the problem of serial order in behavior is the postulated neural representation of all serial elements before the action begins. We studied this question by recording the activity of individual neurons simultaneously in small ensembles in prefrontal cortex while monkeys copied ge...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Averbeck BB,Chafee MV,Crowe DA,Georgopoulos AP

更新日期：2002-10-01 00:00:00

abstract：:An ability to safely harness the powerful regenerative potential of adult stem cells for clinical applications is critically dependent on a comprehensive understanding of the underlying mechanisms regulating their activity. Epithelial organoid cultures accurately recapitulate many features of in vivo stem cell-driven ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murakami K,Terakado Y,Saito K,Jomen Y,Takeda H,Oshima M,Barker N

更新日期：2021-01-26 00:00:00

abstract：:Two human 12-lipoxygenase enzyme (arachidonate:oxygen 12-oxidoreductase, EC 1.13.11.31)-related genes were characterized from 13 distinct clones isolated from three genomic bacteriophage and cosmid libraries. A complete gene (12-lipoxygenase gene 1) spanning approximately 17 kilobases and consisting of 14 exons with s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Funk CD,Funk LB,FitzGerald GA,Samuelsson B

更新日期：1992-05-01 00:00:00

abstract：:The Fbw7 (F-box/WD repeat-containing protein 7) ubiquitin ligase targets multiple oncoproteins for degradation and is commonly mutated in cancers. Like other pleiotropic tumor suppressors, Fbw7's complex biology has impeded our understanding of how Fbw7 mutations promote tumorigenesis and hindered the development of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Davis RJ,Gönen M,Margineantu DH,Handeli S,Swanger J,Hoellerbauer P,Paddison PJ,Gu H,Raftery D,Grim JE,Hockenbery DM,Margolin AA,Clurman BE

更新日期：2018-05-22 00:00:00

abstract：:Genetic data in the mouse have shown that endothelin 3 (ET3) and its receptor B (ETRB) are essential for the development of two neural crest (NC) derivatives, the melanocytes and the enteric nervous system. We report here the effects of ET3 in vitro on the differentiation of quail trunk NC cells (NCC) in mass and clon...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lahav R,Dupin E,Lecoin L,Glavieux C,Champeval D,Ziller C,Le Douarin NM

更新日期：1998-11-24 00:00:00

abstract：:When expressed in Escherichia coli, the human beta 1- and beta 2-adrenergic receptors retain their ligand binding specificity. Their functional integrity was investigated by analyzing receptor-guanine nucleotide-binding regulatory (G) protein coupling by using two splice variants of the alpha subunit of the stimulator...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Freissmuth M,Selzer E,Marullo S,Schütz W,Strosberg AD

更新日期：1991-10-01 00:00:00

abstract：:In phylogenetic reconstruction, two types of bacterial tyrosyl-tRNA synthetases (TyrRS) form distinct clades with many bacterial phyla represented in both clades. Very few taxa possess both forms, and maximum likelihood analysis of the distribution of TyrRS types suggests horizontal gene transfer (HGT), rather than an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Andam CP,Williams D,Gogarten JP

更新日期：2010-06-08 00:00:00

abstract：:Alterations in synaptic input, persisting for hours to days, elicit homeostatic plastic changes in the axon initial segment (AIS), which is pivotal for spike generation. Here, in hippocampal pyramidal neurons of both primary cultures and slices, we triggered a unique form of AIS plasticity by selectively targeting M-t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lezmy J,Lipinsky M,Khrapunsky Y,Patrich E,Shalom L,Peretz A,Fleidervish IA,Attali B

更新日期：2017-11-21 00:00:00

abstract：:Fetal exposure to environmental insults increases the susceptibility to late-onset neuropsychiatric disorders. Alcohol is listed as one of such prenatal environmental risk factors and known to exert devastating teratogenetic effects on the developing brain, leading to complex neurological and psychiatric symptoms obse...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hashimoto-Torii K,Kawasawa YI,Kuhn A,Rakic P

更新日期：2011-03-08 00:00:00

abstract：:The controlled self-assembly of complex molecules into well defined hierarchical structures is a promising route for fabricating nanostructures. These nanoscale structures can be realized by naturally occurring proteins such as tobacco mosaic virus, capsid proteins, tubulin, actin, etc. Here, we report a simple altern...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Valéry C,Paternostre M,Robert B,Gulik-Krzywicki T,Narayanan T,Dedieu JC,Keller G,Torres ML,Cherif-Cheikh R,Calvo P,Artzner F

更新日期：2003-09-02 00:00:00

abstract：:Src tyrosine kinase has long been implicated in colon cancer but much remains to be learned about its substrates. The nuclear receptor hepatocyte nuclear factor 4α (HNF4α) has just recently been implicated in colon cancer but its role is poorly defined. Here we show that c-Src phosphorylates human HNF4α on three tyros...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chellappa K,Jankova L,Schnabl JM,Pan S,Brelivet Y,Fung CL,Chan C,Dent OF,Clarke SJ,Robertson GR,Sladek FM

更新日期：2012-02-14 00:00:00

abstract：:The template-directed synthesis of a bistable donor-acceptor [2]catenane wherein both translational isomers--one in which a tetrathiafulvalene unit in a mechanically interlocked crown ether occupies the cavity of a cyclobis(paraquat-p-phenylene) ring and the other in which a 1,5-dioxynaphthalene unit in the crown ethe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang C,Olson MA,Fang L,Benítez D,Tkatchouk E,Basu S,Basuray AN,Zhang D,Zhu D,Goddard WA,Stoddart JF

