Nicotine dependence predicts repeated use of prescribed opioids. Prospective population-based cohort study.

Abstract:

PURPOSE:The aim of this study was to evaluate prospectively smoking dependence as a predictor of repeated use of prescribed opioids in non-cancer patients. METHODS:We conducted a prospective population-based study cohort of 12,848 men and 15,894 women 30-75 years of age in health surveys in Norway during 2000-2002 with repeated opioid prescriptions (12+, during 2004-2007) recorded in the Norwegian Prescription Database as the outcome measure. Information on history of smoking and potential confounders was obtained at baseline by self-administered questionnaires. For smoking, participants were divided into categories: never; previously heavy (stopped maximum of 5 years earlier; 10+ cigarettes daily); daily not heavy (1-9 cigarettes); dependent daily smokers (10+ cigarettes), and other (previously and/or not daily). Odds ratios (ORs) with 95% confidence intervals (CIs) were estimated by logistic regression. RESULTS:During follow-up, 335 (1.5%) of survey participants were registered with 12+ prescriptions of opioids during the period 2004-2007. The prevalence of repeated prescription frequency of opioids was higher for men and women with a history of smoking. The adjusted OR for prescribed opioids for dependent daily smokers was 3.1 (95% CI: 2.3-4.1), for daily non-heavy smokers 1.8 (1.2-2.7), and for previous heavy smokers 1.8 (1.1-3.0), compared with never-smokers as reference. CONCLUSIONS:Results of the study suggest that smoking dependence may predict more frequent use of opioids.

journal_name

Ann Epidemiol

journal_title

Annals of epidemiology

authors

Skurtveit S,Furu K,Selmer R,Handal M,Tverdal A

doi

10.1016/j.annepidem.2010.03.010

subject

Has Abstract

pub_date

2010-12-01 00:00:00

pages

890-7

issue

12

eissn

1047-2797

issn

1873-2585

pii

S1047-2797(10)00055-4

journal_volume

20

pub_type

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