Abstract：
PURPOSE:Breast density and body mass index (BMI) are correlated attributes and are both potentially modifiable risk factors for breast cancer. However, relationships between these factors and risk of molecularly-defined subtypes of breast cancer have not been established. METHODS:We used breast density and BMI data collected by the Breast Cancer Surveillance Consortium from 1,054,466 women ages 40 to 84 years receiving mammography, including 13,797 women subsequently diagnosed with breast cancer. Cases were classified into three groups on the basis of expression of the estrogen receptor (ER), progesterone receptor (PR), and HER2:1) ER-positive (ER+, n = 10,026), 2) HER2-expressing (ER-negative/PR-negative/HER2-positive, n = 308), or triple-negative (ER-negative/PR-negative/HER2-negative, n = 705). Using Cox regression, we evaluated subtype-specific associations with breast density and BMI. RESULTS:Breast density was similarly positively associated with risk of all subtypes, especially among women ages 40 to 64 years. BMI was positively associated with risks of ER+ and triple-negative breast cancer in women ages 50 to 84 who were not users of hormone therapy. CONCLUSIONS:Breast density is positively associated with breast cancer risk, regardless of disease subtype. Associations with BMI appear to vary more by breast cancer subtype. Additional studies are needed to confirm and further characterize risk factors for HER2-expressing and triple-negative breast cancer.
journal_name
Ann Epidemioljournal_title
Annals of epidemiologyauthors
Phipps AI,Buist DS,Malone KE,Barlow WE,Porter PL,Kerlikowske K,O'Meara ES,Li CIdoi
10.1016/j.annepidem.2012.02.002subject
Has Abstractpub_date
2012-05-01 00:00:00pages
340-8issue
5eissn
1047-2797issn
1873-2585pii
S1047-2797(12)00017-8journal_volume
22pub_type
杂志文章abstract：PURPOSE:Continuous monitoring of health determinants in populations is necessary to predict future disease burdens. The objective of this study was to assess the prevalences of major risk factors for lifestyle diseases for 8 years (1993 to 2000) in representative samples of the general population. METHODS:Independent ...
journal_title：Annals of epidemiology
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abstract：PURPOSE:Whether or which blood heavy metal levels (BHMLs) influence elevating intraocular pressure (IOP) are unknown. We examined the relationship among blood lead, mercury, and cadmium levels, blood pressure (BP), and IOP and assessed whether BP mediates these BHMLs-IOP associations. METHODS:We analyzed data on 8371 ...
journal_title：Annals of epidemiology
pub_type： 杂志文章
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abstract：PURPOSE:The purpose of this study is to map type 2 diabetes susceptibility genes in West African ancestral populations of African-Americans, through an international collaboration between West African and US investigators. DESIGN AND METHODS:Affected sib-pairs (ASP) along with unaffected spouse controls are being enro...
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journal_title：Annals of epidemiology
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pub_type： 杂志文章
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journal_title：Annals of epidemiology
pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章,评审
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更新日期：2006-12-01 00:00:00
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更新日期：2017-01-01 00:00:00
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更新日期：2018-11-01 00:00:00
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journal_title：Annals of epidemiology
pub_type： 杂志文章
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更新日期：2006-12-01 00:00:00
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journal_title：Annals of epidemiology
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