Abstract：
:In this report, we review recent findings concerning the identification of mechanisms that may modulate the role of lipoprotein(a), or Lp(a), in thrombosis and atherogenesis. Lp(a) binds to surface-immobilized plasmin-modified fibrin, thus providing a mechanism for incorporating Lp(a) into the vessel wall. We found that homocysteine and other sulfhydryl-containing amino acids markedly increase the binding of Lp(a) to plasmin-modified fibrin. Our results suggest that homocysteine alters the structure of Lp(a) to expose lysine-binding sites on the apolipoprotein(a) portion of the molecule, and thus provide a potential biochemical link between thrombosis and atherogenesis. We also found that transglutaminases catalyze the incorporation of primary amines into Lp(a). Studies in cell culture systems have found that Lp(a) stimulates endothelial cells to synthesize and release plasminogen activator inhibitor-1. Further, Lp(a) inhibits the activation of transforming growth factor-beta in a coculture of bovine endothelial and smooth muscle cells.
journal_name
Ann Epidemioljournal_title
Annals of epidemiologyauthors
Harpel PC,Borth Wdoi
10.1016/1047-2797(92)90090-dkeywords:
subject
Has Abstractpub_date
1992-07-01 00:00:00pages
413-7issue
4eissn
1047-2797issn
1873-2585pii
1047-2797(92)90090-Djournal_volume
2pub_type
杂志文章abstract：:Phase I of the Trials of Hypertension Prevention was designed to test the effectiveness and safety of three life-style (weight loss, sodium restriction, and stress management) and four nutrition supplement (calcium, magnesium, potassium, and fish oil) interventions in reducing diastolic blood pressure (DBP) in persons...
journal_title：Annals of epidemiology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/1047-2797(92)90062-u
更新日期：1992-05-01 00:00:00
abstract：PURPOSE:We aimed to investigate the prevalence and prognostic impact of tumor mesenchymal epithelial transition factor (MET) expression in stage IV gastric cancers in a real-world clinical setting because existing evidence is sparse. METHODS:The study included archived cancer specimens from 103 stage IV gastric cancer...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2016.05.002
更新日期：2016-07-01 00:00:00
abstract：PURPOSE:The goal of this study was to assess the relationship between hospitalization rates and asthma prevalence in New York City children and investigate the role that sociodemographic factors play in asthma. METHODS:A parent-report questionnaire was distributed in 26 randomly selected New York City public elementar...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2005.06.046
更新日期：2006-05-01 00:00:00
abstract：:Total cholesterol level is significantly related to risk of coronary heart disease (CHD), adjusting for other risk factors in women 50 to 79 years old and in men aged 50 to 64 years, at P < .001. Determining the levels of lipoproteins such as low-density-lipoprotein (LDL) cholesterol and high-density-lipoprotein (HDL)...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/1047-2797(92)90033-m
更新日期：1992-01-01 00:00:00
abstract：PURPOSE:This cross-sectional study sought to identify diabetes accurately in a study population of 3681 women age 75 and older and to determine the association of diabetes with cognitive performance. METHODS:A previously validated test, the Telephone Interview of Cognitive Screening-Modified (TICSm) was given to asses...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/S1047-2797(03)00059-0
更新日期：2003-10-01 00:00:00
abstract：PURPOSE:Local health statistics are increasingly requested for policy-making and programmatic purposes; however, population-based surveys are often inadequate to support direct estimation for small areas. Model-based estimation techniques can be used to create local estimates for public health outcomes. Using the 2014-...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2018.03.015
更新日期：2018-07-01 00:00:00
abstract：PURPOSE:The natural history of the multiple metabolic syndrome (MMS) and its predictors has rarely been addressed in population samples. This study evaluated the predictive role of fasting serum insulin, body mass index (BMI), and waist-to-hip ratio (WHR) on the development of incident MMS components (diabetes, hyperte...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/s1047-2797(97)00047-1
更新日期：1997-08-01 00:00:00
abstract：PURPOSE:As Western populations live longer, peripheral vascular disease will become a greater individual and public health problem. Therefore, the long-term natural history of intermittent claudication (IC) needs further delineation. The study objective was to describe the 21-year mortality and relative risk for cause-...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/s1047-2797(96)00148-2
