Abstract：
PURPOSE:Prospective evidence about whether the association of childhood adversity and psychopathology attenuates across the lifecourse and whether effects on mid-life psychopathology are mediated through adolescent and early adulthood psychopathology is limited. METHODS:Data were from the 1958 British Birth Cohort, a 45-year study of 98% of births in 1 week in 1958 in England, Scotland, and Wales. Outcomes included International Statistical Classification of Diseases (ICD-10) diagnoses for affective and anxiety disorders at 45 years and psychopathology at 16 years and 23 years. Multiple multi-informant measures of childhood adversity were available at 7, 11, and 16 years, with additional retrospective measures of parental sexual and physical abuse at 45 years. Analyses were determined on the basis of N = 9377; 59% of the surviving sample. RESULTS:After adjustment for socioeconomic covariates, childhood adversities were associated with adolescent, early adulthood, and mid-life psychopathology: most associations did not attenuate with age. Mid-life associations were significantly fully or partially mediated by early adulthood psychopathology: cumulative adversity, illness, sexual abuse, and physical abuse remained significantly associated with mid-life psychopathology. CONCLUSIONS:The findings confirm the importance of preventing exposure to adversity and suggest that effects of adversity on mid-life psychopathology may operate through psychopathology in early adulthood. Future research is needed to examine other intermediary factors which may explain these associations.
journal_name
Ann Epidemioljournal_title
Annals of epidemiologyauthors
Clark C,Caldwell T,Power C,Stansfeld SAdoi
10.1016/j.annepidem.2010.02.008subject
Has Abstractpub_date
2010-05-01 00:00:00pages
385-94issue
5eissn
1047-2797issn
1873-2585pii
S1047-2797(10)00031-1journal_volume
20pub_type
杂志文章abstract：:Mexican Americans have a high prevalence of diabetes relative to non-Hispanic whites, but paradoxically experience a lower prevalence of myocardial infarction and lower cardiovascular mortality (at least in men). To determine whether Mexican Americans might be more resistant to the atherogenic effects of diabetes than...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/1047-2797(92)90043-p
更新日期：1992-01-01 00:00:00
abstract：PURPOSE:To examine the associations among Alzheimer's disease, hip fractures, and falls in elderly Canadians > or = 65 years of age (n=1513) who participated in the National Population Health Survey for Health Institutions between 1994 and 1995. METHODS:The survey was designed to provide health-related information for...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2003.08.005
更新日期：2004-05-01 00:00:00
abstract：PURPOSE:This study examined how race-ethnicity, nativity, and education interact to influence disparities in cardiovascular (CV) health, a new concept defined by the American Heart Association. We assessed whether race-ethnicity and nativity disparities in CV health vary by education and whether the foreign-born differ...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2013.04.012
更新日期：2013-07-01 00:00:00
abstract：:The following is based on my remarks on receipt of the 2015 ACE award for outstanding contributions to epidemiology. ...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2016.02.005
更新日期：2016-04-01 00:00:00
abstract：PURPOSE:To carry out pattern analyses of dietary and lifestyle factors in relation to risk of esophageal and gastric cancers. METHODS:We evaluated risk factors for esophageal adenocarcinoma (EA), esophageal squamous cell carcinoma (ESCC), gastric cardia adenocarcinoma (GCA), and other gastric cancers (OGA) using data ...
journal_title：Annals of epidemiology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.annepidem.2010.11.019
更新日期：2011-07-01 00:00:00
abstract：PURPOSE:We sought to examine the importance of childhood circumstances, adult socioeconomic status, and material circumstances to physical and mental functioning among middle-aged women and men. METHODS:The data were collected among the employees of the City of Helsinki by mailed questionnaires from 2000 to 2002 (7148...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2006.11.003
更新日期：2007-06-01 00:00:00
abstract：PURPOSE:This study examines the importance of clinical risk factors for predicting self-ratings of general health status, with and without controls for a broad range of self-reported indicators of physical and psychological well-being. METHODS:Ordered probit models, estimated on 928 respondents aged 54 years and older...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/s1047-2797(03)00077-2
更新日期：2004-01-01 00:00:00
abstract：PURPOSE:To estimate and compare prevalence rates of lifetime health conditions by inferred duration of illicit drug use among the general U.S. adult population and to investigate associations between duration of use of each specific illicit drug (marijuana, cocaine, heroin, hallucinogens, or inhalant) and each lifetime...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2010.01.003
更新日期：2010-04-01 00:00:00
abstract：:Cardiovascular reactivity is the change in blood pressure, pulse, and other parameters of cardiovascular function in response to a challenging task. During the conduct of cardiovascular reactivity protocols, researchers frequently use automated blood pressure devices to measure blood pressure reactivity. However, the ...
