Interleukin-10 as a predictor of major adverse cardiovascular events in a racially and ethnically diverse population: Multi-Ethnic Study of Atherosclerosis.


PURPOSE:To understand if baseline levels of the anti-inflammatory cytokine interleukin-10 (IL-10) are associated with either subclinical atherosclerosis or risk for adverse cardiovascular (CV) events. METHODS:The study included 930 adults from the Multi-Ethnic Study of Atherosclerosis (MESA) ancillary Stress Study. Participants, age 48-90 years at enrollment, were followed for an average of 10.2 years. IL-10 level was measured at the initial Stress Study visit. Cardiovascular outcomes were defined as composite CV death, myocardial infarction, stroke, stroke death, and resuscitated cardiac arrest. Coronary calcification was determined by Agatston coronary artery calcium (CAC) score. The association between IL-10 level and CV event risk was evaluated by Cox proportional hazard modeling, while that of IL-10 level and CAC presence and amount was determined with prevalence risk ratio (PRR) and linear regression modeling, respectively. Models were adjusted for CV risk factors and proinflammatory biomarkers. RESULTS:After full adjustment, IL-10 level did not predict CV events (HR 1.19, 95%CI 0.89, 1.60) and was not associated with CAC prevalence (PRR 1.00, 95%CI 0.94, 1.07), nor amount of CAC in those with nonzero CAC (β -0.01, 95%CI -0.23, 0.21). CONCLUSION:In individuals without clinical heart disease, baseline IL-10 level appears unrelated to risk of CV events and is a poor marker of subclinical coronary atherosclerosis.


Ann Epidemiol


Annals of epidemiology


Goldwater D,Karlamangla A,Merkin SS,Watson K,Seeman T




Has Abstract


2019-02-01 00:00:00












  • Participation in occupational health longitudinal studies: predictors of missed visits and dropouts.

    abstract:PURPOSE:The purpose of this study is to determine whether demographics, health, and job factors influence continued participation of employed persons in a longitudinal intervention study of tertiary prevention for work-related low-back disorders (WR-LBDs). METHODS:Four hundred fifty-four actively employed persons had ...

    journal_title:Annals of epidemiology

    pub_type: 杂志文章


    authors: Oleske DM,Kwasny MM,Lavender SA,Andersson GB

    更新日期:2007-01-01 00:00:00

  • Cancer incidence among Minnesota taconite mining industry workers.

    abstract:PURPOSE:To evaluate cancer incidence among Minnesota taconite mining workers. METHODS:We evaluated cancer incidence between 1988 and 2010 in a cohort of 40,720 Minnesota taconite mining workers used between 1937 and 1983. Standardized incidence ratios (SIRs) with 95% confidence intervals (CIs) were estimated by compar...

    journal_title:Annals of epidemiology

    pub_type: 杂志文章


    authors: Allen EM,Alexander BH,MacLehose RF,Nelson HH,Ramachandran G,Mandel JH

    更新日期:2015-11-01 00:00:00

  • Diabetes predicts long-term disability in an elderly urban cohort: the Northern Manhattan Study.

    abstract:PURPOSE:There are limited data on vascular predictors of long-term disability in Hispanics. We hypothesized that (1) functional status declines over time and (2) vascular risk factors predict functional decline. METHODS:The Northern Manhattan Study contains a population-based study of 3298 stroke-free individuals aged...

    journal_title:Annals of epidemiology

    pub_type: 杂志文章


    authors: Dhamoon MS,Moon YP,Paik MC,Sacco RL,Elkind MS

    更新日期:2014-05-01 00:00:00

  • The effect of physical activity across the menstrual cycle on reproductive function.

    abstract:PURPOSE:To evaluate the association between physical activity (PA) across the menstrual cycle and reproductive function. METHODS:The BioCycle Study (2005-2007) followed 259 healthy premenopausal women not using hormonal contraceptives for up to two menstrual cycles (N = 509 cycles). Serum leptin, estradiol, progestero...