更新日期：1997-04-01 00:00:00
abstract：PURPOSE:Research examining the association between crime and health outcomes has been hampered by a lack of reliable small-area (e.g., census tract or census block group) crime data. Our objective is to assess the accuracy of synthetically estimated crime indices for use in health research by using preterm birth as a c...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2020.11.008
更新日期：2020-12-05 00:00:00
abstract：PURPOSE:Whether or which blood heavy metal levels (BHMLs) influence elevating intraocular pressure (IOP) are unknown. We examined the relationship among blood lead, mercury, and cadmium levels, blood pressure (BP), and IOP and assessed whether BP mediates these BHMLs-IOP associations. METHODS:We analyzed data on 8371 ...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2016.07.002
更新日期：2016-08-01 00:00:00
abstract：PURPOSE:Socioeconomic status (SES) as a risk factor for mortality in type 1 diabetes (T1D) has not been adequately studied prospectively. METHODS:Complete clinical and SES (income, education, occupation) data were available for 317 T1D participants in the Pittsburgh Epidemiology of Diabetes Complications Study within ...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2011.02.011
更新日期：2011-05-01 00:00:00
abstract：PURPOSE:Studies of middle-aged and particularly older-aged adults found that those with higher scores on tests of IQ (cognitive function) had lower rates of later mortality. Interpretation of such findings potentially is hampered by the problem of reverse causality: such somatic diseases as diabetes or hypertension, co...
journal_title：Annals of epidemiology
pub_type： 杂志文章,评审
doi：10.1016/j.annepidem.2006.07.010
更新日期：2007-04-01 00:00:00
abstract：PURPOSE:To evaluate the factors associated with receiving cutaneous injection-related infection (CIRI) care among a representative cohort of supervised injecting facility (SIF) users. METHODS:Data were collected biannually as part of a prospective cohort, the Scientific Evaluation of Supervised Injection study. Kaplan...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2009.03.007
更新日期：2009-06-01 00:00:00
abstract：PURPOSE:To examine the association of depressive symptoms with coronary heart disease (CHD) end points by race and income. METHODS:Study participants were blacks and whites (n = 24,443) without CHD at baseline from the national Reasons for Geographical and Racial Differences in Stroke cohort. Outcomes included acute C...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2015.03.014
更新日期：2015-06-01 00:00:00
abstract：:Injuries are the leading cause of death for females 1 to 34 years old, and a major source of preventable morbidity and mortality in middle-aged and elderly women. In the United States, 43,000 women die from injuries and approximately 1 million women are hospitalized for injuries annually. The leading causes of injury ...
journal_title：Annals of epidemiology
pub_type： 杂志文章,评审
doi：10.1016/1047-2797(94)90059-0
更新日期：1994-03-01 00:00:00
abstract：PURPOSE:We aimed to explore the relationship between physician characteristics and their prescribing behavior regarding category D and X drugs for pregnant women by using a population-based data set in Taiwan. METHODS:The sampled population for the study included 14,430 women. These women received a total of 198,420 p...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2012.11.007
更新日期：2013-02-01 00:00:00
abstract：PURPOSE:Propose a five-step multigating, multimodal procedure for research case definition and identification of attention-deficit/hyperactivity disorder (AD/HD) in population-based epidemiologic studies. METHODS:Subjects included a birth cohort of all children born between 1976 and 1982 who remained in Rochester afte...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2004.12.004
更新日期：2005-07-01 00:00:00
abstract：:In Japan, stroke now ranks third among all causes of death following cancer and heart disease. Stroke was the leading cause of death for 3 decades after 1951. Stroke mortality tended to increase until about 1970, but it decreased and yielded first place to cancer in 1981. Heart disease deaths outnumbered stroke deaths...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/1047-2797(93)90109-h
更新日期：1993-09-01 00:00:00
abstract：PURPOSE:The case-crossover design was originally intended to study brief exposures with immediate and transient effects, and acute outcomes with abrupt onsets. We investigated whether case-crossover methods can be used to study prolonged exposures and insidious outcomes. METHODS:We conducted a case-crossover study of ...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2003.09.012
