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Prognostic impact of tumor MET expression among patients with stage IV gastric cancer: a Danish cohort study.

Abstract：

PURPOSE:We aimed to investigate the prevalence and prognostic impact of tumor mesenchymal epithelial transition factor (MET) expression in stage IV gastric cancers in a real-world clinical setting because existing evidence is sparse. METHODS:The study included archived cancer specimens from 103 stage IV gastric cancer patients (2003-2010). We analyzed MET-protein expression by immunohistochemistry (MET-positive if ≥25% of tumor cells showed MET expression). We calculated overall survival using the Kaplan-Meier method and hazard ratios comparing mortality among MET-positive and MET-negative patients using Cox regression adjusted for age, gender, and comorbidity. RESULTS:We found that 62.1% (95% confidence interval, 52.0-71.5) of patients had MET-positive tumors. Median survival was lower among patients with MET-positive tumors (3.5 months) than among patients with MET-negative tumors (9.6 months), corresponding to an adjusted hazard ratio of 2.2 (95% confidence interval, 1.3-3.7). CONCLUSIONS:Tumor MET expression is prevalent and has substantial prognostic impact in stage IV gastric cancer patients.

journal_name

Ann Epidemiol

journal_title

Annals of epidemiology

authors

Erichsen R,Kelsh MA,Oliner KS,Nielsen KB,Frøslev T,Lænkholm AV,Vyberg M,Acquavella J,Sørensen HT

doi

10.1016/j.annepidem.2016.05.002

subject

Has Abstract

pub_date

2016-07-01 00:00:00

pages

500-503

issue

7

eissn

1047-2797

issn

1873-2585

pii

S1047-2797(16)30129-6

journal_volume

26

pub_type

杂志文章

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