    journal_title:Annals of epidemiology

    pub_type: 杂志文章


    authors: Ahrens KA,Vladutiu CJ,Mumford SL,Schliep KC,Perkins NJ,Wactawski-Wende J,Schisterman EF

    更新日期:2014-02-01 00:00:00

  • Response rates in case-control studies of cancer by era of fieldwork and by characteristics of study design.

    abstract:PURPOSE:The purpose of this study was to describe time trends in response rates in case-control studies of cancer and identify study design factors that influence response rate. METHODS:We reviewed 370 case-control studies of cancer published in 12 journals during indicator years in each of the last four decades. We e...

    journal_title:Annals of epidemiology

    pub_type: 杂志文章


    authors: Xu M,Richardson L,Campbell S,Pintos J,Siemiatycki J

    更新日期:2018-06-01 00:00:00

  • Body mass index and risk of head and neck cancer by race: the Carolina Head and Neck Cancer Epidemiology Study.

    abstract:PURPOSE:Most studies, primarily conducted in populations of European ancestry, reported increased risk of head and neck cancer (HNC) associated with leanness (body mass index [BMI] <18.5 kg/m(2)) and decreased for overweight or obesity (25.0 to <30.0 and >30 kg/m(2), respectively), compared with normal weight (18.5 to ...

    journal_title:Annals of epidemiology

    pub_type: 杂志文章


    authors: Petrick JL,Gaudet MM,Weissler MC,Funkhouser WK,Olshan AF

    更新日期:2014-02-01 00:00:00

  • Comparing biological measurements of vitamin C, folate, alpha-tocopherol and carotene with 24-hour dietary recall information in nonhispanic blacks and whites.

    abstract:PURPOSE:To assess intake of several vitamins in preparation for a large cohort study investigating the effect of diet on risk of colon and prostate cancer. METHODS:The dietary intake of several vitamins were assessed using eight different 24-hour recalls and a 200-item food frequency questionnaire (FFQ) from each subj...

    journal_title:Annals of epidemiology

    pub_type: 杂志文章


    authors: Knutsen SF,Fraser GE,Linsted KD,Beeson WL,Shavlik DJ

    更新日期:2001-08-01 00:00:00

  • Breast density, body mass index, and risk of tumor marker-defined subtypes of breast cancer.

    abstract:PURPOSE:Breast density and body mass index (BMI) are correlated attributes and are both potentially modifiable risk factors for breast cancer. However, relationships between these factors and risk of molecularly-defined subtypes of breast cancer have not been established. METHODS:We used breast density and BMI data co...

    journal_title:Annals of epidemiology

    pub_type: 杂志文章


    authors: Phipps AI,Buist DS,Malone KE,Barlow WE,Porter PL,Kerlikowske K,O'Meara ES,Li CI

    更新日期:2012-05-01 00:00:00

  • Prospective analysis of association between use of statins or other lipid-lowering agents and colorectal cancer risk.

    abstract:PURPOSE:To determine whether 3-hydroxy-3-methylglutaryl coenzyme A inhibitors (statins) are associated with a decreased risk of colorectal cancer. METHODS:The population included 159,219 postmenopausal women enrolled in the Women's Health Initiative in which 2000 pathologically confirmed cases of colorectal cancer wer...

    journal_title:Annals of epidemiology

    pub_type: 杂志文章


    authors: Simon MS,Rosenberg CA,Rodabough RJ,Greenland P,Ockene I,Roy HK,Lane DS,Cauley JA,Khandekar J

    更新日期:2012-01-01 00:00:00

  • Work experience and gender differences in chronic disease risk in older Mexicans.

    abstract:PURPOSE:The purpose of this study is to examine the relationship between labor force participation and gender differences in the prevalence of arthritis, diabetes, and hypertension. METHODS:The Mexican Health and Aging Survey (MHAS) data is nationally representative sample of older Mexicans 50 years and older. Binomia...

