Infectious viral DNA of murine leukemia virus.

abstract：:Methylmalonyl-CoA mutase (EC 5.4.99.2) is a mitochondrial matrix enzyme whose activity is deficient in the inherited disorder methylmalonic acidemia. Previous studies on primary fibroblast cell lines from patients with methylmalonic acidemia have delineated a variety of biochemical phenotypes underlying this disorder....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ledley FD,Jansen R,Nham SU,Fenton WA,Rosenberg LE

更新日期：1990-04-01 00:00:00

abstract：:In 2012, an unusual outbreak of urban malaria was reported from Djibouti City in the Horn of Africa and increasingly severe outbreaks have been reported annually ever since. Subsequent investigations discovered the presence of an Asian mosquito species; Anopheles stephensi, a species known to thrive in urban environme...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sinka ME,Pironon S,Massey NC,Longbottom J,Hemingway J,Moyes CL,Willis KJ

更新日期：2020-10-06 00:00:00

abstract：:The extensive Early Jurassic continental strata of southern Africa have yielded an exceptional record of dinosaurs that includes scores of partial to complete skeletons of the sauropodomorph Massospondylus, ranging from embryos to large adults. In 1976 an incomplete egg clutch including in ovo embryos of this dinosaur...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reisz RR,Evans DC,Roberts EM,Sues HD,Yates AM

更新日期：2012-02-14 00:00:00

abstract：:Mind wandering represents the human capacity for internally focused thought and relies upon the brain's default network and its interactions with attentional networks. Studies have characterized mind wandering in healthy people, yet there is limited understanding of how this capacity is affected in clinical population...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： O'Callaghan C,Shine JM,Hodges JR,Andrews-Hanna JR,Irish M

更新日期：2019-02-19 00:00:00

abstract：:DNase I hypersensitive regions were mapped within the 17.3-kilobase qa (quinic acid) gene cluster of Neurospora crassa. The 5'-flanking regions of the five qa structural genes and the two qa regulatory genes each contain DNase I hypersensitive sites under noninducing conditions and generally exhibit increases in DNase...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baum JA,Giles NH

更新日期：1986-09-01 00:00:00

abstract：:The current model to explain the organization of the mammalian nervous system is based on studies of anatomy, embryology, and evolution. To further investigate the molecular organization of the adult mammalian brain, we have built a gene expression-based brain map. We measured gene expression patterns for 24 neural ti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zapala MA,Hovatta I,Ellison JA,Wodicka L,Del Rio JA,Tennant R,Tynan W,Broide RS,Helton R,Stoveken BS,Winrow C,Lockhart DJ,Reilly JF,Young WG,Bloom FE,Lockhart DJ,Barlow C

更新日期：2005-07-19 00:00:00

abstract：:Amino-terminal sequence determinations are reported of the subunits of biliproteins of prokaryotic unicellular and filamentous cyanobacteria and of eukaryotic unicellular red algae. The biliproteins examined, allophycocyanin, C-phycocyanin, R-phycocyanin, b-phycoerythrin, and phycoerythrocyanin, vary with respect to t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Glazer AN,Apell GS,Hixson CS,Bryant DA,Rimon S,Brown DM

更新日期：1976-02-01 00:00:00

abstract：:Murine and human cDNAs, related to but distinct from c-raf-1, have been isolated and designated mA-raf and hA-raf, respectively. The mA-raf and hA-raf cDNAs detect the same murine and human fragments in Southern blots of restriction enzyme-cleaved murine and human cellular DNA. The murine restriction enzyme fragments ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huebner K,ar-Rushdi A,Griffin CA,Isobe M,Kozak C,Emanuel BS,Nagarajan L,Cleveland JL,Bonner TI,Goldsborough MD

更新日期：1986-06-01 00:00:00

abstract：:During excitation-contraction (e-c) coupling of striated muscle, depolarization of the surface membrane is converted into Ca2+ release from internal stores. This process occurs at intracellular junctions characterized by a specialized composition and structural organization of membrane proteins. The coordinated arrang...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Flucher BE,Franzini-Armstrong C

更新日期：1996-07-23 00:00:00

abstract：:Ribbon synapses of photoreceptor cells and second-order bipolar neurons in the retina are specialized to transmit graded signals that encode light intensity. Neurotransmitter release at ribbon synapses exhibits two kinetically distinct components, which serve different sensory functions. The faster component is deplet...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vaithianathan T,Matthews G