更新日期：2004-04-01 00:00:00
abstract：PURPOSE:Asthma is a major complication of pregnancy, but there are currently no reliable national estimates for the United States of asthma prevalence in pregnancy or in the childbearing years. METHODS:The prevalence of asthma among pregnant women and all childbearing-aged women was estimated and examined by age group...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/s1047-2797(03)00008-5
更新日期：2003-05-01 00:00:00
abstract：PURPOSE:The proportion of cancer deaths in the contemporary United States caused by cigarette smoking (the population attributable fraction [PAF]) is not well documented. METHODS:The PAF of all cancer deaths due to active cigarette smoking among adults 35 years and older in the United States in 2010 was calculated usi...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2014.11.008
更新日期：2015-03-01 00:00:00
abstract：:The Expanded Programme on Immunization (EPI) of the World Health Organization developed a cluster survey design for the rapid assessment of children's vaccination coverage in developing countries. Because of its simplicity and familiarity, the EPI methodology has been used for additional purposes, including the detect...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/1047-2797(94)90086-8
更新日期：1994-07-01 00:00:00
abstract：PURPOSE:While high levels of obesity prevalence and incidence have been well documented, there is less research on obesity dynamics over time. In this article, we sought to understand the body mass index (BMI) trajectories in and out of obesity from adolescence to adulthood. METHODS:We used the National Longitudinal S...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2019.12.003
更新日期：2020-01-01 00:00:00
abstract：PURPOSE:Existing studies on laxatives, used by roughly 40% of the U.S. population experiencing constipation and colorectal cancer (CRC) have yielded inconsistent results, which may be due to a failure to account for differential risks by major laxative types: bulk (fiber-based), and nonbulk (or nonfiber-based). METHOD...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2018.06.011
更新日期：2018-10-01 00:00:00
abstract：PURPOSE:Heterocyclic amines (HCAs), which are found mainly in well-cooked meat, require metabolic activation to function as mutagens and animal carcinogens. Enzymes such as cytochrome P4501A2 (CYP1A2) and N-acetyltransferase (NAT2) perform this task and are subject to interindividual variation. The source of this varia...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/s1047-2797(97)00027-6
更新日期：1997-07-01 00:00:00
abstract：PURPOSE:Socioeconomic disadvantage is often evaluated at single points in the adult life course in health research. Social mobility models suggest that socioeconomic patterns may also influence disease risk. This study examines cumulative socioeconomic disadvantage (CSD) in relation to cardiovascular disease mortality ...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2014.11.018
更新日期：2015-02-01 00:00:00
abstract：PURPOSE:Men who have sex with men (MSM) bear a disproportionate burden of new and existing HIV infections in the United States, with black and Hispanic MSM facing the highest rates. A lack of data on MSM population sizes has precluded the understanding of state-level variations in these rates. METHODS:Using a recently...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2018.04.008
更新日期：2018-12-01 00:00:00
abstract：PURPOSE:Both obesity and gamma glutamyltransferase (GGT) are individually considered to be closely associated with metabolic syndrome (MetS). Whether the 2 factors synergistically associate with MetS is not yet confirmed. The purpose of this study was to investigate whether obesity and GGT are interactively associated ...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2012.09.012
更新日期：2012-12-01 00:00:00
abstract：PURPOSE:Our aim was examine the association between black tea consumption and risk of total stroke and stroke types in a prospective study. METHODS:A total of 74,961 Swedish women and men who were free of cardiovascular disease and cancer at baseline in 1997 were followed up through December 2008. Tea consumption was ...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2012.12.006
更新日期：2013-03-01 00:00:00
abstract：PURPOSE:Much cross-sectional work reports an association between neighborhood disadvantage and adverse birth outcomes. Limitations of this work include that mothers with pre-existing unmeasured morbidity may "select" into, or out of, certain neighborhoods. This selection issue remains a key rival explanation for work c...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2019.05.005
更新日期：2019-08-01 00:00:00