更新日期：2010-08-10 00:00:00

abstract：:When the proximal and distal elements of wire-frame cubes are conflated, observers perceive illusory structures that no longer behave veridically. These phenomena suggest that what we normally see depends on visual associations generated by experience. The necessity of such learning may explain why the mammalian visua...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Purves D,Andrews TJ

更新日期：1997-06-10 00:00:00

abstract：:A hallmark of most neurodegenerative diseases, including those caused by polyglutamine expansion, is the formation of ubiquitin (Ub)-positive protein aggregates in affected neurons. This finding suggests that the Ub system may be involved in common mechanisms underlying these otherwise unrelated diseases. Here we repo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Donaldson KM,Li W,Ching KA,Batalov S,Tsai CC,Joazeiro CA

更新日期：2003-07-22 00:00:00

abstract：:The corticotropin-releasing factor (CRF) ligand family has diverse effects on the CNS, including the modulation of the stress response. The ligands' effects are mediated by binding to CRF G protein-coupled receptors. We have determined the 3D NMR structure of the N-terminal extracellular domain (ECD1) of the mouse CRF...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grace CR,Perrin MH,DiGruccio MR,Miller CL,Rivier JE,Vale WW,Riek R

更新日期：2004-08-31 00:00:00

abstract：:A method using PCR amplification and primer extension with fluorescent oligonucleotides was developed to analyze T-cell repertoires. The sizes of the hypervariable CDR3-like regions of the murine T-cell antigen receptor beta chains were measured for all possible V beta-J beta combinations. This analysis shows that bet...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pannetier C,Cochet M,Darche S,Casrouge A,Zöller M,Kourilsky P

更新日期：1993-05-01 00:00:00

abstract：:The T cell alphabeta receptor (TCR) recognizes foreign peptide antigens bound to proteins encoded in the MHC. The MHC portion of this complex contributes much to the footprint of the TCR on the ligand, yet T cells are usually very specific for individual foreign peptides. Here, we show that the development of peptide-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huseby ES,Crawford F,White J,Kappler J,Marrack P

更新日期：2003-09-30 00:00:00

abstract：:The infectivity of cloned hepatitis B viral DNA (HBV) has been tested in chimpanzees to identify a fully functional HBV genome and to assess the risk associated with its handling. Only one of two HBV DNA sequence variants tested was shown to be infectious. "Clone purified" virus of predicted nucleotide sequence was pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Will H,Cattaneo R,Darai G,Deinhardt F,Schellekens H,Schaller H

更新日期：1985-02-01 00:00:00

abstract：:An effective plant alkaloid chemical defense requires a variety of transport processes, but few alkaloid transporters have been characterized at the molecular level. Previously, a gene fragment encoding a putative plasma membrane proton symporter was isolated, because it was coordinately regulated with several nicotin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hildreth SB,Gehman EA,Yang H,Lu RH,Ritesh KC,Harich KC,Yu S,Lin J,Sandoe JL,Okumoto S,Murphy AS,Jelesko JG

更新日期：2011-11-01 00:00:00

abstract：:Most studies of cytoskeletal organelles have concentrated on molecular analyses of abundant and biochemically accessible structures. In many of the classical cases, however, the nature of the system chosen has precluded a concurrent genetic analysis. The mitotic spindle of the yeast Saccharomyces cerevisiae is one exa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pillus L,Solomon F

更新日期：1986-04-01 00:00:00

abstract：:The two internal transcribed spacers (ITS1 and ITS2) of rDNA of three members of the Ixodes ricinus "complex" (Acari: Ixodidae) were sequenced. Sequence variation was assessed for the North American species I. scapularis, I. dammini, and I. pacificus at three levels: within individual/population, between individuals o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wesson DM,McLain DK,Oliver JH,Piesman J,Collins FH

更新日期：1993-11-01 00:00:00

abstract：:Sympathetic activation of β-adrenoreceptors (β-AR) represents a hallmark in the development of heart failure (HF). However, little is known about the underlying mechanisms of gene regulation. In human ventricular myocardium from patients with end-stage HF, we found high levels of phosphorylated histone 3 at serine-28 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saadatmand AR,Sramek V,Weber S,Finke D,Dewenter M,Sticht C,Gretz N,Wüstemann T,Hagenmueller M,Kuenzel SR,Meyer-Roxlau S,Kramer M,Sossalla S,Lehmann LH,Kämmerer S,Backs J,El-Armouche A

更新日期：2019-10-29 00:00:00

abstract：:Many newly synthesized proteins have to become unfolded during translocation across biological membranes. We have analyzed the effects of various stabilization/destabilization mutations in the Ig-like module of the muscle protein titin upon its import from the N terminus or C terminus into mitochondria. The effects of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sato T,Esaki M,Fernandez JM,Endo T

更新日期：2005-12-13 00:00:00

abstract：:Rod signals in the mammalian retina are thought to reach ganglion cells over the circuit rod-->rod depolarizing bipolar cell-->AII amacrine cell-->cone bipolar cells-->ganglion cells. A possible alternative pathway involves gap junctions linking the rods and cones, the circuit being rod-->cone-->cone bipolar cells-->g...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： DeVries SH,Baylor DA

更新日期：1995-11-07 00:00:00