更新日期：2014-06-10 00:00:00

abstract：:Some of the most important impacts of global climate change will be felt among the populations, predominantly in developing countries, referred to as "subsistence" or "smallholder" farmers. Their vulnerability to climate change comes both from being predominantly located in the tropics, and from various socioeconomic,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morton JF

更新日期：2007-12-11 00:00:00

abstract：:Gold nanoparticles quench the fluorescence of cationic polyfluorene with Stern-Volmer constants (KSV) approaching 1011 M-1, several orders of magnitude larger than any previously reported conjugated polymer-quencher pair and 9-10 orders of magnitude larger than small molecule dye-quencher pairs. The dependence of KSV ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fan C,Wang S,Hong JW,Bazan GC,Plaxco KW,Heeger AJ

更新日期：2003-05-27 00:00:00

abstract：:To study the behavior of hematopoietic stem cells in vivo, we transplanted glucose-6-phosphate dehydrogenase (G6PD) heterozygous (female Safari) cats with small amounts of autologous marrow. The G6PD phenotypes of erythroid burst-forming units and granulocyte/macrophage colony-forming units were repeatedly assayed for...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Abkowitz JL,Persik MT,Shelton GH,Ott RL,Kiklevich JV,Catlin SN,Guttorp P

更新日期：1995-03-14 00:00:00

abstract：:Evidence suggests that cholinergic input to the hippocampus plays an important role in learning and memory and that degeneration of cholinergic terminals in the hippocampus may contribute to the memory loss associated with Alzheimer's disease. One of the more prominent effects of cholinergic agonists on hippocampal ph...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marino MJ,Rouse ST,Levey AI,Potter LT,Conn PJ

更新日期：1998-09-15 00:00:00

abstract：:The structural and functional organization of the Cct complex was addressed by genetic analyses of subunit interactions and catalytic cooperativity among five of the eight different essential subunits, Cct1p-Cct8p, in the yeast Saccharomyces cerevisiae. The cct1-1, cct2-3, and cct3-1 alleles, containing mutations at t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin P,Sherman F

更新日期：1997-09-30 00:00:00

abstract：:The aryl hydrocarbon receptor nuclear translocator (ARNT) is a basic helix-loop-helix Period/ARNT/Single-minded (bHLH-PAS) protein that controls various biological pathways as part of dimeric transcriptional regulator complexes with other bHLH-PAS proteins. The two PAS domains within ARNT, PAS-A and PAS-B, are essenti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Evans MR,Card PB,Gardner KH

更新日期：2009-02-24 00:00:00

abstract：:Magnetic interactions between dissolved oxygen and nitroxide radical spin probes lead to broadening of the ESR lines. We have used a closed-chamber method based on this property to determine the maximum rate of O2 uptake per cell (Vmax per cell) in cultured mammalian cells. A suitable spin probe and a cell suspension ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lai CS,Hopwood LE,Hyde JS,Lukiewicz S

更新日期：1982-02-01 00:00:00

abstract：:We sequenced the genome of Saccharomyces cerevisiae strain YJM789, which was derived from a yeast isolated from the lung of an AIDS patient with pneumonia. The strain is used for studies of fungal infections and quantitative genetics because of its extensive phenotypic differences to the laboratory reference strain, i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wei W,McCusker JH,Hyman RW,Jones T,Ning Y,Cao Z,Gu Z,Bruno D,Miranda M,Nguyen M,Wilhelmy J,Komp C,Tamse R,Wang X,Jia P,Luedi P,Oefner PJ,David L,Dietrich FS,Li Y,Davis RW,Steinmetz LM

更新日期：2007-07-31 00:00:00

abstract：:We present evidence of rapid and reliable associative learning by the terrestrial mollusc, Limax maximus. Slugs were exposed once to a pairing of a highly attractive food odor (potato or carrot) and a saturated solution of quinidine sulfate, a bitter-tasting plant substance. In comparison with control slugs, the expos...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sahley C,Gelperin A,Rudy JW

更新日期：1981-01-01 00:00:00

abstract：:The superior colliculus (SC) is part of a network of brain areas that directs saccadic eye movements, overtly shifting both gaze and attention from position to position, in space. Here, we seek direct evidence that the SC also contributes to the control of covert spatial attention, a process that focuses attention on ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Müller JR,Philiastides MG,Newsome WT

