Vitamin D and melanoma.

Abstract:

PURPOSE:Ultraviolet light from sunlight and other sources is the major environmental risk factor for melanoma of the skin. Humans also derive most of their vitamin D from exposure to sunlight. This article reviews current evidence that vitamin D might play a preventive role in the development of melanoma or affect tumor aggressiveness or melanoma patient outcomes. METHODS:Literature review. RESULTS:The vitamin D receptor has been identified in normal melanocytes as well as melanoma cell lines and primary tissue. A few studies have demonstrated relationships of functional polymorphisms in the vitamin D receptor with melanoma risk or tumor aggressiveness. Identifying an independent influence of vitamin D on melanoma risk is hampered by overwhelming confounding by the carcinogenic influence of ultraviolet radiation on skin melanocytes. Nonetheless an inverse association was suggested in a few studies with greater consumption of dairy foods or other dietary sources. Several lines of evidence are consistent with a potential influence for vitamin D on site-specific aggressiveness of skin melanomas, therapeutic response or patient survival. CONCLUSION:Additional research is needed to determine whether vitamin D may have a preventive role in melanoma incidence or a salutary influence on melanoma patient outcome.

journal_name

Ann Epidemiol

journal_title

Annals of epidemiology

authors

Egan KM

doi

10.1016/j.annepidem.2009.01.005

subject

Has Abstract

pub_date

2009-07-01 00:00:00

pages

455-61

issue

7

eissn

1047-2797

issn

1873-2585

pii

S1047-2797(09)00016-7

journal_volume

19

pub_type

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