    journal_title:Annals of epidemiology

    pub_type: 杂志文章


    authors: Salinas JJ,Peek MK

    更新日期:2008-08-01 00:00:00

  • Nicotine dependence predicts repeated use of prescribed opioids. Prospective population-based cohort study.

    abstract:PURPOSE:The aim of this study was to evaluate prospectively smoking dependence as a predictor of repeated use of prescribed opioids in non-cancer patients. METHODS:We conducted a prospective population-based study cohort of 12,848 men and 15,894 women 30-75 years of age in health surveys in Norway during 2000-2002 wit...

    journal_title:Annals of epidemiology

    pub_type: 杂志文章


    authors: Skurtveit S,Furu K,Selmer R,Handal M,Tverdal A

    更新日期:2010-12-01 00:00:00

  • Genetically predicted 17beta-estradiol and cardiovascular risk factors in women: a Mendelian randomization analysis using young women in Hong Kong and older women in the Guangzhou Biobank Cohort Study.

    abstract:PURPOSE:The role of estrogen in cardiovascular health remains contested with discrepancies between findings from randomized controlled trials and observational studies. Mendelian randomization, which assesses the effect of lifelong endogenous exposure, may help elucidate these discrepancies. METHODS:We used separate s...

    journal_title:Annals of epidemiology

    pub_type: 杂志文章


    authors: Au Yeung SL,Cheng KK,Zhao J,Zhang W,Jiang C,Lam TH,Leung GM,Schooling CM

    更新日期:2016-03-01 00:00:00

  • Income inequality and elderly self-rated health in São Paulo, Brazil.

    abstract:PURPOSE:To test the association between income inequality and elderly self-rated health and to propose a pathway to explain the relationship. METHODS:We analyzed a sample of 2143 older individuals (60 years of age and over) from 49 distritos of the Municipality of São Paulo, Brazil. Bayesian multilevel logistic models...

    journal_title:Annals of epidemiology

    pub_type: 杂志文章


    authors: Chiavegatto Filho AD,Lebrão ML,Kawachi I

    更新日期:2012-12-01 00:00:00

  • Measurement of lactose consumption reliability and comparison of two methods.

    abstract::The objective of this study was to assess the reliability of lactose consumption measured with a food-frequency questionnaire and to compare food-frequency data to prospectively recorded data. A self-administered food-frequency questionnaire (FF1) was completed by 295 women ages 38 to 49. Two months later, 75 received...

    journal_title:Annals of epidemiology

    pub_type: 杂志文章


    authors: Cooper GS,Busby MG,Fairchild AP

    更新日期:1995-11-01 00:00:00

  • Space-time clustering analyses of occurrence of cerebral palsy in Northern England for births 1991 to 2003.

    abstract:PURPOSE:The etiology of congenital cerebral palsy is unclear. Recent studies have suggested that maternal infection is involved. Indirect, but supportive, evidence for an infectious hypothesis would be provided by the finding of space-time clustering. METHODS:We analyzed all 906 cases born during the period 1991-2003 ...

    journal_title:Annals of epidemiology

    pub_type: 杂志文章


    authors: McNally RJ,Colver AF

    更新日期:2008-02-01 00:00:00

  • Moderating effects of interactions between dietary intake and socioeconomic status on the prevalence of metabolic syndrome.

    abstract:PURPOSE:The purpose of this study is to examine how nutrients can affect the relationship between the development of metabolic syndrome (MS) and socioeconomic factors. METHODS:This study was based on data obtained from the 2005 Korea National Health and Nutrition Examination Survey was conducted as a health survey of ...

    journal_title:Annals of epidemiology

    pub_type: 杂志文章


    authors: Paek KW,Chun KH

    更新日期:2011-12-01 00:00:00

  • Extreme maternal education and preterm birth: time-to-event analysis of age and nativity-dependent risks.

