Abstract：
PURPOSE:Although much value has been placed on type I error event probabilities in clinical trials, interpretive difficulties often arise that are directly related to clinical trial complexity. Deviations of the trial execution from its protocol, the presence of multiple treatment arms, and the inclusion of multiple end points complicate the interpretation of an experiment's reported alpha level. The purpose of this manuscript is to formulate the discussion of P values (and power for studies showing no significant differences) on the basis of the event whose relative frequency they represent. METHODS:Experimental discordance (discrepancies between the protocol's directives and the experiment's execution) is linked to difficulty in alpha and beta interpretation. Mild experimental discordance leads to an acceptable adjustment for alpha or beta, while severe discordance results in their corruption. RESULTS:Finally, guidelines are provided for allocating type I error among a collection of end points in a prospectively designed, randomized controlled clinical trial. CONCLUSIONS:When considering secondary end point inclusion in clinical trials, investigators should increase the sample size to preserve the type I error rates at acceptable levels.
journal_name
Ann Epidemioljournal_title
Annals of epidemiologyauthors
Moyé LAdoi
10.1016/s1047-2797(98)00003-9subject
Has Abstractpub_date
1998-08-01 00:00:00pages
351-7issue
6eissn
1047-2797issn
1873-2585pii
S1047-2797(98)00003-9journal_volume
8pub_type
杂志文章,评审abstract：PURPOSE:This study examined how race-ethnicity, nativity, and education interact to influence disparities in cardiovascular (CV) health, a new concept defined by the American Heart Association. We assessed whether race-ethnicity and nativity disparities in CV health vary by education and whether the foreign-born differ...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2013.04.012
更新日期：2013-07-01 00:00:00
abstract：PURPOSE:This cross-sectional study sought to identify diabetes accurately in a study population of 3681 women age 75 and older and to determine the association of diabetes with cognitive performance. METHODS:A previously validated test, the Telephone Interview of Cognitive Screening-Modified (TICSm) was given to asses...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/S1047-2797(03)00059-0
更新日期：2003-10-01 00:00:00
abstract：:We take a critical look at the meaning behind the number 87% given to 25-year-old Sophie, a BRCA1 and BRCA2 carrier. Sophie has been told she has an 87% chance of getting breast cancer. She is contemplating a preventive double mastectomy after genetic counseling and her physician's advice. Some 92% of British general ...
journal_title：Annals of epidemiology
pub_type： 杂志文章,评审
doi：10.1016/j.annepidem.2017.09.005
更新日期：2017-10-01 00:00:00
abstract：:The validity of a 77-item food-frequency questionnaire (FFQ) developed for a multicenter case-control study on diet and cancer in Italy was assessed. Trained interviewers administered the same FFQ to 452 volunteers from three Italian provinces (Pordenone, Genoa, and Forli) completed in two different seasons, at an int...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/1047-2797(95)00129-8
更新日期：1996-03-01 00:00:00
abstract：PURPOSE:Although prospective data are limited, recent cross-sectional studies support obesity as a cause of asthma. They also suggest that the association is present only among women. Our analysis examines possible sex-race differences in the relationship between obesity and asthma. METHODS:We examined data from the 2...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/s1047-2797(03)00054-1
更新日期：2003-11-01 00:00:00
abstract：:Some of the readjustment problems of Vietnam veterans have been attributed to posttraumatic stress disorder (PTSD). This case-control study compared demographic and military characteristics of 374 Vietnam veterans who had PTSD with 373 healthy Vietnam veterans. Veterans were chosen from the Agent Orange Registry, a De...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/1047-2797(91)90022-5
更新日期：1991-11-01 00:00:00
abstract：PURPOSE:The purpose of this study was to develop county-level estimates of poor health-related quality of life (HRQOL) among aged 65 years and older U.S. adults and to identify spatial clusters of poor HRQOL using a multilevel, poststratification approach. METHODS:Multilevel, random-intercept models were fit to HRQOL ...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2016.09.016
更新日期：2017-01-01 00:00:00
abstract：PURPOSE:Few studies have examined the association between intimate partner violence (IPV) and health outcomes for both women and men. The current study examined this relationship for women and men as part of a large cross-sectional public-health survey that collected information on a range of health behaviors and healt...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2008.02.005
