Abstract：
PURPOSE:Propose a five-step multigating, multimodal procedure for research case definition and identification of attention-deficit/hyperactivity disorder (AD/HD) in population-based epidemiologic studies. METHODS:Subjects included a birth cohort of all children born between 1976 and 1982 who remained in Rochester after age 5. Screening for AD/HD required 4 steps, using these sources: school/medical records, computerized diagnostic index, and private psychiatry records. In step 5, research criteria were applied to potential cases. The model for defining cases used combinations of three categories of information (DSM-IV, questionnaire, clinical diagnosis). Validity was tested by comparing medication treatment, substance abuse, school outcomes, and comorbidities between cases who did or did not meet DSM-IV criteria. RESULTS:Among 5718 subjects, 1344 potential cases were identified; 379 met research criteria. No difference in gender, treatment, school outcome, or professional making clinical diagnoses was found between cases who did (N=228) and did not (N=151) meet DSM-IV criteria. However, cases not meeting DSM-IV criteria were more inattentive (33.8% vs. 17.1%; p < 0.001), older (age 12.8 vs. 10.5 years; p=0.01), with less substance abuse (15.2% vs. 26.3%; p < 0.001) and psychiatric comorbidities (43.1% vs. 54.4%; p=0.031). CONCLUSIONS:If only DSM-IV criteria were applied, 151 cases would not have been identified. This study underscores the importance of using multiple sources and combinations of documented information for case definition and identification.
journal_name
Ann Epidemioljournal_title
Annals of epidemiologyauthors
Katusic SK,Barbaresi WJ,Colligan RC,Weaver AL,Leibson CL,Jacobsen SJdoi
10.1016/j.annepidem.2004.12.004keywords:
subject
Has Abstractpub_date
2005-07-01 00:00:00pages
430-7issue
6eissn
1047-2797issn
1873-2585pii
S1047-2797(05)00005-0journal_volume
15pub_type
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