    abstract:PURPOSE:Increasing numbers of women achieve extremely high education, but the association with preterm birth (PTB) is poorly understood, especially over the life course. We sought to determine how very high educational attainment is associated with PTB, and to assess differences by maternal age and nativity. METHODS:D...

    journal_title:Annals of epidemiology

    pub_type: 杂志文章


    authors: Auger N,Abrahamowicz M,Park AL,Wynant W

    更新日期:2013-01-01 00:00:00

  • The accuracy of human papillomavirus vaccination status based on adult proxy recall or household immunization records for adolescent females in the United States: results from the National Immunization Survey-Teen.

    abstract:PURPOSE:We assessed the accuracy of human papillomavirus (HPV) vaccination status based on adult proxy recall and household immunization records for adolescent females in the United States. METHODS:We used data from the 2010 National Immunization Survey-Teen for females aged 13 to 17 years. The accuracy of HPV vaccina...

    journal_title:Annals of epidemiology

    pub_type: 杂志文章


    authors: Ojha RP,Tota JE,Offutt-Powell TN,Klosky JL,Ashokkumar R,Gurney JG

    更新日期:2013-05-01 00:00:00

  • Prevalence and characteristics of children with autism-spectrum disorders.

    abstract:PURPOSE:The purpose of this study was to determine the prevalence of autism spectrum disorders (ASD) and associated characteristics among 8-year-old children. METHODS:This is an ongoing active, population-based surveillance program conducted in South Carolina as part of the Centers for Disease Control and Prevention's...

    journal_title:Annals of epidemiology

    pub_type: 杂志文章


    authors: Nicholas JS,Charles JM,Carpenter LA,King LB,Jenner W,Spratt EG

    更新日期:2008-02-01 00:00:00

  • Cumulative socioeconomic disadvantage and cardiovascular disease mortality in the Alameda County Study 1965 to 2000.

    abstract:PURPOSE:Socioeconomic disadvantage is often evaluated at single points in the adult life course in health research. Social mobility models suggest that socioeconomic patterns may also influence disease risk. This study examines cumulative socioeconomic disadvantage (CSD) in relation to cardiovascular disease mortality ...

    journal_title:Annals of epidemiology

    pub_type: 杂志文章


    authors: Johnson-Lawrence V,Galea S,Kaplan G

    更新日期:2015-02-01 00:00:00

  • Disease determinants of sporadic salmonellosis in four northern California counties. A case-control study of older children and adults.

    abstract::A population-based, case-control study of sporadic salmonellosis was conducted in 1988 and 1989 in four northern California counties. The study included 120 patients and 265 control subjects. Conditional logistic regression analysis (adjusted for age) revealed that patients were more likely to consume undercooked chic...

    journal_title:Annals of epidemiology

    pub_type: 杂志文章


    authors: Kass PH,Farver TB,Beaumont JJ,Genigeorgis C,Stevens F

    更新日期:1992-09-01 00:00:00

  • Clustering of risk factors for coronary heart disease. the longitudinal relationship with lifestyle.

    abstract:PURPOSE:The purpose of this study was to investigate whether or not clustering of biological coronary heart disease (CHD) risk factors exists and to investigate the longitudinal relationship between lifestyle parameters (dietary intake, daily physical activity, smoking behaviour, alcohol consumption) and a biological C...

    journal_title:Annals of epidemiology

    pub_type: 杂志文章


    authors: Twisk JW,Kemper HC,Van Mechelen W,Post GB

    更新日期:2001-04-01 00:00:00

  • Sexual orientation measurement and chronic disease disparities: National Health and Nutrition Examination Survey, 2009-2014.

    abstract:PURPOSE:To examine chronic disease disparities by sexual orientation measurement among sexual minorities. METHODS:We pooled data from the 2009-2014 National Health and Nutrition Examination Survey to examine differences in chronic disease prevalence between heterosexual and sexual minority people as defined by sexual ...

    journal_title:Annals of epidemiology

    pub_type: 杂志文章


    authors: Patterson JG,Jabson JM

    更新日期:2018-02-01 00:00:00

  • Combined measure of pro- and anti-oxidant exposures in relation to prostate cancer and colorectal adenoma risk: an update.

