Abstract：
PURPOSE:The health of infants that are HIV-exposed and -uninfected (HEU) is a major public health concern as HIV becomes a chronic condition. We investigate the interrelationship between maternal viral suppression, maternal weight status, breastfeeding, and infants that are HEU. METHODS:The Kabeho study followed 502 HEU infants in Kigali, Rwanda, for 24 months from 2013 to 2014. We use a structural equation modeling approach to investigate the dynamic relationships between viral suppression, maternal weight change, breastfeeding, and infant length-for-age z-score (LAZ) as defined by the WHO. RESULTS:Older mothers are more likely to be virally suppressed and to breastfeed. Viral suppression and the mother being on antiretroviral treatment for longer were related to lower infant LAZ at three months. A more positive maternal weight change was related to higher infant LAZ at the end of each period. At 12 months, a higher infant LAZ was related to increased probability of continued breastfeeding. At 18 months, continued breastfeeding was related to lower LAZ, and food shortages were related to higher LAZ. CONCLUSION:There is a complex interrelationship between viral suppression, maternal weight change, breastfeeding, and infant LAZ. These relationships demonstrate the link between maternal and infant health in the context of HIV.
journal_name
Ann Epidemioljournal_title
Annals of epidemiologyauthors
Lane C,Adair L,Bobrow E,Ndayisaba GF,Asiimwe A,Mugwaneza Pdoi
10.1016/j.annepidem.2020.08.008subject
Has Abstractpub_date
2021-01-01 00:00:00pages
1-6.e1eissn
1047-2797issn
1873-2585pii
S1047-2797(20)30289-1journal_volume
53pub_type
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journal_title：Annals of epidemiology
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pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2006-12-01 00:00:00
