Abstract：
PURPOSE:Preterm birth is associated with gastric acid-related disorders in infancy, but no investigators have examined this association beyond early childhood. We used antisecretory medication data to explore whether preterm birth is associated with gastric acid-related disorders in young adulthood. METHODS:We conducted a national cohort study of 626,811 individuals born in Sweden in 1973 to 1979, followed up for antisecretory (proton pump inhibitor and H2-receptor antagonist) medication prescriptions from all outpatient and inpatient pharmacies nationwide from 2005 to 2009 (ages 25.5-37.0 years). We excluded individuals with congenital anomalies, and examined potential confounding by other comorbidities identified on the basis of oral anti-inflammatory or corticosteroid medication prescription. RESULTS:Gestational age at birth was inversely associated with antisecretory medication prescription in young adulthood. Adjusted odds ratios for ≥1 antisecretory medication prescription/year were 3.38 (95% confidence interval [95% CI], 1.73-6.62) for individuals born at 22-27 weeks, 1.38 (95% CI, 1.19-1.60) for those born at 28-34 weeks, and 1.19 (95% CI, 1.06-1.32) for those born at 35-36 weeks, relative to those born full-term (37-42 weeks). Exclusion of individuals who were prescribed oral anti-inflammatory or corticosteroid medications (≥1/year) had little effect on these results. CONCLUSIONS:These findings suggest that low gestational age at birth may be independently associated with an increased risk of gastric acid-related disorders in young adulthood.
journal_name
Ann Epidemioljournal_title
Annals of epidemiologyauthors
Crump C,Winkleby MA,Sundquist J,Sundquist Kdoi
10.1016/j.annepidem.2012.02.006subject
Has Abstractpub_date
2012-04-01 00:00:00pages
233-8issue
4eissn
1047-2797issn
1873-2585pii
S1047-2797(12)00021-Xjournal_volume
22pub_type
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abstract：PURPOSE:The Multiple Risk Factor Intervention Trial (MRFIT), a randomized clinical trial for the primary prevention of coronary heart disease, enrolled 12,866 men (including 8194 cigarette smokers) aged 35-57 years at 22 clinical centers across the United States. Participants were randomized either to special intervent...
journal_title：Annals of epidemiology
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更新日期：1996-11-01 00:00:00
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pub_type： 杂志文章
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pub_type： 杂志文章,评审
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更新日期：2007-04-01 00:00:00
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journal_title：Annals of epidemiology
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更新日期：2014-12-01 00:00:00
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pub_type： 历史文章,杂志文章
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更新日期：2019-09-01 00:00:00
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更新日期：2008-08-01 00:00:00
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journal_title：Annals of epidemiology
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更新日期：2008-03-01 00:00:00
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pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1991-08-01 00:00:00
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更新日期：2016-08-01 00:00:00
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更新日期：2013-11-01 00:00:00
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更新日期：1991-05-01 00:00:00
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更新日期：1993-09-01 00:00:00