    abstract:PURPOSE:We previously proposed an oxidative balance score (OBS) and illustrated its practical application by using data from previously completed case-control studies of two neoplasms - sporadic colorectal adenoma and prostate cancer. In the present study we extend our analysis by substituting questionnaire-based measu...

    journal_title:Annals of epidemiology

    pub_type: 杂志文章


    authors: Goodman M,Bostick RM,Gross M,Thyagarajan B,Dash C,Flanders WD

    更新日期:2010-12-01 00:00:00

  • The emerging importance of genetics in epidemiologic research II. Issues in study design and gene mapping.

    abstract:PURPOSE:To provide a synthesis of current approaches to the discovery of genes associated with complex human diseases by examining the joint potential of traditional epidemiologic methods and current molecular techniques for gene discovery. METHODS:A discussion of optimal approaches for defining complex disease phenot...

    journal_title:Annals of epidemiology

    pub_type: 杂志文章,评审


    authors: Ellsworth DL,Manolio TA

    更新日期:1999-02-01 00:00:00

  • Comparison of three lifecourse models of poverty in predicting cardiovascular disease risk in youth.

    abstract:OBJECTIVE:Childhood poverty heightens the risk of adulthood cardiovascular disease (CVD), but the underlying pathways are poorly understood. Three lifecourse models have been proposed but have never been tested among youth. We assessed the longitudinal association of childhood poverty with CVD risk factors in 10-year-o...

    journal_title:Annals of epidemiology

    pub_type: 杂志文章


    authors: Kakinami L,Séguin L,Lambert M,Gauvin L,Nikiema B,Paradis G

    更新日期:2013-08-01 00:00:00

  • A prospective study of alcohol consumption and cataract extraction among U.S. women.

    abstract:PURPOSE:Alcohol consumption has been implicated in the pathogenesis of cataract in some, but not all analytic studies. To date, no prospective analysis of the relationship between alcohol consumption and cataract has been conducted in women. METHODS:We examined the association between alcohol consumption and cataract ...

    journal_title:Annals of epidemiology

    pub_type: 杂志文章


    authors: Chasan-Taber L,Willett WC,Seddon JM,Stampfer MJ,Rosner B,Colditz GA,Speizer FE,Hankinson SE

    更新日期:2000-08-01 00:00:00

  • Accounting for context in studies of health inequalities: a review and comparison of analytic approaches.

    abstract:BACKGROUND:A common epidemiologic objective is to evaluate the contribution of residential context to individual-level disparities by race or socioeconomic position. PURPOSE:We reviewed analytic strategies to account for the total (observed and unobserved factors) contribution of environmental context to health inequa...

    journal_title:Annals of epidemiology

    pub_type: 杂志文章,评审


    authors: Schempf AH,Kaufman JS

    更新日期:2012-10-01 00:00:00

  • Estimating the number of serious road injuries in the Netherlands.

    abstract:PURPOSE:This paper describes a new estimation method of the number of road injuries in The Netherlands. METHODS:The bases for this method are the hospital inpatient registry and the police crash record database. Both databases contain errors and omissions. The police database in particular suffers from serious underre...

    journal_title:Annals of epidemiology

    pub_type: 杂志文章


    authors: Reurings MC,Stipdonk HL

    更新日期:2011-09-01 00:00:00

  • Increasing the accuracy of the Expanded Programme on Immunization's cluster survey design.

    abstract::The Expanded Programme on Immunization (EPI) of the World Health Organization developed a cluster survey design for the rapid assessment of children's vaccination coverage in developing countries. Because of its simplicity and familiarity, the EPI methodology has been used for additional purposes, including the detect...

    journal_title:Annals of epidemiology

    pub_type: 杂志文章


    authors: Brogan D,Flagg EW,Deming M,Waldman R

    更新日期:1994-07-01 00:00:00