更新日期：2008-07-01 00:00:00
abstract：PURPOSE:Standard estimation of ordered odds ratios requires the constraint that the etiologic effects of exposure are homogenous across thresholds of the ordered response. We present a method to relax this often-unrealistic constraint. METHODS:The kernel of the proposed method is the expansion of observed data into "p...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2003.08.003
更新日期：2004-03-01 00:00:00
abstract：PURPOSE:A U-shaped relation between alcohol use and mortality may be due to biological hormesis, differential response (i.e., effect modification) by health status or changes in alcohol use with ill-health and aging (i.e., reverse causality).We examined whether alcohol had the same association with mortality in healthy...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2009.01.011
更新日期：2009-06-01 00:00:00
abstract：PURPOSE:To assess the association of antenatal and postnatal social support with postpartum depression (PPD). METHODS:We carried out a prospective cohort study of 534 pregnant women between February and September 2007 in Hunan, China. The association between prenatal and postnatal social support with PPD was examined....
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2009.03.008
更新日期：2009-09-01 00:00:00
abstract：PURPOSE:We aimed to explore the relationship between physician characteristics and their prescribing behavior regarding category D and X drugs for pregnant women by using a population-based data set in Taiwan. METHODS:The sampled population for the study included 14,430 women. These women received a total of 198,420 p...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2012.11.007
更新日期：2013-02-01 00:00:00
abstract：PURPOSE:The aim of this work was to evaluate whether the number of components influences the diagnostic accuracy of a diet quality index and whether this association is affected by the intercorrelation structure of components and by the association of components with an outcome (intracorrelation). METHODS:Simulated da...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2009.03.019
更新日期：2009-10-01 00:00:00
abstract：PURPOSE:The metabolic syndrome (MS) is conceived as a cluster of disorders that increase risk for coronary heart disease and type 2 diabetes. Studies examining its structure primarily have used an exploratory factor analytic technique, but yielded discrepant results. There also is a lack of research that investigates w...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2005.06.049
更新日期：2006-02-01 00:00:00
abstract：OBJECTIVES:To examine the longitudinal associations between exposure to violence with a weapon during the past year among adolescents and hypertension during adulthood, including the extent to which adult cardiovascular risk factors mediated the association. METHODS:Secondary analysis of the National Longitudinal Stud...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2013.12.004
更新日期：2014-03-01 00:00:00
abstract：:Populations vary in consistency of diets. The precision of estimates (E) of nutrient intake depends both on the ratio (R) of intraindividual to interindividual variances, as well as on the number of days of dietary intake recorded (k). We present baseline data from 872 participants in the Trial of Antihypertensive Int...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/1047-2797(93)90085-i
更新日期：1993-11-01 00:00:00
abstract：PURPOSE:To determine if the timing for requesting signed permission to access personal health services utilization records affects authorization or survey response rates. METHODS:A screening question about in-principle willingness to permit access to personal health services utilization records was included in a mail-...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/s1047-2797(01)00261-7
更新日期：2002-07-01 00:00:00
abstract：PURPOSE:Preterm birth (PTB) has been associated with a later increased risk of maternal cardiovascular disease (CVD). We hypothesized a more pronounced relation between early or recurrent PTB and maternal CVD risk. METHODS:We related PTB severity (earlier gestational age at delivery) and recurrence (>/=2) among women ...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2010.05.007
更新日期：2010-08-01 00:00:00
abstract：:We have provided recent evidence suggesting that a systematic error may be operating in prospective epidemiological mortality studies that have reported "light" or "moderate" regular use of alcohol to be "protective" against coronary heart disease. Using meta-analysis as a research tool, a hypothesis first suggested b...
