Birth weight was longitudinally associated with cardiometabolic risk markers in mid-adulthood.

Abstract:

PURPOSE:Birth weight (BW) is associated with risk of cardiovascular (CV) disease. The findings from studies examined the association of BW with metabolic markers of CV risk were inconsistent and controversial. We examined the association of BW with insulin resistance and blood lipids using repeated measures up to mid-adulthood. METHODS:Data from seven screenings of the Bogalusa Heart Study-a longitudinal study of cardiovascular risk factors in Bogalusa, LA-are analyzed using generalized estimation equations method. Participants with birth data and at least one measurement of study outcomes between 18 and 44 years (n = 2,034) were included. RESULTS:BW is inversely associated with insulin resistance, triglycerides, and total cholesterol (P < .01 for all). For 1-kg decrease in BW, insulin resistance increased by 2.3 units, 95% confidence interval (CI) = 0.7-3.9; triglycerides by 8.7 mg per dL, 95% CI = 4.9-12.4, and total cholesterol by 5.4 mg per dL, 95% CI = 1.8-9.1. The association of body mass with adult blood lipids levels is weaker in persons with low versus normal BW. CONCLUSIONS:The study provides strong evidence of an inverse relationship of BW with adulthood cardiometabolic risk profile. Persons born with low BW are maybe less responsive to preventive interventions aiming at weight reduction.

journal_name

Ann Epidemiol

journal_title

Annals of epidemiology

authors

Mzayek F,Cruickshank JK,Amoah D,Srinivasan S,Chen W,Berenson GS

doi

10.1016/j.annepidem.2016.07.013

subject

Has Abstract

pub_date

2016-09-01 00:00:00

pages

643-7

issue

9

eissn

1047-2797

issn

1873-2585

pii

S1047-2797(16)30235-6

journal_volume

26

pub_type

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