更新日期：2005-01-18 00:00:00

abstract：:Pain is a major health concern even though numerous analgesic agents are available. Side effects and lack of wide-spectrum efficacy of current drugs justify efforts to better understand pain mechanisms. Stabilization of natural epoxy-fatty acids (EFAs) through inhibition of the soluble epoxide hydrolase (sEH) reduces ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Inceoglu B,Wagner K,Schebb NH,Morisseau C,Jinks SL,Ulu A,Hegedus C,Rose T,Brosnan R,Hammock BD

更新日期：2011-03-22 00:00:00

abstract：:The development of seeds in flowering plants is placed under complex interactions between maternal tissues, the embryo, and the endosperm. The endosperm plays a major role in the regulation of seed size. In Arabidopsis thaliana, endosperm size depends on the coordination of the genetic pathway HAIKU (IKU) with epigene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li J,Nie X,Tan JL,Berger F

更新日期：2013-09-17 00:00:00

abstract：:It is generally believed that serial passage at high multiplicity of infection (moi) is required for the generation of defective interfering (DI) particles. High levels of DI RNAs are found associated with persistent infections initiated with laboratory cultures of cucumber necrosis virus (CNV). Two synthetic CNV tran...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rochon DM

更新日期：1991-12-15 00:00:00

abstract：:The serum thymic factor (FTS) utilized in its synthetic or natural form loses its biological activity in a rosette assay after treatment with a metal ion-chelating agent, Chelex 100. This activity is restored by the addition of Zn salts and, to a lesser extent, certain other metal salts. FTS activation is secondary to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dardenne M,Pléau JM,Nabarra B,Lefrancier P,Derrien M,Choay J,Bach JF

更新日期：1982-09-01 00:00:00

abstract：:We determined the nucleotide sequence of about 1 kilobase of DNA 3' to the 5' long terminal repeat of three noninfectious ad one infectious proviral DNA clones of spleen necrosis virus, an avian retrovirus, to determine if the types of nucleic acid changes involved in retrovirus mutation shed light on special features...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： O'Rear JJ,Temin HM

更新日期：1982-02-01 00:00:00

abstract：:Most of the cell-surface molecules involved in T-cell immune responses are N-linked glycoproteins. We have investigated the effects of inhibitors of glycoprotein processing on specific T-cell functions, with the dual aims of examining the functional role of carbohydrate and of testing the usefulness of such compounds ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wall KA,Pierce JD,Elbein AD

更新日期：1988-08-01 00:00:00

abstract：:The carbon budget and dynamics of the Earth's interior, including the core, are currently very poorly understood. Diamond-bearing, mantle-derived rocks show a very well defined peak at δ(13)C ≈ -5 ± 3‰ with a very broad distribution to lower values (∼-40‰). The processes that have produced the wide δ(13)C distribution...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Horita J,Polyakov VB

更新日期：2015-01-06 00:00:00

abstract：:Total nuclear proteins extracted from cell lines representing various stages of differentiation of mouse B lymphocytes were studied by computer analysis of two-dimensional gels. Of the 1438 spots present on the gels, 55 varied significantly in intensity during differentiation. The variations occurred most often in ste...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rabilloud T,Pennetier JL,Hibner U,Vincens P,Tarroux P,Rougeon F

更新日期：1991-03-01 00:00:00

abstract：:Inactivation of the p53 pathway represents the most common molecular defect of human cancer. But in the setting of melanoma, a highly aggressive and invariably fatal malignancy in its advanced disseminated form, mutation/deletion of p53 is relatively rare, whereas its positive regulator ARF is often lost. Here, we sho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ha L,Ichikawa T,Anver M,Dickins R,Lowe S,Sharpless NE,Krimpenfort P,Depinho RA,Bennett DC,Sviderskaya EV,Merlino G

更新日期：2007-06-26 00:00:00

abstract：:Recent findings suggest that neurons can efficiently repair oxidatively damaged DNA, and that both DNA damage and repair are enhanced by activation of excitatory glutamate receptors. However, in pathological conditions such as ischemic stroke, excessive DNA damage can trigger the death of neurons. Oxidative DNA damage...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Canugovi C,Yoon JS,Feldman NH,Croteau DL,Mattson MP,Bohr VA

更新日期：2012-09-11 00:00:00