journal_title：Annals of epidemiology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/1047-2797(90)90019-o
更新日期：1990-10-01 00:00:00
abstract：PURPOSE:A review of recent threats and challenges to epidemiology suggests that some represent an opportunity to advance the discipline while others are a major threat to conducting epidemiologic work. METHODS:Two issues are identified which should advance the publication and conduct of epidemiologic research. Three a...
journal_title：Annals of epidemiology
pub_type：
doi：10.1016/s1047-2797(97)00206-8
更新日期：1998-02-01 00:00:00
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journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2014.06.096
更新日期：2014-09-01 00:00:00
abstract：:The association of physical activity to plasma lipid and lipoprotein levels was examined cross-sectionally in 634 elderly, postmenopausal women whose mean age was 70.7 years. Leisure-time physical activity in kilocalories per week was assessed by the Paffenbarger Questionnaire, a composite index of sports/recreation, ...
journal_title：Annals of epidemiology
pub_type： 杂志文章,多中心研究
doi：10.1016/1047-2797(93)90061-8
更新日期：1993-07-01 00:00:00
abstract：PURPOSE:Gastroesophageal reflux disease is an important and increasingly common condition. Both overweight and high fat food consumption have been implicated as causes of reflux disease. We examined the relationship of overweight, high dietary fat intake, and other factors with reflux disease hospitalization. METHODS:...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/s1047-2797(99)00020-4
更新日期：1999-10-01 00:00:00
abstract：PURPOSE:Examine the complex relationships among metabolic syndrome components in black and white individuals by growth periods. METHODS:Path analyses of metabolic syndrome components were performed on 8203 black and white healthy subjects (64.3% white and 47.9% male) comprising children (4-11 years), adolescents (12-1...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2007.07.090
更新日期：2008-02-01 00:00:00
abstract：PURPOSE:Studies have shown a high prevalence of weight loss in older adults is associated with an increased risk of death. We investigated this in a population-based study. METHODS:Persons living in Beaver Dam, Wisconsin, participated in a baseline examination between 1988 and 1990 (n=4926). A medical examination and ...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2004.12.003
更新日期：2005-08-01 00:00:00
abstract：:The longitudinal relationship between serum levels of lipoproteins and lifestyle measures (e.g., intake of cholesterol, carbohydrates, saturated fatty acids [SFA], polyunsaturated fatty acids [PUFA], the PUFA/SFA (P:S) ratio, alcohol consumption, smoking behavior, and daily physical activity) was investigated over a p...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/1047-2797(96)00003-8
更新日期：1996-05-01 00:00:00
abstract：PURPOSE:The Multiple Risk Factor Intervention Trial (MRFIT), a randomized clinical trial for the primary prevention of coronary heart disease, enrolled 12,866 men (including 8194 cigarette smokers) aged 35-57 years at 22 clinical centers across the United States. Participants were randomized either to special intervent...
