Abstract：
PURPOSE:The purpose of this study was to estimate the heart rate variability (HRV)-related lifetime cardiovascular disease (CVD) risk. METHODS:We followed 9744 participants without baseline CVD and used a life-table approach to estimate lifetime CVD risk (coronary heart disease, heart failure, and stroke) from 45 through 85 years according to several HRV measures (the SD of RR intervals [SDNN], the root mean square of successive differences of successive RR intervals, the mean of all normal RR intervals [meanNN], low-frequency [LF] and high-frequency [HF] power, and the LF/HF ratio). RESULTS:During 192,110 person-years of follow-up, we documented 2856 CVD events. Cox regression analyses with the false discovery rate method correction showed independent associations of SDNN, meanNN, LF, and LF/HF in women with CVD. Lifetime CVD risks in the lowest compared with the highest tertile were significantly increased in men for LF/HF (51.3% [95% confidence interval, 47.3-54.7] vs. 43.9% [40.1-47.2]), and in women for SDNN (39.4% [36.0-43.0] vs. 29.9% [26.3-33.0]), meanNN (39.3% [35.7-42.7] vs. 28.9% [25.7-31.7]), LF (39.4% [35.9-43.0] vs. 30.0% [26.2-33.2]), and LF/HF (37.6% [33.9-40.9] vs. 30.0% [26.8-32.7]). CONCLUSIONS:Greater HRV was modestly associated with lower lifetime CVD risk.
journal_name
Ann Epidemioljournal_title
Annals of epidemiologyauthors
Kubota Y,Chen LY,Whitsel EA,Folsom ARdoi
10.1016/j.annepidem.2017.08.024subject
Has Abstractpub_date
2017-10-01 00:00:00pages
619-625.e2issue
10eissn
1047-2797issn
1873-2585pii
S1047-2797(17)30515-Xjournal_volume
27pub_type
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journal_title：Annals of epidemiology
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journal_title：Annals of epidemiology
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journal_title：Annals of epidemiology
pub_type： 杂志文章
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journal_title：Annals of epidemiology
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更新日期：2018-01-01 00:00:00
