Abstract：
PURPOSE:Both obesity and gamma glutamyltransferase (GGT) are individually considered to be closely associated with metabolic syndrome (MetS). Whether the 2 factors synergistically associate with MetS is not yet confirmed. The purpose of this study was to investigate whether obesity and GGT are interactively associated with MetS. METHODS:A cross-sectional study of 7390 adults (age 32-62 years old) was conducted from 2009 to 2010. RESULTS:Our results showed that greater serum GGT quartiles were positively associated with all MetS components and fatty liver (P < .001). The odds ratio of MetS increased significantly along with quartiles of GGT and obesity. In comparison with subjects with normal body mass index and first quartile GGT, the odds ratio of MetS in obese groups with 1st, 2nd, 3rd, and 4th quartile GGT were 6.8, 14.5, 20.3, and 45.2, respectively, and it remained tenable after adjustment for fatty liver. The synergy index of GGT and obesity on MetS is 2.2 (95% confidence interval, 1.9-2.6). CONCLUSIONS:Serum GGT level in combination with obesity can be a simple but useful tool for risk stratification of developing MetS. Obese individuals with high-normal GGT levels require close monitoring for high risk of MetS.
journal_name
Ann Epidemioljournal_title
Annals of epidemiologyauthors
Hwang AC,Lin YC,Liu PT,Kao YM,Chen JDdoi
10.1016/j.annepidem.2012.09.012subject
Has Abstractpub_date
2012-12-01 00:00:00pages
876-80issue
12eissn
1047-2797issn
1873-2585pii
S1047-2797(12)00390-0journal_volume
22pub_type
杂志文章abstract：:Data are presented contrasting racial and ethnic differences in the use of alcohol and other drugs, and in the morbidity and mortality consequent to substance abuse and dependence. In a review of recent studies, whites were found to have higher rates of use, abuse, and dependence than other racial and ethnic groups, d...
journal_title：Annals of epidemiology
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journal_title：Annals of epidemiology
pub_type： 历史文章,杂志文章
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journal_title：Annals of epidemiology
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journal_title：Annals of epidemiology
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journal_title：Annals of epidemiology
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journal_title：Annals of epidemiology
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更新日期：2010-12-01 00:00:00
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journal_title：Annals of epidemiology
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journal_title：Annals of epidemiology
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更新日期：2019-12-01 00:00:00
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