journal_title：Annals of epidemiology
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/s1047-2797(96)00123-8
更新日期：1997-02-01 00:00:00
abstract：:Trends in stroke incidence, prevalence, fatality, and severity were examined in Framingham Study subjects, aged 55 to 64, during 3 successive decades beginning in 1953, 1963, and 1973. There was no significant decline in incidence or prevalence of total stroke and transient ischemic attacks (TIAs). In women, but not m...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/1047-2797(93)90098-o
更新日期：1993-09-01 00:00:00
abstract：PURPOSE:The purpose of this study was to investigate the association of early social environment with Kawasaki disease (KD). METHODS:We analyzed the data of children aged up to 10 years derived from the 21st Century Longitudinal Survey in Newborns (n = 41,872) in Japan. Parental education, total household income, and ...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2018.10.010
更新日期：2019-01-01 00:00:00
abstract：PURPOSE:The Black Women's Health Study (BWHS) was designed to investigate determinants of health and disease in US black women. More than 64,000 women are enrolled in the BWHS cohort. This study assessed the relative validity of the 68-item food frequency questionnaire (FFQ) used in the BWHS baseline questionnaire. ME...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/s1047-2797(02)00253-3
更新日期：2003-02-01 00:00:00
abstract：PURPOSE:Population-based cancer incidence rates of the corpus uteri, cervix uteri, and ovaries are underestimated if they fail to remove women not at risk for developing the cancers from the denominator in the race calculation. This study compares incidence rates among selected racial groups for these cancers before an...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2006.06.001
更新日期：2006-12-01 00:00:00
abstract：PURPOSE:To examine geographic variation in the incidence of ischemic stroke (IS) and acute myocardial infarction (AMI) in Finland during 1991-2003. METHODS:Data included all cases of first IS (n = 115,383) and AMI (n = 205,213) in persons aged 35-84 years. We used full Bayesian spatial shared component disease models ...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2007.10.008
更新日期：2008-03-01 00:00:00
abstract：PURPOSE:Health of the general population is improving along a number of major health dimensions. Using a cumulative deficits approach, we investigated whether such improvements were evident at the level of minor health traits. METHODS:We selected 37 small-effect traits consistently measured in the 9th (performed in 19...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2008.06.005
更新日期：2008-09-01 00:00:00
abstract：PURPOSE:Preterm birth is associated with gastric acid-related disorders in infancy, but no investigators have examined this association beyond early childhood. We used antisecretory medication data to explore whether preterm birth is associated with gastric acid-related disorders in young adulthood. METHODS:We conduct...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2012.02.006
更新日期：2012-04-01 00:00:00
abstract：PURPOSE:In 1991, California implemented a law that mandated a background check for all firearm purchases with limited exceptions (comprehensive background check or CBC policy) and prohibited firearm purchase and possession for persons convicted within the past 10 years of certain violent crimes classified as misdemeano...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2018.10.001
更新日期：2019-02-01 00:00:00
abstract：PURPOSE:Social and economic contextual factors may promote concurrent sexual partnerships, which can accelerate population HIV transmission and are more common among African Americans than U.S. Whites. We investigated the relationship between contextual factors and concurrency. METHODS:We analyzed past 12-month concur...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2013.08.002
更新日期：2013-11-01 00:00:00
abstract：PURPOSE:The aim of the study is to investigate associations between socioeconomic and occupational factors and lymphoproliferative (LP) diseases. METHODS:We performed a follow-up study on the economically active Swedish population, based on the Swedish Family-Cancer Database. Standardized incidence ratios and 95% conf...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2005.09.002
更新日期：2006-05-01 00:00:00
abstract：:Intervention studies are now viewed as a useful and necessary approach to understanding the relation between nutrition and cancer. Over 20 such studies have been initiated in the past 7 years. Foreign countries may be an attractive site for such investigations, mainly because of desirable population characteristics su...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/1047-2797(90)90010-p
更新日期：1990-12-01 00:00:00
abstract：PURPOSE:The purpose of the study was to examine the risk of severe maternal morbidity (SMM)-a composite of serious, potentially life-threatening conditions related to childbirth-among subgroups of nulliparous women with Asian and Pacific Islander race/ethnicity. METHODS:This study used linked hospital discharge and vi...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2020.07.016
更新日期：2020-12-01 00:00:00
abstract：PURPOSE:We examined the role of smoking in the two dimensions behind the time trends in adult mortality in European countries, that is, rectangularization of the survival curve (mortality compression) and longevity extension (increase in the age-at-death). METHODS:Using data on national sex-specific populations aged 5...
journal_title：Annals of epidemiology
pub_type： 杂志文章
doi：10.1016/j.annepidem.2015.01.007
更新日期：2015-04-01 00:00:00