journal_title：Annals of epidemiology
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.annepidem.2007.01.005
更新日期：2007-05-01 00:00:00
abstract：PURPOSE:The purpose of this study was to determine the prevalence of autism spectrum disorders (ASD) and associated characteristics among 8-year-old children. METHODS:This is an ongoing active, population-based surveillance program conducted in South Carolina as part of the Centers for Disease Control and Prevention's...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2007.10.013
更新日期：2008-02-01 00:00:00
abstract：PURPOSE:The role of estrogen in cardiovascular health remains contested with discrepancies between findings from randomized controlled trials and observational studies. Mendelian randomization, which assesses the effect of lifelong endogenous exposure, may help elucidate these discrepancies. METHODS:We used separate s...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2016.01.005
更新日期：2016-03-01 00:00:00
abstract：PURPOSE:To identify, map, and synthesize the individual-level key associations and modes of exposure for hepatitis C virus (HCV) infection in the Middle East and North Africa (MENA), the most affected region by HCV. METHODS:Source of data was the MENA HCV Epidemiology Synthesis Project database, populated through syst...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2018.03.007
更新日期：2018-07-01 00:00:00
abstract：PURPOSE:The aim of the study is to investigate associations between socioeconomic and occupational factors and lymphoproliferative (LP) diseases. METHODS:We performed a follow-up study on the economically active Swedish population, based on the Swedish Family-Cancer Database. Standardized incidence ratios and 95% conf...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2005.09.002
更新日期：2006-05-01 00:00:00
abstract：PURPOSE:Although vaginal douching is associated with several adverse outcomes, the reasons why women douche have not been studied prospectively. METHODS:Non-pregnant (N = 3620) women aged 15 to 44 years presenting for routine care at 12 clinics in Birmingham, Alabama, participated in a longitudinal study of vaginal fl...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2007.05.015
更新日期：2008-01-01 00:00:00
abstract：PURPOSE:To explore agreement on cancer occurrence and site among Medicare Part A, Massachusetts Cancer Registry, and death certificates. METHODS:We linked these data sources with the cohort of the population-based East Boston Senior Health Project, a component of the National Institute on Aging's Established Populatio...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/s1047-2797(98)00031-3
更新日期：1999-01-01 00:00:00
abstract：PURPOSE:The angiotensinogen gene (AGT), which encodes the precursor of the vasoactive hormone angiotensin II, has been reported to be associated with hypertension in Caucasian and Japanese populations. We examined the relationship between two common molecular variants of AGT, T174M and M235T and blood pressure in two c...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/s1047-2797(98)00060-x
更新日期：1999-05-01 00:00:00
abstract：PURPOSE:Before AIDS, endemic (African) Kaposi sarcoma (KS) was noted to occur in volcanic areas and was postulated to result from dirt chronically embedded in the skin of the lower extremities. The primary cause of all KS types is KS-associated herpesvirus (KSHV) infection, but cofactors contribute to the neoplasia. We...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2009.04.002
更新日期：2009-08-01 00:00:00
abstract：PURPOSE:Much cross-sectional work reports an association between neighborhood disadvantage and adverse birth outcomes. Limitations of this work include that mothers with pre-existing unmeasured morbidity may "select" into, or out of, certain neighborhoods. This selection issue remains a key rival explanation for work c...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2019.05.005
更新日期：2019-08-01 00:00:00
abstract：PURPOSE:Ultraviolet light from sunlight and other sources is the major environmental risk factor for melanoma of the skin. Humans also derive most of their vitamin D from exposure to sunlight. This article reviews current evidence that vitamin D might play a preventive role in the development of melanoma or affect tumo...
journal_title：Annals of epidemiology
pub_type： 杂志文章,评审
doi：10.1016/j.annepidem.2009.01.005
更新日期：2009-07-01 00:00:00
abstract：PURPOSE:Studies have shown a high prevalence of weight loss in older adults is associated with an increased risk of death. We investigated this in a population-based study. METHODS:Persons living in Beaver Dam, Wisconsin, participated in a baseline examination between 1988 and 1990 (n=4926). A medical examination and ...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2004.12.003
更新日期：2005-08-01 00:00:00
